Clinical trials: Brain Vascular Function, active
Acute Ischemic Stroke, Transient Ischemic Attack
Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
The goal of this observational study is to to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; to evaluate the influence of lesion location on autonomic dysfunction; to…
- Trial name
- ARIADNE (NCT06740942)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stroke
Hybrid Robot+FES Stroke Rehabilitation
The investigators have developed a novel robot-guided stretching under intelligent control and combine it with active movement training, which helped increase joint ROM, reduce spasticity and joint stiffness, increase muscle…
- Trial name
- NCT04550728
- Testing
- Ankle robot training group, Ankle robot training and functional electrical stimulation(FES) group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Ischemic Stroke
A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-3 (NCT07645586)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Beijing Tiantan Hospital
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)
- Trial name
- NCT06735651
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgia State University
Stroke
Effect of Cerebellar Fastigial Nucleus Stimulation Combined With Sling Exercise on Motor Function in Hemiplegic Stroke Patients
This study aims to investigate the rehabilitative effects and synergistic potential of combining Fastigial Nucleus Stimulation (FNS) with Sling Exercise Training (SET) on motor function in patients with post-stroke hemiplegia.
- Trial name
- NCT07670936
- Testing
- Cerebellar Fastigial Nucleus Electrical Stimulation, Sling Exercise Therapy
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Shengjing Hospital
Brain Arteriovenous Malformations
Language Function Reorganization in Patients With Arteriovenous Malformations
Brain arteriovenous malformation (AVM) is generally considered as a congenital lesion. Its unique clinical manifestation is that when the unruptured AVM involves and destroys the language function area of the left hemisphere, the…
- Trial name
- NCT07537504
- Testing
- MRI
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Brain Metastases, Adult, Neurocognitive Function
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing…
- Conditions
- Brain Metastases, Adult, Neurocognitive Function, Cancer, Meningioma of Brain
- Trial name
- IG-SRS (NCT04343157)
- Testing
- Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Jona Hattangadi-Gluth
Stroke
Correlation Between Clinical Neurological Biomarkers and Rehabilitation Outcome
Our study purpose is to evaluate the predictive power of various clinical, neurophysiological, and neuroimaging biomarkers-acquired and analyzed using advanced and integrated techniques-on motor functional recovery and disability…
- Trial name
- PREVICTUS (NCT06805929)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele Roma
Stroke
Effects of Low Level Laser Therapy on Wrist Flexors Spasticity and Hand Functions in Patients With Stroke
this study will be conducted to investigate the effect of low level laser therapy (LLLT) on wrist flexors spasticity and hand functions in patient with stroke
- Trial name
- LLL (NCT07171788)
- Testing
- low level laser therapy, selected physical therapy program
- Volunteers
- 40 people
- Sponsor
- Cairo University
Stroke, Hemiplegia
The Effect of Blood Flow Restriction Training Combined With Transcranial Magnetic Stimulation on Limb Function in Hemiplegic Patients After Stroke
This randomized controlled trial aims to evaluate whether combining blood flow restriction training (BFRT) with repetitive transcranial magnetic stimulation (rTMS) improves limb function in stroke patients with hemiplegia.
- Trial name
- BFR-TMS-Stroke (NCT07454954)
- Testing
- Conventional Rehabilitation, Repetitive Transcranial Magnetic Stimulation (rTMS), Blood Flow Restriction Training (BFRT)
- Volunteers
- 69 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Ischemic Stroke
Gait Recovery in Patients After Acute Ischemic Stroke
More than 80% of ischemic stroke (IS) patients have some walking disability, which restricts their independence in the activities of daily living.
- Trial name
- GAITFAST (NCT04824482)
- Testing
- Robot-assisted treadmill gait training (RTGT), Therapist-assisted treadmill gait training (TTGT)
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Olomouc
Stroke
Post-stroke Nurse-led Rehabilitation to Improve Functional Activity and Community Participation in Bangladesh
Stroke causes various levels of disability which decreases physical function for a prolonged period. The purpose of this study is to evaluate the effectiveness of a nurse-led rehabilitation program including a multidisciplinary…
- Trial name
- NCT07384650
- Testing
- in daily routine practice
- Where
- Bangladesh
- Volunteers
- 166 people
- Sponsor
- Hiroshima University
Stroke, Telerehabilitation
Effects of Maximum Versus Minimum Supervised Telerehabilitation on Upper Limb Function in Post Stroke Patients
This single-blinded randomized controlled trial aims to compare the effectiveness of maximum versus minimum therapist supervision during home-based telerehabilitation for improving upper limb motor function, task performance…
- Conditions
- Stroke, Telerehabilitation, Upper Limb
- Trial name
- NCT07803003
- Testing
- Maximum supervision telerehabilitation, Minimum Supervision Telerehabilitation
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Foundation University Islamabad
Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block
Stellate Ganglion Block and Prognosis of Neurological Function After Subarachnoid Hemorrhage
The incidence of cerebral vasospasm after aneurysm subarachnoid hemorrhage (aSAH) is as high as 70%; cerebral vasospasm（CVS） is closely related to delayed cerebral ischemia （DCI）, which is one of the important reasons for poor…
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block, Neurological Prognosis
- Trial name
- NCT07652749
- Testing
- Intervention group
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Beijing Tiantan Hospital
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Acute Ischemic Stroke, Clopidogrel Resistance
Precision Antiplatelet Therapy Guided by Platelet Aggregation Function in Patients With Acute Ischemic STROKE
The objective of this clinical trial is to evaluate the efficacy and safety of platelet aggregation function - guided precision anti - platelet therapy in patients with acute cerebral infarction.
- Trial name
- PATH STROKE C (NCT06853535)
- Testing
- The ticagrelor, The Clopidogrel
- Where
- China
- Volunteers
- 5,138 people
- Sponsor
- Sichuan Provincial People's Hospital
Stroke
Comparing Mirror Therapy and CIMT for Hand and Arm Function in Post-Stroke Patients
The goal of this clinical trial is to find out whether Mirror Therapy (MT) combined with Constraint-Induced Movement Therapy (CIMT) improves hand and arm function after a stroke.
- Trial name
- NCT07139015
- Testing
- CONSTRAINT-INDUCED MOVEMENT THERAPY, MIRROR THERAPY
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Stroke
Foot Drop Rehabilitation and Mobility in Chronic Stroke
Stroke is a leading cause of long-term disability, frequently resulting in motor impairments, balance deficits, and walking difficulties that limit functional independence and quality of life.
- Trial name
- NCT07914413
- Testing
- Conventional Physical Therapy Program, FES-Assisted Gait Training
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Umm Al-Qura University
PreDiabetes, Insulin Resistance
Disease Prevention in Clinical Practice Base on Patient Specific Physiology
It is well known that the Type 2 diabetes and vascular disease are preceded by over ten years by metabolic dysfunction and anatomic changes that can be quantified.
- Conditions
- PreDiabetes, Insulin Resistance, Type2 Diabetes, NASH - Nonalcoholic Steatohepatitis
- Trial name
- STOPDISEASE (NCT03308773)
- Testing
- Lifestyle modification in routine care of patients
- Volunteers
- 5,000 people
- Sponsor
- Pacific Coast Family Medical Group
Stroke, Upper Extremity Paresis
Virtual Reality Based Mirror Therapy
The aim of this study is to examine the effectiveness of 3D virtual reality assisted mirror therapy based rehabilitation applications compared to classical methods used in stroke rehabilitation.
- Conditions
- Stroke, Upper Extremity Paresis, Upper Extremity Paralysis
- Trial name
- NCT06152328
- Testing
- Virtual reality applications based on mirror therapy, Conventional treatment, Mirror therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Abant Izzet Baysal University