Clinical trials: Brain Plasticity
Stroke
VNS-induced Corticospinal Plasticity
The goal of this study is to learn more about the connections between the brain, spinal cord, and muscles and how these connections can be strengthened after neurological injury.
- Trial name
- NCT04088565
- Testing
- Paired-Associative Stimulation (PAS), Vagus Nerve Stimulation (VNS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Hemiplegic Cerebral Palsy
Spinal Cord Associative Plasticity in Cerebral Palsy
Associative plasticity has been used to promote functional recovery from conditions affecting movement. The long term goal of this project is to use electrical stimulation techniques to improve arm and hand function.
- Trial name
- SCAP-CP (NCT07607665)
- Testing
- Paired brain and nerve stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Columbia University
Borderline Personality Disorder (BPD)
Cortical Plasticity of the Tactile Mirror System in Borderline Personality Disorder
People with borderline personality disorder (BPD) show alterations in the empathic abilities, which may involve the functioning of the mirror neuron system in the somatosensory domain.
- Trial name
- SG2019-EXP2 (NCT06702215)
- Testing
- Cross-modal paired associative stimulation (cm-PAS) protocol
- Where
- Italy
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Parkinson Disease
Somatotopy in Parkinson's Disease
This study aims to assess changes in connections within the brain in Parkinson's disease (PD). We will invite up to 10 people with PD to participate in this study and complete several brain scans using PET (Positron Emission…
- Trial name
- NCT04876404
- Testing
- PET/MR Imaging
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pacific Parkinson's Research Centre
Blindness, Brain Mapping
The Connection Between Areas in the Brain of Blind Patients
The purpose of this study is to test the belief that specific areas of the brain are connected differently in blind patients than patients with sight.
- Conditions
- Blindness, Brain Mapping, Healthy
- Trial name
- NCT00001926
- Testing
- O15, Cadwell rTMS
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke With Hemiparesis
Transfer of Grasp Control Across Hands After Stroke
The purpose of this study is to examine if the strong hand can assist in the recovery of muscle function in the weak hand after a stroke.
- Trial name
- NCT00589368
- Testing
- Transfer of grasp control across hands
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Stroke, Cerebral Vascular Accident
Upper Limb Biofeedback Rehabilitation System (RAPAELⓇ Smart Glove Digital Treatment System) Training for Stroke Recovery
This study is to investigate whether the RAPAELⓇ Smart Glove digital treatment system improves the upper extremity function of stroke patients compared to other clinical treatment by measuring serial behavioral and neuroimaging…
- Trial name
- NCT02431390
- Testing
- RAPAELⓇ Smart Glove digital treatment system, Additional occupational therapy
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Pusan National University
Blindness, Cerebrovascular Accident
Mechanisms of Human Plasticity in the Human System
The purpose of this study is to investigate the physiology associated with plasticity of the motor system. Plasticity refers to the process by which neighboring brain cells assume the responsibilities of damaged or diseased brain…
- Conditions
- Blindness, Cerebrovascular Accident, Spinal Cord Injury
- Trial name
- NCT00001661
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
Post-stroke Recovery (PSR_e2020)
The study presented is part of the departmental project entitled: BEHAVIORS AND WELLNESS: A MULTIDISCIPLINARY APPROACH TO PROMOTE THE QUALITY OF LIFE IN VULNERABILITY CONDITIONS - winner of the MIUR grant "Departments of…
- Trial name
- PSR_e2020 (NCT04323501)
- Testing
- Experimental treatment, Control group
- Where
- Italy
- Volunteers
- 134 people
- Sponsor
- Universita di Verona
Multiple Sclerosis
Examining the Effects of Video-game Exercise on Mobility and Brain Plasticity in Individuals With Multiple Sclerosis
Dance Dance Revolution (DDR) may offer an innovative and highly effective format for delivering exercise programs to people with multiple sclerosis (MS).
- Trial name
- NCT01780792
- Testing
- Dance Dance Revolution video game play
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
Cerebrovascular Accident
Preliminary Study of Transcranial Magnetic Stimulation for Stroke Rehabilitation
This is a preliminary study to evaluate the possible use of transcranial magnetic stimulation (TMS), together with exercise, for rehabilitation of chronic stroke patients.
- Trial name
- NCT00050128
- Testing
- rTMS, Magstim
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Autism Spectrum Disorder
The Plasticity of Social Brain Network in Adults With Autism Spectrum Disorder
"Social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states.
- Trial name
- NCT05884853
- Testing
- PEERS
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Stroke, Chronic Stroke
Wireless Nerve Stimulation Device To Enhance Recovery After Stroke
Texas Biomedical Device Center (TxBDC) has developed an innovative strategy to enhance recovery of motor and sensory function after neurological injury termed targeted plasticity therapy (TPT).
- Conditions
- Stroke, Chronic Stroke, Upper Extremity Paresis, Ischemic Stroke
- Trial name
- NCT04534556
- Testing
- Active Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Baylor Research Institute
Chronic Low Back Pain
Changes in Motor Cortex Following Exercises for Chronic Low Back Pain
The motor cortex of the brain changes following chronic pain and injury, and this is linked to pain-associated changes in motor behaviour.
- Trial name
- NCT00864422
- Testing
- Skilled motor training, Walking exercise
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- The University of Queensland
Healthy Control Subjects
Impact of Spaced iTBS on Plasticity in the Motor Cortex
The goal of this clinical trial is to explore the effects of non-invasive brain stimulation protocols using intermittent theta-burst stimulation (iTBS) on brain plasticity in healthy, right-handed individuals aged 18 to 50 years.
- Trial name
- STEP-MC (NCT06735794)
- Testing
- Compressed iTBS, Spaced iTBS
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Stroke, Cerebrovascular Accident
Enhancing Plasticity in Stroke Patients With Severe Motor Deficit
This study will evaluate the effectiveness of sustained peripheral nerve stimulation coupled with functional motor training, to improve hand motor function in poorly recovered stroke patients.
- Trial name
- NCT02633215
- Testing
- S88 Dual Output Stimulator by Grass Technologies
- Volunteers
- 36 people
- Sponsor
- Lumy Sawaki
Suicide, Attempted, Suicide, Ideation
Teen Brain Training (TBT)
A non invasive treatment study including participants at risk for suicide attempts and undergoing neurofeedback training. Neurofeedback is controlling your brain activity in real time inside the scanner.
- Conditions
- Suicide, Attempted, Suicide, Ideation, Depression
- Trial name
- NCT06183580
- Testing
- neurofeedback training involving dACC, neurofeedback training involving amygdala
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Major Depressive Disorder
rTMS Study in Depression to Evaluate the Relationship Between Brain Plasticity and Clinical Outcome
Depression is a highly prevalent condition characterized by persistent low mood, energy, and activity that can affect one's thoughts, mood, behavior, and sense of well-being.
- Trial name
- NCT04032015
- Testing
- TMS
- Sponsor
- Stanford University
Low Back Pain
Manual Therapy as a Form of Sensory Discrimination in Chronic Low Back Pain
This study evaluates whether different explanations given to patients with long lasting back pain influence a physical therapy treatment technique.
- Trial name
- NCT02757378
- Testing
- Neuroplasticity Explanation (Experimental), Biomechanical Explanation (Control)
- Where
- 5 sites in United States
- Volunteers
- 62 people
- Sponsor
- Kevin Farrell
Glioma (Any Grade) in the Brain, Gliomas, Malignant
Brain Connectivity Changes in Glioma Patients During Treatment
The goal of this observational study is to better understand how the brain changes during the treatment of glioma. In particular, the study looks at changes in important brain areas that are responsible for functions such as…
- Conditions
- Glioma (Any Grade) in the Brain, Gliomas, Malignant, fMRI Research, Neurocognitive Function
- Trial name
- GliRecon (NCT07612917)
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Johannes Kepler University of Linz