Clinical trials: Breast-conserving Surgery
Breast Cancer
Partial Breast Irradiation for Low-risk Ductal Carcinoma In Situ After Breast-conserving Surgery
This study is designed to evaluate the feasibility and safety of partial breast irradiation for low risk DCIS after breast-conserving surgery.
- Trial name
- NCT02617082
- Testing
- partial breast irradiation
- Where
- China
- Volunteers
- 828 people
- Sponsor
- Fudan University
Breast Cancer
Safety and Aesthetic Outcomes of Breast Conserving Surgery With Peri-areolar Incision Approach
Cosmetic result after breast-conserving surgery (BCS) would impose great effect upon patient's quality of life. Although peri-areolar incision has been widely used in benign breast tumor excision, mastopexy procedures and…
- Trial name
- NCT01412788
- Testing
- peri-areolar incision, traditional incision
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Breast Neoplasms, Heart Injuries
Prospective Assessment of Radiation-induced Heart Injury in Left-sided Breast Cancer
This study is to prospectively investigate the cardiac dose-sparing effect and clinical benefit of deep inspiration breath-hold (DIBH) technique.
- Conditions
- Breast Neoplasms, Heart Injuries, Radiation Toxicity
- Trial name
- NCT03461588
- Testing
- free-breathing, deep inspiratory breath-holding
- Where
- 2 sites in China
- Volunteers
- 140 people
- Sponsor
- Shu lian Wang
Breast Cancer
Safety of Breast-Conserving Surgery for Multifocal or Multicentric Breast Cancer
The objective of this observational study is to evaluate the oncological safety of breast-conserving surgery combined with standard postoperative radiotherapy in adult female patients diagnosed with multifocal or multicentric…
- Trial name
- NCT07677956
- Testing
- Breast-conserving surgery, postoperative radiotherapy and individualized adjuvant systemic therapy
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
DCIS
Evaluation of the DCIS Score for Decisions on Radiotherapy in Patients With Low/Intermediate Risk DCIS
To evaluate whether the use of the Oncotype DX DCIS score can guide delivery of radiation in women with low to moderate risk DCIS who have had breast conserving surgery
- Trial name
- DUCHESS (NCT02766881)
- Where
- 12 sites in Canada
- Volunteers
- 281 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Breast Cancer
SRG-514 Administered Intraoperatively to Patients Undergoing Breast-conserving Cancer Surgery
This is a multicenter, first-in-human (FIH), open label, Phase 1 dose escalation and recommended Phase 2 dose (RP2D) extension trial with a primary objective to define the RP2D of SRG-514 when administered intraoperatively to…
- Trial name
- NCT06300411
- Testing
- SRG-514
- Where
- 8 sites in United States
- Volunteers
- 25 people
- Sponsor
- SURGE Therapeutics
Cancer of the Breast
Pilot Study of Radiofrequency Ablation of Breast Cancer Lumpectomy Sites to Decrease Re-operation
In this protocol we combine two available and reliable treatments - lumpectomy and RFA. This combination method will provide for excision of the cancer as routinely accomplished and ablation of the cancer bed (lumpectomy site) to…
- Trial name
- eRFA (NCT00571987)
- Testing
- AngioDynamics (previously RITA Med,Inc) radiofrequency delivery system (consisting of a generator and Starburst XL probe)
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Arkansas
Breast Cancer
Comparing the Safety and Cosmetic Outcomes Between Laparoscopic Versus Traditional Open Breast-conserving Surgery
In recent years, laparoscopic breast cancer surgery has received wide attention. It has advantages of minimal invasiveness, clear anatomical exposure, and good aesthetic effects.
- Trial name
- NCT06671249
- Testing
- Laparoscopic breast-conserving surgery, Traditional open breast-conserving surgery
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Patient Reported Outcome, Oncological Safety
Patient Report Outcome and Oncological Safety -Oncoplastic and Conventional BCS Cohort
Breast-conserving surgery (BCS) is the traditional surgical treatment for early-stage breast cancer patients. There are evidences indicating that oncoplastic BCS could improve cosmetic outcomes and/or quality of life, and has…
- Conditions
- Patient Reported Outcome, Oncological Safety, Breast-conserving Surgery, Breast Cancer Female
- Trial name
- NCT05054777
- Testing
- oncoplastic breast-conserving surgery, conventional breast-conserving surgery
- Volunteers
- 5,000 people
- Sponsor
- Shandong Cancer Hospital and Institute
Invasive Breast Carcinoma, Stage II Breast Cancer
Assessing the Accuracy of Tumor Biopsies After Chemotherapy to Determine if Patients Can Avoid Breast Surgery
This phase II trial studies how well biopsy of breast after chemotherapy works in predicting pathologic response in patients with stage II-IIIA breast cancer undergoing breast conserving surgery.
- Conditions
- Invasive Breast Carcinoma, Stage II Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer
- Trial name
- NCT03188393
- Testing
- Biopsy of Breast
- Where
- 381 sites in United States, Canada
- Volunteers
- 105 people
- Sponsor
- NRG Oncology
Breast Cancer Stage I, Breast Cancer Stage II
Patient Reported Outcomes After Oncoplastic Breast Conserving Surgery
The goal of this study is to assess patient satisfaction after oncoplastic breast conserving surgery. With the help of a breast-questionnaire the patient satisfaction will be assessed before the surgery and 4 weeks, 6 months and…
- Conditions
- Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer in Situ
- Trial name
- NCT05724758
- Testing
- Breast-conserving surgery
- Volunteers
- 100 people
- Sponsor
- Brust-Zentrum AG
Breast Cancer
Hypofractionated Vs Conventional Fractionated Radiotherapy After Breast Conserving Surgery
The study was designed to investigate whether hypofractionated radiotherapy(HF-RT) is noninferior to conventionally fractionated radiotherapy (CF-RT) in terms of tumor loco-regional control for patients after breast conserving…
- Trial name
- NCT04025164
- Testing
- Hypofractionated Radiotherapy, Conventional fractionated Radiotherapy
- Where
- 5 sites in China
- Volunteers
- 4,052 people
- Sponsor
- Fudan University
Breast Cancer
Evaluation of the Safety and Efficacy of Single-Port Robot-Assisted Endoscopic Breast-Conserving Surgery and Nipple-sparing Matectomy With Reconstruction in Early-Stage Breast Cancer Patients
This study is testing a new, less invasive way to perform breast cancer surgery using a single-port robotic system (a robot-assisted surgical tool made in China, called the Shurui SR-ENS-600).
- Trial name
- NCT07781163
- Testing
- single-port robot-assisted surgery
- Volunteers
- 30 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Breast Cancer
Breast-Conserving Surgery and Whole-Breast Radiation Therapy With or Without Additional Radiation Therapy to the Tumor in Treating Women With Ductal Carcinoma in Situ (BONBIS)
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery.
- Trial name
- BONBIS (NCT00907868)
- Testing
- partial breast irradiation, whole breast irradiation
- Where
- France
- Volunteers
- 2,004 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Breast Neoplasms
Axillary Ultrasound With or Without Sentinel Lymph Node Biopsy in Detecting the Spread of Breast Cancer in Patients Receiving Breast Conservation Therapy
This randomized clinical trial studies two different tests that are currently being used to detect the spread of breast cancer to the lymph nodes under the arm in candidates for breast conservation therapy.
- Trial name
- NCT01821768
- Testing
- Sentinel Lymph Node Biopsy
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Washington University School of Medicine
Breast Cancer, Breast Neoplasms
Trends of Mastectomy and Breast-Conserving Surgery in Female Breast Cancer Patients
Breast cancer is the most common cancer in women across the world, accounting for 25.2% of cancer cases among females and 14.7% of cancer-related deaths among females worldwide.
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Cancer Female
- Trial name
- NCT03762642
- Testing
- Mastectomy, Breast-Conserving Surgery
- Where
- Saudi Arabia
- Volunteers
- 335 people
- Sponsor
- King Abdulaziz University
Breast Cancer
Cyberknife After Breast Conservative Surgery
Accelerated partial breast irradiation with CyberKnife (CK-APBI) is a promising innovative approach for early breast cancer after conservative surgery, for addressing the need of a radiotherapy target only to the surgical cavity…
- Trial name
- NCT02896322
- Testing
- Partial breast irradiation with cyberknife
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Breast Cancer
Clinical Efficacy and Safety Assessment of Breast-Conserving Surgery for Central Breast Cancer: A Prospective Randomized Controlled Trial
This study enrolled 158 patients with primary central early-stage breast cancer and randomly assigned them to two groups. The control group underwent total mastectomy (with optional prosthetic implantation or autologous tissue…
- Trial name
- NCT06938360
- Testing
- breast-conserving surgery combined with radiotherapy
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Xijing Hospital
Breast Cancer Female
Simulating Outcomes From Breast Conserving Surgery Using 3D Surface Imaging
Most women with breast cancer are able to have an operation to remove the cancer while preserving the breast (breast conserving therapy, BCT).
- Trial name
- NCT03250260
- Testing
- 3-dimensional photograph with simulation, Viewing of a 2-dimensional photographic library
- Where
- United Kingdom
- Volunteers
- 117 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Breast Cancer
Hypofractionated PBI After BCS for Low-risk Breast Cancer Patients
The study was designed to evaluate the feasibility and safety of hypofractionated partial breast irradiation after breast-conserving surgery for low-risk breast cancer patients.
- Trial name
- NCT03411174
- Testing
- hypofractionated partial breast irradiation
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Fudan University