Clinical trials: Brain-Computer Interface
Chronic Stroke
ANIMATOR - RehUP BCI Controlled Robotic Therapy vs. an Attention-based Control
ANIMATOR aims to examine how BCI therapy vs. attention based control therapy can be used to treat people in the chronic phase of stroke with moderate to severe upper extremity impairment.
- Trial name
- ANIMATOR (NCT06538506)
- Testing
- RehUp BCI Intervention, Control Therapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Hemiparesis, Stroke
A Brain Centered Neuroengineering Approach for Motor Recovery After Stroke: Combined rTMS and BCI Training
The purpose of this study is to determine whether the combination of low frequency repetitive transcranial magnetic stimulation (rTMS) and motor-imagery-based brain computer interface (BCI) training is effective for enhancing…
- Trial name
- NCT02132520
- Testing
- rTMS, BCI Training
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Minnesota
Terminal Illness, End-of-Life Care
Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence
Background: Recent electroencephalography (EEG) data indicate that the transition from clinical death to cellular death is marked by highly organized neurophysiological events, including significant surges in gamma-band power…
- Conditions
- Terminal Illness, End-of-Life Care, Death, Brain Death
- Trial name
- NeuroCogPresv (NCT07477028)
- Volunteers
- 20 people
- Sponsor
- Noah Tech, Corp.
Stroke, Cerebrovascular, Hemiplegia and Hemiparesis
BCI Driving FES and Hand Orthosis for Upper Limb Rehabilitation in Chronic Stroke
Multi-center, randomized, sham-controlled, double-blind, longitudinal, experimental clinical study to investigate functional recovery effects on the upper limb in chronic stroke patients and the accompanying neural plasticity…
- Conditions
- Stroke, Cerebrovascular, Hemiplegia and Hemiparesis, Stroke/Brain Attack
- Trial name
- NCT06179745
- Testing
- EEG-based brain-computer interface, Functional Electrical Stimulation, Active hand orthosis
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Essex
Tetraplegia/Tetraparesis, Quadriplegia
UAE-PRIME: A Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
The UAE-PRIME Study is a feasibility study designed to assess the initial clinical safety and functionality of the Neuralink N1 Implant and R1 Robot.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Quadriplegia/Tetraplegia, Cervical Spinal Cord Injury
- Trial name
- UAE-PRIME (NCT06992596)
- Testing
- N1 Implant, R1 Robot
- Where
- United Arab Emirates
- Volunteers
- 10 people
- Sponsor
- Neuralink Corp
Spinal Cord Injury, Tetraplegia C1-C4
Innovative Brain-Computer Interface for People With Spinal Cord Injury
The goal of this clinical trial is to demonstrate control of digital devices through a brain implant in people with spinal cord injury.
- Conditions
- Spinal Cord Injury, Tetraplegia C1-C4, Quadriplegia
- Trial name
- INTENSE-BCI (NCT07640711)
- Testing
- ECoG (electrocorticography) sensing
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- UMC Utrecht
Stroke, Hemiparesis After Stroke
Prospective Real-World Evidence Study of the IpsiHand® System in Adult Stroke Survivors
This study focuses on monitoring real-world customers who have been prescribed the IpsiHand® as part of their rehabilitation post-stroke.
- Conditions
- Stroke, Hemiparesis After Stroke, Brain Computer Interface
- Trial name
- NCT07147881
- Testing
- IpsiHand
- Volunteers
- 100 people
- Sponsor
- Neurolutions, Inc.
Feasibility of Safe Insertion and Neural Recording With a Soft Neural Probe, Brain Surgery
First-In-human Trial of a NovEl Soft and Stretchable Neural probE
The goal of this interventional study is to find out the feasibility of whether the soft neural probe can be used in human brain tissue.
- Trial name
- FINESSE (NCT06673264)
- Testing
- Soft Neural Probe
- Where
- Panama
- Volunteers
- 5 people
- Sponsor
- Axoft, Inc.
Glaucoma, Age Related Macular Degeneration
Assessment of Visual Function With a Portable Brain-computer Interface
1. The purpose of this study is to evaluate the nGoggle's accuracy and repeatability in detecting visual function loss. In addition, the ability to stage glaucomatous damage and investigate the relationship between nGoggle…
- Conditions
- Glaucoma, Age Related Macular Degeneration, Optic Neuropathy, Retinal Degeneration
- Trial name
- NCT03760055
- Testing
- nGoggle
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NGoggle
Healthy Subjects, Neuropsychiatric Disorders
Non-invasive BCI for Cognitive Enhancement
People's perceptual skills can significantly affect their abilities to make optimal decisions, judgments, and actions in real-world dynamic environments.
- Trial name
- NCT05311878
- Testing
- EEG-based perceptual training, Behavior based perceptual training
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Amyotrophic Lateral Sclerosis
Restore Motor Function Through Robotic Arm Exoskeleton and Brain Computer Interface
The current project will aid patients with motor impairment to reduce the need for homecare. Specifically the aim is to develop and implement a robotic exoskeleton and brain computer interface to assist and eventually perform arm…
- Trial name
- REMAP (NCT03900247)
- Testing
- REMAP EEG based BCI and SEM-Glove BioServo
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Pain, Chronic
Brain-Computer Interface (BCI)-Based Feedback for Chronic Pain Management
The feasibility study proposed here will primarily examine the sensitivity of an electroencephalogram (EEG)-based Brain Computer Interface (BCI) in detecting significant differences in brain signals in patients with chronic low…
- Trial name
- NCT03032497
- Testing
- EEG-based BCI analysis of fear avoidance
- Where
- Singapore
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Cerebral Palsy Infantile, Neuromuscular Diseases in Children
Virtual Reality Impact on Powered Mobility: a Feasibility Study
This study explores the potential of Virtual Reality (VR) technology to enhance powered wheelchair (PW) training for children diagnosed with Cerebral Palsy (CP) and neuromuscular diseases (NMDs).
- Trial name
- VR-PMP (NCT06586125)
- Testing
- Powered Mobility Training
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Azienda Usl di Bologna
Functional Neuroimaging
Sensorimotor Imaging for Brain-Computer Interfaces
The investigators will use fMRI to map movement activity in motor and somatosensory cortex using enriched imagery in people with chronic tetraplegia.
- Trial name
- NCT04723823
- Testing
- Motor or sensory imagery with fMRI
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Tetraplegia
Providing Brain Control of Extracorporeal Devices to Patients With Quadriplegia
This research study is being done to develop a brain controlled medical device, called a brain-machine interface or BMI, that will provide people with a spinal cord injury some ability to control an external device such as a…
- Trial name
- NCT01849822
- Testing
- Neural Prosthetic System
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- Richard A. Andersen, PhD
Motor Disorders, Healthy
Non-invasive BCI-controlled Assistive Devices
Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery…
- Conditions
- Motor Disorders, Healthy, Spinal Cord Injuries, Muscular Diseases
- Trial name
- NCT05183152
- Testing
- NMES Feedback, Visual Feedback, TESS
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Stroke, Motor Disorders
BCI-assisted MI Intervention in Subacute Stroke
Stroke is a leading cause of long-term disability. Cost-effective post-stroke rehabilitation programs are critically needed. Brain-Computer Interface (BCI) systems which enable the modulation of EEG sensorimotor rhythms are…
- Trial name
- Promotoer (NCT04353297)
- Testing
- EEG-based BCI system for (hand) Motor Imagery training, Motor Imagery training
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Spinal Cord Injury (SCI), Initial Encounter
Assessment of Neural Signals for the Control of Assistive Devices
The study will investigate the use of motor intention-based cortical signals to trigger epidural spinal cord stimulation (ESCS) with individuals with SCI.
- Trial name
- NCT06533969
- Testing
- Epidural Spinal Cord Stimulation, Electrocorticographic, Electroencephalographic
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Miami
Tetraplegia, Spinal Cord Injuries
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with…
- Conditions
- Tetraplegia, Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions
- Trial name
- BrainGate2 (NCT00912041)
- Testing
- Placement of the BrainGate2 sensor(s) into the motor-related cortex
- Where
- 6 sites in United States
- Volunteers
- 27 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Academic Anxiety, Test Anxiety
AVE-Neurofeedback for Academic Anxiety and Divergent Thinking
Academic anxiety is one of the most prevalent psychological challenges among adolescents and has been associated with impaired executive functioning, attentional control, autonomic dysregulation, and reduced creative performance.
- Conditions
- Academic Anxiety, Test Anxiety, Divergent Thinking
- Trial name
- AVE-NFB (NCT07745335)
- Testing
- Audiovisual Entrainment Neurofeedback (AVE-NFB), Neurofeedback Only, Audiovisual Entrainment
- Where
- 3 sites in Indonesia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Daniswara Raditya Suprapto