Clinical trials: Brain Neoplasm
Surgical Site Infection, Brain Tumor
Infection Prevention Bundle in Brain Tumor Surgery
This study aimed to evaluate the effectiveness of an infection prevention bundle on surgical site infections in patients undergone brain tumor surgery.
- Trial name
- NCT04285697
- Testing
- infection prevention bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Medulloblastoma
Social Cognition and Brain Integrity in Survivors of Pediatric Medulloblastoma
Survivors of pediatric medulloblastoma (MB) are at-risk for neurocognitive and social deficits, including specific skills such as facial affect recognition which is the ability to recognize the emotional expressions of another…
- Trial name
- NCT02747576
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Breast Cancer Females
Short-term Impacts of Endocrine Therapy on Cardiovascular and Brain Health Outcomes in Breast Cancer
Aromatase inhibitors are the most used endocrine therapy for hormone-positive breast cancer. While there is a clear linear relationship between the duration of aromatase inhibitor use and the cumulative incidence of…
- Trial name
- STRIVE (Acute) (NCT06781762)
- Testing
- N/A (Usual Care)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Stroke, Spinal Cord Diseases
Use of tDCS Stimulation in Neurological and Gynaecological Conditions
The aim of the study is to test the effect of tDCS stimulation on upper and lower limb function in neurological patients and to reduce pain in gynaecological patients.
- Conditions
- Stroke, Spinal Cord Diseases, Nerve Root Disorder, Endometriosis
- Trial name
- tDCS (NCT06891690)
- Testing
- tDSC stimulation
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Brain Tumors
Spectral Precise Image Study for Brain Tumors
The goal of this observational study is to explore the image quality of spectral CT deep learning reconstruction technology (Spectral Precise Image) of patients with confirmed brain tumors.
- Trial name
- NCT07620470
- Testing
- This is an observational data collection study
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Target Controlled Infusion, Intracranial Neoplasm
Comparison of Opioid Consumption During TCI Guided by NOL Index or Standard Care Undergoing Intracranial Tumor Surgery
In this prospective, randomized controlled study, we hypothesized that nociception level index monitoring reduced opioid administration during surgery.
- Conditions
- Target Controlled Infusion, Intracranial Neoplasm, Opioid, Nociceptive Pain
- Trial name
- NOLopioid (NCT05732896)
- Testing
- Nociception Leve Indeks
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
Embolic Stroke of Undetermined Source, Ischemic Stroke
Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis
A stroke is the second cause of deaths after heart attack, one of the most important causes of malfunction as far as adults are concerned and the second as for the frequency cause of dementia.
- Conditions
- Embolic Stroke of Undetermined Source, Ischemic Stroke, Atrial Fibrillation and Flutter, Myocardial Infarction
- Trial name
- NCT03377465
- Testing
- ADMA (asymmetric dimethylarginine) , NTproBNP (N-terminal pro b-type natriuretic peptide), IL-6 (Interleukin 6), Adiponectina, Leptine, Syndecan, Resistin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Brain Tumor, Microbiota
MICRO-BRAIN 2024: Study on Pediatric Brain Tumors
In recent years, there has been growing interest in the human gut microbiota, whose health is characterised by high microbial diversity.
- Trial name
- NCT07417085
- Testing
- Biological samples, Fecal samples
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meyer Children's Hospital IRCCS
CADASIL, Cavernous Angioma
Biological Collection of the Rare Diseases of the Brain and Eye Vessels Cohort - 2
CERVCO is the French National Reference Centre for Rare Cerebrovascular and Retinal Diseases, accredited by the Ministry of Health since 2005.
- Conditions
- CADASIL, Cavernous Angioma, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy, Small Vessel Disease
- Trial name
- B-MRVC2 (NCT07650110)
- Testing
- Biocollection, Neurological evaluation and Biocollection
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pituitary Adenomas
Genome-wide Association Study of Pituitary Tumors
Pituitary adenomas is a very common disease, but the cause and genetics hasn't been identified. The investigators are going to use genome-wide association study to identify genes that may be related to pituitary adenomas.
- Trial name
- NCT01442220
- Where
- China
- Volunteers
- 12,500 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Independent Living, Disability Free Survival
A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE)
The STAREE study will examine whether treatment with statin (atorvastatin 40mg) compared with placebo will prolong disability free survival and reduce major cardiovascular events amongst healthy elderly people (≥70 years).
- Conditions
- Independent Living, Disability Free Survival, Elderly, Healthy
- Trial name
- STAREE (NCT02099123)
- Testing
- Atorvastatin
- Where
- 6 sites in Australia
- Volunteers
- 9,971 people, healthy volunteers welcome
- Sponsor
- Monash University
Brain Tumor, MRI
Brain Diseases on 7.0T Magnetic Resonance Imaging
This clinical trial studies the use of 7-Tesla (7T)and 3T magnetic resonance imaging (MRI) in detecting brain diseases. 7T MRI has increased detection sensitivity, including more accurate lesion delineation, higher inter-rater…
- Conditions
- Brain Tumor, MRI, Cerebrovascular Disease
- Trial name
- NCT05287750
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Malignant Brain Tumors
PRESENCE Project: An Early Palliative Care Intervention in Brain Tumors
The purpose of this pilot study is to investigate the feasibility of an early palliative care intervention (PRESENCE: Providing Resources Education, Support, and Enabling New brain tumor patients to Cope Effectively) and the…
- Trial name
- NCT01652768
- Testing
- Research Questionnaires, Palliative Care Team, Educational Information Session for Patients and Caregivers
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
High Grade Gliomas, Hypoxia Brain
Brain Radiotherapy Imaging for High-grade Glioma Using Hypoxia Targeting Through Oxygen-Enhanced Response
High-grade gliomas (HGGs) are the most common type of brain cancer in adults. Life expectancy for patients with HGGs is low. Radiotherapy aims to cure the tumour, but this is hard because HGGs are resistant to treatment.
- Conditions
- High Grade Gliomas, Hypoxia Brain, Glioblastoma (GBM), Brain Neoplasms, Adult
- Trial name
- BRIGHTER (NCT07670455)
- Testing
- Oxygen-Enhanced MRI (OE-MRI)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Brain Tumor, Head and Neck Cancer
Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients
The goal of this trial is to determine whether it is possible to minimize radiation dose to parts of the brain that are important for thinking and learning in children who require radiation to treat their tumor, and if this will…
- Trial name
- CogRT (NCT05658731)
- Testing
- substructure informed planning, Neurocognitive Testing, MRI
- Where
- 2 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Gd-based Contrast Media Exposure During Breast MRI Scans
Evaluation of Gadolinium Deposits in Healthy Women Participating in a High Risk Screening Program for Early Breast Cancer Detection
Purpose: To determine whether patients at high risk to develop breast cancer having received at least 6 cumulative dosages of macrocyclic Gd-based contrast media in the context of breast cancer screening by means of…
- Trial name
- NCT03393442
- Testing
- Brain MRI scan
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pituitary Adenoma
Evaluation of Early Retinal Vascular Modifications After Endoscopic Endonasal Pituitary Surgery
This study evaluates the retinal vascular features using optical coherence tomography angiography in patients that received endoscopic endonasal approach for the removal of an intra-suprasellar pituitary adenoma compressing the…
- Trial name
- NCT04425954
- Testing
- Endoscopic Endonasal Pituitary Surgery
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Federico II University
Breast Cancer, Cognitive Dysfunction
Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation
This study will test the preliminary efficacy of transcranial direct current stimulation (tDCS) to improve fatigue and cognition in women with a history of breast cancer and persistent fatigue.
- Conditions
- Breast Cancer, Cognitive Dysfunction, Fatigue
- Trial name
- NCT03143894
- Testing
- tDCS
- Where
- 3 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Malignant Glioma
Prognostic Awareness and Patient-Physician Communication in Malignant Glioma
The purpose of this study is to learn more about the understanding patients with brain tumors have of their disease and their communication with their physician.
- Trial name
- NCT02023346
- Testing
- surveys and cognitive tests
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cerebral Cavernous Malformation, Cavernous Angioma
Biomarkers of CASH
The project aims to develop prognostic and diagnostic blood tests for symptomatic brain hemorrhage in patients diagnosed with cavernous angiomas, a critical clinical challenge in a disease affecting more than a million Americans.
- Conditions
- Cerebral Cavernous Malformation, Cavernous Angioma, Hemorrhagic Microangiopathy
- Trial name
- NCT04467489
- Testing
- observational
- Where
- 4 sites in United States
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- University of Chicago