Clinical trials: Breathing Mechanics
COPD
Pathogenesis and Outcomes of Sleep Disordered Breathing in Chronic Obstructive Pulmonary Disease (COPD)
This research is being conducted to examine the effects of nasal insufflation of warm and humidified air through a small nasal cannula on sleep, breathing pulmonary function, and daytime exercise capability.
- Trial name
- NCT01764165
- Testing
- Oxygen, High flow of room air
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Shoulder Arthroscopic Surgery
The Effect of the Shoulder Arthroscopic Surgery on Respiratory Mechanics
During shoulder arthroscopic surgery, extravasation of irrigation fluid can occur around the shoulder and trachea, compressing the upper airway.
- Trial name
- NCT01407328
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Pulmonary Disease, Chronic Obstructive
Mechanisms of Dyspnea Relief During Exercise in COPD Patients Following Treatment With Tiotropium (Spiriva)
To explore the mechanisms of dyspnea relief during exercise in patients with COPD following treatment with tiotropium bromide (Spiriva)
- Trial name
- NCT00274027
- Testing
- tiotropium bromide
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Boehringer Ingelheim
Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury
Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients
Neuromuscular blockade (NMB) is proposed in patients with moderate to severe acute respiratory distress syndrome (ARDS). The supposed benefit of these muscle relaxants could be partly linked to their effects on respiratory…
- Trial name
- NCT05697666
- Testing
- Modulation of the depth of the neuromuscular blockade
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Diaphragm Dysfunction, COPD Exacerbation
Influence of Respiratory Mechanics on Diaphragmatic Dysfunction in COPD Patients Who Have Failed NIV (RHYDIAN)
Although non-invasive mechanical ventilation (NIV) is the gold standard treatment for patients with acute exacerbation of COPD (AECOPD) who develop respiratory acidosis, failure rate are still high ranging from 5% to 40%.
- Conditions
- Diaphragm Dysfunction, COPD Exacerbation, Mechanical Ventilation
- Trial name
- RHYDIAN (NCT03852394)
- Testing
- Respiratory mechanics assessment
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Modena and Reggio Emilia
Covid19, ARDS, Human
Respiratory Mechanics and Gas Exchange Characteristics in Patient With SARS-CoV-2
The combination of different ventilatory strategies and its effects on respiratory mechanics and gas exchange in patients under mechanical ventilation with acute respiratory distress syndrome secondary to coronavirus-19 has been…
- Trial name
- NCT04486729
- Testing
- High PEEP with end inspiratory pause, Low PEEP - FiO2 high, High PEEP without end inspiratory pause
- Where
- Argentina
- Volunteers
- 15 people
- Sponsor
- Sanatorio Anchorena San Martin
Obesity, Morbid, Bariatric Surgery (Sleeve Gastrectomy )
Flow-Controlled vs Volume-Controlled Ventilation in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery
The goal of this clinical trial is to compare the effects of flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV) on hemodynamic and respiratory parameters in obese patients undergoing elective laparoscopic…
- Conditions
- Obesity, Morbid, Bariatric Surgery (Sleeve Gastrectomy ), Mechanical Ventilation
- Trial name
- NCT07641829
- Testing
- Flow-Controlled Ventilation (FCV), Volume-Controlled Ventilation (VCV)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Ankara Training and Research Hospital
Bronchoconstriction, Inhaled Salbutamol
Salbutamol, Pharmacogenetics and Breathing Mechanics
Athletes using asthma medications called β2-agonists win a disproportionately high number of medals at Olympic Games. Due to a large variety in the genes that affect how individuals respond to β2-agonists, the investigators will…
- Conditions
- Bronchoconstriction, Inhaled Salbutamol, Cycling Performance
- Trial name
- NCT01903785
- Testing
- Salbutamol
- Where
- Canada
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Surgery
Esophageal Balloon Measurements to Better Characterize Thoraco-abdominal Interrelationship Mechanics.
Esophageal pressure measurements in surgical patients requiring mechanical ventilation during abdominal laparoscopic or robotic surgeries requiring intra-abdominal insufflation.
- Trial name
- NCT03624491
- Testing
- Esophageal pressure measurement guided ventilation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
COPD, One Lung Ventilation
Effects of Dexmedetomidine on Respiratory Mechanics and Oxygenation During One Lung Ventilation With Chronic Obstructive Lung Disease
COPD is often associated with the airflow limitation and the pulmonary hyperinflation. During the one-lung ventilation (OLV), COPD patients' physiologic dead space increases and hypercapnia may develop.
- Trial name
- NCT02185430
- Testing
- saline infusion, dexmedetomidine infusion
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Pre-eclampsia, Pregnancy
Gestational Changes in Hemodynamics and Respiratory Mechanics in Association With Pre-Eclampsia
This study focuses on elucidating the changes of hemodynamics assessed by USCOM and respiratory mechanics assessed by impedance oscillometry (IOS) over the course of pregnancy and the postpartum period.
- Conditions
- Pre-eclampsia, Pregnancy, Post Partum
- Trial name
- TREMOFLO (NCT07695909)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mechanical Ventilation, Lung Infection
Breath and Air Stacking on Respiratory Mechanics in Tracheostomized Patients
The researchers hypothesized that the aid of the resuscitator by the technique Air Stacking increase lung volume, promoting increased lung compliance and improvement of the ventilatory pattern.
- Trial name
- NCT04012489
- Testing
- Breath Stacking, Air Stacking
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Brazilian Institute of Higher Education of Censa
Anesthesia Complication, Mechanical Ventilation Complication
PCV-VG in Pediatric Laparoscopic Surgery
This Study will aim to compare the effects of Pressure Controlled Ventilation - Volume Guarantee (PCV-VG) mode with volume control ventilation (VCV) and pressure control ventilation (PCV) modes on respiratory mechanics (including…
- Trial name
- NCT06245317
- Testing
- Mechanical Ventilation Mode
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Assiut University
Prematurity, Respiratory Distress Neonatal
Effect of Automated Oxygen Control on Early-childhood Lung Mechanics
Preterm infants are at higher risk of long-term respiratory problems and abnormal lung function in childhood. Respiratory support including mechanical ventilation, that is the use of a machine to move air into and out of the…
- Conditions
- Prematurity, Respiratory Distress Neonatal, Oxygen Delivery
- Trial name
- NCT07866820
- Testing
- Forced oscillometry technique
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust
Acute Lung Injury, Acute Respiratory Distress Syndrome
The Specific Lung Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients in Supine and Prone Position
The investigators aim is to study the specific lung elastance in ALI/ARDS patients during invasive mechanical ventilation, in supine and prone position.
- Trial name
- NCT00568659
- Testing
- specific elastance
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Policlinico Hospital
Lung Transplantation
SI-EVLP Study: STRESS INDEX in Lung Reconditioning
In order to minimize mechanical stress the investigators propose to implement EVLP procedure with a ventilation monitoring guided by the analysis of the Paw-t shape.
- Trial name
- NCT01729637
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- University of Turin, Italy
Hypoventilation, Hypoxemia
Oxygen Supplementation and Ventilator Hyperinflation in the Endotracheal Suction (OSVHES)
This is a double crossover study where all patients are randomly allocated to one of two treatment sequences associated with endotracheal aspiration.The first treatment (A) uses two suctioning methods for each patient: one…
- Trial name
- OSVHES (NCT02440919)
- Testing
- Hyperoxygenation 100% FiO2, Hyperoxygenation 20% FiO2, Hyperinflation (PEEP- ZEEP) Basal FiO2
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Universidade Federal de Sao Carlos
ARDS, Mechanical Ventilation
Continuous Flow Ventilation With the Ventijet System in Acute Respiratory Distress Syndrome: a First-in-Human Feasibility and Non-Inferiority Trial
This prospective, non-randomized, single-arm, proof-of-concept clinical trial evaluates the physiological performance and safety of the Ventijet System, a hybrid ventilation system based on continuous high-velocity gas flow.
- Conditions
- ARDS, Mechanical Ventilation, Hypoxemic Respiratory Failure
- Trial name
- Ventijet (NCT07121257)
- Testing
- VENTIJET system
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Hospital del Mar
Deep Sedation
Comparison of Oxygenation Methods in Sedation
Abstract Backgrounds and objectives: Dental treatments, especially in children who can not be cooperated, may require deep sedation due to intense anxiety and fear.
- Trial name
- NCT03893877
- Testing
- nasal cannula, nasal mask
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Respiratory Mechanics, Hemodynamics
vNOTES vs Laparoscopy: Respiratory Mechanics and Hemodynamics
Pneumoperitoneum and Trendelenburg position are unavoidable in laparoscopic surgery and are known to have adverse effects on intraoperative respiratory mechanics and hemodynamics.
- Trial name
- NCT07667907
- Testing
- vNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery, Laparoscopic Gynecological Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital