Clinical trials: Breathing
Asthma, Bronchospasm
Virtual Teach-to-Goal Education vs. Brief Education for Children
The purpose of this study is to evaluate the effectiveness of two different ways to teach hospitalized children how to use a metered dose inhaler and to follow-up after discharge home from the hospital to determine durability of…
- Conditions
- Asthma, Bronchospasm, Shortness of Breath
- Trial name
- V-TTG vs BI (NCT04373499)
- Testing
- Virtual Teach to Goal, Brief Intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Inhalation Therapy; Complications
The Effect of Watching Informative Animation on Fear and Anxiety in Children
The aim of this project was to determine the effect of showing informative animations to children on anxiety and fear during inhalation therapy. This project is a randomized controlled trial.
- Trial name
- NCT05861232
- Testing
- Behavioral
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mukader Kaya
Oxidative Stress
Inspired Oxygen on Oxidative Stress and Breath Volatile Organic Compound Composition in Healthy Volunteers
High inspiratory oxygen fractions are known to induce oxidative stress and lipid peroxidation. The degrading products of oxidative stress induced lipid peroxidation are in part volatile and appear in breath where they can be…
- Trial name
- NCT02577692
- Testing
- Oxygen, Ambient
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Klinikum der Universitaet Muenchen, Grosshadern
Meditation, Pain
Study of Affect Induction for Lab Induced Pain in Healthy Undergraduates
The goal of this clinical trial is to test if a mindfulness-enhanced positive affect induction (MPAI) works well to reduce pain intensity and pain unpleasantness from a cold water pain test in undergraduate college students who…
- Conditions
- Meditation, Pain, Mindfulness, Affect
- Trial name
- NCT05619419
- Testing
- Mindfulness-enhanced positive affect induction, Breathing Meditation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Birch Pollen Allergy, Healthy Control Subjects
Effect of the Nasal Provocation on the Breathing Style
The purpose of this study is to find out how the provocation of the nose changes breathing style (specifically, frequency and tidal volume changes)
- Trial name
- NCT02146300
- Testing
- 1. session birch pollen nasal exposure 2. session xylometazoline nasal exposure
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Pneumonia, Atelectasis
Bronchoscopy Anesthesia and Neuropsychological Assessment in Children (BANACH) Study
Fiberoptic bronchoscopy plays a very important role in the diagnosis and treatment of respiratory diseases in children.In China,this procedure is mainly performed under two different anesthesia methods：sedation and general…
- Conditions
- Pneumonia, Atelectasis, Cough
- Trial name
- NCT03359044
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Obesity Hypoventilation Syndrome, Ketogenic Dieting
Ketogenic Diet for Obesity Hypoventilation Syndrome
Obesity hypoventilation syndrome (OHS) is a condition that occurs in small percentage of obese people that causes high carbon dioxide and low oxygen levels in the blood.
- Conditions
- Obesity Hypoventilation Syndrome, Ketogenic Dieting, Hypercapnic Respiratory Failure
- Trial name
- KETOHS (NCT04108819)
- Testing
- Ketogenic Diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pulmonary Aspiration of Gastric Contents
SMART Study (Sellick's Maneuver Assisted Real Time) to Deliver Target Cricoid Pressure in Simulated Environment
Cricoid force is applied during airway management to prevent pulmonary aspiration of regurgitated gastric contents. This force is usually applied by a nurse or anaesthesia assistant.
- Trial name
- NCT02749175
- Testing
- Cricoid force sensor monitor system
- Where
- Singapore
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Healthcare Workers, Stress Level
Effects of VR-based Respiratory Training on Motor Reaction Time and Correctness, Stress Levels, Attention, Motor Skills, Postural Stability and Sleep Quality in Shift Healthcare Workers
This study investigates the effects of virtual reality (VR)-based respiratory training on various physiological and cognitive functions in shift-working healthcare professionals, including paramedics and nurses.
- Conditions
- Healthcare Workers, Stress Level, Emergency Department, Shift Work Sleep Disorder
- Trial name
- NCT06926257
- Testing
- Experimental group (B) - breathing training using VR, Experimental group (C) - breathing training using relaxation music
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Pediatric ALL, Respiratory Insufficiency
Multicenter HomeVENT: Home Values and Experiences Navigation Track
This is a multicenter study to test a decision-making support process for families and clinicians facing decisions about chronic home ventilation for a child.
- Conditions
- Pediatric ALL, Respiratory Insufficiency, Communication
- Trial name
- HomeVENT (NCT06102330)
- Testing
- HomeVENT decision support tool
- Where
- 4 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Nursing Students
The Effect of 4-7-8 Breathing Exercise Training on Sleep Quality
Research; it will be carried out Kilis 7 Aralik University Yusuf Serefoglu Health Sciences Faculty, Department of Nursing. The training will take approximately 20 minutes in an empty classroom and will be planned when the…
- Trial name
- NCT06103344
- Testing
- 4-7-8 Breathing Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Uğur Doğan
Acute Mountain Sickness, High Altitude Pulmonary Edema
Risk Factors Associated With High Altitude Sickness: A Case-Control Study
Research Title: RISK FACTORS ASSOCIATED WITH HIGH ALTITUDE SICKNESS: A CASE-CONTROL STUDY Rationale: The Study will help us to identify risk factors of high altitude sickness among Nepalese and International patients.
- Conditions
- Acute Mountain Sickness, High Altitude Pulmonary Edema, High Altitude Cerebral Edema
- Trial name
- NCT06039475
- Where
- Nepal
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Healthy Subjects
Pharmacokinetics & Tolerability Study of MAP0004 in Smoking and Non-Smoking Adult Volunteers
Compare the pharmacokinetics of Dihydroergotamine Mesylate (DHE) delivered by oral inhalation (MAP0004) or Intravenous (IV) DHE in smokers versus non-smokers.
- Trial name
- NCT01199965
- Testing
- MAP0004, IV DHE
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Allergan
Mechanical Ventilation Complication, Pediatric ALL
Measuring Thickness of the Normal Diaphragm in Children Via Ultrasound.
Critically ill children treated with invasive mechanical ventilation (iMV) in a paediatric intensive care unit (PICU) may suffer from complications leading to prolonged duration of ventilation and PICU stay.
- Conditions
- Mechanical Ventilation Complication, Pediatric ALL, Intensive Care Unit Acquired Weakness
- Trial name
- NCT04589910
- Testing
- diaphragm thickness and thickening fraction
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Obstructive Sleep Apnea, Polysomnography
Screening Moderate to Severe Obstructive Sleep Apnea With Wearable Device
The goal of this study is to find the best method to use Wellue O2 ring to screen for moderate to severe obstructive sleep apnea.
- Conditions
- Obstructive Sleep Apnea, Polysomnography, Pulse Oximetry
- Trial name
- NCT06454318
- Testing
- Wellue O2 ring
- Where
- Thailand
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Thammasat University Hospital
Healthy
Healthy Normal Volunteers Looking at Exposure and Effects of Multiple Doses of Technosphere® Insulin (TI) Using the Gen2C Inhaler
This is an open-Label, Randomized Study in Healthy Normal Volunteers looking at exposure and effects (PK/PD) of multiple doses of Technosphere® Insulin (TI) using the Gen2C inhaler.
- Trial name
- NCT01490762
- Testing
- Technosphere Insulin Inhalation Powder using the Gen2C inhaler, Regular Human Insulin
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Mannkind Corporation
Thoracic Surgical Procedures, One-lung Ventilation (OLV)
Study of Cardiac Power Index During Supine, Lateral, and Between Left and Right Positions During Two- and One-Lung Ventilation (OLV): Comparison of Hemodynamic Changes After Lung Recruitment Maneuver and Fluid Challenge Among Responders and Non-Responders (SVI, MAP, CPI Changes).
The aim of this trial is to study the changes of the Cardiac Power Index (CPI) during supine and lateral decubitus position in two and one lung ventilation respectively.
- Conditions
- Thoracic Surgical Procedures, One-lung Ventilation (OLV), Hemodynamic Changes
- Trial name
- NCT07037225
- Testing
- Fluid challenge during one-lung ventilation (OLV) in the lateral decubitus position, Hemodynamic monitoring
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Maria Fountoulaki
Communication Barriers
Understanding Communication Barriers in Acute Care: A Mixed-Methods Needs Assessment Among Healthcare Providers Caring for Non-Verbal Patients With Spinal Cord Injury and Tracheostomy in the ICU
Communication impairment is common among critically ill patients who are mechanically ventilated, have tracheostomies, or have neurological injuries such as spinal cord injury.
- Trial name
- NCT07796035
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Asthma
A Study to Investigate the Safety, Tolerability and Effects of AZD8630 in Healthy Subjects and Subjects With Asthma on Inhaled Corticosteroids and Long-acting Beta-agonists
This is a first in human (FIH) clinical study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8630 in healthy adults (Part A) and adult asthma patients on medium to high dose inhaled…
- Trial name
- NCT05110976
- Testing
- AZD8630
- Where
- 29 sites in United States, Germany and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Surgery
Esophageal Balloon Measurements to Better Characterize Thoraco-abdominal Interrelationship Mechanics.
Esophageal pressure measurements in surgical patients requiring mechanical ventilation during abdominal laparoscopic or robotic surgeries requiring intra-abdominal insufflation.
- Trial name
- NCT03624491
- Testing
- Esophageal pressure measurement guided ventilation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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