Clinical trials: Breast-conserving Surgery
Breast Cancer
Study to Evaluate Surgical Excision Margins in Malignant Breast Lumpectomies With the PEAK PlasmaBlade
The purpose of this research study is to find out more about distinguishing between cancerous and non-cancerous breast cancer cells at the edges of tumors.
- Trial name
- NCT00972010
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Sarah Blair, M.D.
Breast Cancer
A Prospective Clinical Study Investigating the Use of the Histolog Scanner for Intraoperative Assessment of Surgical Margins in Patients Undergoing Breast-conserving Surgery for Histologically Confirmed Breast Cancer. The Histolog Scanner Operates on the Principle of Confocal Microscop
A prospective clinical study investigating the use of the Histolog Scanner for intraoperative assessment of surgical margins in patients undergoing breast-conserving surgery for histologically confirmed breast cancer.
- Trial name
- NCT07341542
- Testing
- Histolog scanner
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Silesian Hospital in Opava
Breast Cancer
Prospective Study on Exemption of Tumor Bed Boost Radiotherapy for pCR Patients After Breast Conserving Surgery With Neoadjuvant Therapy
This study is a multicenter, single-arm, phase II clinical trial, aiming to evaluate the safety and efficacy of tumor bed dose escalation radiotherapy for patients with primary breast lesions achieving pCR (ypT0) after…
- Trial name
- NCT07113613
- Testing
- Exemption from additional radiotherapy on the tumor bed after surgery
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Palpable Breast Cancer
A Pilot Multi-Institutional Study to Evaluate the Accuracy of a Breast Cancer Locator in Patients With Palpable Cancers
The project objective is to determine whether the Breast Cancer Locator (BCL) can safely and effectively localize breast cancers in patients treated at locations distant from the site of BCL manufacture.
- Trial name
- BCL (NCT03573661)
- Testing
- Breast Cancer Locator (BCL)
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer
Preoperative Magnetic Resonance Imaging to Obtain Adequate Resection Margins in Breast Conserving Surgery, (PRIMAR) Trial
The goal of this randomised study is to investigate if a supplementary preoperative breast Magnetic Resonance Imaging (MRI) improves the assessment of breast cancer and can help surgical planning such that sufficient resection…
- Trial name
- PRIMAR (NCT05825768)
- Testing
- Breast MRI, standard breast imaging
- Where
- 2 sites in Denmark
- Volunteers
- 227 people
- Sponsor
- Aarhus University Hospital
Breast Cancer, Proton Therapy
Ultra-Hypofractionated vs. Moderately Hypofractionated Proton Therapy for Early Breast Cancer After Lumpectomy
Breast-conserving surgery (BCS) followed by whole-breast irradiation (WBI) remains the standard therapeutic approach for early-stage breast cancer.
- Trial name
- UPH-BC (NCT07135661)
- Testing
- moderate hypofractionated proton radiotherapy, ultra-hypofractionated proton radiotherapy
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Breast Cancer
Reconstruction of Partial Mastectomy Defects With Pectoralis Myo-glandular Local Flap.
Increasing number of breast cancer patients are being treated with conservative surgery; without the need for mastectomy. The cosmetic sequel of breast conservative surgery can be unsatisfactory to the patient and may necessitate…
- Trial name
- NCT04091958
- Testing
- Pectoralis myo-glandular flap reconstruction.
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University
Breast Neoplasms
PICTURE Breast L: Patient Information Combined for Local Therapy oUtcome Assessment in bREast Cancer - Longitudinal
This project which is fully funded by the European Union FP7 Program is designed to pull together all the information we obtain from scans and x-rays to design a personalised 3-D digital model of each patient, their anatomy and…
- Trial name
- PICTURE L (NCT02341820)
- Where
- 3 sites in Netherlands, Portugal and 1 more
- Volunteers
- 83 people
- Sponsor
- University College, London
Invasive Breast Carcinoma
Application of Single-Port Robot-Assisted Breast-Conserving Surgery Via Axillary Approach for Breast Cancer.
Evaluate the safety,feasibility and quality of life(QoL)of single-port robotic surgery in breast-conserving surgery, compare and analyze the advantages and disadvantages of single-port robotic surgery and open surgery in terms of…
- Trial name
- 单孔机器人-SPR (NCT06738654)
- Testing
- robot-surgery, traditional open surgry
- Where
- 2 sites in China
- Volunteers
- 64 people
- Sponsor
- Xu Yan
Malignant Neoplasm of Breast
Accelerated Partial Breast Irradiation Versus Standard or Hypofractionated Whole-Breast Irradiation, in Early Breast Cancer, After Breast-conserving Surgery
Radiotherapy has been confirmed as an important treatment breast-conserving surgery reducing the risk of any recurrence of breast cancer and breast cancer-related mortality in patients with early breast cancer.
- Trial name
- LAPIDARY (NCT04669873)
- Testing
- Active Comparator: Standard, Experimental 1: Hypofractionated radiotherapy, Experimental 2: Accelerated Partial Breast Irradiation
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Instituto Brasileiro de Controle do Cancer
Breast Cancer
PersonaLized neoAdjuvant Strategy ER Positive and HER2 Negative Breast Cancer TO Increase BCS Rate
In ER+ and HER2- breast cancer(BC) patients for whom BCS is not feasible, we investigate the rate of BCS can be increased while decreasing unnecessary chemotherapy thru selective neoadjuvant chemotherapy or neoadjuvant endocrine…
- Trial name
- NCT03900637
- Testing
- Leuprorelin acetate, Letrozole, MammaPrint
- Where
- South Korea
- Volunteers
- 122 people
- Sponsor
- Seoul National University Hospital
Breast Cancer Female
CLI and FAR for Intraoperative Margin Assessment
This study is a prospective, single arm interventional study to evaluate the diagnostic accuracy of intraoperative Cerenkov luminescence imaging (CLI) plus flexible autoradiography (FAR) using the LightPath® Imaging System for…
- Trial name
- CLI-FAR (NCT05496101)
- Testing
- Intraoperative CLI + FAR LightPath imaging
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Breast Cancer
Cavity Shaving in Breast Conserving Surgery for Breast Cancer Patients
This randomized controlled trial is to evaluate the impact of additional cavity shaving (CS) on pathological cavity margin (CM) status in breast cancer patients.
- Trial name
- NCT02648802
- Testing
- Cavity shaving, Standardized BCS+CM assessment.
- Where
- China
- Volunteers
- 181 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Systemic Immune-inflammatory Index, Erector Spinae Plane Block
Impact of Erector Spinae Plane Block on Systemic Immune-inflammation Index
The primary objective of the study is to determine whether there is a relationship between postoperative SII and erector spinae plane block application.
- Conditions
- Systemic Immune-inflammatory Index, Erector Spinae Plane Block, Breast Conserving Surgery
- Trial name
- NCT07137702
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Taner Abdullah
Breast Cancer, Breast Cancer Female
Preoperative Stereotactic Ablative Body Radiotherapy (SABR) for Early-Stage Breast Cancer
This study involves a course of radiation to the tumor that is delivered BEFORE surgery. The type of radiation is called stereotactic ablative body radiation therapy (SABR).
- Conditions
- Breast Cancer, Breast Cancer Female, Breast Adenocarcinoma
- Trial name
- NCT03137693
- Testing
- Standard of Care Schedule Variation: SABR, Breast-conserving Surgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Postoperative Pain, Preoperative Sleep Quality
The Effect of Sleep Quality Before Breast Surgery on Postoperative Pain
This study aimed to investigate the relationship between preoperative sleep quality and postoperative pain in patients undergoing mastectomy or breast-conserving surgery under general anesthesia.
- Trial name
- NCT07892924
- Testing
- Sleep Quality and Postoperative Pain Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Breast Conserving Surgery
Tumour Localisation With Magnetic Clip Before Neoadjuvant Chemotherapy.
The feasibility of the use of magnetic clips for tumour localisation before preoperative chemotherapy in combination with superparamagnetic iron oxide nanoparticles (SPIO) as tracer for sentinel lymph node (SLN) detection and in…
- Trial name
- MagLocal (NCT06463600)
- Testing
- Magseed, Metallic clip and guide wire
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- Sahlgrenska University Hospital
Breast Cancers
Partial Breast Re-irradiation for Breast Cancer
Breast cancer is the most common malignancy in women. Breast-conserving surgery (BCS) with adjuvant whole-breast irradiation (WBI) is currently the standard of care in the oncological treatment of primary breast cancer and offers…
- Trial name
- BREAST (NCT06954623)
- Testing
- Radiation Therapy
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Carcinoma Breast
Ten Years Results of a Score System to Address Adjuvant Therapies After Breast Conserving Surgery for Ductal Carcinoma in Situ of the Breast
By this non-randomized prospective study, it's evaluated the outcome of patients underwent BCS for DCIS at whom an established score system to address adjuvant therapies have been prospectively applied, according to the wideness…
- Trial name
- DCIS (NCT03002766)
- Testing
- Breast conservative surgery
- Where
- Italy
- Volunteers
- 224 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Stage IA Breast Cancer, Stage IIA Breast Cancer
Intraoperative Radiation Therapy in Treating Patients With Breast Cancer Undergoing Breast-Conserving Surgery
This phase IV trial studies the side effects of intraoperative radiation therapy and how well it works in treating patients with breast cancer undergoing breast-conserving surgery.
- Trial name
- NCT01570998
- Testing
- Intraoperative Radiation Therapy, Laboratory Biomarker Analysis
- Where
- 25 sites in United States
- Volunteers
- 1,259 people
- Sponsor
- University of California, San Francisco