Clinical trials: Breast Neoplasms, completed
Breast Cancer
A Non-interventional Study for Women With HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer to Evaluate the Real-world Effectiveness of Treatment Algorithms Beginning With Ribociclib + AI/FUL, or With Endocrine Therapy or Chemotherapy as First Line Treatment
This is a non-interventional observational study conducted in Germany to evaluate the real-world effectiveness, tolerability, safety, and quality of life in patients with locally advanced/metastatic HR+/HER2- breast cancer…
- Trial name
- RIBANNA (NCT06311383)
- Testing
- First-line Ribociclib + endocrine therapy, First-line endocrine therapy, First-line chemtherapy
- Where
- 265 sites in Germany
- Volunteers
- 2,610 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer
Predicting Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Using Machine Learning Models.
This retrospective observational study aims to develop and validate a clinicopathology-based machine learning model to predict pathological complete response (pCR) following neoadjuvant chemotherapy in patients with breast…
- Trial name
- NCT07426653
- Volunteers
- 298 people
- Sponsor
- Florence Nightingale Hospital, Istanbul
Breast Cancer, Advanced Malignant Solid Tumors
Study Evaluating Neratinib (HKI-272) In Combination With Vinorelbine In Subjects With Solid Tumors And Metastatic Breast Cancer
The purpose of this study is to identify the highest tolerable dose of neratinib (HKI-272) in combination with vinorelbine and to assess the safety of the combination of the two drugs as well as to obtain preliminary information…
- Trial name
- NCT00706030
- Testing
- neratinib, vinorelbine
- Where
- 35 sites in United States, Belgium and 9 more
- Volunteers
- 92 people
- Sponsor
- Puma Biotechnology, Inc.
Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
Efficacy Study of Herceptin to Treat HER2-negative CTC Breast Cancer
This is a randomized phase II trial for patients with HER2 negative primary Breast Cancer (BC) who after completing (neo) adjuvant chemotherapy and surgery have detectable circulating tumour cells (CTC) in peripheral blood.
- Conditions
- Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast, Circulating Tumor Cells
- Trial name
- TREAT-CTC (NCT01548677)
- Testing
- trastuzumab
- Where
- 80 sites in Belgium, France and 2 more
- Volunteers
- 1,317 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Breast Cancer
NEXT (Nutrition and EXercise During Adjuvant Treatment) Study
This study will offer a supervised exercise program and healthy eating education to women with breast cancer undergoing chemotherapy as a physician-referred program and measure the adoption, adherence and satisfaction with the…
- Trial name
- NExT (NCT01806181)
- Testing
- Exercise
- Where
- 2 sites in Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Stem Cells
Isolation and Characterization of Mammary Stem Cells
Background: Cancer stem cells in breast cancer have been identified as a small population of tumor cells whose self-renewal mechanism is highly deregulated. This deregulation seems to be necessary for cancer to develop.
- Trial name
- NCT00340392
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Metformin in Breast Cancer, Visualized With Positron Emission Tomography
The general purpose of the trial is to investigate whether metformin is taken up into the breast tumor. Studies in the last few years have shown an effect of metformin on cell proliferation on breast cancer.
- Trial name
- NCT02882581
- Testing
- 11C-metformin
- Where
- 2 sites in Denmark
- Volunteers
- 7 people
- Sponsor
- Aarhus University Hospital
Breast Cancer
MR-guided RAdiotherapy to Breast With Dose Escalation to regionaL Lymph NodEs
Radiotherapy to the breast and lymph nodes is routinely planned using CT scans. The introduction of magnetic resonance imaging (MRI) has the potential to better visualise the lymph nodes and so define a smaller treatment area or…
- Trial name
- MIRABELLE (NCT03405519)
- Testing
- Radiotherapy planning using both CT and MRI scans
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Breast Cancer
Abraxane, Avastin, and Gemcitabine as First-Line Therapy for Patients With Metastatic Breast Cancer
The investigators hypothesize that the combination of Gemzar®, Abraxane® and Avastin will increase the progression-free survival (PFS) in patients with first line metastatic breast cancer and in patients who received neoadjuvant…
- Trial name
- NCT00503906
- Testing
- Avastin, Gemcitabine, Abraxane
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Breast Adenocarcinoma, DS Stage I Plasma Cell Myeloma
Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement
This randomized phase III trial studies two different schedules of zoledronic acid to compare how well they work in reducing bone-related complications in patients with breast cancer, prostate cancer, or multiple myeloma that has…
- Conditions
- Breast Adenocarcinoma, DS Stage I Plasma Cell Myeloma, DS Stage II Plasma Cell Myeloma, Metastatic Malignant Neoplasm to the Bone
- Trial name
- NCT00869206
- Testing
- zoledronic acid
- Where
- 504 sites in United States, Puerto Rico
- Volunteers
- 1,822 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer
Design and Feasibility of a Mediterranean Diet
Epidemiological observations indicate that a Greek-Mediterranean dietary pattern has great potential for cancer prevention, but more definitive data on the preventive effects of this diet are needed.
- Trial name
- NCT00120016
- Testing
- dietary counseling
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Breast Cancer
Evaluation of the Cardioprotective Effect of L-carnitine and Silymarin in Patients Receiving Anthracycline Chemotherapy
the study aim to protect patients received anthracyclines containing chemotherapy from cardiotoxcity induced by anthracyclines derivatives.
- Trial name
- NCT04434404
- Testing
- L-Carnitine 500Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 83 people
- Sponsor
- Horus University
Breast Neoplasms, Lymphedema
The Use of Selenium to Treat Secondary Lymphedema - Breast Cancer
The primary objective of this study to assess the effectiveness of selenium compared to placebo in reducing the lymphedema in-patients with breast cancer.
- Trial name
- NCT00188604
- Testing
- sodium selenite
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Cancer
Pilot Study of Patient's Adherence to TYKERB™/TYVERB™ + Capecitabine in Metastatic Breast Cancer
This is a 6-week, single arm, pilot study to test the study procedure, educational materials, and measurement instruments for the educational intervention in HER2 overexpressing metastatic or advanced breast cancer patients
- Trial name
- NCT01462604
- Testing
- non-drug intervention educational programme
- Where
- 7 sites in Hong Kong, Pakistan and 2 more
- Volunteers
- 27 people
- Sponsor
- GlaxoSmithKline
Neoplasms, Breast
Continuation Study of Lapatinib Monotherapy or Lapatinib in Combination With Other Anti-cancer Agents
This study is designed to provide continued access to lapatinib as monotherapy or as part of a combination regimen to cancer subjects who are currently participating in a phase I trial that has met its study objectives.
- Trial name
- NCT00790816
- Testing
- Lapatinib in combination with an anti-cancer agent, Lapatinib, Lapatinib in combination with an anti-cancer agent as specified by parent protocol
- Where
- 23 sites in United States, Canada and 3 more
- Volunteers
- 500 people
- Sponsor
- Novartis Pharmaceuticals
Neuropathy
Analysis of Markers in the Blood Correlated With Neuropathic Pain
The purpose of this study is to analyze associations between symptoms and specific markers in the blood in patients suffering from neuropathic pain linked to diseases of different origin.
- Trial name
- NCT02208206
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Christoph Stein, MD
Breast Cancer
Efficacy and Safety of Adjuvant Metformin for Operable Breast Cancer Patients
The investigators hypothesize that adjuvant metformin use in breast cancer patients with overweight or pre-diabetes mellitus (DM) may improve their body condition including weight loss.
- Trial name
- NCT00909506
- Testing
- Metformin
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Seoul National University Hospital
Breast Neoplasm Female
Palbociclib Combine With Anti-HER2 Therapy in Triple Positive ABC
This study is to find out that if HER-2 positive and HR positive patients could benefit from trastuzumab and pertuzumab combined with palbociclib and endocrine therapy.
- Trial name
- NCT05969184
- Testing
- CDK4/6 inhibitor (Qilu),Trastuzumab (Hanquyou)
- Where
- 2 sites in China
- Volunteers
- 94 people
- Sponsor
- Peking University Cancer Hospital & Institute
Female Breast Cancer, Older Adults
Melatonin Supplementation and Exercise Program in Breast Cancer Women
Introduction: Breast cancer (BC) remains the leading cause of cancer in women with nearly 1.4 million new cases worldwide annually and 27.000 in Spain.
- Conditions
- Female Breast Cancer, Older Adults, Exercise Trainning Progrmam
- Trial name
- MEXBSO (NCT06696378)
- Testing
- Melatonin 6 mg
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- University of Valladolid
Breast Cancer, Cancer Survivors
Effects of Exercise Oncology Intervention in Fitness Capacity and Body Composition in Breast Cancer Survivals
The goal of this interventional study is to analyze the impact of a supervised oncological exercise intervention in surviving breast cancer patients.
- Trial name
- WIM_22 (NCT05882578)
- Testing
- Oncological physical exercise intervention, Active Physical Activities intervention
- Where
- Spain
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Tigers Running Club
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