Clinical trials: Breast Cancer, Breast Neoplasms
Breast Cancer, Sentinel Lymph Node
Sentinel Lymph Node Localisation With an Ultra-low Dose of Magtrace in Breast Cancer Patients
The overall aim is to demonstrate that the use of superparamagnetic iron oxide nanoparticles (SPIO) as a tracer in an ultra-low dose (0.1 ml) is non-inferior for sentinel lymph node (SLN) detection in patients with breast cancer…
- Trial name
- MagSnow2 (NCT06169072)
- Testing
- Superparamagnetic Iron Oxide, Technetium99
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Vastra Gotaland Region
Metastatic Breast Cancer
Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Participants With HR+/HER2- Metastatic Breast Cancer
The primary objective of this study is to assess and compare the efficacy and safety of sacituzumab govitecan-hzi versus treatment of physician's choice (TPC) in participants with hormonal receptor-positive (HR+) human epidermal…
- Trial name
- TROPiCS-02 (NCT03901339)
- Testing
- Sacituzumab Govitecan-hziy, Eribulin, Capecitabine
- Where
- 113 sites in United States, Belgium and 7 more
- Volunteers
- 543 people
- Sponsor
- Gilead Sciences
Metastatic Breast Cancer
CARE Initiative: Real-world Emulation of the PALOMA-2 Trial
The goal of this non-interventional study is to emulate the PALOMA-2 randomized controlled trial of palbociclib as first-line therapy in patients with estrogen receptor-positive (ER+)/human epidermal growth factor receptor…
- Trial name
- NCT06607601
- Testing
- Palbociclib, Letrozole
- Volunteers
- 724 people
- Sponsor
- Aetion, Inc.
Breast Cancer
Study on the Safety and Efficacy of Autogenous Tumor Infiltrates Lymphocytes for the Treatment of Advanced Breast Cancer
Prospective, single-center, single-arm, open-label,interventional study evaluating adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocyte (TIL) infusion (HS-IT101) after lymphodepletion preparative with…
- Trial name
- NCT05505812
- Testing
- HS-IT101
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Metastatic Breast Cancer
Therapy of Metastatic Breast Cancer With Paclitaxel and Liposomal Doxorubicin
Today metastatic breast cancer is regarded as cureless. The treatment is palliative in intent and the goals of treatment include improvement of quality of life and if possible prolongation of life.
- Trial name
- MyoPac (NCT00691912)
- Testing
- liposomal Doxorubicin, Myocet / Paclitaxel
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Claudia Lorenz-Schlüter
Chemotherapy-induced Peripheral Neuropathy
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Chemotherapy induced peripheral neuropathy (CIPN) is a common side effect of many forms of chemotherapy having a negative impact on the quality of life for cancer survivors due to numbness, decreased sensation, pain (of various…
- Trial name
- NCT03272919
- Testing
- Arm 1: Investigational INF, Arm 2: standardized muscle stretching and strength
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Loma Linda University
Metabolic Syndrome, Obesity Associated Disorder
Dedicated Breast CT for Quantitative Breast Density Measurements in Mexican-origin Women in Southern Arizona
The overall objective of this clinical study is to determine the feasibility of breast CT for breast density assessment and association of CT-derived density measures with metabolic syndrome in overweight/obese Mexican-origin…
- Trial name
- NCT04799665
- Testing
- Breast CT
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Breast Carcinoma, Cervical Carcinoma
The Ohio State University (OSU) SCREEN Community Program
This clinical trial develops and tests how well a multi-level intervention (MLI), The Ohio State University (OSU) SCREEN Community Program, works to increase screening and follow-up for breast, cervical and colorectal (CRC)…
- Conditions
- Breast Carcinoma, Cervical Carcinoma, Colorectal Carcinoma
- Trial name
- NCT06666192
- Testing
- Cancer Screening, Discussion, Educational Activity
- Where
- United States
- Volunteers
- 2,067 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Seroma Following Procedure
The Effect of Octreotide on Wound Drainage After Mastectomy
Patients who had mastectomy for breast cancer usually have drainage of some fluid from the site of surgery. This could be prolonged and may lead to other negative consequences after surgery.
- Trial name
- NCT05682209
- Testing
- Octreotide Injection, Sterile water
- Where
- Nigeria
- Volunteers
- 41 people
- Sponsor
- Ikechukwu Bartholomew Ulasi
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
RBX7455 Before Surgery for the Treatment of Operable Breast Cancer
This clinical trial studies the side effects and possible benefits of RBX7455 given before surgery in treating patients with breast cancer that can be removed by surgery (operable).
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT04139993
- Testing
- Microbiota-based Formulation RBX7455
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Breast Carcinoma
Diagosis of Breast Carcinoma: Characterization of Breast Lesions With CLEARPEMSONIC : Feasibility Study
Breast cancer is the first cancer in women, the second etiology of death by cancer and the first cause for women between 35 and 55 years.
- Trial name
- NCT01569321
- Testing
- MRI, PET-CT scan, PEM scan with ClearPemSonic
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Metastatic Breast Cancer
Pilot Study Using Molecular Profiling to Find Potential Targets & Select Treatments for Pts With Met br ca
The purpose of this study is to determine the response rate, that is the % of patients with non-progression of their metastatic breast cancer after 4 months on treatment that was selected by molecular testing and proteomics.
- Trial name
- Side-Out (NCT01074814)
- Testing
- Approved therapy will be assigned based on molecular profile and RPMA results
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Translational Drug Development
Breast Neoplasm Female
THRIVE Breast Cancer App Study
This study will test the use of a web-enabled app that is integrated directly with patients' electronic health records, with and without tailored feedback.
- Trial name
- THRIVE (NCT03592771)
- Testing
- THRIVE App, Tailored Feedback Messages
- Where
- 2 sites in United States
- Volunteers
- 304 people
- Sponsor
- Emory University
Triple Negative Breast Neoplasms
Comparative Efficacy of Xiaopi Granules and Decoction in Triple-negative Breast Cancer: a Randomized Controlled Trial
The goal of this clinical trial is to compare the efficacy of xiaopi granules and decoction in improving the pathological complete response (pCR) of neoadjuvant chemotherapy of triple-negative breast cancer.
- Trial name
- NCT06154109
- Testing
- Xiaopi granules, Xiaopi decoction
- Volunteers
- 90 people
- Sponsor
- Zhiyu Wang
Unspecified Adult Solid Tumor, Protocol Specific
Chemotherapy Plus Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow or peripheral stem cell transplantation may allow the doctor to give…
- Trial name
- NCT00003899
- Testing
- filgrastim, cyclophosphamide, melphalan
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Breast Cancer, Chemotherapy-Induced Alopecia
Effects of a Web-Based Alopecia Education Program in Women With Breast Cancer
This randomized controlled trial evaluated the effects of a web-based alopecia education program on body image, self-esteem, chemotherapy-induced alopecia-related quality of life, and psychological well-being among women with…
- Trial name
- NCT07724314
- Testing
- Web-Based Alopecia Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Gulay Akman
Breast Cancer, Oestrogen Receptor Positive Breast Cancer
Effect of Capivasertib on ctDNA in ER Positive Breast Cancer
There is growing evidence that cancer DNA (called circulating tumour DNA - ctDNA) in the blood is often an early sign that the cancer is likely to return.
- Trial name
- CaptAin (NCT06613516)
- Testing
- Capivasertib
- Where
- United Kingdom
- Sponsor
- Imperial College London
Breast Neoplasms
Single-cell RNAseq Breast Cancer
Molecular characterization of persistent tumor cells remaining after NAC and infiltrating immune cells, for example, M2 macrophages, could strongly contribute to identifying targeted therapeutic approaches for this disease.
- Trial name
- SCRBC (NCT05807516)
- Testing
- Single-cell RNA sequencing (scRNAseq), whole-exome sequencing (WES)
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Regina Elena Cancer Institute
Breast Cancer
Trial of Fulvestrant, MK-0646, and Dasatinib for Metastatic Hormone Receptor-Positive HER2-Negative Breast Cancer
The goals of this clinical research study are to learn the tolerable and effective doses of the drug MK-0646 that can be given in combination with Sprycel (dasatinib) and Faslodex (fulvestrant) to patients with hormone…
- Trial name
- NCT00903006
- Testing
- Fulvestrant, MK-0646, Dasatinib
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Nab-Paclitaxel in Patients With ER+/HER2- Recurrent Metastatic Breast Cancer
This study is a single-arm, open, multi-center clinical study of nab-paclitaxel as the therapy ER+/HER2- recurrent metastatic breast cancer。
- Trial name
- NCT04194684
- Testing
- nab-paclitaxel
- Volunteers
- 108 people
- Sponsor
- Chinese Academy of Medical Sciences
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