Clinical trials: Brain Swelling
Intracranial Hypertension, Increased Intracranial Pressure
Bedside Ultrasound Measurement of Optic Nerve Sheath Diameter for Detecting Raised Intracranial Pressure
Raised intracranial pressure (ICP) is a serious medical emergency that requires prompt recognition to prevent brain damage. While invasive pressure monitoring and brain CT scans are commonly used, bedside transorbital…
- Conditions
- Intracranial Hypertension, Increased Intracranial Pressure, Brain Edema, Traumatic Brain Injury
- Trial name
- NCT07799714
- Volunteers
- 85 people
- Sponsor
- Assiut University
Head Trauma
Early Induced Hypernatremia for the Prevention and Management of Brain Edema
The purpose of this study is to estimate the effect of an early induced hypernatremia protocol (150-155 milliequivalent/L) versus normonatremia plus mannitol (135 - 145 milliequivalent/L) in terms of neurologic outcome in…
- Trial name
- EHIBE (NCT02798601)
- Testing
- Hypernatremia
- Sponsor
- Hospital Pablo Tobón Uribe
Intracerebral Hemorrhage
Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
This first-in-patient phase 2a pilot study will assess the safety and tolerability of MW01-6-189WH (hereafter called MW189) in patients with Intracerebral Hemorrhage (ICH).
- Trial name
- BEACH (NCT05020535)
- Testing
- MW189, Saline
- Where
- 11 sites in United States
- Volunteers
- 120 people
- Sponsor
- Johns Hopkins University
Brain Edema, Metabolic Disturbance
Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation
Usage of osmotic agents is a standard practice in neuroanesthesia since cerebral edema is a very common situation for patients with pathology in the brain.
- Conditions
- Brain Edema, Metabolic Disturbance, Electrolyte and Fluid Balance Conditions
- Trial name
- NCT03573999
- Testing
- Mannitol, NaCl 7.5%
- Where
- 2 sites in Greece
- Volunteers
- 54 people
- Sponsor
- Aristotle University Of Thessaloniki
Cerebral Edema, Brain Metastases
Glyburide vs Placebo as Prophylaxis Against Cerebral Edema in Patients Receiving Radiosurgery for Brain Metastases (RAD 1502/UAB 1593)
Primary Objectives: Pilot Portion: To determine the feasibility and safety of administering oral glyburide to non-diabetic patients receiving stereotactic radiosurgery (SRS) for newly diagnosed brain metastases.
- Trial name
- NCT02460874
- Testing
- Glyburide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Acute Ischemic Stroke, Mechanical Thrombectomy
Rapid Local Ischemic Postconditioning in Acute Ischemic Stroke
The objective of this clinical trial is to determine whether rapid local ischemic postconditioning (RL-IPostC) is effective in preventing brain edema and safe in acute ischemic stroke (AIS) patients treated with mechanical…
- Conditions
- Acute Ischemic Stroke, Mechanical Thrombectomy, Ischemic Postconditioning, Brain Edema
- Trial name
- RAPID-SAVE (NCT06307743)
- Testing
- rapid local ischemic postconditioning
- Volunteers
- 135 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Endovascular Therapy, Brain Edema
Early Identification of Malignant Brain Edema in laRge Artery oCclusive Stroke After Endovascular Therapy (EMBRACE Study)
To design and validate a predictive model for malignant brain edema after endovascular thrombectomy.
- Conditions
- Endovascular Therapy, Brain Edema, Prediction Model, Ischemic Stroke
- Trial name
- EMBRACE (NCT06451887)
- Where
- China
- Volunteers
- 1,950 people
- Sponsor
- Zhejiang Provincial People's Hospital
Stroke, Intracranial Hypotension
Safety & Tolerability of Hypertonic Saline Administration Via Intraosseous Access
Hypertonic saline is used to treat elevated intracranial pressure. Intraosseous vascular access has been used to administer fluids and medications. This study combines these to administer 3% hypertonic saline via IO.
- Conditions
- Stroke, Intracranial Hypotension, Cerebral Edema
- Trial name
- NCT03276494
- Testing
- Intraosseous, Hypertonic saline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ohio State University
Stroke, Acute, Brain Edema
Automatic PredICtion of Edema After Stroke
To use machine learning for early detection of malignant brain edema in patients with MCA ischemia
- Trial name
- APICES (NCT04057690)
- Where
- 19 sites in Austria, Germany and 1 more
- Volunteers
- 1,687 people
- Sponsor
- University Hospital Tuebingen
Aneurysmal Subarachnoid Hemorrhage
Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH)
DECIDE-SAH is an international, multicenter, retrospective, observational, non-interventional secondary-use cohort study of adults with aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- DECIDE-SAH (NCT07872774)
- Testing
- Decompressive craniectomy
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Essen
Traumatic Brain Injury, Cerebral Edema
Trial of Dexamethasone for Traumatic Brain Injured Patients With Brain Contusions and Pericontusional Edema
The DEXCON-TBI trial is a multicenter, pragmatic, randomized, triple-blind, placebo controlled trial to quantify the effects of the administration of dexamethasone on the prognosis of TBI patients with brain contusions and…
- Conditions
- Traumatic Brain Injury, Cerebral Edema, Head Injury Trauma
- Trial name
- DEXCON-TBI (NCT04303065)
- Testing
- Dexamethasone Oral
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Jon Pérez Bárcena
Hemodynamic Instability, Water on the Brain
Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients.
This study aims to investigate the inner mechanism during different dehydration therapies such as mannitol injection and hypertonic saline.
- Conditions
- Hemodynamic Instability, Water on the Brain, Intracranial Pressure Increase
- Trial name
- NCT03828032
- Testing
- Mannitol injection, Hypertonic saline injection
- Volunteers
- 80 people
- Sponsor
- Ting Li
Cerebral Edema
Evaluation of the Cerebral Edema in Children Having Diabetic Ketoacidosis
The purpose of this study is to determine cerebral edema with evaluation of measurement of diameter of optic nerve sheath.
- Trial name
- NCT02937441
- Testing
- Ultrasonic Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Cukurova University
Fluid Therapy, Brain Edema
Effects of Intraoperative GDFT on the Postoperative Brain Edema
Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain.
- Conditions
- Fluid Therapy, Brain Edema, Brain Tumor
- Trial name
- NCT03323580
- Testing
- GDFT, traditional fluid therapy
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Beijing Tiantan Hospital
Traumatic Brain Injury, Head Injury
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial.
- Conditions
- Traumatic Brain Injury, Head Injury, Head Injuries, Closed, Brain Hemorrhage, Traumatic
- Trial name
- NCT05622461
- Testing
- Road-to-recovery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Brain Edema, Brain Edema Caused by Drugs
A Pharmacovigilance Study of Brain Oedema
Literature reports the development of brain oedema following the use of certain drugs. Therefore, this study aims to present a comprehensive disproportionality analysis of brain oedema cases reported to the Food and Drug…
- Trial name
- NCT04311359
- Testing
- Drugs, Generic
- Where
- Pakistan
- Volunteers
- 9,524 people
- Sponsor
- University of Peshawar
Cerebral Edema, Saline Solution, Hypertonic
Small-Volume, Patient-Specific, Balanced Hypertonic Fluid Protocol Validation
Many patients with traumatic brain injuries (including strokes, blood clots, or other brain injuries) are given concentrated salt water solutions (hypertonic saline) in order to treat brain swelling (cerebral edema).
- Trial name
- NCT03330704
- Testing
- 3% Sodium Chloride, 23.4% Sodium Chloride, 8.4% Sodium Bicarbonate
- Where
- United States
- Sponsor
- Stanford University
Intracerebral Hemorrhage, Cerebral Edema
Fingolimod as a Treatment of Cerebral Edema After Intracerebral Hemorrhage
The purpose of this study is to test the safety and effectiveness of a single dose of fingolimod in patients with primary spontaneous intracerebral hemorrhage (ICH).
- Conditions
- Intracerebral Hemorrhage, Cerebral Edema, Stroke Hemorrhagic, Intracerebral Hemorrhage, Hypertensive
- Trial name
- FITCH (NCT04088630)
- Testing
- Fingolimod, Open-label Fingolimod
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Wake Forest University Health Sciences
Brain Edema, Brain Tumor
An Open-Labeled, Extended-Use of XERECEPT (hCRF) for Patients in Studies NTI 0302, 0303, or Other Designated Studies
The purpose of this study is to examine the long-term safety and tolerability of human corticotropin-releasing factor (hCRF), XERECEPT®, in patients requiring dexamethasone (Decadron) to treat peritumoral brain edema.
- Trial name
- NCT00226655
- Testing
- hCRF [XERECEPT (corticorelin acetate injection)]
- Where
- 32 sites in United States, Canada
- Volunteers
- 112 people
- Sponsor
- Celtic Pharma Development Services
Arterial Aneurysm
SMCV Assessment on Brain Swelling in Patients With SAH From Ruptured Artery Aneurysm
Superficial cerebral veins findings in assessment of brain swelling in patients with aneurysmal subarachnoid hemorrhage who underwent intravenenous DSA examinations
- Trial name
- SMCV (NCT05714735)
- Testing
- Cerebral Venography
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Xuanwu Hospital, Beijing