Clinical trials: Breath Holding
Lung Cancer, Left Sided Breast Cancer
A Prospective Study to Evaluate Continuous Positive Airway Pressure Devices to Reduce Pulmonary Dose
Data collection and assessment on patients with left-sided breast cancer or undergoing lung stereotactic body radiation therapy (SBRT) utilizing continuous positive airway pressure (CPAP) devices.
- Trial name
- NCT05142358
- Testing
- Continuous Positive Airway Pressure, Deep inspiratory breath hold, Free Breath
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Case Comprehensive Cancer Center
Breathhold
Valproic Acid in Treating Cyanotic Breath Holding Spells
Breath holding spells (BHS) are common non-epileptic paroxysmal behavioral involuntary episodes occurring in up to 5.9% of healthy children.
- Trial name
- NCT04482764
- Testing
- Valproic Acid
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Lung Cancer
Quantifying Lung Tumor Movement Under Deep Inspiration Breath Holds
Radiotherapy is a common treatment for lung cancer. One Challenge of delivering radiation treatment to lung tumors accurately is tumor movement which occurs as a patient breathes.
- Trial name
- NCT00643370
- Testing
- CT scan of the chest under deep inspiration breath hold
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- AHS Cancer Control Alberta
Breast Cancer
A Prospective Trial to Compare Deep Inspiratory Breath Hold (DIBH) With Prone Breast Irradiation
This phase II trial studies how well deep inspiratory breath hold or prone breast radiation therapy works in reducing cardiac dose in patients with breast cancer or ductal carcinoma in situ.
- Trial name
- NCT03437161
- Testing
- Radiation Therapy (RT)
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Healthy Volunteers, Effect of CPAP on Chest Movement
Effect of CPAP on Breath Hold and Chest Movement in Normal Volunteers
CPAP will be applied to normal volunteers inorder to understand CPAP's effects on breathing and chest wall motion.
- Trial name
- CPAP_normal (NCT02545686)
- Testing
- Chest wall movement assessment without CPAP, Breath hold assessment without CPAP, Chest wall movement assessment with CPAP
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
MRI, MRI Image Enhancement
Optimizing Liver MRI Using Breath-Holding With and Without Oxygen
The goal of this interventional study (clinical trial) is to learn if different breath-holding techniques, with and without extra oxygen, can improve the quality of abdominal Magnetic Resonance Imaging (MRI) images in healthy…
- Trial name
- NCT07135401
- Testing
- Breath-hold conditions
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy Volunteers
Assessment of 2 Different Techniques for Suppression of Respiratory Motion in Lung Cancer Treatment With Proton Therapy Using Magnetic Resonance Imaging (MRI)
Since 1996 proton therapy has been applied very successfully at the Paul Scherrer Institute in Switzerland to irradiate deep-seated, stationary tumors. In order to treat tumors within an organ which moves due to breathing (e.g.
- Trial name
- NCT03669341
- Testing
- Deep Inspiration Breath Hold (DIBH), High Frequency Percussive Ventilation (HFPV)
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Paul Scherrer Institut, Center for Proton Therapy
Lung Cancer
Pilot Study of SGRT Alone vs. SGRT With Fiducials for Breath Hold SBRT tx of the Lung
This is a pilot study designed to to provide data and experience comparing two different techniques of breath hold SBRT treatments. The first technique will include SGRT, but with the assistance of implanted fiducials.
- Trial name
- NCT04060927
- Testing
- SGRT
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Wake Forest University Health Sciences
Pediatric Cancer
Radiotherapy Delivery in Deep Inspiration for Pediatric Patients
TEDDI is a non-randomised phase II trial in Scandinavia. All pediatric patients, referred for radiotherapy in the thorax or abdomen and irrespective of diagnosis, are eligible.
- Trial name
- TEDDI (NCT03315546)
- Testing
- radiotherapy delivery in deep-inspiration
- Where
- 3 sites in Denmark, Finland
- Volunteers
- 25 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Reproductive Disorder
IMPACT OF BREATH CONTROL AND RETENTION ON PATIENT STRESS. E.S IN MEDICALLY ASSISTED REPRODUCTION
the investigator propose for patient in the course of Medically Assisted Reproduction a study with to arm: one arm active "Breathing Control and Retention" and the other arm control
- Trial name
- BHBB (NCT06357208)
- Testing
- Breathing Control and Retention
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Esophageal Cancer
BReath Hold TecHniquEs for Radiotherapy of Esophageal Carcinoma
The main objective of the first part of the study is to determine the most optimal method for DIBH (active breathing control vs voluntary coached) and its reproducibility.
- Trial name
- BROTHER (NCT06317272)
- Testing
- DIBH using ABC technique, DIBH using VC technique
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- University Medical Center Groningen
Essential Tremor, Dystonic Tremor
VIM DBS Respiratory Modulation: N-of-1 Trial
Research from our group has demonstrated modulation of PEFR in patients with STN and PAG stimulation. However, the effect of VIM (motor thalamus) stimulation remains to be investigated.
- Trial name
- NCT05381688
- Testing
- VIM DBS
- Sponsor
- University of Oxford
Lung Cancer, Breast Cancer
Exploratory Study on Therapy for Breath Hold in Radiotherapy
Due to breathing and other motions, tumours, such as breast and lung cancer, as well as their surrounding organs (e.g. the heart), move, which poses a challenge for radiotherapy treatment.
- Trial name
- NCT03729661
- Testing
- Nasal High Flow Therapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht Radiation Oncology
Breast Neoplasm, Radiotherapy
HOBBIT 3: Mental Exercises and Temporal Alteration
In the HOBBIT-trial by Vakaet et al. A protocol was developed to increase breath-hold time using (voluntary) hyperventilation and oxygenation to achieve DIBH times around 3 minutes.
- Conditions
- Breast Neoplasm, Radiotherapy, Breath Holding, Mental Test
- Trial name
- HOBBIT-META (NCT06100068)
- Testing
- Mental Exercises and Temporal Alteration
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Breast Cancer, Radiotherapy
BRAVE-HEART: Breast Cancer Radiotherapy Using Active Breathing Coordinator to aVoid Exposure of HEART
The BRAVE-HEART trial is an ambispective, observational, non-randomized study conducted at Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Policlinico San Matteo (Pavia, Italy).
- Trial name
- BRAVE-HEART (NCT07299812)
- Testing
- Breast Radiotherapy with or without Deep Inspiration Breath Hold (DIBH)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Pancreas Cancer
Breath-Hold Technique for Pancreatic Stereotactic Body Radiation Therapy (SBRT) Patients
The Investigator proposes the development of an extended reality (xR) training platform for patients undergoing radiation treatment for pancreatic cancer.
- Trial name
- NCT04843306
- Testing
- Biofeedback, Active Breathing Control Technique
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Breathing, Mouth
Impact of Diaphragmatic Breathing Coaching on Deep Inspiration Breath Hold Reproducibility and Organ Protection
To learn if coaching participants on diaphragmatic breathing will help participants to take larger, more reproducible breaths and feel less anxiety about their treatments.
- Trial name
- NCT06747533
- Testing
- CT simulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Thoracic Cancer, Abdominal Cancer
VisionRT-based Deep Inspiration Breath-hold (DIBH) Respiratory Motion Management Strategy, A Pilot Study for Thoracic and Abdominal Tumors
A more recent competing technology for implementing the DIBH technique is real-time surface photogrammetry using the AlignRT system (Vision RT Ltd., London, UK).
- Trial name
- NCT04686500
- Testing
- Tidal volume measured by spirometer and DIBH surface from CT image
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
Lung Carcinoma, Malignant Respiratory Tract Neoplasm
Continuous Positive Airway Pressure Device or Deep Inspiration Breath Hold in Reducing Tumor Motion in Patients Undergoing Stereotactic Body Radiation Therapy for Lung Cancer
This pilot phase I/II trial studies how well a continuous positive airway pressure device or deep inspiration breath hold works in reducing tumor movement in patients undergoing stereotactic body radiation therapy (SBRT) for lung…
- Conditions
- Lung Carcinoma, Malignant Respiratory Tract Neoplasm, Metastatic Malignant Neoplasm in the Lung
- Trial name
- NCT03422302
- Testing
- Biphasic Positive Airway Pressure, Computed Tomography, Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy
Load and Hold: Impact of 7-Day Creatine Monohydrate Loading on Breath-Hold Cycling Performance
The present study aims to investigate the effects of creatine monohydrate supplementation on maximal breath-hold exercise performance on a bicycle ergometer in trained breath-hold divers.
- Trial name
- BREATHE-C (NCT07233707)
- Testing
- Creatine Monohydrate
- Where
- Greece
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Harokopio University