Clinical trials: Breast Reduction
Lymphedema, Recurrent Breast Cancer
Sentinel and/or Axillary Lymph Node Biopsy With or Without Axillary Reverse Mapping in Reducing Incidence and Severity of Arm Lymphedema in Stage 0-2 Patients.
Lymph node biopsy followed by axillary reverse mapping may reduce the incidence and severity of arm lymphedema. This randomized phase II trial is studying how well sentinel and/or axillary lymph node biopsy with or without…
- Conditions
- Lymphedema, Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer
- Trial name
- NCT01276054
- Testing
- technetium Tc 99m sulfur colloid, methylene blue, indocyanine green solution
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Southern California
Capsular Contracture Associated With Implant, Foreign-Body Reaction
Experimental and Clinical Investigation of the Implant Surface Roughness Reduction Effect on Early-stage Fibrosis
The goal of this single-center, randomised double-blinded trial is to compare the early stage fibrosis progression around conventional textured expander and the SmoothSilk® expander with reduced surface roughness in women…
- Conditions
- Capsular Contracture Associated With Implant, Foreign-Body Reaction, Wounds and Injuries, Tissue Expander Disorder
- Trial name
- NCT05648929
- Testing
- Patient Satisfaction Questionnaire, Pregnancy test, Blood draw
- Where
- Austria
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Familial Ovarian Cancer, Familial Breast Cancer
Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer
Individuals and families with known or suspected syndromes that include breast, ovarian or genetically-related cancers are enrolled in this family study, which is a syndrome-specific sub-set of the long-standing DCEG Human…
- Conditions
- Familial Ovarian Cancer, Familial Breast Cancer, BRCA1-associate Malignancies, BRCA2-associated Malignancies
- Trial name
- NCT00040222
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Risk Reduction
Restore-B: A Trial Comparing Prepectoral Implant-based Breast Reconstruction With and Without Mesh
The goal of this feasibility randomised controlled clinical trial (RCT) is to compare mesh-assisted to no-mesh pre-pectoral implant based immediate breast reconstruction in women undergoing mastectomy for treatment of breast…
- Trial name
- NCT06112977
- Testing
- Prepectoral implant-based immediate breast reconstruction
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Chronic Fatigue
Fatigue Reduction Diet
There are over 2 million breast cancer survivors today. Persistent cancer-related fatigue (PCRF), a state of being tired or weary, is one of the most common and distressing symptoms experienced by breast cancer (BC) survivors.
- Trial name
- FRD (NCT01902745)
- Testing
- Social Cognitive Theory
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Scar, Hypertrophic Scar
The Efficacy and Molecular Mechanism of Botulinum Toxin in the Reduction of Breast Reduction Mammoplasty Scar Formation
1. Test the ability of botulinum toxin type A, when injected into the surgical incision at the time of surgery, to decrease postoperative scar scores compared to control (normal saline) in a double-blinded randomized control…
- Conditions
- Scar, Hypertrophic Scar, Mammary Disorder
- Trial name
- NCT03887377
- Testing
- Botulinum Toxins, Normal saline
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Breast Cancer
REduction of Physical Inactivity Facing the CAncer
Study 1: The investigator hypothesizes that the level of knowledge about the benefits of physical activity, physical activity level and physical fatigue level observed in cancer patients, would influence their beliefs about…
- Trial name
- RESCA (NCT02867475)
- Testing
- Intrinsic Physical activity motivation, Extrinsic Physical activity motivation
- Where
- France
- Volunteers
- 420 people
- Sponsor
- Centre Antoine Lacassagne
Inquiry Based Stress Reduction
Pilot Clinical Trial (Phase II) of Inquiry-based Stress Reduction (IBSR) Program for Survivors of Breast Cancer
The IBSR (Inquiry-based stress reduction) intervention, developed by Byron Katie (www.thework.com), trains subjects to reduce their perceived level of stress by self-inquiry of their thoughts and beliefs connected to stressful…
- Trial name
- NCT01244087
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Breast Cancer Prevention
Phase II Study of Metformin for Reduction of Obesity-Associated Breast Cancer Risk
Overweight and obesity are well established risk factors for breast cancer that develop after menopause. The increased postmenopausal breast cancer risk in women who are overweight or obese is likely to be attributed to multiple…
- Trial name
- NCT02028221
- Testing
- Metformin
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- University of Arizona
Breast Cancer
Paravertebral Block and Reduction in Opioid Consumption After Mastectomy
This prospective randomized study evaluates the efficacy of paravertebral block in reducing opioid consumption during mastectomy and its impact on acute and chronic postoperative pain.
- Trial name
- BPV-MAST (NCT07817797)
- Testing
- Paravertebral Block, Multimodal Analgesia
- Where
- Tunisia
- Volunteers
- 40 people
- Sponsor
- University Tunis El Manar
Malignant Breast Tissue Neoplasm
Is Dietary Nitrate Effective in Reducing Aerobic Glycolysis in Breast Cancer?
Breast cancer is the most prevalent cancer affecting women, with 1 in 8 women in the UK developing breast cancer in their life time.
- Trial name
- BEET (NCT03944226)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- University of Aberdeen
Breast Cancer
Study Assessing the Potential for Reduced Rates of Implant Failure Using Multi-Beam Intensity-Modulated Radiation Therapy for Locally Advanced Breast Cancer Patients With Implant Reconstructions
The purpose of this study is to determine if a radiation treatment called "Multi-beam Intensity Modulated Radiation Therapy"(IMRT) can reduce side effects related to your implant if they are a candidate for radiation therapy.
- Trial name
- NCT02086578
- Testing
- Breast MRI, Breast-Q© questionnaire, Multi-Beam IMRT
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Mindfulness-based Stress Reduction (MBSR) Program Combined With Endurance Exercise Training: a Help in Treatment for Breast Cancer
Integrative approaches to promote wellness and reduce the distress associated with cancer are considered as essential components of cancer care.
- Trial name
- MBSR (NCT02900326)
- Testing
- Endurance exercise training, Mindfulness-based-stress-reduction, Both interventions together
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Pain, Postoperative
Opioid Counseling in Pain Management
The purpose of this study is to evaluate the effect of perioperative opioid counseling within a specific group of patient population who are undergoing bilateral reduction mammoplasty.
- Trial name
- NCT03985358
- Testing
- Opioid counseling plus standard of care instructions
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Breast Cancer, Joint Pain
Curcumin in Reducing Joint Pain in Breast Cancer Survivors With Aromatase Inhibitor-Induced Joint Disease
This phase I trial studies how well curcumin works in reducing joint pain in patients who are breast cancer survivors and have joint disease caused by treatment with aromatase inhibitors.
- Trial name
- NCT03865992
- Testing
- Curcumin, Nanoemulsion, Quality-of-Life Assessment
- Where
- 4 sites in United States
- Volunteers
- 42 people
- Sponsor
- City of Hope Medical Center
Postoperative Analgesia in Breast Reduction Surgery, Postoperative Pain
Comparison of Serratus Plane Block and Rhomboid Intercostal Plane Block for Postoperative Analgesia in Breast Reduction Surgery
This prospective, randomized clinical study aims to compare the analgesic efficacy of serratus plane block (SPB) and rhomboid intercostal plane block (RIPB) for postoperative analgesia in patients undergoing elective bilateral…
- Conditions
- Postoperative Analgesia in Breast Reduction Surgery, Postoperative Pain, Postoperative Pain Breast Reduction, Pain, Postoperative
- Trial name
- SAPB-RIPB (NCT07229092)
- Testing
- Serratus Anterior Plane Block (SAPB), Rhomboid Intercostal Plane Block (RIPB), No Regional Block (Control)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Konul Karaja
Risk Reduction
Social Media And Risk-reduction Training for Infant Care Practices (SMART)
The goal of this proposal is to address serious and ongoing challenges related to adherence to public health recommendations known to reduce the risk of SIDS.
- Trial name
- SMART (NCT01713868)
- Testing
- Safe Sleep Nursery Education, Breastfeeding Nursery Education, Breastfeeding Mobile Health Messaging
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Shoulder Symptoms After Lymph Node Dissection
Pulsed Electromagnetic Fields (PEMF) and Post-Axillary Surgery Morbidity
The most important prognostic indicator for the breast cancer patient is the axillary lymph node status. With the introduction of the sentinel lymph node biopsy, many women were spared the morbidity of a full axillary lymph node…
- Trial name
- NCT01255631
- Testing
- PEMF Device
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Mammographically Dense Breast
Afimoxifene in Reducing the Risk of Breast Cancer in Women With Mammographically Dense Breast
This randomized phase II trial studies how well afimoxifene works in reducing the risk of breast cancer in women with mammographically dense breast. Estrogen can cause the growth of breast cancer cells.
- Trial name
- NCT03063619
- Testing
- Afimoxifene, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- 5 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Gender Dysphoria, Opioid Use
The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery
Despite recent advancements with regional and local anesthesia, postoperative pain continues to be a major concern for patients undergoing breast surgery.
- Conditions
- Gender Dysphoria, Opioid Use, Pain, Postoperative
- Trial name
- NCT04474366
- Testing
- Ropivacaine 0.2% Injectable Solution, Saline (0.9%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco