Clinical trials: Breath Analysis
Phenylketonuria (PKU)
Simple Breath Test to Examine Phenylalanine Metabolism
Phenylketonuria(PKU)is a rare condition caused by the body's inability to properly breakdown an amino acid called phenylalanine(PHE), due to a missing enzyme, phenylalanine hydroxylase(PAH).
- Trial name
- NCT02009904
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
Fructose Breath-testing in Irritable Bowel Syndrome (IBS)
Background: Breath testing for food intolerances is becoming routine in patients with functional gastrointestinal disorders (FGID).
- Trial name
- NCT02614313
- Testing
- Open breath test with fructose, Blinded breath test with fructose
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brain-Gut Research Group
Puerperal: [Major Infection] or [Sepsis]
Diagnostic Breath Analysis Study to Detect Sepsis
Analysis of exhaled breath samples using a high-speed gas chromatography medical device will identify Volatile Organic Compounds (VOC) that are specifically associated with SIRS and Sepsis.
- Trial name
- NCT02532959
- Testing
- Diagnostic Breath Analysis
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Landon Pediatric Foundation
Breath Test
HOspital Versus Primary Care Breath Test Environment (HOPE) Study
Through the HOPE study, the intention would be to determine whether exhaled breath volatile organic compound (VOC) profiles in Primary care differ from Secondary care.
- Trial name
- HOPE (NCT06611293)
- Testing
- Breath test
- Where
- 2 sites in United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Gastroparesis
13C-Spirulina Nitrogen Content GEBT Study
The purpose of this study is to determine whether there is a difference in the human in vivo response to 13C-Spirulina meals manufactured using 13C-Spirulina containing different levels of protein (as measured by %nitrogen).
- Trial name
- NCT04635306
- Testing
- Approved GEBT test meal
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairn Diagnostics
Chronic Pancreatitis, Healthy Volunteers
BreathID® Test: A Non-invasive Modality to Detect Pancreatic Exocrine Insufficiency
13C breath di-peptide tests are an effective non-invasive tool to detect pancreatic exocrine function in patients with Chronic Pancreatitis.
- Trial name
- NCT01259544
- Testing
- benzoyl-L-tyrosyl-[1-13C]alanine (Bz-Tyr-Ala)
- Where
- India
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Meridian Bioscience, Inc.
Healthy Subjects
Analysis of Breath Volatile Organic Compounds After Dyspnea Induced in the Healthy Subject.
The dyspnea is a common symptom in patients with many respiratory diseases particularly chronic obstructive airway diseases, but also cardiovascular pathologies, obesity, or also in the deconditioned healthy subjects.
- Trial name
- Volatopnee (NCT04418973)
- Testing
- VOCs analysis in exhaled air
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hopital Foch
Lung Neoplasm, Lung Disease
The Value of VOCs Analysis in Exhaled Breath for Pulmonary Benign and Malignant Lesion Diagnosis
The purpose of this study is to analysis the volatile organic gases(VOCs) in exhaled breath of pulmonary lesion patients and healthy controls, in order to find the difference of composition and concentration among groups.
- Trial name
- VOCs (NCT02965300)
- Where
- China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
SARS-CoV-2 Infection
Breath Analysis for SARS-CoV-2 in Infected and Healthy Subjects
Recently published studies could demonstrate that detection of specific biomarkers in breath could be applied for the diagnosis of SARS-CoV-2.
- Trial name
- NCT04547114
- Testing
- Multicapillary column coupled ion mobility spectrometry
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Klinikum Bayreuth GmbH
Inactivity, Physical, Aging
Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spectrum
The purpose of this study is to determine how anabolic sensitivity, in response to the ingestion of a liquid protein meal, differs across the lifespan, between biological sexes, and with varying physical activity levels.
- Conditions
- Inactivity, Physical, Aging, Healthy Aging, Growth & Development
- Trial name
- NFRF (NCT06744491)
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Air Pollution
The Effect of Juice Types on the Responses to Air Pollution
The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike.
- Trial name
- NCT02027415
- Testing
- Beet juice, Orange juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Weightlifting, Breathing
The Effects of Cervical and Thoracic Manipulation Therapy Applied to Weightlifting Athletes
The effects of manipulation therapy on the autonomic nervous system have been examined in the literature and while no sympathetic or parasympathetic changes were found after upper thoracic manipulation, a decrease in sympathetic…
- Conditions
- Weightlifting, Breathing, Breath Tests, Athlete
- Trial name
- NCT06606795
- Testing
- Spinal Manipulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Liver Cirrhosis, Hepatocellular Carcinoma (HCC)
A Simple Breath Test to Detect Liver Cancer and Monitor Liver Conditions
Liver cancer is often diagnosed too late for effective treatment. The VOCAL2 study is developing a simple, non-invasive breath test to help detect liver cancer earlier and monitor liver conditions like cirrhosis.
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma, Cholangitis, Sclerosing
- Trial name
- VOCAL2 (NCT06864195)
- Where
- United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cystic Fibrosis
Breath Analysis in in Adults With Cystic Fibrosis (CF)
Exploratory comparative evaluation of exhaled breath composition in cystic fibrosis patients with age and gender-matched healthy adults in order to identify a disease-specific exhaled breath pattern as well as to gain insight…
- Trial name
- NCT02209571
- Testing
- Venous blood markers
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Gestational Diabetes
A Study Using Breath Tests to Identify Patients at Risk for Gestational Diabetes
The aim of our study is to evaluate the feasibility, and diagnostic value of oral 13C labelled glucose breath test compared to the GCT and OGTT tests.
- Trial name
- NCT07347262
- Testing
- Noninvasive Breath Test in Order to Identify Patients at Risk for Developing Gestational Diabetes
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Congenital Sucrase-Isomaltase Deficiency
Adult Pilot Study for Reference Ranges and Optimal Cut-offs for the Sucrose Challenge Test and Sucrose Breath Test
An adult pilot study to establish the normal reference range and optimal cutoffs for the oral 50g Sucrose Challenge Test (SCT) and the 50g 13C-Sucrose Breath Test (CBT) for patients with CSID and healthy controls.
- Trial name
- NCT05045495
- Testing
- Sucrose Hydrogen Methane Breath Test
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- QOL Medical, LLC
Irritable Bowel Syndrome
Sucrose Breath Test to Determine Intestinal Permeability in IBS
Irritable Bowel Syndrome (IBS) is a growing clinical diagnosis affecting 10-20% of the US population. While current diagnostic criteria aids in correctly diagnosing IBS, the cause of the disease still remains unclear.
- Trial name
- NCT01674088
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Metabolic Solutions Inc.
Diet, Healthy, Breath Analysis
Why Calories Are Not the Same - a Gut Explanation?
The aim of this study is to understand how the gut microbiome influences how much dietary energy humans excrete via feces. This study is based on the hypothesis that levels of methane in exhaled breath represent two different gut…
- Trial name
- GutEnergy (NCT06932666)
- Testing
- Diet A group, Diet B group
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Small Bowel Disease, Motility Disorder
Study of Oro-cecal Transit Time in Healthy Subjects Using Scintigraphy and Lactulose Hydrogen Breath Test.
Radionuclide scintigraphy is the gold standard technique to interpret OCTT but there is no normative data available for its interpretation in Indian population.
- Conditions
- Small Bowel Disease, Motility Disorder, Irritable Bowel Syndrome
- Trial name
- NCT05004207
- Testing
- 99mTc Scintigraphy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Delayed Gastric Emptying
Reference Values for Gastric Emptying
Healthy volunteers will ingest a 13C-octaoate containing test meal and 13C in expiratory air will be followed. Normal values will be calculated data of these tests.
- Trial name
- 13C (NCT02397577)
- Testing
- Solid test meal, liquid test meal on two separate occations
- Where
- Switzerland
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Zurich