Clinical trials: Breast Tumor Tissue
Breast Cancer
Study to Determine the Antitumor Activity of New CAR-macrophages in Breast Cancer Patients' Derived Organoids
Cell-based immune therapy using modified macrophages is a promising therapeutic approach in breast cancer. The objective of this cohort study is to collect tumor samples to develop patients' derived organoids to test the…
- Trial name
- CARMA (NCT05007379)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Oscar Lambret
Breast Cancer
Breast Cancer Margin Delineation Using Polarization Subtraction Imaging Technology
This study will evaluate LumaScan, an innovative polarization microscope for real time, intraoperative imaging and evaluation of the surface of excised tissue excised during Breast Conservation Surgery (BCS) for non invasive and…
- Trial name
- NCT02207179
- Testing
- LumaScan Image Guided Surgery
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- LumaMed
Antibody-drug Conjugates, HER2-low Breast Cancer
Analysis of Exploring Optimized Sequential Treatment Strategies of Antibody-Drug Conjugates (ADCs) in HER2-Low-Expressing Breast Cancer
This study retrospectively analyzes the clinical data of HER2-low breast cancer (IHC 1+/2+ and FISH-negative) patients treated with sequential antibody-drug conjugates (ADCs).
- Conditions
- Antibody-drug Conjugates, HER2-low Breast Cancer, Breast Neoplasms
- Trial name
- NCT06877416
- Testing
- Non-intervention research
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Sun Yat-sen University
Breast Neoplasms
The Detection of Cell-in-cell Structure (CICs) in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy
Breast cancer is the most common malignant tumor in women worldwide and neoadjuvant therapy has been the standard care for local advanced breast cancer.
- Trial name
- NCT05642104
- Testing
- Neoadjuvant therapy
- Where
- China
- Volunteers
- 175 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Breast Cancer, Breast Neoplasms
Target-specific immunoPET Imaging of Breast Cancer
The aim of this study is to establish and optimize the Trop2/HER2-targeted PET/CT imaging method, and its physiological and pathological distribution characteristics, on the basis of which the diagnostic efficacy of the above…
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Cancer Metastatic
- Trial name
- NCT06715826
- Testing
- [18F]F-RESCA-RT4, [18F]F-RESCA-RB14
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Breast Cancer Lymphedema
Axillary Reverse Mapping (ARM) in Breast Cancer Surgery to Prevent Lymphedema. (ARMtrial)
Breast cancer related lymphedema (BCRL) is a debilitating and distressing condition affecting approximately one out of five breast cancer survivors.
- Trial name
- NCT03333226
- Testing
- Axillary Reverse Mapping (ARM)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University Hospital of Ferrara
TNBC, TNBC - Triple-Negative Breast Cancer
An Open-Label, Multicenter, Non-Randomized Expanded Access Protocol (EAP) Designed to Provide Leronlimab to Patients With Locally Advanced or Metastatic Triple-Negative Breast Cancer (mTNBC)
This Expanded Access Program provides investigational access to leronlimab (PRO 140) for patients with advanced or metastatic triple-negative breast cancer (TNBC) who lack satisfactory treatment options and are unable to…
- Conditions
- TNBC, TNBC - Triple-Negative Breast Cancer, TNBC, Triple Negative Breast Cancer
- Trial name
- NCT07536815
- Testing
- leronlimab (PRO 140)
- Where
- United States
- Sponsor
- CytoDyn, Inc.
Pain
Acupuncture and Breast Cancer Rehabilitation
The patients were divided into two randomized groups with 24 patients per group, which were given weekly treatment for 10 weeks, one group treated with Kinesiotherapy lasting 30 minutes and the other group followed Kinesiotherapy…
- Trial name
- ACUP (NCT02691208)
- Testing
- Kinesiotherapy, Acupuncture
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Federal University of São Paulo
Breast Cancer
A Study of Herceptin (Trastuzumab) in Combination Chemotherapy in Patients With Metastatic or Locally Advanced Breast Cancer
This study will define an optimal chemotherapy dose regimen of Myocet in combination with paclitaxel and intravenous Herceptin and will evaluate the efficacy and safety of this dose regimen in patients with metastatic or locally…
- Trial name
- NCT02015676
- Testing
- trastuzumab, paclitaxel, Myocet
- Where
- Spain
- Volunteers
- 69 people
- Sponsor
- Hoffmann-La Roche
Shoulder Pain, Breast Cancer
Physiotherapy in Women With Peripheral Persistent Pain Following Breast Cancer Treatment
The aim of this study is to determine the effectiveness of a multimodal physiotherapy intervention including scapula exercises in addition to deep dry needling and neurodynamic techniques versus scapula exercises only versus…
- Trial name
- NCT02735668
- Testing
- Shoulder Conventional Exercises, Multimodal Physiotherapy, Scapular exercises
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- University of Alcala
Breast Cancer
A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Patients With Primary Breast Cancer
This study will evaluate the effect of Avastin (15mg/kg iv) in combination with Docetaxel and Xeloda, given as pre-operative therapy to patients with primary breast cancer.
- Trial name
- NCT02005549
- Testing
- bevacizumab [Avastin], docetaxel, capecitabine [Xeloda]
- Where
- Austria
- Volunteers
- 18 people
- Sponsor
- Hoffmann-La Roche
Breast Cancer
Evaluation of the Efficacy of Estramustine in Patient With Breast Cancer Progression After Treatment With Aromatase Inhibitor.
Despite advances in early detection and treatment strategy, about 25 to 40% of patients treated for breast cancer develop metastasis. Some patients are in a therapeutic impasse situation.
- Trial name
- EFESE (NCT02866955)
- Testing
- Estramustine, Tamoxifen
- Where
- 21 sites in France
- Volunteers
- 100 people
- Sponsor
- Institut de Cancérologie de Lorraine
Breast Cancer
Monitoring and Predicting Chemotherapy Response Using DOSI
RATIONALE: New imaging procedures, such as diffuse optical spectroscopy imaging, may help measure a patient's response and allow doctors to plan better treatment.
- Trial name
- ACRIN6691 (NCT01217385)
- Testing
- DOSI
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- American College of Radiology Imaging Network
Non-Small Cell Lung Cancer, Pancreatic Adenocarcinoma
Safety and Efficacy of BA1302 in Patients With Advanced Solid Tumors
This is a first-in-human (FIH), multicenter, open-label Phase I study to evaluate the safety, tolerability, PK profile, immunogenicity, and preliminary efficacy of BA1302 in patients with advanced solid malignancies.
- Conditions
- Non-Small Cell Lung Cancer, Pancreatic Adenocarcinoma, Breast Cancer, Melanoma
- Trial name
- NCT06596915
- Testing
- BA1302
- Where
- China
- Volunteers
- 167 people
- Sponsor
- Shandong Boan Biotechnology Co., Ltd
Breast Cancer, Leukemia
Phase I/II Study of Escalating-Dose Melphalan w/Autologous SCS & Amifostine Cytoprotect
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Breast Cancer, Leukemia, Lymphoma, Neuroblastoma
- Trial name
- NCT00003425
- Testing
- filgrastim, amifostine trihydrate, cyclophosphamide
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Kentucky
Breast Neoplasms, Postmenopausal Disorder
Gene Expression Profile of Breast Cancer Samples After Vitamin D Supplementation
The purpose of this study is to evaluate whether calcitriol supplementation may reduce tumor cell proliferation and influence gene expression profile of breast cancer samples from post-menopausal patients.
- Trial name
- NCT00926315
- Testing
- calcitriol
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Breast Cancer
Weekly and Every 3 Week Administration of Paclitaxel Liposome Injection in Metastatic Breast Cancer
This is a open-label study in patients with metastatic breast cancer to evaluate the antitumor activity and safety of weekly dose-dense paclitaxel liposome injection compared to 3-weekly regimen.
- Trial name
- NCT02142790
- Testing
- paclitaxel liposome injection
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanjing Luye Sike Pharmaceutical Co., Ltd.
Breast Cancer, Physical Activity
Development of Exercise Promotion Program Using a Mobile Community
This study aims to investigate the effect of a mobile community based on a smart phone application to enhance physical activities of breast cancer survivors.
- Trial name
- NCT03190720
- Testing
- Mobile community
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Asan Medical Center
Breast Cancer
Physical Exercise During Preoperative Chemotherapy for Breast Cancer
Neoadjuvant chemotherapy (NACT) is increasingly used in breast cancer. The best proof of NACT efficacy is pathological complete response (pCR), i.e. the absence of invasive tumour on post-NACT surgical histopathology.
- Trial name
- Neo-ACT (NCT05184582)
- Testing
- Physical training
- Where
- 13 sites in Australia, Finland and 2 more
- Volunteers
- 712 people
- Sponsor
- Karolinska Institutet
Breast Cancer
Surveillance Markers of Utility for Recurrence After Neoadjuvant Chemotherapy for Breast Cancer
This is a nested multicenter, prospective cohort study within the I-SPY 2 TRIAL for women undergoing neoadjuvant chemotherapy for primary breast cancer who are also undergoing definitive surgical resection and have clinical or…
- Trial name
- NCT02830282
- Testing
- Blood Collection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
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