Clinical trials: Breast Reduction
Breast Neoplasms
Prediction of Everolimus-induced Interstitial Lung Disease
The investigators will determine which factors are predictive for the development and severity of everolimus-induced interstitial lung disease and will develop a prediction model based on these risk factors.
- Trial name
- PREVENT (NCT01978171)
- Where
- 2 sites in Netherlands
- Volunteers
- 27 people
- Sponsor
- Radboud University Medical Center
Breast Carcinoma
Cosmetic Evaluation of Lumpectomy Versus Oncolytic Mammoplasty With Bilateral Breast Reduction for Early Stage Breast Cancer
This study will evaluate the cosmetic outcome and examine factors contributing to cosmetic outcome in women treated with lumpectomy or bilateral breast reduction mammoplasty/mastopexy (BRM) followed by hypofractionated whole…
- Trial name
- NCT01400399
- Where
- 3 sites in United States
- Volunteers
- 84 people
- Sponsor
- Coastal Carolina Radiation Oncology
HER2 Positive Breast Cancer, Left Ventricular Function Systolic Dysfunction
Cardiac Safety Study in Patients With HER2 + Breast Cancer
HER2 positive breast cancer cells have more HER2 receptor (a protein on the surface of cells) than normal breast cells. Approximately 30% of patients with breast cancer have HER2 positive breast cancer.
- Trial name
- SAFE-HEaRt (NCT01904903)
- Testing
- Trastuzumab, Pertuzumab, Ado Trastuzumab Emtansine
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Medstar Health Research Institute
Pain, Discomfort
TAmoxifen Versus LIdocaine Cream. A Randomized Clinical Trial for Reducing Pain and Discomfort During Mammography
This is a double-blind placebo-controlled randomized clinical trial to test the use of tamoxifen or lidocaine for diminishing the pain and discomfort while performing mammography, intending to include 450 patients distributed…
- Trial name
- TALI (NCT02801786)
- Testing
- Lidocaine, Tamoxifen
- Where
- Brazil
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Cancer-related Fatigue, Neutropenia, Malignant
PG2 Breast Cancer Evaluation in Adjuvant Medicine Study
Adjuvant chemotherapy usually is recommended after surgery for breast cancer patients who are at significant risk for disseminated disease. Chemotherapy has been demonstrated to reduce the risk of breast cancer recurrence.
- Trial name
- PG2 BEAM (NCT03314805)
- Testing
- Astragalus polysaccharides 500 mg, EC Chemotherapy
- Where
- 5 sites in Taiwan
- Volunteers
- 67 people
- Sponsor
- PhytoHealth Corporation
Secondhand Tobacco Smoke Exposure Reduction
Reducing Breast Cancer Risk in Korean American Women
The goals of the study are to develop a culturally and linguistically appropriate intervention to reduce SHS exposure for LEP Korean women using a family-focused intervention approach targeting Korean Americans ages 18 and above…
- Trial name
- NCT04079556
- Testing
- Tobacco LHW
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Breast Neoplasms, Cardiac Event
Clinical Study of Xinmailong Injection on Reducing Cardiovascular Toxicity in Adjuvant Chemotherapy in Breast Cancer
Totally 60 subjects will be included in the study. The present study was aimed to observe and evaluate the effect of Xinmailong injection on reducing cardiovascular toxicity associated with adjuvant chemotherapy after breast…
- Conditions
- Breast Neoplasms, Cardiac Event, Chemotherapeutic Toxicity
- Trial name
- NCT03785704
- Testing
- Xinmailong Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College
Ovarian Neoplasms, BRCA 1 Gene Mutation
Ovarian Cancer Liquid Biopsy for Early Assessment & Detection in Individuals With BRCA1/2 Pathogenic Variants
The goal of this clinical study is to evaluate the feasibility and acceptability of the Galleri multi-cancer early detection blood test in people with BRCA1 or BRCA2 gene changes who are at high risk for ovarian cancer.
- Conditions
- Ovarian Neoplasms, BRCA 1 Gene Mutation, BRCA 2 Gene Mutation, Serous Tubal Intraepithelial Carcinoma
- Trial name
- OC-LEAD (NCT07764744)
- Testing
- Galleri Multi-Cancer Early Detection (MCED) Blood Test
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Weill Medical College of Cornell University
HER2-positive Breast Cancer
Protocol for Herceptin as Adjuvant Therapy With Reduced Exposure to Chemotherapy (PHARE-C)
RATIONALE: According to previous results from PHARE study, a subgroup of patients with low-risk cancer (< 3 cm) without axillary lymph node involvement or small (< 2 cm) with minimal lymph node involvement (1 positive node)…
- Trial name
- PHARE-C (NCT05388500)
- Testing
- Paclitaxel + Trastuzumab, Trastuzumab
- Volunteers
- 800 people
- Sponsor
- Institut de cancérologie Strasbourg Europe
Breast Cancer
Mammogram Mail- and Phone-based Interventions
The project aims to evaluate four different versions and modalities of interventions encouraging mammogram screening among all eligible women due or overdue for screening.
- Trial name
- NCT05853848
- Testing
- Postcard, Letter, Auto-dialer
- Where
- United States
- Volunteers
- 14,386 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Cancer Survivors, Obesity
Inspiratory Muscle Training in Obese Breast Cancer Survivors
The investigators propose a randomized controlled trial to determine the effectiveness of inspiratory muscle training in improving exercise tolerance among stage 0-III obese breast cancer survivors.
- Conditions
- Cancer Survivors, Obesity, Breast Cancer
- Trial name
- IMOCS (NCT05193149)
- Testing
- Inspiratory muscle training, Exercise training
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Neutropenia
Reduced Dose of Pegfilgrastim as Support for Chemotherapy for Breast Cancer
Pegfilgrastim is a long-acting recombinant human granulocyte-colony stimulating factor as support for chemotherapy, which can be used conveniently.
- Trial name
- NCT05283616
- Testing
- Pegfilgrastim
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
A Dietary Supplement (Resistant Potato Starch) for Reducing Musculoskeletal Symptoms in Individuals Planning to Receive Aromatase Inhibitor Therapy, AIMSS-RPS Trial
This phase II trial tests the safety and effectiveness of a dietary supplement called resistant potato starch for reducing musculoskeletal symptoms in patients with stage 0-III breast cancer or who are at high risk for breast…
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- AIMSS-RPS (NCT07443943)
- Testing
- Starch, Potato
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Breast Cancer, Cognitive Symptom
MBSR During AI Therapy for Breast Cancer
This study will use non-invasive neuroimaging (i.e., MRI) to examine whether Mindfulness-Based Stress Reduction (MBSR) improves neural markers of cognitive function for postmenopausal women taking aromatase inhibitor (AI) therapy…
- Trial name
- NCT03253627
- Testing
- Health Enhancement Program, Mindfulness-Based Stress Reduction
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- New York University
Margin, Tumor-Free, Breast Cancer
Impact of Systematic Shaving on Margins
The objective of this clinical trial is to demonstrate the reduction of positive margins in the definitive pathology of patients undergoing breast-conserving surgery with the systematic shaving technique compared to conventional…
- Conditions
- Margin, Tumor-Free, Breast Cancer, Surgery
- Trial name
- NCT05782686
- Testing
- Margin shaving
- Where
- Spain
- Volunteers
- 234 people
- Sponsor
- Hospital Universitari de Bellvitge
Breast Cancer
Radiation Therapy Planning Techniques in Reducing Damage to Normal Tissue in Women Undergoing Breast-Conserving Surgery for Ductal Carcinoma of the Breast
RATIONALE: Diagnostic procedures, such as multifunctional magnetic resonance imaging and CT scans, may help reduce normal tissue damage in patients undergoing radiation therapy for cancer.
- Trial name
- NCT00602628
- Testing
- questionnaire administration, adjuvant therapy, biopsy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Radiodermatitis, Breast Neoplasms
Effects of Herbal Products on Reduction of Radiation-induced Dermatitis in Breast Cancer Patients
The herbal products on reduction of radiation-induced dermatitis in patients with breast cancer
- Conditions
- Radiodermatitis, Breast Neoplasms, Adverse Effect of Radiation Therapy
- Trial name
- NCT02922244
- Testing
- Control, Cucumber cream, Centella cream
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Chulabhorn Cancer Center
Breast Cancer
Assessment of Ability of Breath Hold for Left-sided Breast Cancer Radiation Therapy to Reduce Side Effects to Heart
The purpose of this research study is to demonstrate that Deep Inspiration Breath Hold (DIBH), the technique used at the University of North Carolina (UNC) for left-side breast cancer radiation therapy, can reduce side effects to…
- Trial name
- NCT01849614
- Testing
- Cardiac SPECT perfusion scan
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Neoplasms
Reducing Neutropenia Incidence With Pegfilgrastim Administration on Day 3 After Chemotherapy
Patients who experienced neutropenia after receiving pegfilgrastim on day 1 of the first round are randomly assigned to either the control or experimental arm.
- Trial name
- NEUTHREE (NCT05949333)
- Testing
- Eflapegrastim
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Eunseong Medical Foundation Good GANG-AN HOSPITAL
Stage IV Breast Cancer
Mindfulness-Based Stress Reduction in Helping Participants With Metastatic Breast Cancer
This randomized trial studies how well a mindfulness-based stress reduction program helps participants with breast cancer that has spread to other places in the body.
- Trial name
- NCT03683147
- Testing
- Laboratory Biomarker Analysis, Meditation-Based Stress Reduction Program, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Roswell Park Cancer Institute