Clinical trials: Brain Structural Connectivity
Emotion Regulation, Estradiol
Estradiol's Effect on Brain Volume and Connectivity
Ovarian hormones are not only modulators of cognitive function, emotion regulation and mental health, but also seem to affect brain plasticity and functional connectivity, During the menstrual cycle, women experience cyclic…
- Trial name
- NCT06312033
- Testing
- Estradiol Valerate
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Neuropathic Pain, Insomnia
Sleep and Neuropathic Pain - Intervention Study on Pregabalin
The goal of this clinical study is to study sleep and its microstructure in neuropathic pain patients who have or who do not have a clinically significant sleep disturbance, before and during (after 1-month stabile dosage)…
- Conditions
- Neuropathic Pain, Insomnia, Sleep Disorder
- Trial name
- NCT06155916
- Testing
- Pregabalin
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- Helsinki University Central Hospital
Friedreich's Ataxia, Motor Disorders
Electroencephalogram in Patients With Friedreich's Ataxia for the Study of the Structural and Functional Connectome.
Prospective, exploratory, multicenter pilot study investigating the structural and functional connectome in patients with Friedreich's Ataxia (FRDA) using high-density electroencephalogram (HD-EEG).
- Trial name
- CONNETTOMA (NCT07095062)
- Testing
- HD-EEG recordings, combined with cognitive and motor assessment
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Cannabis Use Disorder, PREG1
The Influence of in Utero Cannabis Exposure on Neonatal Brain Morphology and Structural Connectivity
Cannabis is the most commonly used drug by women during pregnancy with an estimated prevalence of use in Colorado of 5.7%. THC and its metabolites freely cross the placenta and blood-brain barrier to bind with cannabinoid…
- Conditions
- Cannabis Use Disorder, PREG1, Drug Use, Fetal Exposure During Pregnancy
- Trial name
- NCT03718520
- Testing
- no intervention, this is a purely observational study
- Where
- 2 sites in United States
- Volunteers
- 168 people
- Sponsor
- University of Colorado, Denver
Falling, Community Dwelling Older Adults
Neurophysiological Changes After Perturbation-based Training in Older Adults
This is an assessor-blinded neurophysiological study. Participants will be randomly assigned to a perturbation-based training (PBT) or a walking (control) group.
- Conditions
- Falling, Community Dwelling Older Adults, Postural Stability, Brain Connectivity
- Trial name
- NCT06573658
- Testing
- Perturbation-based balance training (PBT), Walking exercise (control)
- Where
- Hong Kong
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Low Back Pain, Mechanical
Radiofrequency Denervation and Brain Imaging
The goal of this observational study is to learn about changes in brain and its activity of following radiofrequency denervation treatment for chronic low back pain.
- Trial name
- NCT05641948
- Testing
- MRI scan
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Aberdeen
Migraine Disorders
A Functional MRI Study on Erenumab Treatment Effects in Episodic Migraine Patients
The purpose of this study is to investigate the effects of erenumab on central sensitization and brain networks connectivity of migraine patients
- Trial name
- RESET BRAIN (NCT03977649)
- Testing
- erenumab
- Where
- 5 sites in Italy
- Volunteers
- 62 people
- Sponsor
- Novartis Pharmaceuticals
Alzheimer Disease, Sleep
Sleep, Rhythms and Risk of Alzheimer's Disease
Alterations in sleep and the sleep / wake cycle, which are particularly common in Alzheimer's disease patients, could represent an early biomarker for cognitive decline and onset of dementia .
- Trial name
- AMImage3 (NCT04044495)
- Testing
- Multimodal brain imaging (MRI), Actimetry, Sleep Diary
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Bordeaux
Alzheimer Disease
Imaging of Brain Structural/Functional Connectivity and Amyloid and Tau Lesions in APOE4 Carriers.
To advance current knowledge on the vascular contributions to dementia
- Trial name
- Protocol_Z (NCT03816228)
- Testing
- F 18 T807 Flortaucipir
- Where
- United States
- Sponsor
- Tammie L. S. Benzinger, MD, PhD
Epilepsies
Structural and Functional Connectivity in Partial Epilepsies Studied with MRI and MEG
Surgery may be an effective therapy for refractory focal epilepsies with a clear delineated focus but surgical benefits are less clear for patients with a poorly defined focus such as non lesional refractory partial epilepsies.
- Trial name
- NCT01313260
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Gender Identity Disorder
Effects of Sex Steroid Hormones on Human Brain Function, Structure and Connectivity
This ultrahigh-field MRI study gives us the unique opportunity to measure changes in brain function and structure induced by long-term opposite-sex steroid hormone administration in transsexual subjects. Our aim is 1.
- Trial name
- NCT01292785
- Testing
- Hormones
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Alcohol Addiction
Effects of Frontopolar TMS in Alcohol Craving
The goal of this interventional study is to learn if continuous theta burst stimulation (cTBS) applied over the left frontopolar cortex can reduce psychological, physiological, and neurobiological markers of alcohol craving in…
- Trial name
- TMS-SUD (NCT07064590)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in Germany
- Volunteers
- 34 people
- Sponsor
- Goethe University
Seasonal Affective Disorder, Major Depressive Disorder
Investigation of Seasonal Variations of Brain Structure and Connectivity in SAD
Seasonal Affective Disorder (SAD) is a subtype of Major Depressive Disorder, characterized by a recurrent temporal relationship between the season of year, the onset and the remission of a major depressive episode.
- Conditions
- Seasonal Affective Disorder, Major Depressive Disorder, Neuroimaging
- Trial name
- NCT03313674
- Testing
- Bright Light Therapy
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Glaucoma
Magnetic Resonance Imaging of Cerebral Connectivity and Volume in Neurodegeneration and Glaucoma
The EVOLUTION is a 10-year extension of the ENVOL study. It seeks to compare the evolution of structural and functional connectivity (Hub Disruption Index) and cerebral volume on 3T MRI of the brain in glaucoma patients and…
- Trial name
- EVOLUTION (NCT07802769)
- Testing
- MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Dysmenorrhea
Brain Structural and Functional Connectivity Changes in the Period of Dysmenorrhea: a Prospective fMRI Study
Observational prospective study with an analysis of the changes in brain structure and related functional connectivity in women with dysmenorrhea.
- Trial name
- NCT06178406
- Testing
- dysmenorrhea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
PostTraumatic Stress Disorder
PTSD Among Victims of Sexual Abuse and Changes in Structural and Functional Brain Connectivity
The goal of this study is to identify the early modifications in fronto-temporal connectivity in female victims who developed PTSD, compared to female victims who did not develop the disorder, and to healthy control females.
- Trial name
- COPTSD (NCT01405495)
- Testing
- MRI-based techniques (sMRI, fMRI, DTI, ASL)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Neuropathic Pain
Structural and Functional Brain Reorganization in Neuropathic Pain: Basal State of Local Cerebral Blood Flow and Functional Connectivity
Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation).
- Trial name
- CONNECT (NCT02858466)
- Testing
- MRI scan
- Where
- France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Multiple Sclerosis, Relapsing-Remitting
Exploration of Brain Changes Due to a Targeted Ballet Program in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) affecting roughly 900,000 people in the United States that frequently results in impaired mobility.
- Trial name
- NCT04073940
- Testing
- Targeted Ballet Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Illinois at Urbana-Champaign
Traumatic Brain Injury
Predicting Cognitive and Emotional Health From Neurocircuitry Following TBI
Abnormalities in structural and functional connectivity between brain regions have been suggested as putative biomarkers of mild traumatic brain injury (TBI) and significant contributors to neuropsychological functioning and…
- Trial name
- NCT01803048
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Tumor, Brain
Bridging Brain Structure and Function by Correlating Structural Connectivity, Cortico-Cortical Transmission and Direct Electro-Stimulation
Elucidating the structure-function relationship of the brain is one of the main open questions in neuroscience. The capabilities of diffusion MRI-based (dMRI) techniques to quantify the connectivity strength between brain areas…
- Trial name
- NCT03503110
- Testing
- electrocorticography with electrostimulation, dRMI
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nice