Clinical trials: Brain to Brain Communication, open to volunteers
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Dementia, Hip Fracture
Communication for Early Mobilisation of People Living With Dementia Following Surgery for Hip Fracture
This goal of this study is to identify ways that healthcare professionals communicate that are effective in helping a person living with dementia to stand or walk after surgery for a broken hip (hip fracture).
- Conditions
- Dementia, Hip Fracture, Early Mobilisation, Communication Research
- Trial name
- VOICE-HF (NCT07418268)
- Volunteers
- 200 people
- Sponsor
- University of Nottingham
Dementia
Adapting Changing Talk: Online (CHATO) to CHATO-Inclusive
This study will adapt and test online interactive training for nursing home staff that improves staff communication and reduces behavioral symptoms of persons with dementia that they care for.
- Trial name
- NCT06636214
- Testing
- CHATO-I
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Stroke, Dysarthria
Deep Brain Stimulation + Therapy for Stroke
The purpose of this study is to evaluate the safety and potential benefits of combining deep brain stimulation (DBS) with targeted speech and swallowing rehabilitation in individuals who have experienced a stroke and have…
- Conditions
- Stroke, Dysarthria, Apraxia, Dysphagia
- Trial name
- NCT07849114
- Testing
- Boston Scientific Vercise Deep Brain Stimulation (DBS) System, Rehabilitation Training Protocol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Pirondini, Elvira, PhD
Alzheimer Disease
Learning Amyloid and Tau Results
This is a prospective, single-cohort, single-center, observational study to assess if learning one's Alzheimer's disease biomarker test result impacts longitudinal psychosocial, behavioral, and neuropsychological outcomes, and to…
- Trial name
- NCT07222930
- Testing
- Disclose amyloid, tau results, Follow-up Assessments
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Primary Progressive Aphasia(PPA), Semantic Dementia
Intervention for Communication Quality of Life in Primary Progressive Aphasia
The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and…
- Conditions
- Primary Progressive Aphasia(PPA), Semantic Dementia, Logopenic Progressive Aphasia (LPA), Nonfluent Aphasia, Progressive
- Trial name
- Multi-PA (NCT07219680)
- Testing
- Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Maya Henry
Central Auditory Processing Disorder, Hearing Impaired (Partially)
A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound
The goal of this clinical trial is to determine the efficacy of Clemastine Fumarate in the presence of engineered sound to treat age-related central auditory processing disorder (CAPD).
- Conditions
- Central Auditory Processing Disorder, Hearing Impaired (Partially), Hearing, Hearing Abnormality
- Trial name
- CAPD-LOOT (NCT07304024)
- Testing
- Clemastine Fumarate Combined With Engineered Sound, Clemastine Fumarate Combined With Pink Noise
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- University of Colorado, Denver
Hemiplegia, Aphasia
The Effect of Upper Extremity Motor Function, Trunk Control and Motor Imagery Ability on Turkish Language Skills in Individuals With Stroke
A large number of people have a stroke each year and it is a major cause of disability worldwide. Upper limb motor impairments, aphasia, body control problems and decreased motor imagery ability are common after stroke.
- Conditions
- Hemiplegia, Aphasia, Stroke, Trunk
- Trial name
- NCT06946082
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Izmir Bakircay University
Aphasia
LEXURE for Post-Stroke Aphasia
This study evaluates the efficacy of digital language rehabilitation using LEXURE for the treatment of post-stroke aphasia. Half of participants will receive structured language training using the LEXURE application, while the…
- Trial name
- NCT07570264
- Testing
- LEXURE, Workbook
- Where
- 12 sites in South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Nunaps Inc
Medication Review, Polypharmacy
Prioritising Patient Medication Review: Hospitals Reaching Out
To examine the effect of a cross-sectoral medication review intervention to admitted multi-morbid, polypharmacy patients aged 65+ at SHS in two settings; an acute admission unit (typical admission time < 48 hours) and a medical…
- Conditions
- Medication Review, Polypharmacy, General Practitioners, Interdisciplinary Communication
- Trial name
- PriPMed (NCT06451692)
- Testing
- Clinical pharmacist
- Where
- Denmark
- Volunteers
- 800 people
- Sponsor
- University of Southern Denmark
Stuttering, Fluency Disorder
Using Non-invasive Brain Stimulation to Explore Potential Treatments to Reduce Speech Errors in Adults Who Stutter
The goal of this study is to find out whether a type of noninvasive brain stimulation can help reduce speech errors, such as repetitions, blocks, and prolongations, in people who stutter.
- Trial name
- NCT07354139
- Testing
- High - Definition Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas at Dallas
Primary Progressive Aphasia, Dementia
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA…
- Conditions
- Primary Progressive Aphasia, Dementia, Dementia, Frontotemporal, Alzheimer Disease
- Trial name
- NCT05741853
- Testing
- Video-Implemented Script Training for Aphasia (VISTA), Lexical Retrieval Training (LRT)
- Where
- 3 sites in United States, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stephanie Grasso
Amyotrophic Lateral Sclerosis, Neuromuscular Disease
Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)
The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI).
- Conditions
- Amyotrophic Lateral Sclerosis, Neuromuscular Disease, Stroke, Tetraplegia/Tetraparesis
- Trial name
- CONNECT-ONE (NCT07357428)
- Testing
- Connexus Brain-Computer Interface
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Paradromics
Down Syndrome
Non-Invasive Brain Stimulation to Improve Language in Down Syndrome.
Down syndrome (DS) is associated with cognitive deficits, caused by alterations in neuroplasticity and synaptic transmission. Non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), can…
- Trial name
- NCT07044804
- Testing
- Active Group (Active Anodal tDCS to the left IFG or Cathodal tDCS to the left IFG)
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Floriana Costanzo
Aphasia, Stroke
Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke.
- Conditions
- Aphasia, Stroke, Aphasia Following Cerebral Infarction, Aphasia, Acquired
- Trial name
- TMS (NCT06842745)
- Testing
- Transcranial Magnetic Stimulation (TMS), Speech-Language Therapy (SLT)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pennsylvania
Brain to Brain Communication
Linked Outcomes in Various EEG-Hyperscanning Setups
The goal of this observational study is to investigate how brains of healthy controls respond when they interact with their romantic partner compared to when they interact with a stranger.
- Trial name
- LOVEH (NCT07385027)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Neurodegenerative Diseases, Dementia
Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis
This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network.
- Trial name
- NAVAIDD (NCT06339190)
- Testing
- Venepuncture
- Where
- 2 sites in Australia
- Volunteers
- 1,000 people
- Sponsor
- Monash University
Cerebral Palsy, Mobile Phone Use
Using Augmented Reality to Promote Physical Activity in Children With Cerebral Palsy
Children with cerebral palsy (CP), Gross Motor Functional Classification Scale (GMFCS) I-II will be recruited to participate in a home based physical activity intervention for 4 weeks.
- Conditions
- Cerebral Palsy, Mobile Phone Use, Pediatric ALL, Physical Disability
- Trial name
- NCT06096272
- Testing
- Augment Reality Exergames
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Los Angeles
Cognitive Abnormality
Evaluation of a Decision-Support Tool for Blood Biomarker Testing for Alzheimer's Disease in Primary Care
The goal of the current study is to evaluate a decision-support tool intended to help primary care providers (PCPs) communicate with patients about blood biomarker testing for Alzheimer's Disease, enhancing shared-decision making…
- Trial name
- NCT07812337
- Testing
- Shared decision-making support tool
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Stroke, Aphasia
Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute…
- Conditions
- Stroke, Aphasia, Aphasia Following Cerebral Infarction
- Trial name
- NCT06968663
- Testing
- Transcranial Magnetic Stimulation (TMS), Modified Constraint Induced Language Therapy (mCILT)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Pennsylvania