Clinical trials: Brain Plasticity
Stroke, Sensorimotor Impairment
Learning in Stroke
After a stroke, plasticity occurs in the brain from microscopic to network level with positive but also negative consequences for functional recovery.
- Trial name
- NCT05511467
- Testing
- Visuomotor learning task
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Stroke
Efficacy of Fluoxetine - a Trial in Stroke
The purpose of this study is to investigate whether routine administration of fluoxetine 20mg once daily in the 6 months initiated during the acute stroke improves the patient's functional outcome.
- Trial name
- EFFECTS (NCT02683213)
- Testing
- Fluoxetine
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Karolinska Institutet
Mild Cognitive Impairment
Countervail Cognitive and Cerebral Decline in Mild Cognitive Impairment Patients Using Non-medical Interventions
Cognitive decline represents a major threat among the deleterious effects of population aging. The investigators propose to conduct an RCT (randomized controlled trial) on the subpopulation of MCI patients, and examine whether…
- Trial name
- COPE (NCT04546451)
- Testing
- Music practice, Psychomotor therapy
- Where
- 2 sites in Switzerland
- Volunteers
- 48 people
- Sponsor
- School of Health Sciences Geneva
Diabetes Mellitus
Improvement of Sensibility in the Foot in Diabetic Patients Induced by EMLA-application to the Lower Leg
Sensory input from the foot as well as all other body parts results in activation of sensory cortex. It is well known that the cortical body map is experienced-dependant and can rapidly change in response to changes in activity…
- Trial name
- NCT00959595
- Testing
- EMLA cream
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Lund University Hospital
Developmental Coordination Disorder
Rhythmic Motor Learning in Children With Developmental Coordination Disorders
The importance of play and physical activity include many benefits on positively improving health and well-being, enhancing children's and young people's thinking and performance in school, improving their sleep and enabling…
- Trial name
- EPIC2 (NCT03150784)
- Testing
- EPIC Club
- Where
- 5 sites in United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Cerebrovascular Stroke
Noninvasive Brain Stimulation to Evaluate Neural Plasticity After Stroke
The purpose of this study is to examine how different areas in the brain interact with each other and how using brain imaging and brain stimulation approaches can influence these interactions.
- Trial name
- NCT02465034
- Testing
- Transcranial Magnetic Stimulation, Traditional Paired Associative Stimulation, Median Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Infants at Risk of Cerebral Palsy
A Randomized Controlled Trial of Hybrid Environmental Enrichment-Based Early Intervention in Infants at Risk of Cerebral Palsy
This randomized controlled trial aims to evaluate the effects of a hybrid environmental enrichment-based early intervention grounded in the Homeostasis-Enrichment-Plasticity (HEP®) Approach in infants at risk of cerebral palsy…
- Trial name
- NCT07116148
- Testing
- HEP-Based Early Intervention, Conventional Early Intervention
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Medipol University
Parkinson Disease(PD)
Cycling and Treadmill With Dual Task for Parkinson's Disease Improvement
Motor impairment in lower extremities is common in individuals with Parkinson disease (PD). Development sensitive test for early motor deviations is important.
- Trial name
- NCT06355947
- Testing
- Cognitive cycling training, Cognitive treadmill training
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Parkinson Disease
Group Therapy With Transcranial Direct Current Stimulation in Patients With Parkinson's Disease
To determine the effectiveness of group therapy along with transcranial direct current (tDCS) stimulation on motor symptoms, balance and quality of life in patients with Parkinson's disease(PD).
- Trial name
- GTBQ-PD (NCT04174573)
- Testing
- GTO, GT-tDCS
- Volunteers
- 64 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Cerebral Palsy, Prematurity
NEO Rehab Program for Premature Infants at Risk for Cerebral Palsy
The goal of this project is to investigate the acceptability, feasibility and fidelity of an innovative NICU rehabilitation program that will include six multimodal, gestational age (GA) appropriate, parent-administered…
- Conditions
- Cerebral Palsy, Prematurity, Early Intervention, Family Centered Care
- Trial name
- NCT04330859
- Testing
- NeoRehab Bundle, Routine care
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Virginia
Stroke
Observational Learning in Stroke Patients
This study will determine how people who have had a stroke learn to perform a movement by observation, as compared with people who have not had a stroke.
- Trial name
- NCT00083642
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer Disease, Mild Cognitive Impairment
ALzheimer and MUsic THerapy: Effects of Music Lessons on Brain Plasticity, Mood, and Quality of Life in Alzheimer Patients
Music has powerful effects on memory in patients with neurodegenerative diseases. However, although there is anecdotal evidence for beneficial effects of active music interventions in patients with Alzheimer's disease (AD), there…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, MCI With Increased Risk for Alzheimer Disease
- Trial name
- ALMUTH (NCT03444181)
- Testing
- Music lessons, Training intervention
- Where
- Norway
- Volunteers
- 136 people
- Sponsor
- University of Bergen
Stroke
Umbilical Cord Derived Mesenchymal Stem Cells Treatment in Ischemic Stroke
The study aims at estimating the safety and efficacy of the intravenous injection of human umbilical cord mesenchymal stem cell(hUC-MSC) for patients suffering from ischemic stroke in recent 3 months.
- Trial name
- Recruiting (NCT02580019)
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Neuropathic Pain, Phantom Limb Pain
Mindful SensoriMotor Therapy With Brain Modulation in Highly Impaired Extremities
Brief summary: This single-arm, pilot clinical investigation aims to evaluate Mindful SensoriMotor Therapy (MSMT) enhanced with brain modulation as a treatment of pain due to sensorimotor impairment, such as Phantom Limb Pain…
- Trial name
- NCT04897425
- Testing
- Mindful SensoriMotor Therapy Enhanced with Brain Modulation
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Chalmers University of Technology
Median Nerve Disease, Ulnar Nerve Disease
Sensory Reeducation in Peripheral Nerve Injuries of Hand
Objectives: To develop a protocol for early treatment using sensory reeducation through the mirror after surgical reconstruction of the median nerve and / or ulnar hand, and its comparison with the evolution of the return of skin…
- Conditions
- Median Nerve Disease, Ulnar Nerve Disease, Peripheral Nerve Disease
- Trial name
- HandtherRCT (NCT01215760)
- Testing
- Training with a mirror, No mirror therapy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Chronic Obstructive Pulmonary Disease
Understanding the Importance of Plasticity in the Brain Mechanisms of Dyspnoea Perception
Dyspnoea is the uncomfortable shortness of breath that debilitates millions of patients with lung disease, heart failure and cancer. It is often very difficult to treat.
- Trial name
- NCT01985750
- Testing
- d-cycloserine
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Post-stroke Upper Limb Hemiparesis, Repetitive Transcranial Magnetic Stimulation (rTMS)
Repetitive Transcranial Magnetic Stimulation Combined With Bimanual Therapy for Upper Limb Stroke Rehabilitation
The goal of this clinical trial is to evaluate whether combining repetitive transcranial magnetic stimulation (rTMS) with machine-assisted bimanual therapy (BT) can improve upper limb function in stroke patients.
- Conditions
- Post-stroke Upper Limb Hemiparesis, Repetitive Transcranial Magnetic Stimulation (rTMS), Bimanual Therapy, Neuromodulation
- Trial name
- NCT07054424
- Testing
- Conventional occupation therapy, stretching exercise, rTMS
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Ischemic, Healthy
Stochastic Resonance Stimulation in Brain Plasticity and Post Stroke Motor Recovery
This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.
- Trial name
- NCT03839810
- Testing
- stochastic resonance electrical stimulation
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Cryptogenic Epilepsy
Diffusion Tensor Imaging in Epilepsy With Continuous Spikes and Waves During Sleep
Continuous Spikes and Waves during Sleep (CSWS) is a rare paediatric epileptic encephalopathy. Even if the correlation between the severity of the epilepsy and the cognitive consequences is well established, the mechanisms…
- Trial name
- POCS-DTI (NCT03035513)
- Testing
- Continuous spikes and waves during slow sleep (CSWS)
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Facial Palsy, Surgery
Brain Plasticity and Emotion Recognition in Patients With Facial Palsy Before & After Surgical Rehabilitation: MEG Study
Facial palsy (of one hemiface) affects the sensorimotor representation of the face of the patients, and possibly also their mental representation of emotional facial expressions.
- Trial name
- FACE_REHAB_MEG (NCT06809127)
- Testing
- Behavioral tasks with MEG recording
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France