Clinical trials: Brain Plasticity
Chronic Back Pain
Transition From Acute to Chronic Back Pain : Effect of L-dopa,Gender,and Associated Brain Plasticity
This is a 6-month double-blinded, randomized, placebo-controlled clinical trial of pharmacological treatment (carbidopa/levodopa and celecoxib) for acute/subacute back pain.
- Trial name
- NCT04082715
- Testing
- carbidopa/levodopa and celecoxib
- Where
- China
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Alzheimer Disease
Combined Aerobic Exercise and Cognitive Training in Seniors With Genetic Susceptibility for Alzheimer's Disease
The study aims to investigate the effect of a long-term combined aerobic exercise and cognitive training program on cognitive function, daily function, psychosocial status, and neural plasticity in seniors with genetic…
- Trial name
- NCT05163067
- Testing
- Combined aerobic exercise and cognitive training program
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Fluid Inteligence, Modafinil
Pharmacological Cognitive Enhancement
There is growing debate on the use of drugs that can promote cognitive enhancement. Amphetamine-like drugs have been employed as cognitive enhancers, but all of them have important side effects and may induce addiction.
- Conditions
- Fluid Inteligence, Modafinil, Healthy Young Subjects, Resting State Networks
- Trial name
- MODREST (NCT01684306)
- Testing
- Modafinil
- Where
- Italy
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Stroke
Brain Plasticity Mapping Post-stroke
The investigators believe that the initial cerebral connectivity as well as its evolution immediate post-stroke could be correlated to the amount of motor recovery.
- Trial name
- MAPPY (NCT03223571)
- Testing
- Motor rehabilitation training
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Stroke
Transcranial Direct Current Stimulation to Improve Hand Movement in Stroke Patients
This study will examine whether hand movement in stroke patients can be improved by applying electrical stimulation to the side of the brain affected by the stroke.
- Trial name
- NCT00307385
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia
Brain Function in Focal Dystonia
Objectives The main objectives of this proposal are (1) to characterize motor learning abnormalities in patients with focal dystonia; (2) to show, using transcranial magnetic stimulation, that this abnormal motor learning went…
- Trial name
- NCT00102999
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Young Adults
Boosting and Mapping Non-invasive Brain Stimulation Techniques
In this study we applied TMS to the hand area of M1 whilst acquiring fMRI of the brain. This study tested whether a higher-frequency form of brain stimulation, called high-gamma (100Hz) intermittent theta burst stimulation…
- Trial name
- BoMAP NIBS (NCT07431697)
- Testing
- Intermittent theta burst stimulation (iTBS) as a protocol of repetitive transcranial magnetic stimulation (rTMS)
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Cerebral Stroke
Cortical and Biomechanical Dynamics of Ankle Robotics Training in Stroke
Reduced mobility is often a long-term problem facing those who have chronic leg weakness resulting from stroke. Recent innovations in stroke therapy have applied motor learning principles to improve motor skills through regular…
- Trial name
- AbotMot (NCT01072032)
- Testing
- Anklebot (Ankle Robot)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- VA Office of Research and Development
Attention Deficit Hyperactivity Disorder
Online Neuroplasticity Training for Remediation of ADHD in Adolescent Children (ONTRAC)
This project shall rigorously evaluate the effectiveness of a novel, neuroplasticity-based internet-deliverable cognitive training program, which specifically targets the treatment of core cognitive dysfunctions observed in…
- Trial name
- NCT01772485
- Testing
- Cognitive Training, Active Control
- Where
- India
- Volunteers
- 31 people
- Sponsor
- Posit Science Corporation
Healthy Subjects
Plasticity of the Compassionate Brain
The purpose of the study is to look at the long term effects of a complex socio-affective mental training program on a neuroscientific-, hormonal-, behavioral-, biological, and subjective measures-level.
- Trial name
- NCT01833104
- Testing
- Presence - Perspective - Affect, Presence - Affect - Perspective., Affect
- Where
- 2 sites in Germany
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
CVA (Cerebrovascular Accident), Paresis
Robotic Enhanced Error Training of Upper Limb Function in Post-stroke Patients
Background: Stroke is a common cause of morbidity, including paresis, and stroke survivors often have reduced function in their paretic arm.
- Trial name
- NCT05174676
- Testing
- Dextreme
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Reuth Rehabilitation Hospital
Stroke With Hemiparesis
Strategies for Recovery of Dexterity Post Stroke
Motor learning can be affected by the sensory difficulties that may be experienced as a result of a stroke. This study will help us better understand what kinds of sensory information can help with the re-learning of grasping…
- Trial name
- NCT01977027
- Testing
- Alternate Hand Training or Affected Hand Training
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Stroke, Cerebrovascular Accident
Non-invasive Brain Stimulation and Occupational Therapy To Enhance Stroke Recovery
The purpose of this study is to determine whether a non-painful, non-invasive, brain-stimulation technique called transcranial direct current stimulation (tDCS) combined with traditional physical-occupational therapy (OT) will…
- Conditions
- Stroke, Cerebrovascular Accident, CVA, Acute Stroke
- Trial name
- TDCS+OT (NCT00792428)
- Testing
- Real Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Multiple Sclerosis
The Effect of Exercise on Strength and Mobility and Corresponding CNS Plasticity in Multiple Sclerosis Patients
This study is a unique blend of new technologies never used in combination with individuals diagnosed with Multiple Sclerosis (MS).
- Trial name
- remapping (NCT01816100)
- Testing
- specifically design 6 month resistance training program, 6 months weight resistance and balance program
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Nebraska
Cerebrovascular Disorders, Memory
Roflumilast to Treat Cognitive Sequela After Stroke
The aim of the current project is to validate the effects of chronic rolflumilast treatment (12 weeks) on cognitive functions (i.e.
- Conditions
- Cerebrovascular Disorders, Memory, Functional Recovery, Drug Intervention
- Trial name
- ROSTMEMA (NCT04854811)
- Testing
- Roflumilast Oral Tablet
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Maastricht University
Stroke
Clinical Implications of FKBP5 in Stroke
With contemporary lifestyle changes and global aging, it is important yet unknown how stress interacts to post-stroke outcomes. This proposal aims to study the link between the stress-responsive FKBP51-related pathways and neural…
- Trial name
- NCT05198037
- Testing
- Bihemispheric tDCS
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Brain Health, Longevity
L-serine and Strength Training in the Elderly
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older…
- Conditions
- Brain Health, Longevity, Cognitive Performance, Strength Training Effects
- Trial name
- AAAging (NCT07466290)
- Testing
- Strength training, L-serine supplementation, Control (cornstarch)
- Where
- Austria
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Cerebrovascular Accident, Aphasia
Dopaminergic Enhancement of Learning and Memory in Aphasia
The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.
- Trial name
- NCT00102869
- Testing
- levodopa
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Stroke
Cranial Nerve Neuromodulation to Improve Arm Function and Brain Plasticity in Stroke
Following a stroke, persistent residual muscle weakness in the upper limb (UL) drastically impacts the individuals' quality of life and level of independence.
- Trial name
- CN-NINM (NCT06386510)
- Testing
- Strength training, Cranial nerve non-invasive neuromodulation
- Where
- 3 sites in Canada
- Volunteers
- 74 people
- Sponsor
- Université de Sherbrooke
Stroke, Hemiparesis
IpsiHand System for Rehabilitation of the Arm and Hand After Stroke
This study aims to assess whether the NeuroLutions Upper Extremity Rehabilitation System (known as IpsiHand) will help stroke patients regain strength and functional movements in their arm.
- Trial name
- NCT04123808
- Testing
- IpsiHand Treatment
- Sponsor
- Columbia University