Clinical trials: Breakthrough Pain
Laparoscopic Cholecystectomy
Dexamethasone-Enhanced TAP Block in Lapchole
The transversus abdominis plane (TAP) block is widely used as part of analgesia for abdominal surgeries such as laparoscopic cholecystectomy. While bupivacaine is commonly used for TAP blocks with reported success.
- Trial name
- NCT07182110
- Testing
- Dexamethasone enhanced TAP Block, Marcaine- 0.25%
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makassed General Hospital
Breakthrough Bleeding, Breakthrough Spotting
Management of Breakthrough Bleeding During Extended Therapy Use With NuvaRing®
The purpose of this research study is to evaluate the best way to manage breakthrough spotting and bleeding during an extended use regimen of NuvaRing®.
- Trial name
- NCT00475553
- Testing
- remove ring if bleeding or spotting occurs more than 5 days, If bleeding does not remove ring
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Breakthrough Pain
Staccato Fentanyl Single and Multidose PK
The Phase I clinical trial in approximately 50 healthy volunteers will be conducted at a single clinical center in two stages. Stage 1 is an open-label, cross-over comparison of a single dose of Staccato Fentanyl and an…
- Trial name
- NCT00402350
- Testing
- Inhaled Fentanyl 25 mcg, Intravenous Fentanyl 25 mcg, Inhaled Fentanyl 25 mcg x 2
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Breakthrough Pain
Programmed Intermittent Epidural Bolus Compared With Continuous Infusion in Multiparous Women
The goal of this randomized controlled trial is to examine the impact of programmed intermittent bolus epidural analgesia technique on the incidence of breakthrough pain during labor in multiparous women compared to continuous…
- Trial name
- NCT06580327
- Testing
- programmed intermittent Bolus epidural analgesia, continuous epidural infusion
- Where
- Israel
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Postoperative Pain
Incidence and Clinical Features of Breakthrough Pain After Brachial Plexus Block in Diabetic Patients
This observational study aims to determine the incidence and clinical characteristics of rebound-breakthrough pain after ultrasound-guided brachial plexus block in adult patients with type 2 diabetes mellitus.
- Trial name
- NCT07833930
- Where
- China
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Breakthrough Pain
PIEB Compared With CEI on Breakthrough Pain in Nulliparous Women
The goal of this randomized controlled trial is to examine the impact of programmed intermittent bolus epidural analgesia technique on the incidence of breakthrough pain during labor in nulliparous women compared to continuous…
- Trial name
- NCT06494280
- Testing
- programmed intermittent Bolus epidural analgesia, continuous epidural infusion
- Where
- Israel
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Menstrual Migraines, Menstrual Bleeding
Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives.
This study will examine the combined effects of a continuous oral contraceptive (OC) regimen with supplemental estradiol therapy on headache severity and occurrence in subjects with documented Menstrually Associated Migraines…
- Conditions
- Menstrual Migraines, Menstrual Bleeding, Menstrual Spotting
- Trial name
- Estradiol/MAM (NCT01251263)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Migraines, Bleeding
Prevention of Menstrual Migraines: Using Frovatriptan or Placebo During Hormone Free Intervals
This study will examine the combined effects of a continuous oral contraceptive (OC) regimen with supplemental frovatriptan therapy on headache severity and occurrence in subjects with documented Menstrually Associated Migraines…
- Conditions
- Migraines, Bleeding, Spotting
- Trial name
- MAM (NCT00700128)
- Testing
- frovatriptan
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Breakthrough Pain, Palliative Medicine
Paediatric Breakthrough Pain Assessment
Many children and young people with life-limiting and life-threatening illnesses get sudden bursts of pain called breakthrough pain. At the moment, there aren't any good ways to measure this pain in children and young people.
- Conditions
- Breakthrough Pain, Palliative Medicine, Oncology Pain, Pediatric ALL
- Trial name
- BEACON (NCT06790719)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Analgesia, Post-Operative Pain
A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy
With this pilot investigation, the investigators aim to challenge the reliance on opiate analgesia following colon and rectal surgery.
- Conditions
- Analgesia, Post-Operative Pain, Breakthrough Pain, Colectomy
- Trial name
- NCT05200806
- Testing
- Non-Narcotic ERAS Post-Operative Pain Management
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Vermont