Clinical trials: Breast-conserving Surgery
Retrospective Study
Predicting Outcomes of Breast-Conserving Surgery in Breast Cancer Patients Using the Modified 5-Item Frailty Index
Background: Breast cancer is the most common malignancy among women worldwide, with breast-conserving surgery (BCS) being a key treatment.
- Trial name
- NCT06770647
- Where
- Germany
- Volunteers
- 96,586 people
- Sponsor
- Technical University of Munich
Breast Cancer
Toxicity Outcomes of Simultaneous Integrated Boost in Adjuvant Breast Radiotherapy Acronym
This prospective study systematically evaluates toxicity outcomes in breast cancer patients treated with adjuvant radiotherapy using the simultaneous integrated boost (SIB) technique after breast-conserving surgery.
- Trial name
- SIB (NCT07407192)
- Testing
- Adjuvant Breast Radiotherapy With Simultaneous Integrated Boost (SIB)
- Where
- Slovenia
- Volunteers
- 93 people
- Sponsor
- Institute of Oncology Ljubljana
Breast Cancer
A Study to Evaluate the Use of Supine MRI Images in Breast Conserving Surgery
This is a 2 Phase study. In the first phase of the study, patients with palpable invasive breast cancer underwent pre-operative supine MRI and optical scanning in the surgical position.
- Trial name
- NCT01929395
- Testing
- Supine MRI
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer
Lidocaine Mucilage-ICG as an Optical Agent for Tumor Delineation During Breast-conserving Surgery
Around 15%-30% of patients receiving breast-conserving surgery (BCS) for invasive breast carcinoma or ductal carcinoma in situ (DCIS) need a reoperation due to tumor-positive margins at final histopathology.
- Trial name
- LI-CTD (NCT04438577)
- Testing
- Lidocaine mucilage-ICG
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shantou Central Hospital
Pain Score, Pain Postoperative
Pain Sensitivity Questionnaire Applied in Preoperative Period in Lumpectomy
Objective: The Pain Sensitivity Questionnaire (PSQ) is a clinically valuable tool that has been shown to correlate with various experimental pain sensitivity assessments in healthy individuals and patients with chronic pain.
- Trial name
- Lumpectomy (NCT06928064)
- Testing
- Prediction of Postoperative Pain Severity Using Pain Sensitivity Questionnaire Applied in Preoperative Period in Patients Undergoing Breast-Conserving Surgery (Lumpectomy).
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Breast Cancer
The Comparison Between M-E-BCS and C-O-BCS.
This study is a multicenter, open-label, randomized controlled trial. The study aims to evaluate differences in operative efficiency (e.g., operative time), economic effect, surgical safety (e.g., surgical complication rates)…
- Trial name
- MECO (NCT07539545)
- Testing
- Minimal accessory-incision-assisted endoscopic breast-conserving surgery, Conventional open breast-conserving surgery
- Where
- China
- Volunteers
- 1,366 people
- Sponsor
- Du Zhenggui
Patient Reported Outcome Measures, Breast Reconstruction
Patient Report Outcome-Reconstruction and Oncoplastic Cohort
Available studies that focused on patient-reported outcomes (PROs) were mainly from one institution or of small sample size. The variations across hospitals and regions were not fully analyzed.
- Conditions
- Patient Reported Outcome Measures, Breast Reconstruction, Oncoplastic Breast-conserving Surgery, Breast Cancer
- Trial name
- PRO-ROC (NCT04030845)
- Testing
- breast reconstruction, oncoplastic breast-conserving surgery
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Fudan University
Breast Cancer
Role of Axillary Lymph Node Dissection for Residual MACROMETASTASES After NEOADJUVANT Chemotherapy in Patients With HER2+ and Triple Negative Breast Cancer: The OPBC-11/MACRONAC Study
In this multicenter retrospective cohort study the aim is to determine the safety of omission of axillary lymph node dissection in patients with TNBC and HER2+ tumors with residual macrometastases (in the SLN/TAD/TAS or MARI…
- Trial name
- MACRONAC (NCT07546695)
- Testing
- Data Collection from medical records of from an already existing database "ONCOLOGICAL BREAST SURGERY DATABASE OF THE UNIVERSITY HOSPITAL OF BASEL" which was initiated in 2016.
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast-Conserving Surgery
A Novel Intraoperative Fluorescence-guided System for Evaluating Margins During Breast-conserving Surgery for Breast Cancer
The goal of this clinical trial is to learn if a novel intraoperative fluorescence-guided system (EndoSCell Scanner) can help surgeons more accurately remove all cancerous tissue during breast-conserving surgery in female…
- Trial name
- NCT07352930
- Testing
- EndoSCell Scanner (ES Scanner) System
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Guangdong Provincial People's Hospital
Inflammatory Breast Cancer
Conserving Surgery in Inflammatory Breast Cancer After Neoadjuvant Chemotherapy
Inflammatory breast cancer is an aggressive and rare form of breast cancer, which accounts for 2-3% of all breast cancers. The classic presentation of inflammatory breast cancer includes erythema, edema, and peau d'orange of at…
- Trial name
- ConSIBreC (NCT06131632)
- Testing
- Breast conserving surgery, Radical modified mastectomy
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer
Cosmetic and Functional Outcomes After Breast Conserving Surgery
The initial aesthetic and functional conditions are recorded with the help of the Breast Cancer Treatment Outcome Scale (BCTOS),an international validated questionnaire, and the Breast Cancer Conservative Treatment - cosmetic…
- Trial name
- NCT01496001
- Testing
- Lumpectomy, axillary block dissection, breast conserving surgery, Radiotherapy
- Where
- Hungary
- Volunteers
- 300 people
- Sponsor
- National Institute of Oncology, Hungary
Radiotherapy, Breast Cancer
The Postoperative Radiotherapy in N1 Breast Cancer Patients
This study is a multicenter, randomized, phase 3 clinical trial in patients with breast cancer, randomizing radiotherapy group (postmastectomy radiation therapy (PMRT)/whole breast irradiation plus regional radiotherapy…
- Trial name
- PORT-N1 (NCT05440149)
- Testing
- No PMRT for mastectomy / No regional RT for BCS, PMRT for mastectomy / WBI + Regional RT for BCS
- Where
- South Korea
- Volunteers
- 1,106 people
- Sponsor
- Seoul National University Hospital
Breast Cancer
Intraoperative Margin Assessment in Breast Cancer With HSI-Raman
Breast-conserving surgery (lumpectomy) aims to remove cancer while preserving healthy tissue, but up to 20% of patients require a second operation because cancer cells remain at the edge (margin) of the removed tissue.
- Trial name
- Spectra-BREAST (NCT07111728)
- Testing
- Spectra-BREAST system in Invasive Breast Cancer, Spectra-BREAST system in DCIS Breast Cancer
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Breast Cancer Female
Prone Breast Radiotherapy Treatment Planning Observational Study
The study purpose is to evaluate whether or not clinical characteristics of women with breast cancer can predict which position for radiation treatment, prone or supine, will be associated with a dosimetry gain.
- Trial name
- HUGProne (NCT02237469)
- Testing
- Prone and supine simulation
- Where
- Switzerland
- Volunteers
- 280 people
- Sponsor
- Vincent Vinh-Hung
Breast Cancer
"The Efficacy of 'Radioguided Occult Lesion Localization' (ROLL) Versus 'Wire-guided Localization' (WGL) in Breast Conserving Surgery for Non-palpable Breast Cancer: a Randomized Clinical Trial"
Rationale: Approximately 25% of breast cancers detected are non palpable. Accordingly, a localization technique is required to help the surgeon to find and remove the cancer.
- Trial name
- ROLL (NCT00539474)
- Testing
- Radio guided occult lesion localisation
- Where
- 4 sites in Netherlands
- Volunteers
- 316 people
- Sponsor
- UMC Utrecht
Breast Neoplasm, Cosmetic Outcome
Aspects of Breast-conserving Surgery
Prospective study of cosmetic outcome and quality of life for women undergoing breast cancer surgery using patient a reported outcome measure (BREAST-Q) and a computer program validated to assess cosmetic outcomes after breast…
- Conditions
- Breast Neoplasm, Cosmetic Outcome, Quality of Life
- Trial name
- NCT04227613
- Where
- Sweden
- Volunteers
- 351 people
- Sponsor
- Lund University
Margin Assessment, Breast Cancer
Spectral Cancer Tissue Recognition - I
This analytical performance study aims to validate the SPCTRone system for use in breast conserving surgery of breast cancer patients.
- Trial name
- SPCTR-I (NCT07459062)
- Where
- 2 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- SPCTR
Breast Cancer
MRI in Women With Newly Diagnosed Breast Cancer Prior to Breast Conserving Surgery
To see if performing breast MRI before a lumpectomy will help the surgeon successfully remove the entire cancer with normal tissue margins in a single operation thereby reducing the need for additional surgical procedures.
- Trial name
- NCT00695916
- Testing
- Breast MRI
- Sponsor
- Stanford University
Breast Neoplasm
Randomized Study of Elective Regional Lymph Node Irradiation in N1 Breast Cancer
This study evaluates the impact of elective regional lymph node irradiation on N1 breast cancer patients receiving post-lumpectomy radiotherapy and anthracycline plus taxane (AT)-based chemotherapy.
- Trial name
- NCT03269981
- Testing
- Whole breast irradiation, Whole breast and nodal irradiation
- Where
- South Korea
- Volunteers
- 827 people
- Sponsor
- Samsung Medical Center
Breast Cancer
Quality of Life and Cosmetic Outcomes of Breast-Conserving Surgery According to Localization Method
The goal of this clinical trial is to compare Quality of Life and cosmetic outcomes in Breast Conservative Carcer surgery depending on localization method (intraoperative Ultrasound, wire and radioactive seed).
- Trial name
- TRIGUIDE (NCT06186011)
- Testing
- Wire-guided surgery, Radioactive seed localization, Intraoperative ultrasound localization
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital Clinic of Barcelona