Clinical trials: Breast Surgery
Breast Cancer
Subpectoral Plexus Block With Multi-level TPVB for Surgical Anesthesia During Primary Breast Cancer Surgery
The objective of this study is to compare two different doses of local anesthetics (10ml vs 20ml of 0.25% levobupivacaine) for subpectoral plexus block (SPPB) in addition to ultrasound guided multi-level of thoracic paravertebral…
- Trial name
- NCT04933266
- Testing
- Subpectoral plexus block (low dose), Subpectoral plexus block (High dose)
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Post-surgical Pain, Pain, Chronic
Intercostobrachial Nerve Sparing to Reduce Post-Surgical Pain
Sacrifice of the intercostobrachial nerve (ICBN) during surgery is associated with development of persistent post-surgical pain (PPSP), which affects up to 60% of breast cancer surgery patients.
- Conditions
- Post-surgical Pain, Pain, Chronic, Intercostal Pain, Breast Cancer
- Trial name
- INSPIRE (NCT03421522)
- Testing
- ICBN preservation surgery
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Surgical Site Infection
Antibiotics After Breast Reduction:Clinical Trial With Randomization
This study was designed to determine the role of antibiotics reduction mammaplasty influence surgical site infections rates.
- Trial name
- NCT02569866
- Testing
- Cephalexin
- Where
- Brazil
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Breast Cancer
Vaccine Therapy Plus Sargramostim and Chemotherapy in Treating Women With Stage II or Stage III Breast Cancer
RATIONALE: Vaccines made from a gene-modified virus may make the body build an immune response to kill tumor cells. Colony-stimulating factors such as sargramostim may increase the number of immune cells found in bone marrow or…
- Trial name
- NCT00052351
- Testing
- recombinant fowlpox-CEA(6D)/TRICOM vaccine, recombinant vaccinia-CEA(6D)-TRICOM vaccine, sargramostim
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
PhysSurg-B : Physical Activity in Relation to Surgical Operations - Breast Cancer
The purpose of this study is to investigate whether a training program with intensified physical exercise prior to and after surgery for breast cancer enhances postoperative recovery.
- Trial name
- PhysSurg-B (NCT02560662)
- Testing
- Physical activity
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Vastra Gotaland Region
Breast Cancer, Axillary Lymph Nodes
Using LUminoMark vs Coventional Practice for Targeted Axillary Surgery
The purpose of this study was to compare the use of LuminoMarkTM as a method of targeting axillary lymph nodes with other existing methods used in each institution, such as charcoal staining, needle targeting, and…
- Conditions
- Breast Cancer, Axillary Lymph Nodes, Target Lesion
- Trial name
- LUCAS (NCT06903429)
- Testing
- Targeting of axillary lymph nodes using LuminoMark, Targeting of axillary lymph nodes using conventional method
- Volunteers
- 330 people
- Sponsor
- Kyungpook National University Chilgok Hospital
Breast Cancer
Coated VICRYL* Plus Suture Compared to Chinese Silk in Scheduled Breast Cancer Surgery
This is a 90-day study to evaluate cosmetic outcome and Surgical Site Infection in approximately 100 patients from 6 centers in China undergoing scheduled modified radical mastectomy for breast cancer.
- Trial name
- NCT00768222
- Testing
- silk suture, VICRYL* Plus suture
- Where
- 6 sites in China
- Volunteers
- 101 people
- Sponsor
- Ethicon, Inc.
Regional Anesthesia Morbidity, Postoperative Pain
Retrolaminar Thoracic Paravertebral Block
This clinical study will be conducted on female patients admitted to The General Surgery Department of Tanta Faculty of Medicine for a period of 9 months.
- Trial name
- NCT04162951
- Testing
- Ordinary approach paravertebral block, Retrolaminar paravertebral block
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Tanta University
Lymphedema, Surgery
Intraoperative Evaluation of Axillary Lymphatics
This study will assess the feasibility of using the OnLume Imaging System for fluorescence-guided surgery along with indocyanine green (ICG) dye in the operating room for the axillary reverse mapping (ARM) procedure in women with…
- Conditions
- Lymphedema, Surgery, Breast Cancer
- Trial name
- NCT05094102
- Testing
- OnLume Imaging System, Indocyanine green
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Wisconsin, Madison
Breast Neoplasm Female, Breast Reconstruction
Axillary Versus Primary Breast Approach for Second-stage Breast Reconstruction
The goal of this clinical trial is to compare the safety of axillary or primary breast approach for second-stage operation in expander-implant breast reconstruction for breast cancer patients.
- Conditions
- Breast Neoplasm Female, Breast Reconstruction, Wound Complication
- Trial name
- AvBSR (NCT05600153)
- Testing
- implant exchange operation
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Recurrent Breast Carcinoma, Ipsilateral Recurrence
Preoperative Partial Breast Reirradiation and Repeat Breast-conserving Surgery in Patients With Recurrent Breast Cancer: the REPEAT Trial
Over the past decades, interest in second breast-conserving therapy (BCT) has increased due to, among others, advancements in radiotherapy techniques.
- Trial name
- REPEAT (NCT06640881)
- Testing
- ablative single-dose PBI
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Amsterdam UMC, location VUmc
Gynecomastia
Treatment of Mild and Moderate Cases of Gynaecomastia
This study aims to compare liposuction and periareolar surgical excision in mild and moderate cases of gynecomastia as regard cosmosis, complications, patient satisfaction, operation time, and hospital stay.
- Trial name
- NCT04966078
- Testing
- liposuction, surgical excision
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Breast Cancer Female, Postoperative Pain
Study of Lipid Mediators in Chronic Postoperative Pain - LICP
This interventional prospective study aims firstly to investigate variations in lipid levels in blood samples and their potential relationship with the duration and/or intensity of post-operative pain.
- Trial name
- LICP (NCT06907810)
- Testing
- Blood sample + questionnaire
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Université Catholique de Louvain
Anxiety
Peri-operative Slow-paced Breathing to Reduce Anxiety in Breast Cancer Surgery Patients
The purpose of this single-center trial is to examine the effects of a slow-breathing technique performed at induction of anesthesia in patients undergoing surgery for breast cancer on anxiety, scored by Spielberger's State-Trait…
- Trial name
- SlowPACE (NCT06192225)
- Testing
- pre-trained guided slow paced breathing (~6 breaths per minute)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- The Netherlands Cancer Institute
Implants, Breast
Sonication of Explanted Breast Implants for Detection of Subclinical Infection
Objective. Capsular contracture is a frequent complication after breast implantation with unclear etiology. Summary Background Data: Microorganisms may trigger chronic periimplant inflammation with subsequent capsular fibrosis.
- Trial name
- NCT01138891
- Volunteers
- 121 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Early Stage Breast Carcinoma
Sentinel Node Vs Observation After Axillary Ultra-souND
The hypothesis of this trial are that: avoiding axillary surgery does not worsen the outcome of patients with small breast cancer the absence of the pathological information on the risk of recurrence given by nodal status is not…
- Trial name
- SOUND (NCT02167490)
- Testing
- Arm 1: sentinel node biopsy
- Where
- 18 sites in Chile, Italy and 2 more
- Volunteers
- 1,560 people
- Sponsor
- European Institute of Oncology
Surgical Site Infection, Capsular Contracture Associated With Breast Implant
Postoperative Antibiotics Following Primary and Secondary Breast Augmentation
Postoperative antibiotics are routinely used for implant-based breast augmentation at the investigators' institution. From 2017-2019, the investigators' institution has conducted approximately 270 primary and secondary breast…
- Conditions
- Surgical Site Infection, Capsular Contracture Associated With Breast Implant, Antibiotic Resistant Infection, Antibiotic Side Effect
- Trial name
- NCT04834310
- Testing
- Cefazolin, Cephalexin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Breast Cancer
Efficacy of Preoperative Pectoral Nerve Block for Intraoperative Opioid Sparing Effect and Postoperative Analgesia
The purpose of this study is to determine whether pectoral nerves blocks（PECS） would reduces the opioid consumption during the surgery and postoperative pain after breast cancer surgery.
- Trial name
- NCT03210220
- Testing
- Pecs II block
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Gachon University Gil Medical Center
The Impact of Adipose Tissue Quality on Fat Graft Retention
Lipofilling: Optimal Harvesting Techniques for Breast Reconstruction After Mastectomy in Plastic Aesthetic and Reconstructive Surgery
The primary aim of this project is to standardize the method for lipofilling by identifying the best technique. In this context, the study will investigate the impact of adipose tissue composition and ideal quantity of the…
- Trial name
- LipoTech (NCT05286424)
- Testing
- fat grafting
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
Breast Hypertrophy
Comparison of Superomedial and Inferior Pedicle Techniques in Mammaplasty
The aim of this study is to evaluate Superomedial pedicle and Inferior pedicle techniques in breast reduction for Egyptian females and compare between both pedicles regarding cosmetic outcomes, possible complications, patient…
- Trial name
- NCT03669679
- Testing
- Breast reduction
- Volunteers
- 19 people
- Sponsor
- Assiut University