Clinical trials: Brain Plasticity
Weight Loss, Wait-List Control
Neurotrophic Indicators of Cognition, Executive Skills, Plasticity, and Adverse Childhood Experiences Study
Adverse childhood experiences (ACEs) are repeatedly shown to predict negative biopsychosocial health outcomes, including obesity.
- Trial name
- NICE SPACES (NCT04076722)
- Testing
- Stress reactivity stimuli
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Central Cord Syndrome
The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI
Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS).
- Trial name
- NCT00790361
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Electromagnetic Fields, Neuronal Plasticity
Neuromodulation With Low Frequency-Pulsed Electromagnetic Fields
Non-depolarizing magnetic fields, like Low Frequency-Pulsed Electromagnetic Fields (LF-PEMFs) have shown the ability to modulate living structures, principally by influencing synaptic activity and ion channels on cellular…
- Conditions
- Electromagnetic Fields, Neuronal Plasticity, Transcranial Magnetic Stimulation
- Trial name
- NCT03537469
- Testing
- CTU Mega 20 real device
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Depression
Neurorestorative Effects of Electroconvulsive Therapy (ECT) in Patients With Severe Late Life Depression
To study the potential neurorestorative effects of electroconvulsive therapy (ECT) in depressed patients by measuring brain derived neurotrophic factor (BDNF) serum levels and hippocampal volumes in severely depressed patients…
- Trial name
- NCT02667353
- Testing
- ECT, Etomidate, Succinylcholine
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebrovascular Accident
Electrical Stimulation to Improve Hand Function in Patients With Chronic Stroke
This study will determine whether an electric shock to the forearm can improve hand function in patients with chronic stroke and, if so, whether the improvement is related to brain reorganization.
- Trial name
- NCT00023569
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia
Cerebellum and Cortical Plasticity: the Case of Dystonia
Purpose Objective : Sensorimotor adaptation allows the modification of the motor command taking into account the errors detected during execution of prior movements. It involves a large cortico-subcortical network.
- Trial name
- CERDYS (NCT01272154)
- Testing
- Transcranial magnetic stimulation
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Visual Field Defect, Stroke
Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training
The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual…
- Conditions
- Visual Field Defect, Stroke, Hemianopia, Quadrantanopia
- Trial name
- VIBRANT (NCT07105358)
- Testing
- transcranial random noise stimulation (tRNS), Perceptual learning-based training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgetown University
Injury of the Right Upper Extremity
Effects of Sensory and Motor Deprivation on Brain Plasticity
Investigation of changes in gray and white matter during immoblisation after injury of the right upper extremity via two MR Investigations of the brain at two different times.
- Trial name
- NCT01029093
- Testing
- no intervention, MRI and motor skill test
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Healthy
Brain Changes Associated With Learning a Motor Task
This study will determine: 1) whether learning a task with the dominant hand is accompanied by changes in the area of the brain that controls hand movement, and 2) how the brain is able to make these changes.
- Trial name
- NCT00076466
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson, Parkinson Disease
Neuroplasticity in Parkinson's Disease
The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes…
- Trial name
- NCT05286736
- Testing
- Neuroimaging, Quantitative assessments
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Stroke, Healthy
Motor Learning in Stroke Patients and Healthy Volunteers
This study will try to elucidate learning processes associated with motor training in the weak arm of stroke patients compared with healthy controls.
- Trial name
- NCT00021710
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injuries (SCI), Spinal Cord Injury, Chronic
BCI-Assisted SCS-EXS for Gait Optimization
The goal of this clinical trial is to evaluate the safety and technical feasibility of a novel brain-machine interface (BCI)-assisted spinal cord stimulation (SCS) and exoskeleton (EXS) system in patients with spinal cord injury…
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Chronic, Spinal Cord Injury, Spinal Cord Injury Cervical
- Trial name
- BASEGO (NCT06939660)
- Testing
- BCI-SCS-EXS
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson Disease
The Learning Effects of Attentional Strategy on Dual-task Walking in Patients With Parkinson's Disease: Behavioral Performance and Neural Plasticity
[year1] 1. To compare the effects of dual-task training with two different task priority instruction in people with Parkinson's disease and healthy controls on dual-task weight shifting performances. 2.
- Trial name
- NCT03895125
- Testing
- [year1] dual-task training with task priority strategy, [year2-3] dual-task training with internal and external focus
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Brain Injuries
D-aspartate and Therapeutic Exercise
An important mechanism responsible for clinical recovery after neurological damage of different types is synaptic plasticity. Nervous tissue can enhance or de-energize inter-neuronal transmission at synaptic level in a lasting…
- Trial name
- DAsp&TerapEx (NCT03228524)
- Testing
- D-Aspartate, Therapeutic exercise
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Mild Cognitive Impairment
Brain Plasticity Following Aerobic Exercise in Patient With Mild Cognitive Impairment: Neuroimaging Study
The proposed study aims to explore brain mechanisms mediating the cognitive benefits of aerobic exercise in patients with mild cognitive impairment- a prodromal stage of Alzheimer disease.
- Trial name
- NCT02114580
- Testing
- physical training
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cortical Excitability, Brain Stimulation
Neuroplastic Alterations of the Motor Cortex by Caffeine
Caffeine is a psychostimulant drug. It acts as a competitive antagonist at adenosine receptors, which modulate cortical excitability as well.
- Conditions
- Cortical Excitability, Brain Stimulation, Caffeine
- Trial name
- NCT04011670
- Testing
- 200 mg caffeine tablet, Non-active tablet
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Stroke, Feedback, Psychological
Intervention Study of EMG Biofeedback Assisted Force Control to Treat Stroke Movement Disorder
Force generation and force level control are important neuromuscular control mechanism for successful execution of movement for our daily activities.
- Conditions
- Stroke, Feedback, Psychological, Motor Deficit
- Trial name
- NCT01962662
- Testing
- EMG biofeedback training, U/E exercise
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Premature Childbirth
Evaluation of Brain Plasticity in Premature Infants at School Age After Cognitive Remediation
Infantile brain plasticity is still a poorly known phenomenon. However, neuropsychological disorders and behavioral deficits are common disorders that can have serious consequences for school enrollment, family and social…
- Trial name
- EPIREM (NCT03972761)
- Testing
- Magnetic Resonance Imaging (MRI) 3 tesla
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Brain Aging
Synaptic Plasticity Imaging With Diffusion MRI
Diffusion MRI employed in functional imaging has the potential to probe directly brain activation instead of blood changes like the BOLD technique.
- Trial name
- NCT01686516
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stroke, Hemiparesis
Late LTP-like Plasticity Effects of tDCS in Chronic Stroke Patients
Rationale: About 80% of stroke patients suffer motor impairments, but current therapies have limited effects on motor recovery. Therefore, investigating new potential therapeutic approaches is crucial.
- Trial name
- NCT02399540
- Testing
- Conventional Paired tDCS, Conventional Unpaired tDCS, Late LTP-like Plasticity tDCS
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- Erasmus Medical Center