Clinical trials: Brain Stroke
Stroke, Post-stroke Cognitive Impairment (PSCI)
Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER)
Post-stroke cognitive impairment (PSCI) refers to a clinical syndrome characterized by cognitive impairment that occurs after a stroke event and persists for at least 24 weeks.
- Trial name
- Be-CLEVER (NCT05976152)
- Testing
- dl-3-butylphthalide
- Where
- China
- Volunteers
- 3,200 people
- Sponsor
- Fudan University
Acute Ischemic Stroke
Optimizing Door-to-reperfusion Times of One-stop Management in Acute Ischemic Stroke
Time is one of the most important in the decision of treatment of acute ischemic stroke. The optimal One-stop management from admission to recanalization associated with reduction of in-hospital times.
- Trial name
- ORETOM (NCT05644938)
- Testing
- Standard workflow, One-stop
- Where
- Vietnam
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Can Tho Stroke International Services Hospital
Stroke, Intracranial Atherosclerosis
Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis
Purpose: Intracranial atherosclerosis is a common condition in Korean population consisting over 25% of ischemic stroke etiology.
- Trial name
- STAMINA-MRI (NCT02458755)
- Testing
- High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Stroke, Ischemic, Intracranial Atherosclerosis
Effects of Medical Treatment of ICAS With Hemodynamic Disorders Based on MR-FFR
This multicenter prospective cohort study aims to compare the difference in the effects of medical treatment within 1 year between the two groups of ICAS patients divided hemodynamically by Magnetic Resonance Fractional Flow…
- Trial name
- NCT06196398
- Testing
- Standard Medical Treatment on the basis of anti-platelet therapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Cerebral Vascular Accident
Efficacy of rTMS and VCT on Upper Limb Function in Patients With Stroke
Stroke is the major cause of motor impairment and physical disabilities in the adult population. Spasticity and loss of dexterity are the common problems in stroke.
- Trial name
- NCT03350087
- Testing
- intermittent theta burst stimulation, continuous theta burst stimulation, iTBS+cTBS group
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
MELAS Syndrome
Glutamine Supplement in MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes) Syndrome
The purpose of this study is to assesses the efficacy of oral supplementation with glutamine over three months on several amino acids and lactate concentration measured in cerebrospinal fluid and cerebral lactate measured by…
- Trial name
- NCT04948138
- Testing
- Glutamine oral supplementation
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- Jesús González de la Aleja Tejera
Stroke
The Evaluation of Safety, Tolerability and Pharmacokinetics of Stroke Targeting Drug in Healthy Volunteers
The purpose of this study in to evaluate safety, tolerability, pharmacokinetics of JPI-289 in healthy male subjects.
- Trial name
- JPI-289 (NCT01983358)
- Testing
- JPI-289
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Stroke, Gait Disorders, Neurologic
Dynamic Ultrasound of the Calf Muscles After Stroke
Muscle behaviour of calf muscles can be studied during dynamic conditions using dynamic ultrasound. In particular, the medial gastrocnemius is suitable for measurements with dynamic ultrasound due to its superficial location.
- Trial name
- Stroke_DynUS (NCT06250478)
- Testing
- Dynamic ultrasound of the calf muscles
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Acquired Brain Injury Including Stroke
Effect of Functional Electrical Stimulation (FES) on Handwriting Rehabilitation After Acquired Brain Injury (ABI)
Study Purpose Functional Electrical Stimulation (FES) enhances motor recovery by increasing the functional range of motion to significantly improve muscle force deficits following an acquired brain injury.
- Trial name
- NCT07774715
- Testing
- Functional Electrical Stimulation (FES) on Handwriting Rehabilitation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Texas Woman's University
Acute Stroke
Smartphone-App Based Prediction of Large Vessel Occlusion
The aim of this non-interventional study is to evaluate a German version of the triage stroke-score FAST-ED performed by ambulance service personnel in a pre-hospital setting using a smartphone app (Join-Triage, Allm).
- Trial name
- NCT04404504
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Essen
Stroke, Hemiplegic Gait
Effect of Anterioposterior Weight Shifting Training With Visual Biofeedback in Patients With Step Length Asymmetry After Stroke
To investigate the effect of anteroposterior weight shifting training with visual biofeedback on step length asymmetry. Reduced speed and asymmetry of stepping is a specific characteristic of hemiplegic gait.
- Trial name
- NCT02207933
- Testing
- AP shifting training, Gait training
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Yonsei University
Stroke, Transcatheter Aortic Valve Replacement (TAVR)
A Clinical Study on the Use of the Sentinel Cerebral Protection Device During TAVR for the Prevention of Procedure-Related Stroke
After more than a decade of development, transcatheter aortic valve replacement (TAVR) is now a standard, guideline-recommended treatment for all symptomatic patients with severe aortic stenosis, regardless of their surgical…
- Conditions
- Stroke, Transcatheter Aortic Valve Replacement (TAVR), Aortic Stenosis Treated With TAVI
- Trial name
- SENTINEL-TAVR (NCT07045233)
- Testing
- Sentinel® Cerebral Protection System, MRI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Stroke Rehabilitation
Inspiratory Muscle Training in Patients With Stroke in Subacute Phase.
Assess the effect of inspiratory muscle training on lung function, muscle strength and trunk balance in survivors of stroke in the subacute phase of the disease
- Trial name
- NCT03800485
- Testing
- IMT
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Stroke, Non-communicable Disease
Make My Day - a Stroke Prevention Program
The purpose of this study is to evaluate the effects of a person-centered stroke prevention program implemented in primary healthcare.
- Trial name
- NCT05279508
- Testing
- Make My Day - stroke prevention program
- Where
- Sweden
- Volunteers
- 122 people
- Sponsor
- Karolinska Institutet
Stroke, Upper Limb Function
Investigating the Effects of Transcranial Stimulation to Advance Stroke Rehabilitation
Non-invasive brain stimulation (NIBS) has the potential to boost rehabilitation after stroke by creating a 'pro-plastic' environment, where the brain is more adaptable in response to movement (motor) training.
- Trial name
- T-STAR (NCT06842095)
- Testing
- Transcranial Alternating Current Stimulation (beta-tACS)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Spinal Cord Injuries, Stroke
Wheelchair Cushion Comparison Study: SAFETY
Purpose: To examine the safety of the use of two wheelchair cushions for healthy individuals with intact sensation and individuals post stroke and spinal cord injury with impaired sensation.
- Conditions
- Spinal Cord Injuries, Stroke, Healthy Adults
- Trial name
- NCT03430375
- Testing
- Alternating air wheelchair cushion, Static air cushion
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Dysphagia, Stroke
Fostering Eating After Stroke With Transcranial Direct Current Stimulation
Swallowing difficulties are common after a stroke and can lead to serious complications like pneumonia and malnutrition. Unfortunately, there are no effective treatment for improving swallowing in stroke patients.
- Trial name
- FEASt (NCT01919112)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Stroke
Additional Effects of Motor Imaginary Technique Along With Task Oriented Trunk Control Training
The aim of this randomized controlled trial is determine additional effects of motor imagery technique along with task oriented training on trunk control, posture, balance and mobility.
- Trial name
- NCT06877819
- Testing
- Motor Imaginary Technique alongwith task-oriented training, Task Oriented Training
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Stroke
Vitamin D and Stroke
Stroke remains one of the most devastating neurological diseases, often causing death, or gross physical impairment. It is the second most common cause of death worldwide and a major cause of acquired disability in adults.Vitamin…
- Trial name
- NCT02916030
- Testing
- Vit D
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Antiphospholipid Syndrome, Ischemic Stroke
Comparison of Clopidogrel-based Antiplatelet Therapy Versus Warfarin as Secondary Prevention Strategy for AntiPhospholipid Syndrome-related STROKE
Antiphospholipid syndrome (APS) has a close association with ischemic stroke; however, the optimal treatment strategy for APS-related stroke has yet to be established.
- Conditions
- Antiphospholipid Syndrome, Ischemic Stroke, Transient Ischemic Attack, Cerebrovascular Disease
- Trial name
- APS-STROKE (NCT05995600)
- Testing
- Antiplatelet Drug, Warfarin
- Where
- 32 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
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