Clinical trials: Brain Plasticity
Gender Dysphoria
Cross-sex Hormone Therapy and Neuronal Plasticity
Transgender women (male-to-female) were invited to participate in this study to test the impact of Cross-Sex Hormone Therapy (CSHT) in the brain.
- Trial name
- NCT03651427
- Testing
- Estradiol
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Stroke, Chronic, Aging
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors.
- Conditions
- Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction
- Trial name
- AMPLIFI (NCT06950060)
- Testing
- High intensity cycling, Low-intensity cycling, Health education session
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy Volunteers
Interhemispheric Interaction of Parieto-Motor Cortico-Cortical Plasticity
Background: The two hemispheres of the brain are connected. Changes in one hemisphere affect the other through this connection. Research has shown that training new skills in one hand improves the same skills for the other hand.
- Trial name
- NCT03253731
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amblyopia, Anisometropic Ambyopia
Visual Cortex Stimulation in Patients With Amblyopia
This study will examine whether direct current (DC) polarization (electrical stimulation) of the visual cortex can cause a temporary improvement of vision in an amblyopic eye of an adult.
- Conditions
- Amblyopia, Anisometropic Ambyopia, Amblyopia, Suppression
- Trial name
- NCT00097162
- Testing
- Anodal stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Eye Institute (NEI)
Stroke, Ischemic
Microcirculation and Plasticity After Stroke
Reperfusion is the main goal of early medical interventions after stroke, such as thrombolysis and thrombectomy. Recanalization works only if applied early - the earlier the better, but with a statistical cutoff of 4.5 hours…
- Trial name
- IMPreST (NCT04035746)
- Testing
- Observation of microcirculation and plasticity of the brain
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich
Stroke Patients With Cognitive Decline
Effects and Mechanism of Two Hybrid Exercise-cognitive Trainings in Mild Ischemic Stroke With Cognitive Decline
The purposes are to: (1) examine and compare the effects of two hybrid interventions on brain plasticity, physiological biomarkers and behavioral outcomes, including cognitive and physical functions, from pre- to post-training…
- Trial name
- NCT03230253
- Testing
- Sequential training, Dual training, Control training
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Chang Gung Memorial Hospital
Spinal Cord Injuries
Finding the Best Combination of Brain and Spinal Cord Stimulation With Hand Training After Spinal Cord Injury
While physical exercise remains the foundation for any rehabilitation therapy, the team seeks to improve the benefits of exercise by combining it with the concept of "Fire Together, Wire Together" - when brain stimulation is…
- Trial name
- NCT06104735
- Testing
- Synaptic Pairing Interval, Frequency, Bouts
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Bronx VA Medical Center
Parkinson Disease, Physical Activity
Physical Training Induced Plasticity of Motor Control Mechanisms in Parkinson's Disease Patients
There are experimental evidences of the important role of exercise in the PD, that induces similar effects to pharmacotherapy. So far, the mechanisms of the impact of these changes on the brain subcortical and cortical regions…
- Trial name
- NCT03753503
- Testing
- exercise, conventional physical therapy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Multiple Sclerosis, Parkinson Disease
Biomarkers of Synaptic Damage in Multiple Sclerosis
A prospective and retrospective cohort study of about five years will be performed on blood and cerebrospinal fluid samples taken for diagnostic reasons from recruited patients within the Neuromed Neurology Unit.
- Conditions
- Multiple Sclerosis, Parkinson Disease, Amyotrophic Lateral Sclerosis, Alzheimer Disease
- Trial name
- NCT03217396
- Testing
- lumbar puncture
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Neuromed IRCCS
Blindness
Brain Plasticity of Verbal Memory in the Blind
This study will examine whether blind people develop changes in the brain that improve memory function. Previous studies have shown that blind people, on average, perform better in memory tasks than sighted people.
- Trial name
- NCT00059189
- Testing
- Magstim Rapid Magnetic Stimulator
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amblyopia
Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast.
- Trial name
- NCT05522972
- Testing
- Video Game Vision Training, Perceptual Learning, Occlusion Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Carpal Tunnel Syndrome (CTS)
Photobiomodulation for Median Nerve Neuroplasticity in Carpal Tunnel Syndrome: A Randomized Controlled Trial
Carpal Tunnel Syndrome (CTS) is the most common peripheral entrapment neuropathy, causing pain, paresthesia, and hand dysfunction due to median nerve compression at the wrist.
- Trial name
- PBM-CTS-RCT (NCT07714720)
- Testing
- Photobiomodulation (Low-Level Laser Therapy), Routine Physiotherapy Programme
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- University of Lahore
Cerebral Palsy, Typically Developing Children
Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study
This project examines the use of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic approach to improve motor function in children with cerebral palsy (CP).
- Trial name
- NCT07567053
- Testing
- MRI, HD-EEG Recording, rTMS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cook Children's Health Care System
Schizophrenia
Evaluation of a Cognitive Adaptive E-treatment in Schizophrenia-diagnosed Adults
This study is a multi-site, double-blind, randomized, controlled clinical trial to assess the safety and effectiveness of plasticity-based, adaptive, computerized-based cognitive remediation treatment versus a computer-based…
- Trial name
- e-CAeSAR (NCT01422902)
- Testing
- Plasticity-based Cognitive Training, Non-plasticity-based Training
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Posit Science Corporation
Stroke, Hemiplegia
The Efficacy & Safety of rTMS for Upper-limb Motor Function Recovery in Subcortical and Brainstem Stroke
The purpose of this study is to evaluate the efficacy and safety of repetitive transcranial magnetic stimulation applied with an electromagnetic therapy stimulator 'ALTMS-A' for upper-limb motor function recovery with the sham…
- Conditions
- Stroke, Hemiplegia, Subcortical Infarction
- Trial name
- NCT05535504
- Testing
- Low-frequency rTMS (experimental)
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Bundang Hospital
Parenting, Child Development
Evaluating a Strengths-based Community-grounded Intervention
Structural inequities and historical underinvestment in marginalized communities create developmental contexts that constrain access to high-quality education, healthcare, stable housing, and other critical resources.
- Conditions
- Parenting, Child Development, Brain Development, Household and Family
- Trial name
- NCT06701240
- Testing
- ParentChild+, FamilyNutrition+
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Human Brain and Cognition
Investigating the Plasticity of Human Predictive Coding Through Neuromodulation
The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and…
- Trial name
- PREDICOM (NCT06374433)
- Testing
- Occipital tACS at IAF-2Hz, Occipital tACS at IAF+2Hz, Frontal tACS at 4-7 Hz
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Autism Spectrum Disorder
Cognitive Training in Children With ASD
Plasticity refers to susceptibility of an organism to change. Cognitive training is an intervention approach based on the notion of plasticity.
- Trial name
- NCT02813564
- Testing
- Cognitive Assessment & Video-game INtervention Solutions (CAVINS)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Traumatic Brain Injury
Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic Brain Injury
Impairments in spatial memory and spatial navigation are commonly reported amongst patients presenting post-traumatic brain injury (TBI).
- Trial name
- NCT07271524
- Testing
- Transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 25 people
- Sponsor
- Friedhelm Hummel
Stroke
Imaging the Effects of Bihemispheric Transcranial Stimulation and Motor Training After Stroke.
Functional and structural magnetic resonance imaging (MRI) will be used to investigate neural correlates of bihemispheric transcranial direct current stimulation (tDCS) associated with upper limb rehabilitation in chronic stroke…
- Trial name
- NCT04195412
- Testing
- tDCS + upper limb rehabilitation
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- D'Or Institute for Research and Education