Clinical trials: Breast Tumor Tissue
Breast Cancer (Triple Negative Breast Cancer (TNBC))
RNA-Immunotherapy of IVAC_W_bre1_uID and IVAC_M_uID
The Mutanome Engineered RNA Immuno-Therapy (MERIT) study introduced a novel concept for Individualized Cancer Immunotherapy (IVAC®) to treat each patient with the relevant and immunogenic RNA vaccines for a given patient's tumor.
- Trial name
- TNBC-MERIT (NCT02316457)
- Testing
- IVAC_W_bre1_uID, IVAC_W_bre1_uID/IVAC_M_uID
- Where
- 4 sites in Germany, Sweden
- Volunteers
- 42 people
- Sponsor
- BioNTech SE
Cancer
Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant
RATIONALE: Giving donor natural killer cells to patients who have undergone donor bone marrow transplant may make the transplant work better and keep cancer cells from coming back.
- Trial name
- NCT00569283
- Testing
- therapeutic allogeneic lymphocytes
- Where
- 2 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- Asan Medical Center
Lung Cancer, Breast Cancer
Cambridge Brain Mets Trial 1
Proof of principle phase 1b / randomised phase 2 study of afatinib penetration into cerebral metastases for patients undergoing neurosurgical resection, both with and without prior low-dose, targeted radiotherapy.
- Conditions
- Lung Cancer, Breast Cancer, Brain Cancer, Advanced Breast Cancer
- Trial name
- CamBMT1 (NCT02768337)
- Testing
- Afatinib, 2 Gy targeted radiotherapy, 4 Gy targeted radiotherapy
- Where
- 6 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Surgery of Breast Cancer
Database of Data Collection
For several years, the Paoli-Calmettes Institute has been centralizing the retrospective collection of clinical data of patients operated on for histologically proven breast cancer.
- Trial name
- BDD-G3S (NCT03461172)
- Testing
- Surgery of breast cancer, Clinical data collection
- Where
- France
- Volunteers
- 50,000 people
- Sponsor
- Institut Paoli-Calmettes
Metastatic Breast Cancer
Docetaxel Combined With Ketoconazole in Treatment of Breast Cancer
Patients with locally advanced or metastatic breast cancer and with measurable primary breast tumor will be treated with 70mg docetaxel combined with ketoconazole.
- Trial name
- NCT00212095
- Testing
- docetaxel and ketoconazole
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- National University Hospital, Singapore
Breast Cancer, Fatigue
Combined Strength Training and Functional Endurance Exercise Regimen on Cancer -Related Fatigue and Physical Performance
Primary Objective: -Determine if a specific exercise regimen (combined strength training/functional endurance) reduces the level of fatigue among women with breast cancer while undergoing adjuvant or neoadjuvant chemotherapy…
- Trial name
- NCT00421057
- Testing
- Combined Strength Training and Functional Endurance Exercise, Questionnaire
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
ZD1839 (Iressa™) In Combination With Docetaxel As First-Line Treatment In Patients With Metastatic Breast Cancer
This is a multicentre, randomised (2:1), double blind, non-comparative phase II trial of ZD1839 and placebo in combination with chemotherapy in patients with metastatic breast cancer.
- Trial name
- NCT00247481
- Testing
- Gefitinib, Docetaxel
- Where
- 5 sites in France
- Volunteers
- 77 people
- Sponsor
- AstraZeneca
Breast Cancer, Tear
Tear Based Sample Collection Breast Cancer Detection
This study aims to collect tear samples from 50 women who have been recently diagnosed with breast cancer.
- Conditions
- Breast Cancer, Tear, Breast Cancer Female
- Trial name
- NCT04974567
- Testing
- Schirmer Strip
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Namida Lab
Breast Cancer
Magnetic Resonance Imaging in Radiotherapy for Breast Cancer
This is a single-center, prospective pilot study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (MRI) simulation into the planning of radiation treatment (RT) for breast cancer.
- Trial name
- MIRROR (NCT05902507)
- Testing
- Magnetic Resonance Imaging Simulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Breast Cancer
A Home-based Physical Activity Intervention in Breast Cancer Survivors
The aim of this current study was to investigate the effects of a pragmatic home-based physical activity programme on primarily physical activity levels and secondarily weight maintenance, health-related quality of life (HRQoL)…
- Trial name
- PHAB (NCT02408107)
- Testing
- Physical activity
- Volunteers
- 80 people
- Sponsor
- Dudley Group NHS Foundation Trust
Breast Cancer, Mastectomy
Mastectomy Flap Temperature Study
The purpose of this research study is to measure tissue temperatures and generate a prospective database of participants undergoing mastectomy with or without breast reconstruction at Wake Forest Baptist Hospital (WFBH) in order…
- Trial name
- NCT05395936
- Testing
- Myocardial Probe Temperature Screen, Data Collection
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer
A Phase I Dose Escalation Study of Single Fraction Pre-operative Partial Breast (S-PBI) for Early Stage Breast Cancer
The purpose of this phase I trial is to evaluate dose-limiting toxicity while dose escalating single-fraction preoperative S-PBI to a presumed radioablative dose over 3 cohorts, starting with 30Gy in 1 fraction and advancing to…
- Trial name
- NCT04040569
- Testing
- Radiomics on MRI
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Adenocarcinoma, Metastatic Breast Carcinoma
Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer
This pilot phase I trial studies the side effects of direct tumor microinjection and fludeoxyglucose F-18 positron emission tomography (FDG-PET) in testing drug sensitivity in patients with non-Hodgkin lymphoma, Hodgkin lymphoma…
- Conditions
- Breast Adenocarcinoma, Metastatic Breast Carcinoma, Recurrent Breast Carcinoma, Recurrent Hodgkin Lymphoma
- Trial name
- NCT03432741
- Testing
- Belinostat, Carfilzomib, Copanlisib Hydrochloride
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Cancer, Breast, Neuropathy
Tango for Neuropathy Among Breast Cancer Survivors
Group dance classes have been found to improve markers of quality of life and physical health (i.e., balance) among some populations engaged in rehabilitation, such as the elderly and individuals with Parkinson Disease.
- Trial name
- NCT05114005
- Testing
- Rhythmic Auditory Stimulation, Evidence-Based Exercise
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Hematologic Cancer, Colon Cancer
Precision Physical Exercise for Personalized Onco-Hematology.
Physical exercise, particularly strength training, has become an effective strategy to improve physical function, muscle mass, and quality of life in cancer patients.
- Conditions
- Hematologic Cancer, Colon Cancer, Breast Cancer, Lymphoma
- Trial name
- PEPOH (NCT07286539)
- Testing
- Supervised Intervention, Home-based Intervention
- Volunteers
- 150 people
- Sponsor
- University of Salamanca
Breast Cancer
Combination Chemotherapy Following Surgery in Treating Women With Early Stage Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which combination chemotherapy regimen is more effective following surgery for breast…
- Trial name
- NCT00003012
- Testing
- CMF regimen, cyclophosphamide, epirubicin hydrochloride
- Where
- 10 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Scottish Cancer Therapy Network
Breast Cancer
High Dose Rate Intracavitary Brachytherapy as the Sole Method of Radiation Therapy for Breast Carcinoma
The purpose of this study is to understand the side effects (skin reaction, infection and abscess formation) at the site of radiation treatment, which my occur during the treatment and following 2 months using a new method of…
- Trial name
- NCT00165581
- Testing
- High Dose Intracavitary Brachytherapy
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
SPY Intra-Operative Angiography & Skin Perfusion in Immediate Breast Reconstruction w/ Implants
The investigators hope to learn the value of the SPY ELITE® intra-operative angiography in reducing post-operative complications associated with low breast skin blood flow after breast reconstruction using implants.
- Trial name
- NCT01315119
- Testing
- SPY Intra-Operative Angiography
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Advanced Solid Cancers, Breast Cancer
A Study of Investigational Drug CFI-402257 in Patients With Advanced Solid Tumors
This is a phase 1 study of investigational agent CFI-402257 in patients with advanced cancer. The purpose of this study is to see how safe and tolerable CFI-402257 is in cancer patients as well as the pharmacokinetics (PK).
- Trial name
- NCT02792465
- Testing
- CFI-402257, Fulvestrant
- Where
- 3 sites in Canada
- Volunteers
- 52 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Mindfulness-Based Intervention in Breast Cancer Patients Undergoing Chemotherapy
There is evidence that mindfulness-based interventions (MBIs) such as meditation, mindfulness-based stress reduction (MBSR) and yoga might improve Quality of Life (QOL) and reduce stress in breast cancer survivors.
- Trial name
- NCT02067351
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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