Clinical trials: Breast-conserving Surgery
Breast Cancer, Breast-conserving Surgery
Intra-SURGerY High-resolution Specimen PET/CT Imager for Margin Assessment in Early-stage Breast Cancer
This study is a diagnostic open-label, prospective, single-arm non-inferiority clinical trial. The primary endpoint is the accuracy to detect positive invasive margins in invasive ductal carcinoma (IDC) patients by…
- Trial name
- SURGYPET (NCT06474975)
- Testing
- AURA 10 PET/CT
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- European Institute of Oncology
Breast Cancer, Quality of Life
Factors Influencing Breast Cancer Resection Volumes And Their Impact on Treatment Outcome (FIBRATIO)
The number of breast cancer survivors is constantly growing. Breast conserving surgery (BCS) is equal or superior to mastectomy both regarding survival and quality of life (QoL).
- Conditions
- Breast Cancer, Quality of Life, Patient Satisfaction, Resection Margin
- Trial name
- FIBRATIO (NCT05257577)
- Testing
- Breast conserving surgery
- Where
- 4 sites in Finland
- Volunteers
- 220 people
- Sponsor
- Tampere University Hospital
Early-stage Breast Cancer, Breast Conserving Surgery
Shandong Cancer Hospital Affiliated to Shandong University
In this study,the eligible breast cancer patients will be randomized divided into two groups. the study group receive the accelerated hypo-fractioned whole breast irradiation with a concurrent boost to the tumor bed (WBI 2.5Gy…
- Trial name
- NCT02958033
- Testing
- Whole Breast irradiation Plus simultaneous tumor bed Boost
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shandong Cancer Hospital and Institute
Breast Cancer
Accelerated Hypofractionated Radiotherapy (AHF-RT) for the Treatment of Breast Cancer
The goal of this study is to explore the safety, effectiveness, quality of life, and cost effectiveness of accelerated hypofractionated radiotherapy (AHF-RT) as treatment after lumpectomy in patients with early stage breast…
- Trial name
- NCT01278212
- Testing
- accelerated hypofractionated radiotherapy (AHF-RT)
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Louisville
Breast Cancer
ExclUsive endocRine Therapy Or Radiation theraPy for Women Aged ≥70 Years Early Stage Breast Cancer
Rationale and relevance for patients and the scientific community. In low risk early stage patients ≥70 years, exclusive radiation therapy (RT) approach might be superior in terms of Health-Related Quality of Life (HRQoL), when…
- Trial name
- EUROPA (NCT04134598)
- Testing
- Breast irradiation (RT), Endocrine Therapy (ET): letrozole, anastrozole, exemestane, tamoxifen
- Where
- Italy
- Volunteers
- 926 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Breast Cancer
3-Dimensional Conformal Radiation Therapy or Internal Radiation Therapy After Breast-Conserving Surgery in Treating Women With Stage I or Stage II Breast Cancer
RATIONALE: Specialized radiation therapy, such as 3-dimensional conformal radiation therapy, that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Trial name
- NCT00802711
- Testing
- 3-dimensional conformal radiation therapy, brachytherapy
- Where
- Ireland
- Volunteers
- 6 people
- Sponsor
- Cancer Trials Ireland
Breast Cancer
Does Scar Massage Improve Postoperative Pain and Function in Women With Breast Cancer?
All patients undergoing breast cancer surgery are left with scars which can significantly affect their physical and psychological well being.
- Trial name
- NCT00175344
- Testing
- Scar massage.
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of British Columbia
Invasive Breast Cancer
Adding Preoperative Radiotherapy Based on Early Treatment Response in Breast Cancer
RAPID-NeoBC is a prospective, multicentre, response-adapted study with a randomized component for adults with operable, nonmetastatic invasive breast cancer receiving guideline-recommended neoadjuvant systemic therapy.
- Trial name
- RAPID-NeoBC (NCT07892508)
- Testing
- Response-adapted preoperative radiotherapy, Guideline-recommended neoadjuvant systemic therapy, Serial contrast-enhanced breast MRI and breast-specific gamma imaging
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer, Radiation Toxicity
Accelerated Partial Breast Irradiation With 3D-CRT and IMRT
The purpose of this study is to determine in a phase II clinical trial whether accelerated partial breast irradiation after breast conserving surgery using 3 dimensional external beam radiotherapy (3D-CRT) and intensity modulated…
- Conditions
- Breast Cancer, Radiation Toxicity, Side Effects
- Trial name
- APERT (NCT02003560)
- Testing
- accelerated partial breast irradiation
- Where
- Hungary
- Volunteers
- 90 people
- Sponsor
- National Institute of Oncology, Hungary
Breast Cancer
Does Intra-operative MarginProbe Use Reduce Re-excision Rates?
The new device we are looking at is called the MarginProbe. It is a disposable probe which measures the margins of tissue removed to check they are clear of cancer cells, during breast conservation surgery.
- Trial name
- MarginProbe (NCT02774785)
- Testing
- MarginProbe
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- Manchester University NHS Foundation Trust
Pain Management in Breast Surgery, Pain After Surgery
Comparison of the Analgesic Efficacy of Erector Spinae Plane Block in Breast-Conserving Surgery Versus Serratus Anterior Block Combined With Additional Pecto-Intercostal II Block
This prospective randomized study will compare the effects of Erector Spinae Plane Block (ESPB) and Serratus Anterior Plane Block combined with Pectoral Nerve Block Type II (SAPB + PECS II) on intraoperative analgesia and…
- Conditions
- Pain Management in Breast Surgery, Pain After Surgery, Regional Anaesthesia
- Trial name
- NCT07368413
- Testing
- SAPB + PECS II Technique, Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Kayseri City Hospital
Breast Cancer
IORT Following Breast Conserving Surgery for Early Stage Breast Cancer Registry
This is a prospective, registry trial which will enroll women aged 65 and above with early stage, low risk breast cancer who will be treated with partial mastectomy and intraoperative radiation therapy (IORT).
- Trial name
- NCT03536897
- Testing
- IORT
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Mount Carmel Health System
Breast Cancer
Percutaneous Removal and Margin Ablation for Breast Cancer
We hypothesize that radiofrequency ablation after single-insertion image guided vacuum assisted biopsy (IVEB) can be used to achieve negative margins in small unicentric breast cancers (≤1.5 cm).
- Trial name
- NCT00574301
- Testing
- Percutaneous Removal and Margin Ablation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arkansas
Breast Cancer, Ductal Carcinoma in Situ
Intraoperative Radiation Therapy (IORT) in DCIS
The goal of this study is to examine the role of Intraoperative Radiotherapy (IORT) in Ductal Carcinoma In-Situ (DCIS) and to improve the understanding of the clinical, radiographic, and patient-related impact of adopting IORT.
- Trial name
- NCT03216421
- Testing
- Quality of Life Questionnaires
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- Columbia University
Breast Cancer After Breast Conserving Surgery Indicating Postoperative Radiotherapy With Boost
Hypofractionation With Simultaneous Integrated Boost for Early Breast Cancer
Hypofractionation with simultaneous integrated boost has been investigated in a few trials and appears to be safe and feasible with less lung toxicity in smaller studies.
- Trial name
- NCT01948726
- Testing
- Hypofractionation with simultaneous integrated boost
- Where
- 19 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Schleswig-Holstein
Breast Cancer, Breast Carcinoma in Situ
Oncologic, Cosmetic and Patient Reported Outcomes in Value-Based Breast Surgery (OnCoPRO Value)
The study aspires to provide outcomes on surgery, quality of life and time-to-event outcomes following the development and validation of a standardised surgical assessment tool in a shared decision-making framework for patients…
- Conditions
- Breast Cancer, Breast Carcinoma in Situ, Breast Cancer Invasive, Breast Asymmetry
- Trial name
- OncoPROValue-1 (NCT06401304)
- Where
- 3 sites in Australia, Sweden and 1 more
- Volunteers
- 1,200 people
- Sponsor
- Uppsala University
Breast Cancer, Postoperative Recovery
ERAS Protocols in Breast Conserving Surgery
Enhanced Recovery After Surgery (ERAS) protocols have been of increasing interest in the surgical community for decades. The emphasis has been development of protocols to maximize pain control post-operatively without the use of…
- Trial name
- ERAS (NCT06938581)
- Testing
- ERAS Protocol, Standard Perioperative Care
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Nebraska
Breast Cancer
The Impact of Preoperative Breast MRI in Patients With Breast Cancer Selected for Breast Conserving Surgery
The purpose of this prospective observational study is to evaluate the impact of preoperative breast MRI in patients with breast cancer selected for breast- conserving surgery.
- Trial name
- NCT01391806
- Where
- Norway
- Volunteers
- 145 people
- Sponsor
- Nordlandssykehuset HF
Breast Cancer, Breast Surgery
A Retrospective Analysis of Robot-Assisted Versus Endoscopic Breast-Conserving Surgery for Breast Cancer
Robotic surgical systems provide notable advantages including enhanced dexterity, a magnified three-dimensional high-definition view, and high-resolution imaging, thereby improving operative stability and precision.
- Trial name
- NCT07321145
- Testing
- Robotic breast-conserving surgery, Endoscopic breast-conserving surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Breast Cancer, Surgery
Real Time Tissue Characterisation Using Mass Spectrometry REI-EXCISE iKnife Study
REI-EXCISE is a multicentre, prospective, non-randomised feasibility study, aimed to evaluate the diagnostic accuracy of rapid ionisation mass spectroscopy using an iKnife device.
- Trial name
- REI-EXCISE (NCT03432429)
- Testing
- REIMS iKnife
- Where
- 3 sites in United Kingdom
- Volunteers
- 158 people
- Sponsor
- Imperial College London