Clinical trials: Breath Analysis
Diaphragm Elevated, Paresis
FOT Assessment of Hemi-diaphragm Dysfunction After Upper Extremity Nerve Blocks
Upper extremity nerve blocks of the brachial plexus using local anesthetic can inadvertently affect the ipsilateral phrenic nerve and result in hemidiaphragm dysfunction.
- Trial name
- NCT04005235
- Testing
- Thorasys Tremoflo C-100 Airwave Oscillometry System (FOT)
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Nova Scotia Health Authority
Cancer of the Breast, Cancer of Stomach
Vocorder Device Validation in Clinical Settings - Continuous Monitoring of Individuals (Vocorder Clinical Validation-VCV)
This is performed under Vocorder project that is Co-Funded by the European Union. (Grant Agreement 101115442 VOCORDER HORIZON EIC-2022-PATHFINDERCHALLENGE-01).
- Conditions
- Cancer of the Breast, Cancer of Stomach, Colon Cancer, Lung Cancers
- Trial name
- VCV (NCT06711939)
- Where
- Greece
- Volunteers
- 515 people, healthy volunteers welcome
- Sponsor
- Mitera Hospital
Irritable Bowel Syndrome
Efficacy of Hydrogen Breath Test in the Patients With Irritable Bowel Syndrome
Irritable bowel syndrome is characterized by abdominal discomfort and bowel habit change. It is increasing worldwide. But the pathophysiology of the irritable bowel syndrome is not proven.
- Trial name
- NCT02242175
- Testing
- Glucose breath test (hydrogen breath test)
- Where
- South Korea
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Diabetes, Hyperglycemia
Miniaturized Breath-based Sensor for the Detection of Hypo- and Hyperglycemia
The purpose of this study is to determine whether an array of biosensors can noninvasively identify hyperglycemic or hypoglycemic events in persons diagnosed with diabetes through noninvasive detection of volatile organic…
- Conditions
- Diabetes, Hyperglycemia, Hypoglycemia (Diabetic)
- Trial name
- NCT07696273
- Testing
- Sensing Device and Tedlar Bags
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Liver Cirrhosis, Hepatocellular Carcinoma (HCC)
A Simple Breath Test to Detect Liver Cancer and Monitor Liver Conditions
Liver cancer is often diagnosed too late for effective treatment. The VOCAL2 study is developing a simple, non-invasive breath test to help detect liver cancer earlier and monitor liver conditions like cirrhosis.
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma, Cholangitis, Sclerosing
- Trial name
- VOCAL2 (NCT06864195)
- Where
- United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Dyspepsia, Peptic Ulcer Disease
Minimally Invasive Evaluation of Dyspepsia by Combined Magnetically Controlled Capsule Endoscopy and Urea Breath Test: a Pilot Prospective Cohort Study
The combined diagnostic accuracy of MCCE and UBT in Hong Kong patients with uninvestigated dyspepsia between age 35 to 60 years for structural pathology and HP infection is comparable to that of conventional UGI endoscopy with…
- Conditions
- Dyspepsia, Peptic Ulcer Disease, Gastroesophageal Reflux, Ugi Malignancies
- Trial name
- MCUDYSPEPSIA (NCT04918472)
- Testing
- MCCE
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Respiration, Artificial
Ventilatory Weaning Guided by a New Index
Mechanical ventilation (MV) is an essential therapy for patients with acute respiratory failure. The ventilatory weaning process should be started when the precipitating causes of the use of the ventilatory prosthesis are…
- Trial name
- NCT04512677
- Testing
- Timed Inspiratory Effort (TIE index)
- Where
- 2 sites in Brazil
- Volunteers
- 144 people
- Sponsor
- Universidade Federal Fluminense
Cirrhosis, Microbiota
Exploring Clinical Characteristics of Liver Disease Patients Based on Digestive Metabolic Exhaled Air
Cirrhosis is a common digestive system disease and represents the final stage of the progression of various chronic liver diseases.
- Conditions
- Cirrhosis, Microbiota, Breath Tests
- Trial name
- NCT06968234
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Functional Gastrointestinal Disorders
13C-Octanoic Acid Breath Test on Gastric Emptying in Celiac Patients With Functional Disorders
The goal of this interventional study is the evaluation of a diet low in fodmaps on gastric emptying in celiac patients with functional disorders.
- Trial name
- NCT07089498
- Testing
- Dietary Intervention (Low Fodmap Gluten Free Diet)
- Where
- 2 sites in Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Diabetes Mellitus, Type 2, Liver Diseases
Validate Smart Breath Analyzer as Screening Tool for Diabetic, Hepatic, Renal, Lung, and Other Metabolic Disorders
This is a prospective, multicentric, non-treatment study to build and validate a portable, non-invasive smart breath analyzer that can screen underlying health issues using exhaled breath.
- Conditions
- Diabetes Mellitus, Type 2, Liver Diseases, Kidney Diseases, Lung Diseases
- Trial name
- RESPYR-SBA (NCT07646015)
- Where
- India
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Respyr
NASH - Nonalcoholic Steatohepatitis, Cirrhosis
Companion Protocol for Methacetin Breath Test (MBT) in Conatus Protocol IDN-6556-14
To validate the ability of the Methacetin Breath Test (MBT) to detect clinically significant portal hypertension (CSPH)/severe portal hypertension (SPH) defined as hepatic venous pressure gradient (HVPG) ≥ 10 mmHg and HVPG ≥ 12…
- Conditions
- NASH - Nonalcoholic Steatohepatitis, Cirrhosis, Portal Hypertension
- Trial name
- NCT03439189
- Testing
- Methacetin Breath Test, Emricasan
- Where
- France
- Volunteers
- 343 people
- Sponsor
- Meridian Bioscience, Inc.
Tuberculosis
eNose-TB: Electronic Nose for Tuberculosis Screening
An electronic-nose (e-nose) is being investigated as a diagnostic tool for tuberculosis by examining exhaled breath of the patients. Universitas Gadjah Mada has developed an e-nose device for TB diagnostic tool.
- Trial name
- NCT04567498
- Testing
- exhaled breath sampling
- Where
- 3 sites in Indonesia
- Volunteers
- 1,778 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Respiratory Diseases, Lung Diseases
In Vitro Assessment of a Breath-synchronized Vibrating Mesh Nebulizer During Non Invasive Ventilation
Using an adult lung bench model of non invasive ventilation, the aim of the study is to compare an experimental system of breath-synchronized vibrating mesh nebulizer to a conventional vibrating mesh nebulizer during non invasive…
- Conditions
- Respiratory Diseases, Lung Diseases, Cystic Fibrosis, COPD
- Trial name
- Synchro-Neb (NCT02084043)
- Testing
- Nebulization of Amikacin during NIV (RR: 15 cycles/minute), Nebulization of Amikacin during NIV (RR: 25 cycles/minute)
- Where
- Belgium
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University Hospital St Luc, Brussels
Mechanical Ventilation, Spontaneous Breathing Trial
Trial of Spontaneous Breathing Test
The hypothesis is that the Spontaneous Breathing Test (SBT) without pressure support (PS) is not inferior to the SBT with pressure support in relation to the following outcomes: a) extubation failure; b) time on MV.
- Conditions
- Mechanical Ventilation, Spontaneous Breathing Trial, Extubation Readiness, Extubation Failures
- Trial name
- NCT06593288
- Testing
- Pressure Support Ventilation, continuous positive airway pressure (CPAP)
- Where
- Brazil
- Volunteers
- 170 people
- Sponsor
- University of Sao Paulo
Pulmonary Embolism
Exploratory Metabolomics Study of Exhaled Breath in Pulmonary Embolism
Pulmonary embolism is a frequent and recurrent pathology, especially in the elderly. It is often preventable, with high mortality and morbidity, making it a major public health issue.
- Trial name
- MetabolAir (NCT04001179)
- Testing
- Pulmonary embolism diagnosis by nuclear medicine imaging
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Strasbourg, France
Pulmonary Embolism
Non-invasive Diagnosis of Pulmonary Embolism by Use of Biomarkers in Exhaled Breath
In this study, a new, non-invasive method for diagnosis of pulmonary embolism (PE) will be tested. In pre-clinical studies, the investigators have identified 151 putative biomarkers for pulmonary embolism in the exhaled breath…
- Trial name
- NILEX (NCT06135220)
- Testing
- New method for diagnosis of pulmonary embolism (PE) in order to validate/consolidate 151 putative identified biomarkers for PE in the exhaled breath.
- Where
- Denmark
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Gastrointestinal Disease, Esophageal Cancer
PMRR-NO: Pulmonary Metabolic Radiation Response Versus Exhaled Nitric Oxide
The goal of this clinical research study is to use a new breathing test that measures the amount of nitric oxide (NO) you exhale.
- Conditions
- Gastrointestinal Disease, Esophageal Cancer, Lung Cancer
- Trial name
- NCT00867477
- Testing
- Breathing Test, Respiratory Symptoms Questionnaire, Pet Scan
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- M.D. Anderson Cancer Center
Helicobacter Pylori Infection, Helicobacter Pylori
H. Pylori Eradication With Argon Plasma During Endoscopy
The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori, Helicobacter Pylori Gastrointestinal Tract Infection, H. Pylori Infection
- Trial name
- HEAPE (NCT06529159)
- Testing
- HEAPE, Pre-HEAPE
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Helicobacter Pylori Infection, Dyspepsia
Pylori Duo for Adjunctive Treatment and Prevention of Recurrence of Helicobacter Pylori Infection
This randomized, double-blind, placebo-controlled, single-center clinical trial will evaluate the efficacy and safety of Pylori Duo as an adjunctive treatment in adult patients with confirmed Helicobacter pylori infection.
- Conditions
- Helicobacter Pylori Infection, Dyspepsia, Gastrointestinal Adverse Effects
- Trial name
- NCT07729293
- Testing
- Omeprazole, Pylera (Bismuth subcitrate potassium, metronidazole, tetracycline) given in combination with omeprazole, Pylori Duo
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Gala Servicios Clinicos S.L.
Gastroparesis
The Effect of Single Doses of the Motilin Receptor Agonist GSK962040 in Type I Diabetic Patients With Gastroparesis
The purpose of this study is to assess the pharmacodynamic effects (gastric emptying), safety, tolerability, and pharmacokinetics of single doses of GSK962040 in Type 1 diabetic patients with gastroparesis.
- Trial name
- NCT00861809
- Testing
- GSK962040 25 mg, GSK962040 50 mg, GSK962040 1250 mg
- Where
- 2 sites in Belgium, Sweden
- Volunteers
- 11 people
- Sponsor
- GlaxoSmithKline