Clinical trials: Breast-conserving Surgery
Breast Cancer
Clinical Trial Comparing Outcomes of Breast Conserving Operations With Classic v High-frequency Electrocoagulation
The aim of this study is to assess the outcomes of breast conserving therapy operation depending on the type of surgical tool used: classic electrocoagulation with higher operative temperatures and high frequency…
- Trial name
- NCT01216254
- Testing
- classic v high-frequency electrocoagulation
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Gdansk
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Swebcg 91:A RT. Breast Conserving Surgery With or Without Radiotherapy for Breast Cancer Patients
The main goal of the trial was to analyse the value of radiotherapy after breast conserving surgery for patients with breast cancer, and to find groups of patients where the treatment could be omitted.
- Trial name
- NCT06637202
- Testing
- postoperative radiotherapy
- Where
- Sweden
- Volunteers
- 1,187 people
- Sponsor
- Region Skane
Breast Cancer
Analysis of Breast-Conserving Surgery Plus Whole-Breast Irradiation Versus Mastectomy
This is a retrospective propensity score-matched analysis of a large institutional cohort of patients in order to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving…
- Trial name
- NCT05126667
- Testing
- Breast-conserving surgery, Mastectomy
- Volunteers
- 9,710 people
- Sponsor
- European Institute of Oncology
Breast Cancer, Radiation Dermatitis
A DB Randomized Study of R1 and R2 WaterJel / AloeVera Jell in Prevention of Radiation Dermatitis in Breast Cancer
The purpose of this study is to evaluate the effects of topical R1 and R2 for prophylaxis of acute radiation dermatitis in patients with breast cancer receiving radiotherapy.
- Conditions
- Breast Cancer, Radiation Dermatitis, Erythema
- Trial name
- NCT01597921
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Water-Jel
Breast Cancer
Omitting vs. Doing Intraoperative Frozen Section Biopsy for Margin Status in Breast Conserving Surgery
Study phase: 3 Indication: Breast cancer patients undergoing breast conserving surgery Primary objectives: To determine the effect of selective omission of intraoperative margin evaluation via frozen section on margin positive…
- Trial name
- OFF-MAP (NCT03975179)
- Testing
- Omission of intraoperative frozen section biopsy for margin status, Frozen section biopsy for margin status
- Where
- 2 sites in South Korea
- Volunteers
- 1,292 people
- Sponsor
- Samsung Medical Center
Female Breast Cancer
Ultra-hypofractionated Radiotherapy in Breast Cancer Patients
The present multicenter, retrospective and prospective observational study, aims to evaluate an ultra-hypofractionated whole breast irradiation schedule (WBI, 26 Gy in 5 fractions), in order to confirm literature data (FAST-F…
- Trial name
- NCT05586256
- Testing
- ultra-hypofractionated whole breast irradiation
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University Of Perugia
Breast Cancer, Breast-conserving Surgery
Efficacy and Accuracy of Combined Localization Versus Single Localization in Non-palpable Breast Cancer After Neoadjuvant Therapy
The standard method for localizing non-palpable breast cancer is currently clip localization, its positive margin rate still remains around 20-50%. This study aims to compare the accuracy and efficacy of single vs.
- Trial name
- NCT05838001
- Testing
- Wire-guided localization and marker clip localization, marker clip localization
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer
Breast Cancer With Low Risk Of Local Recurrence: Partial and Accelerated Radiation With Three-Dimensional Conformal Radiotherapy (3DCRT) Vs. Standard Radiotherapy After Conserving Surgery (Phase III Study
This study was designed and developed in the Emilia Romania research and innovation program (PRI ER). The study does not have commercial sponsors and comes under the independent studies provided for by Ministerial Decree…
- Trial name
- NCT01803958
- Testing
- partial breast irradiation, whole breast irradiation
- Where
- Italy
- Volunteers
- 3,302 people
- Sponsor
- Regione Emilia-Romagna
Early Stage Breast Carcinoma
EXamining PErsonalised Radiation Therapy for Low-risk Early Breast Cancer
This is a randomised, phase III, non-inferiority trial evaluating radiation therapy versus observation following breast conserving surgery and planned endocrine therapy in patients with stage I breast cancer of luminal A subtype…
- Trial name
- EXPERT (NCT02889874)
- Testing
- Omission of radiation therapy
- Where
- 68 sites in Argentina, Australia and 7 more
- Volunteers
- 1,167 people
- Sponsor
- Breast Cancer Trials, Australia and New Zealand
Breast Neoplasms, Breast Cancer
Evaluating and Comparing Two Surgical Methods for Treatment of Early Stage Breast Cancer
The goal of this study is to compare two different types of breast surgery. In the first type, the doctor removes only the tumor.
- Conditions
- Breast Neoplasms, Breast Cancer, Breast Tumors, Cancer of Breast
- Trial name
- NCT01271738
- Testing
- Remove tumor only, Removal of tumor and tissue
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Emory University
Breast Carcinoma
Impact of Tumor Bed Localisation on Dosimetry Boost Irradiation in Patients Undergoing Breast Conserving Surgery
PRIMARY STUDY OBJECTIVES: To evaluate dosimetric outcomes in tumor bed boost irradiation in patients undergoing breast conservative surgery using three different surgical techniques SECONDARY OBJECTIVES- Evaluation of cosmesis in…
- Trial name
- NCT03710018
- Where
- India
- Volunteers
- 21 people
- Sponsor
- Tata Memorial Centre
Breast Cancer
Partial Breast Irradiation Using Accelerated Intensity Modulated Radiotherapy
This is a phase I- II feasibility study for delivering partial breast irradiation (PBI) in selected patients with early stage, lymph node negative, breast cancer after breast-conserving surgery using accelerated Intensity…
- Trial name
- NCT00581529
- Testing
- IMRT
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan Rogel Cancer Center
Recurrent Breast Carcinoma, Ipsilateral Recurrence
Preoperative Partial Breast Reirradiation and Repeat Breast-conserving Surgery in Patients With Recurrent Breast Cancer: the REPEAT Trial
Over the past decades, interest in second breast-conserving therapy (BCT) has increased due to, among others, advancements in radiotherapy techniques.
- Trial name
- REPEAT (NCT06640881)
- Testing
- ablative single-dose PBI
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Amsterdam UMC, location VUmc
Breast Reconstruction
Immediate Breast Reconstruction With Free Greater Omentum
Luminal subtype breast cancer, accounting for 70 to 80% of all breast cancers, has been reported to be associated with good prognosis.
- Trial name
- NCT03370250
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital
Breast Cancer, Women
Evaluation of the Effects of the Couple-based Family Nursing for Women With Breast Cancer
The women with breast cancer and their spouses experienced physical and mental distresses together, nevertheless, the spouses were the significant supporters for patients during post-surgery rehabilitation.
- Conditions
- Breast Cancer, Women, Mastectomy, Breast-Conserving Surgery
- Trial name
- NCT05100914
- Testing
- Couple-based family nursing
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Defense Medical Center, Taiwan
Breast Cancer, Breast-conserving Surgery
Feasibility Study for the SIRA-1000, SIRA® RFA Electrosurgical Device as an Adjunct to Breast Conserving Surgery
This study aims to assess the safety and clinical accuracy of the SIRA-1000, SIRA® RFA Electrosurgical Device in ablating margins post-lumpectomy in patients undergoing breast conserving surgery for breast cancer.
- Conditions
- Breast Cancer, Breast-conserving Surgery, Breast Cancer - Infiltrating Ductal Carcinoma, ER/PR+Her2neu
- Trial name
- NCT07206121
- Testing
- Radiofrequency ablation alone, Radiofrequency ablation Electrosurgical Device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Innoblative Designs, Inc.
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Manual Lymphatic Drainage Breast Massage in Breast Cancer Patients After Breast Conserving Surgery
This phase II trial evaluates manual lymphatic drainage breast massage for reducing treatment-related side effects in women undergoing radiation therapy after breast conserving surgery for breast cancer that has not spread to…
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Localized Breast Carcinoma
- Trial name
- NCT06297265
- Testing
- Lymphedema Management, Questionnaire Administration, Adjuvant breast radiation therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Southern California
Breast Neoplasms, Mastectomy, Segmental
Acellular Dermal Matrix(SureDerm BCS) in Breast-Conserving Surgery for Breast Cancer Patients
The goal of this clinical trial is to evaluate whether the use of an acellular dermal matrix (SureDerm) can improve cosmetic satisfaction and is safe in women with breast cancer undergoing breast-conserving surgery.
- Trial name
- NCT07345026
- Testing
- Acellular Dermal Matrix (SureDerm BCS), Standard Breast-Conserving Surgery
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Seoul St. Mary's Hospital
Breastcancer
Outcome of 15 Versus 5 Fractions in Adjuvant Breast Radiotherapy in Women Over 65 Years
This study will evaluate the effect of highly accelerated external beam radiotherapy (EBRT) in 5 fractions over 10 days compared to 15 fractions over 3 weeks for early as well as locally-advanced stage breast cancer.
- Trial name
- HAI-5-III (NCT03121248)
- Testing
- WBI 5 fractions, WBI 15 fractions, LNI 5 fractions
- Where
- Belgium
- Volunteers
- 144 people
- Sponsor
- University Hospital, Ghent
Breast Cancer
High Five (HiFi) Accelerated Partial Breast Irradiation Study
To establish the role of adjuvant multicatheter interstitial high-dose-rate brachytherapy in doubly accelerated and radiobiologically equivalent irradiation scheme of 5 x 5,4 Gy in 3 days of treatment (High Five, HiFi-APBI)…
- Trial name
- HiFi (NCT05142202)
- Testing
- Breast Irradiation after Breast-Conserving Surgery
- Where
- Poland
- Volunteers
- 147 people
- Sponsor
- The Greater Poland Cancer Centre