Clinical trials: Brain Plasticity
Healthy
Brain Power: Resistance Training and Cognitive Function
Primary Objectives: 1. To ascertain whether a 12-month, twice-weekly or once-weekly resistance training (RT) program will significantly improve executive function in community-dwelling women aged 65 to 75 years old compared with…
- Trial name
- NCT00426881
- Testing
- Exercise Training
- Where
- 2 sites in Canada
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Age-related Cognitive Decline
Train the Brain With Music: Brain Plasticity and Cognitive Benefits Induced by Musical Practice in Elderly People
This longitudinal study aims to countervail age-related cognitive and cerebral decline in healthy retired people through intensive piano / keyboard music practice in Switzerland and Germany.
- Trial name
- TBM (NCT03674931)
- Testing
- musical practice, music education
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Cerebrovascular Disorders, Healthy
Non-Invasive Electrical Stimulation of the Human Brain
This study is designed to allow researchers to use transelectrical stimulation to explore the function of the human nervous system and improve diagnosis of neurological disorders.
- Conditions
- Cerebrovascular Disorders, Healthy, Nervous System Diseases, Spinal Cord Injuries
- Trial name
- NCT00001216
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease
Somatotopy in Parkinson's Disease
This study aims to assess changes in connections within the brain in Parkinson's disease (PD). We will invite up to 10 people with PD to participate in this study and complete several brain scans using PET (Positron Emission…
- Trial name
- NCT04876404
- Testing
- PET/MR Imaging
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pacific Parkinson's Research Centre
Stroke
Exercise and Genotype in Sub-acute Stroke
This study will investigate the impact of cardiovascular exercise on brain plasticity among patients in sub-acute stages after stroke, and whether genotype modulates the response to this intervention.
- Trial name
- NCT05076747
- Testing
- Cardiovascular training, Standard Therapy
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- McGill University
Stroke
Cortical Ischemic Stroke and Serotonin
In this study the investigators want to test the hypotheses that, serotonergic neuromodulation increases perilesional neuroplasticity, leading to improved behavioural outcomes through a more efficient allocation of functional…
- Trial name
- CISS (NCT02865642)
- Testing
- Serotonin Uptake Inhibitors
- Where
- 2 sites in Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Corticospinal Plasticity, Neuromuscular Plasticity
Study of the Reaction of the Brain to Various Stimulations
Physical activity is considered a therapeutic strategy in its own right in a vast majority of disabling chronic disorders. It leads to an increase in physical and probably cognitive capacity, thanks to its effects on both…
- Trial name
- NCT03334526
- Testing
- physical training, mental training, electrical stimulation
- Where
- France
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Lower Back Pain
Back Pain Response to Different Acupuncture Methods
Acupuncture has been used for many years to help relieve pain. However, it is not clear how acupuncture works. We are doing this study to learn about the effects of different forms of acupuncture on chronic low back pain.
- Trial name
- LBP (NCT01598974)
- Testing
- Traditional Acupuncture, Laser Acupuncture
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Blindness
Sensory Substitution and Brain Plasticity Following Vision Loss
The goal of this clinical investigation is to learn how the brain responds when visual information is converted into patterns of sound or touch in blind and sighted participants.
- Trial name
- SenSubMRI (NCT07450677)
- Testing
- Electrotactile display (BrainPort), Vision-to-sound converter (AI Sight)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cognitive Change
Brain Exercises for Synaptic Plasticity
The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts…
- Trial name
- BEST (NCT03058055)
- Testing
- Origami, Reading
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Developmental Coordination Disorder
Rhythmic Motor Learning in Children With Developmental Coordination Disorders
The importance of play and physical activity include many benefits on positively improving health and well-being, enhancing children's and young people's thinking and performance in school, improving their sleep and enabling…
- Trial name
- EPIC2 (NCT03150784)
- Testing
- EPIC Club
- Where
- 5 sites in United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Cerebrovascular Accident, Aphasia
Dopaminergic Enhancement of Learning and Memory in Aphasia
The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.
- Trial name
- NCT00102869
- Testing
- levodopa
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Autism
Brain Plasticity of Autism in Response to Early Behavioral Intervention: A Multimodal MRI Study
Autism is a well-recognized neurodevelopmental disorder severely affecting the health of children. While the unclear neurobiological basis of autism and the lack of effective medication, the most commonly used approach for…
- Trial name
- NCT02807766
- Testing
- Behavior modification, Behavior modification and sensory integration training, Behavior modification and applied behavioral analysis
- Where
- 2 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Movement Disorders, Parkinson Disease
Non-invasive Assessment of Synaptic Plasticity
The pathophysiological mechanisms underlying Movement Disorders, including Parkinson's disease, have been related to altered synaptic plasticity affecting several structures of the central nervous system.
- Trial name
- NEUROPLAST (NCT05353517)
- Testing
- Device: focal muscle vibration and theta burst stimulation
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Dravet Syndrome (DS)
Biomarkers of Neurodegeneration, Synaptic Plasticity and Neuroinflammation in Dravet Syndrome
Dravet syndrome (DS) is a developmental and epileptic encephalopathy, usually caused by de novo pathogenic SCN1A variants, characterized by early-onset prolonged febrile seizures, subsequent drug-resistant polymorphic epilepsy…
- Trial name
- TEMBO-DS (NCT07801404)
- Where
- 9 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Parkinson, Parkinson Disease
Neuroplasticity in Parkinson's Disease
The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes…
- Trial name
- NCT05286736
- Testing
- Neuroimaging, Quantitative assessments
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy, Blindness
Multisensory Body and Space Representations (BASES-EXTINCTION)
To accurately control body movements to interact with objects, our brain needs representations of the body and the nearby space.
- Trial name
- NCT03201341
- Testing
- Electrooculogram (EOG), Surface Electromyography (EMG), Electrodermal response
- Where
- France
- Volunteers
- 1,540 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Dystonia
Brain Function in Focal Dystonia
Objectives The main objectives of this proposal are (1) to characterize motor learning abnormalities in patients with focal dystonia; (2) to show, using transcranial magnetic stimulation, that this abnormal motor learning went…
- Trial name
- NCT00102999
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Weight Loss, Wait-List Control
Neurotrophic Indicators of Cognition, Executive Skills, Plasticity, and Adverse Childhood Experiences Study
Adverse childhood experiences (ACEs) are repeatedly shown to predict negative biopsychosocial health outcomes, including obesity.
- Trial name
- NICE SPACES (NCT04076722)
- Testing
- Stress reactivity stimuli
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Central Cord Syndrome
The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI
Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS).
- Trial name
- NCT00790361
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's