Clinical trials: Bronchial Hyperreactivity
Asthma
Ability of Aridol to Detect Bronchial Hyperresponsiveness in Suspected Asthmatics
This is a Phase 3 study to determine the sensitivity and specificity of the Aridol bronchial challenge test to detect bronchial hyperresponsiveness in patients with suspected asthma.
- Trial name
- NCT00252291
- Testing
- Aridol, Methacholine, Exercise challenge
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Syntara
Asthma
Study Comparing Budesonide Hydrofluoroalkane (HFA) vs Chlorofluorocarbon (CFC) Pressurized Metered Dose Inhalers (pMDI) in Patients With Mild to Moderate Asthma
This study is being carried out to see if budesonide with HFA is effective, safe and well tolerated compared with budesonide CFC.
- Trial name
- NCT00667992
- Testing
- Budesonide HFA, Budesonide CFC
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 99 people
- Sponsor
- AstraZeneca
Esophageal Atresia
Respiratory Complications of Operated Esophageal Atresia in Children
The respiratory complications of esophageal atresia have already been identified. They are mainly related to tracheomalacia linked to the esophageal malformation, and are aggravated by frequently associated gastroesophageal…
- Trial name
- ATRESIA (NCT05527873)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Strasbourg, France
Bronchial Hyperreactivity
Methacholine Challenge Testing: Comparison of FEV1 and IOS Parameters in Adult Asthma Patients
A classic methacholine challenge test is considered positive when forced expiratory volumen after one second (FEV1) decrease 20%.
- Trial name
- NCT06034145
- Testing
- No intervention
- Volunteers
- 500 people
- Sponsor
- Allergi- og Lungeklinikken, Elsinore
Asthma
Pediatric Asthma Study Using Stepwise Treatment With Two Food And Drug Administration Approved Asthma Medications
This study was designed to evaluate if, in children with asthma, a stepwise treatment (five levels varying from once daily fluticasone propionate 100mcg until twice daily a fixed combination of salmeterol and fluticasone…
- Trial name
- NCT00158834
- Testing
- Salmeterol/Fluticasone propionate combination product, Fluticasone propionate
- Where
- 16 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- GlaxoSmithKline
Asthma.
Effect of Aerobic Training in Moderate or Severe Asthmatic Patients
Exercise training has been proposed as adjunctive therapy in asthma to improve many clinical outcomes; however its effects on bronchial hyperresponsiveness (BHR) and inflammation, characteristic features in asthma, remains poorly…
- Trial name
- ETA1 (NCT02033122)
- Testing
- Aerobic training, Breathing exercise
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Instituto de Investigação em Imunologia
Allergic Rhinitis, Asthma
Leukotriene D4 Nasal Provocation Test in Allergic Rhinitis
Leukotrienes play critical roles in the inflammatory process in allergic rhinitis and bronchial asthma, therefore, anti-leukotriene therapy is part of treatment for asthma.
- Trial name
- NCT01963741
- Testing
- leukotriene D4, histamine
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Dyspnea
Pulmonary Function Test, Bronchial Hyperresponsiveness and Quality of Life in Patients With Vocal Cord Dysfunction (VCD)
Vocal cord dysfunction is a rare clinical picture. It is labeled as a sudden and threatening dyspnea. Patients with VCD may also present cough, hoarseness, wheezing, and chest tightness, but an inspiratory stridor is the most…
- Trial name
- VCD (NCT00906867)
- Testing
- Methacholine challenge testing, Rhino-laryngoscopy
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Atopic Dermatitis
Bronchial Hyperreactivity in Atopic Dermatitis Patients - a 10 Year Follow-up
The investigators will contact 64 patients with atopic dermatitis (AD) who participated in a long-term tacrolimus ointment trial in Helsinki 10 years ago, and ask them to participate in this follow-up study.
- Trial name
- NCT00795496
- Testing
- Histamine provocation, Skin prick tests, Serum IgE blood testing
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- University of Helsinki
COVID-19
Small Airway Disease And Bronchial Hyperreactivity In Patients With Post Acute Covid-19 Syndrome
The aim of this work is to estimate the frequency of small airway disease and/or the bronchial hyperreactivity in follow up of postacute covid survivors.
- Trial name
- NCT06374420
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Asthma
SERETIDE Vs FLIXOTIDE In Mild Persistent Asthma (GINAII)
An 18 months randomised double-blind study with two parallel arms with start dose of inhaled SERETIDE 50/100mcg BD or FLIXOTIDE 100mcg BD, Phase I is 6 months where the patient will be up-titrated until well controlled is…
- Trial name
- NCT00455923
- Testing
- Seretide, Flixotide
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- GlaxoSmithKline
Asthma
A Comparative Bronchial Provocation Study With Mannitol and Methacolinie in a Korean Population
Asthmatic patients and non-asthmatic controls were recruited prospectively from four referral hospitals in Korea. Participants were challenged with each of methacholine and mannitol inhalation on different days.
- Trial name
- NCT02104284
- Testing
- methacholine and mannitol bronchial challenge tests
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- BL&H Co., Ltd
Asthma
Down-titration of Steroids in Patients With Difficult Asthma With no Bronchial Hyperreactivity
An 8 week 'real-life' inhaled corticosteroid (ICS) dose reduction study in patients with severe asthma without evidence of bronchial hyperactivity.
- Trial name
- DOSIS (NCT03321877)
- Testing
- Change to dose of patient's regular medication
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Bispebjerg Hospital
Allergic Rhinitis, Asthma
Allergic Inflammation in Rhinitis Patients Following Nasal Allergen Challenge
Allergic rhinitis is a common condition caused by inflammation of nasal mucosa. The study was performed to gain information on this inflammation, including effect of intranasal corticosteroid treatment hereupon and potential…
- Trial name
- NCT01657097
- Testing
- INCS
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Aarhus
Asthma, Bronchial Hyperresponsiveness
Bronchial Hyperreactivity During Histamine Passive Exposure
Bronchial hyperresponsiveness consists in excessive response to bronchial stimuli.Bronchial challenge test is used to confirm/exclude asthma (metacholine or histamine).Protection are used to avoid passive exposure of the…
- Trial name
- NCT01937494
- Testing
- histamine-benzylic alcohol (magistral preparation)
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Respiratory Distress Syndrome, Pneumonia
Telemedicine in the Generals Practitioners Office
Pediatrician does physical examination through telemedicine and in real life to see whether the telemedicine consultation corresponds with the real life examination. Goal is to determine: 1. Check practical feasability 2.
- Conditions
- Respiratory Distress Syndrome, Pneumonia, Bronchiolitis, Croup
- Trial name
- NCT04168554
- Testing
- Telemedicine
- Volunteers
- 40 people
- Sponsor
- Rijnstate Hospital
Chronic Asthma
The Effect of Prasugrel on Bronchial Hyperreactivity and on Markers of Inflammation in Patients With Chronic Asthma
Cysteinyl leukotrienes (cys-LTs) are lipid inflammatory mediators that abound in mucosal inflammation and play a validated role in the pathogenesis of human asthma.
- Trial name
- PRINA (NCT01305369)
- Testing
- Prasugrel
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- University of Milan
Hyperreactive Airway
Evaluating the Capacity of High-sensitivity Serum CRP Levels to Predict Bronchial Hyper Responsiveness in School Age Children
Background: Bronchial hyper responsiveness (BHR) assessed by methacholine challenge test (MCT) may aid in the diagnosis of asthma, while negative MCT can help to exclude the diagnosis.
- Trial name
- NCT01963585
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
Reversibility of Bronchial Obstruction in Children Born Preterm
This observational study aims to compare responses to different, commonly used inhaled bronchodilators in children born preterm with bronchial obstruction at spirometry.
- Conditions
- Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity, Chronic Lung Disease of Newborn, Preterm Birth Complication
- Trial name
- NCT06110481
- Where
- Czechia
- Volunteers
- 73 people
- Sponsor
- Charles University, Czech Republic
Asthma
Examination of the Bronchoprotective Effect of Endothelin Receptor Blockade in Asthma
The purpose of this study will be to determine if blockade of endothelin 1 signalling via endothelin receptor A using ambrisentan or dual blockade (A\&B) via bosentan can provide protection against methacholine induced…
- Trial name
- NCT01617746
- Testing
- Ambrisentan, Bosentan
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Glasgow