Clinical trials: Breast Tumor Tissue
Breast Cancer
A Study of the Experimental Drug BKM120 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer, With or Without PI3K Activation
This study evaluated whether the addition of daily BKM120 to weekly paclitaxel was effective and safe in treating patients with HER2- locally advanced or metastatic breast cancer.
- Trial name
- BELLE-4 (NCT01572727)
- Testing
- Paclitaxel, BKM120
- Where
- 112 sites in United States, Australia and 20 more
- Volunteers
- 416 people
- Sponsor
- Novartis Pharmaceuticals
Human Mammary Carcinoma
A Phase 1-2, XIAP Antisense AEG35156 With Weekly Paclitaxel in Patients With Advanced Breast Cancer
This is an open-label multicenter, phase 1-2 study. Following determination of the recommended AEG35156 dose in combination with weekly paclitaxel in the initial Phase 1 part of this study, additional patients will be enrolled in…
- Trial name
- NCT00558545
- Testing
- AEG35156
- Where
- 10 sites in United States
- Volunteers
- 61 people
- Sponsor
- Aegera Therapeutics
Hereditary Breast and Ovarian Cancer Syndrome
Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers
Breast cancer (BC) is a major health problem and the most prevalent cancer among women.In a substantial proportion of familial cases, germ-line mutations in either BRCA1/2 can be detected.
- Trial name
- NCT01367639
- Testing
- Inquiry Based Stress Reduction (IBSR) program
- Where
- Israel
- Volunteers
- 67 people
- Sponsor
- Sheba Medical Center
Breast Cancer
Evidence Based Dissemination for Mammography Adherence in Safety Net Communities
Breast cancer is the most common cancer and the second leading cause of cancer related death in American women. Regular screening, early diagnosis, and timely treatment initiation have been shown to reduce breast cancer morbidity…
- Trial name
- NCT02296177
- Testing
- Peace of Mind Program
- Where
- United States
- Volunteers
- 4,448 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Breast Cancer
A Study of Pertuzumab and Trastuzumab Subcutaneous (SC) Treatment in Combination With a Taxane in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer
This open-label, multicenter, Phase IIIb study will assess the safety, tolerability and efficacy of a combination therapy of intravenous (IV) pertuzumab (Perjeta), trastuzumab (Herceptin) SC, and taxane chemotherapy (docetaxel…
- Trial name
- SAPPHIRE (NCT02019277)
- Testing
- Docetaxel, Nab-paclitaxel, Paclitaxel
- Where
- 13 sites in Australia
- Volunteers
- 50 people
- Sponsor
- Hoffmann-La Roche
Breast Cancer
Bevacizumab and Trastuzumab With Weekly Paclitaxel Followed, After Surgery, by Encapsuled Liposomal Doxorubicin, Cyclophosphamide and Trastuzumab as Adjuvant Treatment After Surgery on Women With Her2+ Breast Cancer
The purpose of this study is to determine the efficacy of the combined therapy Bevacizumab, trastuzumab and paclitaxel in neo-adjuvant therapy in patients with breast cancer HER 2+ followed by surgery and adjuvant therapy…
- Trial name
- NCT01321775
- Testing
- Bevacizumab,Trastuzumab,Paclitaxel,Cyclophosphamide,Myocet
- Where
- 3 sites in Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Universitario Madrid Sanchinarro
Breast Cancer
Community Volunteers Promoting Physical Activity Among Cancer Survivors
Physical activity programs, when offered in research settings, have been shown to improve quality of life and reduce fatigue among breast cancer survivors.
- Trial name
- MFT2 (NCT00948701)
- Testing
- Moving Forward Together 2
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Breast Cancer, Genitourinary Syndrome
Radiofrequency and Exercise-based Rehabilitation on Symptoms Associated With Pelvic Floor Dysfunctions in Breast Cancer
Breast cancer has a high impact, affecting 2.3 million women worldwide in 2022. In Spain, there were 40,203 new cases in 2023. In addition to the economic and social costs, patients suffer genitourinary dysfunctions due to cancer…
- Conditions
- Breast Cancer, Genitourinary Syndrome, Radiofrequency, Physical Exercise
- Trial name
- NCT06694519
- Testing
- manometry through the PHENIX series device (model: PHENIX LIBERTY; manufacturer: ELECTRONIC CONCEPT LIGNON INNOVATION, Montpelier, France)., PFIQ-20 questionnaire (Pelvic Floor Impact Questionnaire Short Form), ICIQ-SF (International Consultation on Incontinence Questionnaire - Short Form)
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- SERGIO MONTERO NAVARRO
Breast Cancer
Evaluating the Use of Magnetic Resonance Imaging and Contrast Enhanced Mammography After MagTrace® Use
Rationale: MagTrace® will be implemented as standard of care for sentinel lymph node biopsy, since it has several advantages compared to a radioactive technique.
- Trial name
- MagTrace2 (NCT05637528)
- Testing
- MRI
- Volunteers
- 25 people
- Sponsor
- Zuyderland Medisch Centrum
Breast Cancer
Effect of Intercessory Prayer in Patients With Breast Cancer in Radiotherapy Treatment: Clinical Trial
Living with breast cancer and forms of treatment, among them radiation therapy can cause both side effects such as pain, fatigue and skin changes that affect the well-being, as anxiety, feelings of isolation and changes in…
- Trial name
- NCT02716467
- Testing
- intercessory prayer, Radiotherapy
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Breast Cancer, Cancer of Breast
Shave Margins in Breast Conservation Therapy
The investigators propose a randomized controlled superiority trial of standard breast-conserving surgery (BCS) versus BCS with cavity shave margins (CSM).
- Conditions
- Breast Cancer, Cancer of Breast, Cancer of the Breast
- Trial name
- SMART (NCT02462200)
- Testing
- Breast-conserving surgery (BCS), Cavity shave margins (CSM), BREAST-Q Questionnaire
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Washington University School of Medicine
Breast Cancer
Effect of 4-Hydroxytamoxifen Gel on Breast Density, Salivary Sex Steroids, and Quality of Life in Premenopausal Women
RATIONALE: High estrogen levels may be associated with dense breast tissue and an increased risk of developing breast cancer. 4-hydroxytamoxifen gel (a substance made when tamoxifen breaks down in the body) may be effective in…
- Trial name
- NCT00084344
- Testing
- 4-hydroxytamoxifen, breast imaging study, radiomammography
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Breast Cancer
An Observational Study of Avastin (Bevacizumab) in Patients With HER2-metastatic or Locally Advanced Breast Cancer
This observational study will evaluate the safety and efficacy of triple negative or HR+ patients with HER2-metastatic or locally advanced breast cancer treated with Avastin (bevacizumab) as first line therapy for at least 12…
- Trial name
- NCT01461044
- Where
- 82 sites in France
- Volunteers
- 228 people
- Sponsor
- Hoffmann-La Roche
Impaired Cognition, Chemo-brain
Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer
This research study evaluates the effect of chemotherapy on cognition (thinking) and the brain in people with breast cancer.
- Conditions
- Impaired Cognition, Chemo-brain, Breast Cancer
- Trial name
- NCT02290834
- Testing
- Cognitive, functional and subjective assessments, MRI, PET Scan
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Breast Computed Tomography (CT) as a Diagnostic Tool
Lay Summary The American Cancer Society has recommended that all women over the age of 40 have an annual mammogram for many years. This recommendation has been associated with a substantial decrease in breast cancer deaths.
- Trial name
- NCT00957307
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Emory University
Bone Diseases, Breast Neoplasms
Women's Health Initiative (WHI)
To address cardiovascular disease, cancer, and osteoporosis, the most common causes of death, disability, and impaired quality of life in postmenopausal women.
- Conditions
- Bone Diseases, Breast Neoplasms, Cardiovascular Diseases, Colonic Neoplasms
- Trial name
- NCT00000611
- Testing
- hormone replacement therapy, estrogens, progestins
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Breast Cancer
Evaluation of Breast Cancer Surgical Margins Using Optical Spectroscopy
This study will apply optical spectroscopy to intraoperative margin assessment during surgery for breast cancer. We hypothesize that a combination of fluorescence spectroscopy and diffuse reflectance spectroscopy will reliably…
- Trial name
- NCT00214292
- Testing
- fluorescence spectroscopy and diffuse spectroscopy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Metastatic Breast Cancer
Prospective Observational Study in Patients With Metastatic Breast Cancer Treated With Anthracyclines
This is an open, multicentre, prospective observational (non-interventional) study, performed in Belgium. Principal objectives: 1.
- Trial name
- NCT01555944
- Where
- 24 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Teva Pharma
Triple Negative Breast Neoplasms
Capecitabine Plus Pembrolizumab in Patients With Triple Negative Breast Cancer After Chemo-immunotherapy and Surgery
The goal of this clinical trial is to evaluate the efficacity and safety of pembrolizumab and capecitabine on the invasive disease-free survival, in participants who have triple negative breast cancer (TNBC) with residual disease…
- Trial name
- CAPPA (NCT05973864)
- Testing
- Pembrolizumab injection, Capecitabine tablets, Local radiotherapy
- Where
- 20 sites in France
- Volunteers
- 220 people
- Sponsor
- UNICANCER
Breast Cancer
Effect of Early vs Late Drainage Removal in Women After Radical Mastectomy With Axillary Clearance
The aim of the study is to assess whether early drainage removal in patients with less than 150ml of lymph in postoperative day 1 can reduce total lymphorrhoea
- Trial name
- CHLONKA (NCT01221064)
- Testing
- Early drainage removal, Late drainage removal
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Gdansk
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