Clinical trials: Breathing Mechanics
Atelectasis
Minimizing Lung Injury During Laparoscopy in Steep Trendelenburg Position
The investigators hypothesize that the level of PEEP is often suboptimally applied in certain operative conditions, such as in laparoscopy with head down (Trendelenburg) positioning.
- Trial name
- optiPEEP (NCT04900714)
- Testing
- Decremental PEEP, Lung ultrasound score, Blood gas analysis
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Acute Respiratory Distress Syndrome, Acute Lung Injury
Iloprost Effects on Gas Exchange and Pulmonary Mechanics
This study will examine the hypothesis that iloprost maintains and improves ventilation perfusion matching in patients with pulmonary hypertension and ARDS/ALI as reflected by 1) an improved PaO2/FIO2 ratio as calculated from the…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Pulmonary Hypertension
- Trial name
- NCT01274481
- Testing
- Iloprost
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
Spinal Stenosis, Lumbosacral Region
Stability Comparison of TIVA and Sevoflurane in Prone Spinal Surgery(TIVA:Total Intravenous Anesthesia)
Key Points: 1. Objective: o To compare the effects of Total Intravenous Anesthesia (TIVA) and sevoflurane anesthesia on respiratory mechanics, hemodynamic parameters, and neuromonitoring during prone position spinal surgeries. 2.
- Trial name
- TIVA (NCT06558695)
- Testing
- Sevoflurane, TIVA
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Patients at Risk of Acute Respiratory Failure
Early Detection of Acute Respiratory Failure Using an Intelligent Respiratory Monitoring System
Introduction: The monitoring of respiratory patterns is crucial in the management of respiratory diseases, but in many cases, it still relies on subjective and visual assessment.
- Trial name
- NCT07164586
- Testing
- Respiratory Pattern Monitoring, Diaphragmatic Excursion, Respiratory muscle electrical activity
- Where
- 3 sites in Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Ventilator-Induced Lung Injury, Lung Ventilator
Respiratory Mechanics During One-lung Ventilation
Intraoperative lung protective ventilatory strategy has been widely recognized to reduce postoperative pulmonary complications in laparotomy and laparoscopic surgeries.
- Conditions
- Ventilator-Induced Lung Injury, Lung Ventilator, One-lung Ventilation
- Trial name
- NCT04519606
- Testing
- Optimal lung compliance during OLV
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- E-DA Hospital
Brain Injuries
Influence of Respiratory Mechanics on Brain-specific Monitoring in Brain-injured Patients
Increase in intracranial pressure (ICP) could be associated with increase in positive end-expiratory pressure (PEEP) level. Data are however disparate and interactions between ventilation with high PEEP and intracranial…
- Trial name
- ABIVENT (NCT04013698)
- Testing
- PEEP level 5 cmH2O, PEEP level 15 cmH2O
- Where
- Switzerland
- Sponsor
- Piquilloud Imboden Lise
Respiratory Muscles, Breathing Exercises
Respiratory Muscles and Inspiratory Muscle Training
The effects of inspiratory muscle training (IMT) remain controversial. Many studies have examined the effect IMT has on exercise performance, but any changes to the body that come from IMT have yet to be looked at.
- Trial name
- IMT (NCT02243527)
- Testing
- Inspiratory Muscle Training
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pulmonary Infection
Expiratory Rib Cage Compression in Mechanically Ventilated Patients
This is a randomized crossover study, designed to evaluate if the manual expiratory rib cage compression technique improves respiratory mechanics and is effective in secretion removal in mechanically ventilated patients.
- Trial name
- NCT01525121
- Testing
- Expiratory Rib Cage Compression
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Centro Universitário Augusto Motta
Intraoperative Ventilation, Respiratory Mechanics
Peak Airway Pressure and Respiratory Mechanics During PRVC Ventilation in Laparoscopic Surgery
This study aims to evaluate peak airway pressure and respiratory mechanics during pressure-regulated volume control (PRVC) ventilation in patients undergoing elective laparoscopic abdominal surgery.
- Trial name
- NCT07543939
- Testing
- PRVC Ventilation
- Where
- Saudi Arabia
- Volunteers
- 52 people
- Sponsor
- Specialized Medical Center (SMC)
Heart Defects, Congenital
Right Lateral Positioning of Postoperative Pediatric Cardiac Surgery
Directly following cardiac surgery for congenital heart disease; patients are not receiving routine turning every two hours to prevent pressure ulcers, because a negative influence on hemodynamic parameters is assumed.
- Trial name
- NCT02622152
- Testing
- Right lateral position (2 hours), Left lateral position (30 minutes), Supine position (30 minutes)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Weaning Failure, Central Respiratory Depression
Exploration of Mechanisms for Weaning Failure
This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline…
- Conditions
- Weaning Failure, Central Respiratory Depression, Diaphragm Injury, Phrenic Nerve Disorder
- Trial name
- NCT06424314
- Testing
- Monitoring of respiratory mechanics parameters
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Anesthesia
Assessment of Airways Mechanical Properties by FOT and LIR During Anesthesia
The aims of the present study are: 1. To evaluate the effect of the induction of anaesthesia and paralysis in terms of changes in oscillatory mechanics parameters 2.
- Trial name
- NCT01506284
- Testing
- Forced oscillatory technique (FOT) and laser interferometry (LIR).
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Uppsala University Hospital
Prostate Cancer, Anesthesia
Low-flow Versus Minimal-flow Sevoflurane Anesthesia During Robot-assisted Laparoscopic Radical Prostatectomy
Study Synopsis This protocol is formatted for ClinicalTrials.gov-style registration and manuscript-facing documentation. It is based on the uploaded Turkish ethics protocol and keeps the original core design: comparison of…
- Conditions
- Prostate Cancer, Anesthesia, Respiratory Mechanics
- Trial name
- NCT07475533
- Testing
- Common Anesthetic Management
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Chronic Obstructive Pulmonary Disease
Asymptomatic Versus Symptomatic Mild COPD: Comparisons at Rest and at Exercise
The current definition of chronic obstructive pulmonary disease (COPD) is based on the presence of persistent airflow obstruction assessed by spirometry. About half of the subjects with mild COPD (i.e.
- Trial name
- NCT02235025
- Testing
- Cardio-pulmonary exercise testing
- Where
- France
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Preterm Birth, Respiratory Distress Syndrome
Sustained Lung Inflation and Pulmonary Mechanics in Preterm Infant
Lung protection should start in the delivery room where, from the first breaths, the preterm infant can be helped to clear the lung fluid and to recruit alveolar spaces and establish the functional residual capacity (FRC).
- Conditions
- Preterm Birth, Respiratory Distress Syndrome, Lung Diseases
- Trial name
- NCT02493920
- Testing
- Sustained lung inflation, mask using a T-piece system (Fabian,Acutronic Medical Systems AG, Switzerland).
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Heart Failure
Pathophysiological Mechanisms of Activity-Related Dyspnea in Heart Failure: A Pilot Study
Dyspnea (breathlessness) on exertion is the most prevalent and distressing symptom of heart failure (HF). Nevertheless, the mechanisms of dyspnea in HF remain poorly understood.
- Trial name
- NCT02007486
- Testing
- Cardiopulmonary Exercise Testing
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- McGill University
Ventilator Weaning, Respiration, Artificial
Two Cycling Off Modes in Pressure Support: Study of Respiratory Mechanics, Breathing Comfort and Asynchrony Patterns
Objective: To compare termination criteria (TC) of pressure support ventilation (PSV). Design: Randomized cross-over clinical trial. Setting: Intensive Care Units.
- Trial name
- NCT00910286
- Testing
- Pulmonary Ventilator
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Hospital de Clinicas de Porto Alegre