Clinical trials: Brain-computer Interface
Spinal Cord Injury Cervical, Tetraplegia/Tetraparesis
Implantable Wireless Brain-Computer Interface Systems in Patients With Tetraplegia
Objectives of Study: This trial aims to evaluate the safety and efficacy of an implantable wireless brain-computer interface system in patients with tetraplegia resulting from spinal cord injury.
- Conditions
- Spinal Cord Injury Cervical, Tetraplegia/Tetraparesis, Spinal Cord Injuries (SCI)
- Trial name
- LEAP (NCT07784088)
- Testing
- IWBCIS
- Where
- China
- Volunteers
- 34 people
- Sponsor
- BCIFlex Medical Technology Co., Ltd.
Epilepsy in Children, Epilepsy
Invasive Brain-Computer Interfaces for Attention
The goal of this interventional study is to compare if the use of a brain-machine interface (BCI) therapy can improve the symptoms of attentional deficit by producing brain changes in the networks that modulate attention.
- Trial name
- NCT06940089
- Testing
- Attention Intervention using a customized BCI decoder, Attention Intervention without using a customized BCI decoder
- Where
- United States
- Sponsor
- University of Texas at Austin
Spinal Cord Injuries
Motor Conditioning to Enhance the Effect of Physical Therapy
Spinal Cord Injury (SCI) affects person's ability to move and feel sensation from the body. About half of patients with tetraplegia (high level SCI) have an incomplete injury, i.e.
- Trial name
- NCT04367623
- Testing
- Brain computer interface based therapy
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- NHS Greater Glasgow and Clyde
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Glaucoma, Age Related Macular Degeneration
Assessment of Visual Function With a Portable Brain-computer Interface
1. The purpose of this study is to evaluate the nGoggle's accuracy and repeatability in detecting visual function loss. In addition, the ability to stage glaucomatous damage and investigate the relationship between nGoggle…
- Conditions
- Glaucoma, Age Related Macular Degeneration, Optic Neuropathy, Retinal Degeneration
- Trial name
- NCT03760055
- Testing
- nGoggle
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NGoggle
Non-Verbal Communication, Degenerative Neurologic Disease
Brain-computer Interface Commercial Readiness
The goal of this clinical trial is to evaluate the commercial readiness of an Augmentative and Alternative Communication Brain-Computer Interface (AAC-BCI) device for people with minimal movement who benefit from expressive…
- Trial name
- NCT06521736
- Testing
- AAC-BCI device
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Kendrea Garand
Emotion Regulation
Affect Regulation Based on Brain-computer Interface Towards Treatment for Depression
The primary objective is to examine the feasibility and efficacy of a locally developed brain-computer interface (BCI) based system training for regulating mood in healthy elderly.
- Trial name
- NCT03696667
- Testing
- BCI
- Where
- 2 sites in Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institute of Mental Health, Singapore
Brainstem Stroke, ALS
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)
People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert.
- Conditions
- Brainstem Stroke, ALS, Tetraplegia, Spinal Cord Injuries
- Trial name
- BG-Tablet-01 (NCT06511934)
- Testing
- BrainGate Neural Interface System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Tetraplegia/Tetraparesis, Quadriplegia
GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
The GB-PRIME Study is an early feasibility study designed to assess the clinical safety and functionality of the Neuralink N1 Implant and R1 Robot.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Quadriplegia/Tetraplegia, Cervical Spinal Cord Injury
- Trial name
- GB-PRIME (NCT07127172)
- Testing
- N1 Implant, R1 Robot
- Where
- 2 sites in United Kingdom
- Volunteers
- 7 people
- Sponsor
- Neuralink Corp
Locked-In Syndrome
First Study With a Brain Implant to Help Locked-in Patients Communicate at Home
In this study a new means of communication for people with locked-in syndrome will be tested. The investigators will record brain signals directly from the surface of the brain by means of a completely implantable system.
- Trial name
- UNP (NCT02224469)
- Testing
- ECoG (electrocorticography) sensing
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- UMC Utrecht
Tetraplegic Motor Dysfunction Following Brainstem or Spinal Cord Injury
Safety and Efficacy of High-Channel Implanted BCI for Motor Function Improvement in Tetraplegia Patients
This is an open-label single-arm clinical study conducted at designated clinical trial institutions, with three overall phases: a 3-month main study, a 3-month extension, and a 3-month follow-up.
- Trial name
- HC-IBCI-SE-TMF (NCT07457645)
- Testing
- Invasive BCI
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Zhongshan Hospital
Stroke
Lifescapes System in Post-stroke Hand Recovery
Stroke is a leading cause of long-term disability, with 30-60% of survivors remaining unable to use their affected arms after discharge.
- Trial name
- NCT07784920
- Testing
- Lifescapes
- Where
- 2 sites in Singapore
- Volunteers
- 32 people
- Sponsor
- National University Hospital, Singapore
Stroke
A Closed-loop Brain-computer Interface for Stroke
It may be hard to acquire stable sensorimotor rhythm from the affected motor cortex for patient without a response of paretic hand.
- Trial name
- NCT04465786
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Expressive Aphasia, Aphasia Following Cerebral Infarction
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with aphasia to generate text on a computer screen and audible…
- Conditions
- Expressive Aphasia, Aphasia Following Cerebral Infarction, Aphasia Following Nontraumatic Intracerebral Hemorrhage, Aphasia Non Fluent
- Trial name
- BG2-Aphasia (NCT07791459)
- Testing
- BrainGate Neural Interface System
- Volunteers
- 5 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Perinatal Stroke, Hemiparetic Cerebral Palsy
Creating an Engaging BCI/FES Therapy for Children With Perinatal Stroke Using Social Media
The goal of this trial is to evaluate the feasibility of a brain-computer interface controlled functional electrical stimulation (BCI-FES) social media integrated system for children with hemiparetic cerebral palsy .
- Trial name
- NCT07133347
- Testing
- Brain computer interface controlled functional electrical stimulation therapy integrated with social media
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Glaucoma, Macular Degeneration
BCI and Evaluation of Visual and Task Performance in Subjects With Eye Diseases
The purpose of this research study is to better understand the impact of visual impairment caused by different eye diseases on the ability to perform daily activities and compare it to that in patients without eye diseases.
- Conditions
- Glaucoma, Macular Degeneration, Glaucoma Suspect, Optic Neuropathy
- Trial name
- NCT03318549
- Testing
- Visual Performance tests, Brain-computer interface
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Miami
Healthy Subjects
Mind-body Awareness Training and Brain-computer Interface
Mind-Body Awareness Training (MBAT), in the forms of various yoga and meditative practices, has become increasingly prevalent due to an increase in awareness of the potential health benefits, and improvements in concentration…
- Trial name
- NCT03221374
- Testing
- Mindfulness Based Stress Reduction
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Carnegie Mellon University
Healthy Children, CP (Cerebral Palsy)
Training Upper Limbs of Neurodiverse Children by Connecting Brain Activities to a Virtual Reality Based Game
This study is testing ways to help children with cerebral palsy (CP) improve how their hands work. Investigators want to see if brain activity using a virtual reality (VR) program can make their hands work better.
- Conditions
- Healthy Children, CP (Cerebral Palsy), CP, Cerebral Palsy
- Trial name
- NCT06818877
- Testing
- Brain-Computer Interface (BCI)-HABIT-VR, Hand and Bimanual Intensive Therapy Virtual Reality (HABIT-VR)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Stroke, Cerebrovascular, Hemiplegia and Hemiparesis
BCI Driving FES and Hand Orthosis for Upper Limb Rehabilitation in Chronic Stroke
Multi-center, randomized, sham-controlled, double-blind, longitudinal, experimental clinical study to investigate functional recovery effects on the upper limb in chronic stroke patients and the accompanying neural plasticity…
- Conditions
- Stroke, Cerebrovascular, Hemiplegia and Hemiparesis, Stroke/Brain Attack
- Trial name
- NCT06179745
- Testing
- EEG-based brain-computer interface, Functional Electrical Stimulation, Active hand orthosis
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Essex
Phantom Limb Pain After Amputation, Lower Limb Amputation
Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation
The study will investigate the application of a non-pharmacological operant conditioning approach to reduce phantom limb pain (PLP). PLP afflicts 60-90% people who have lost a limb.
- Conditions
- Phantom Limb Pain After Amputation, Lower Limb Amputation, Upper Limb Amputation, Phantom Pain
- Trial name
- OCS-PLP (NCT05880251)
- Testing
- Operant Conditioning with Peripheral Stimulation, Control Group with Peripheral Stimulation Only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development