Clinical trials: Brain Trauma
Brain Concussion, mTBI - Mild Traumatic Brain Injury
Screening Instruments for Measuring Visual Symptoms in Victims of Concussion
Visual dysfunction after mild traumatic brain injury (mTBI) is common but often remain undiscovered during longer periods of time. No valid, reliable and easy-to-use screening instrument for uncovering visual dysfunction exists.
- Trial name
- VisCom (NCT05862571)
- Where
- Denmark
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Dementia, Hip Fractures
Care Delivery in Acute Hospital Settings: an Observational Study
This small observational study is a contractual component of a 5-year (2013-18) NIHR funded programme called PERFECTED (Peri-operative Enhanced Recovery hip FracturE Care of paTiEnts with Dementia) whose overall aim is to develop…
- Trial name
- PERFECTED (NCT02212353)
- Testing
- Observational study, not interventional
- Volunteers
- 180 people
- Sponsor
- University of East Anglia
Traumatic Brain Injury, Posttraumatic Epilepsy
Allopregnanolone for the Treatment of Traumatic Brain Injury
This study will provide initial data on the safety and effectiveness of allopregnanolone in improving neurobehavioral outcome and reducing mortality in adults with moderate and severe traumatic brain injury.
- Trial name
- NCT01673828
- Testing
- Allopregnanolone injection
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Michael A. Rogawski, MD, PhD
Sports-related Concussion
The Impact of Riboflavin on Sports-related Concussion
The purpose of this study is to investigate the effectiveness of riboflavin to decrease the duration of time for a student-athlete to return to participation in sports after a sports related concussion.
- Trial name
- NCT02772237
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Traumatic Brain Injury, Cognitive Impairment
"Cognitive Rehabilitation With Direct Current Transcranial Stimulation in Post-Traumatic Brain Injury Patients"
The goal of this clinical trial is to investigate the impact of daily self-administered transcranial direct current stimulation (tDCS) therapy on the cognitive function of individuals with moderate to severe cognitive impairment…
- Trial name
- tDCS-TEC (NCT06228872)
- Testing
- Cognitive Computerized Training (CCT) plus Anodic transcranial Direct Current Stimulation (tDCS)
- Where
- Chile
- Volunteers
- 38 people
- Sponsor
- Mutual de Seguridad Hospital Clinico
Persistent Concussion Symptoms
Study of an Exercise Program (STEP) for Youth With Concussion
To compare the efficacy of a sub-threshold aerobic exercise intervention provided with mobile health coaching (STEP-mhc) and a light stretching program (LS) to LS alone for 11-18 yo youth with persistent concussion symptoms.
- Trial name
- STEP (NCT02673112)
- Testing
- Subthreshold exercise (STEP) with mobile health coaching, Light stretching (LS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seattle Children's Hospital
Blast Injury
Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure
This is a 4-year, longitudinal study of 100 active-duty Navy SEALs. The goal of the study is to determine whether repeated blast exposure affects SEAL brain health and to develop an initial diagnostic testing protocol that…
- Trial name
- NCT07131475
- Testing
- PBR28 TSPO PET
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Brain-injury, Stroke
Mechanical Ventilation in Brain-injured Patients
Protective ventilation (association of a tidal volume < 8 ml/kg with a positive end expiratory pressure) is poorly used in severe brain-injured patients.
- Conditions
- Brain-injury, Stroke, Subarachnoid Haemorrhage, Traumatic Brain Injury
- Trial name
- BI-VILI (NCT01885507)
- Testing
- Pass recommendations on ventilation factors and extubation
- Where
- 22 sites in France
- Volunteers
- 560 people
- Sponsor
- Nantes University Hospital
Concussion, Mild
The Combined Effect of Chronic Cannabis Use and Subconcussive Head Impacts on Brain Health
The purpose of this pilot study is to better understand the effects of chronic cannabis (THC) use on the neural responses to subconcussive head impacts, as a form of repetitive soccer headings.
- Trial name
- NCT04641832
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Indiana University
Traumatic Brain Injury
A Study of Modified Stem Cells in Traumatic Brain Injury (TBI)
The primary purpose of the clinical study is to evaluate the clinical efficacy of intracranial administration of SB623 cells on patients with chronic motor deficit from Traumatic Brain Injury.
- Trial name
- STEMTRA (NCT02416492)
- Testing
- SB623 cells
- Where
- 36 sites in United States, Japan and 1 more
- Volunteers
- 63 people
- Sponsor
- SanBio, Inc.
Traumatic Brain Injuries, Intracranial Hypertension
Effectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain Injury
Traumatic brain injury (TBI) patients often exhibit an increase in their intracranial volume due to blood collection or brain tissue edema.
- Trial name
- E-SPACE-TBI (NCT06776614)
- Testing
- Decompressive Craniectomy, Expansion Craniotomy
- Volunteers
- 292 people
- Sponsor
- Meditech Foundation
Traumatic Chronic Encephalopathy
Cerebral and Cognitive Impact of Female Professional SoccerPractice
The objective of this study is to evaluate, using MRI, the microstructural consequences and the onset of any cognitive impairment in female professional soccer players at the end of their career, who have experienced repeated…
- Trial name
- TCFOOT F (NCT06788262)
- Testing
- Cerebral MRI
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Traumatic Brain Injury, TBI
Exploring Relationships Among Balance Performance, Cognitive Dysfunction, Affective Dysregulation, and Community Integration in Veterans With Traumatic Brain Injury (TBI)
The overarching goal of the proposed study, named SYNERGY, is to explore relationships among balance performance, cognitive function, affective dysregulation, as they relate to the community re-integration in Veterans with TBI.
- Trial name
- NCT02366442
- Testing
- Exploring relationships among balance performance, cognitive dysfunction, affective dysregulation, and community integration in Veterans with Traumatic Brain Injury (TBI).
- Volunteers
- 80 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Alcohol Use Disorder, Mild Traumatic Brain Injury
Pilot rTMS for AUD+mTBI
This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder.
- Conditions
- Alcohol Use Disorder, Mild Traumatic Brain Injury, Post-traumatic Stress Disorder
- Trial name
- TMS_AUD+mTBI (NCT03995173)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development
Occlusion or Malformation of a Cerebral Vessel
Comparison of Two Protocols of Optimization of X Ray Radiations in Pediatric Interventional Neuroradiology
Interventional Neuroradiology replaces surgery. This technology requires various exposition to X rays : number of X rays photographs, radioscopy, distance between patient and detector, speed of acquisition of X-rays photographs…
- Trial name
- MINIRAD (NCT02008305)
- Testing
- protocol of optimization ALARA, protocol of optimization Philips
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Traumatic Brain Injury, Post-concussive Symptoms
MEG and DTI of Neural Function and Connectivity in Traumatic Brain Injury
The overall hypothesis is that the long-term cognitive and behavioral sequelae of traumatic brain injury (TBI) are due to selective disruption of the long association white matter tracts of the cerebral hemispheres, with…
- Trial name
- Dana-REAC (NCT01298557)
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Traumatic Brain Injury
Feasibility of the Radio-Frequency Microstimulator System to Improve Arm Function Following Traumatic Brain Injury
This study will evaluate the feasibility of using fully implanted microstimulators to rehabilitate arm function in patients who have suffered a traumatic brain injury.
- Trial name
- NCT01488981
- Testing
- Upper Extremity Therapy without stimulation, Upper Extremity Therapy with stimulation from the Radiofrequency Microstimulator (RFM) System (Alfred Mann Foundation, Santa Clarita, CA)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- The Alfred E. Mann Foundation for Scientific Research
PTSD, Post Traumatic Stress Disorder
Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI
The investigators want to test a treatment for posttraumatic stress disorder (PTSD) especially designed for military veterans and service members with mild or moderate traumatic brain injuries (TBI) and PTSD.
- Conditions
- PTSD, Post Traumatic Stress Disorder, Traumatic Brain Injury
- Trial name
- T3 for PTSD (NCT07351305)
- Testing
- Non-Trauma Treatment for TBI and PTSD
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Neural Injury
Brain Connectivity Analysis
Stroke remains the leading cause of permanent disability. The neuromodulation technique of transcranial Direct Current Stimulation (tDCS) has the potential to serve as an adjuvant therapy to enhance neuronal connectivity…
- Trial name
- Neurehab (NCT06823102)
- Testing
- tDCS
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- IRCCS San Raffaele Roma
Traumatic Brain Injury
Problem Solving for Caregivers of Persons With Brain Injury
This study was designed to evaluate a behavioral intervention program to improve medication adherence in adults with hypertension. The study was withdrawn prior to enrollment.
- Trial name
- NCT00164645
- Testing
- Problem Solving Therapy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention