Clinical trials: Bronchoalveolar Lavage
Asthma, Pulmonary Fibrosis
Segmental Bronchoalveolar Lavage
Bronchoalveolar lavage (BAL) is a diagnostic and therapeutic procedure conducted by placing a small fiberoptic scope into the lung of a patient, and injecting sterile water (saline) into the lung and removing the fluid.
- Trial name
- NCT00001618
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Graft Versus Host Disease, Infection
Early Diagnosis of Aspergillosis in Patients at High Risk of Fungal Infection Caused by Treatment for Hematologic Cancer or Other Disease
RATIONALE: Studying ways to diagnose fungal infections early may help doctors plan the best treatment. PURPOSE: This clinical trial is studying laboratory tests to see how well they find aspergillosis early in patients at high…
- Conditions
- Graft Versus Host Disease, Infection, Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT00462657
- Testing
- polymerase chain reaction, bronchoalveolar lavage, immunoenzyme technique
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- St. Bartholomew's Hospital
Bronchoscopy
Utility of Syringe Based Suction Versus Channel Suction in Bronchoalveolar Lavage
Bronchoalveolar lavage (BAL) is a common technique among pulmonologists. Its goal is to collect cells from alveolar units. This is done by wedging a flexible bronchoscope in a bronchus, instilling saline, and removing the saline…
- Trial name
- NCT01853904
- Testing
- Bronchoscopy/ BAL with Channel Suction, Bronchoscopy/BAL with Syringe Suction
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Ventilator-Associated Pneumonia
Impact of Using Mini-Bronchoalveolar Lavage as a Diagnostic Test for Ventilator-Associated Pneumonia
The proposed study will evaluate adult patients admitted to the medical or surgical intensive care units (ICUs) at San Francisco General Hospital (SFGH).
- Trial name
- NCT00319644
- Testing
- Bronchoalveolar lavage
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of California, San Francisco
Pneumonia
Serial Changes in sTREM-1 During Ventilator-associated Pneumonia (VAP)
Triggering receptor expressed on myeloid cells (TREM)-1 is a recently described molecule that plays an important role in myeloid cell-activated inflammatory responses.
- Trial name
- NCT00976157
- Testing
- Bronchoscopy BAL
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- Mackay Memorial Hospital
Traumatic Brain Injury, Ventilator Associated Pneumonia
Effect of E-BAL on Severity of VAP Assessed Through CPIS on the Patients of Traumatic Brain Injury in Neurocritical Care, Also Effect on Days of Ventilation and ICU Stay.
Severe traumatic brain injury (STBI) is a leading cause of disability, mortality, and economic burden worldwide. The impact of severe traumatic brain injury (STBI) on the economy of developing countries like Pakistan is…
- Trial name
- NCT04977843
- Testing
- EARLY BRONCHOALVEOLAR LAVAGE
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Jinnah Hospital
Interstitial Lung Diseases
Bronchoalveolar Lavage in Interstitial Lung Diseases to Characterization of Specific Inflammatory Cellular Infiltrate in Different Interstitial Lung Diseases
Interstitial lung disease (ILD) represents a various group of disorders characterized by inflammation and fibrosis within the lung parenchyma.[1] ILD refers to a group of diffuse parenchymal lung disorders, including a spectrum…
- Trial name
- NCT07208201
- Testing
- bronchoscopy
- Volunteers
- 66 people
- Sponsor
- Maha Ahmed Abd EL Gawad Mohammed Okasha
Pneumonia
Bronchoalveolar Lavage Combined With High-throughput Sequencing Technology
High-throughput sequencing technology/Metagenomic next generation sequencing (mNGS) has extensive applications in fields such as whole-genome sequencing, transcriptome, gene expression regulation, and epigenetics.
- Trial name
- NCT07005466
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Pulmonary Alveolar Proteinosis
Study of Subcutaneous Injection of Low-dose rhGM-CSF +/- WLL in PAP.
The purpose of this study is to establish an efficient and economic treatment scheme by evaluation of the safety and efficacy of subcutaneous injection of low-dose rhGM-CSF, or of similar injection after whole lung lavage , in…
- Trial name
- PAP (NCT01983657)
- Testing
- rhGM-CSF, Whole Lung Lavage(WLL)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Pain
Bispectral Index as an Analgesia Monitoring in Severely Ill Patient: Effect of Remifentanyl
The aim of this protocol is to study the prophylactic effect of remifentanil on bispectral index variation during a nociceptive stimuli.
- Trial name
- NCT00162591
- Testing
- remifentanyl
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infectious Pneumonia, Coma
Key to Improve DiagNosis in Aspiration Pneumonia
To evaluate the diagnostic performance of amylase assay performed from bronchial alveolar fluid to differentiate aseptic chemical inhalation pneumonitis from an infectious inhalation pneumonitis in comatose patients with…
- Trial name
- KIDNAP (NCT03182387)
- Where
- France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Bordeaux
Influenza, Acute Lung Injury
Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage
The influenza A/H1N1v pandemic virus causes severe pneumonia that can lead to acute respiratory distress syndrome and death even in healthy young individuals.
- Conditions
- Influenza, Acute Lung Injury, Acute Respiratory Distress Syndrome
- Trial name
- FluBAL (NCT01089400)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Meconium Aspiration Syndrome
Surfactant Lavage vs. Bolus Surfactant in Neonates With Meconium Aspiration
The objective of this pilot study is to examine the feasibility and safety of performing a larger trial to assess outcomes following treatment of meconium aspiration syndrome with surfactant lavage compared to bolus surfactant.
- Trial name
- NCT00312507
- Testing
- Bovine Lipid Extract Surfactant (administered by lavage), Bovine Lipid Extract Surfactant (administered by bolus)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Ventilator Associated Pneumonia, Covid19
Incidence of VAP in Patients With Severe COVID-19
Combined retrospective and prospective cohort study to evaluate the incidence of microbiologically confirmed VAP in mechanically ventilated patients with COVID-19.
- Trial name
- CoV-AP (NCT04766983)
- Testing
- bronchoalveolar lavage
- Where
- Italy
- Volunteers
- 323 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ventilator-associated Bacterial Pneumonia, Mechanical Ventilation Complication
The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia
Ventilator-associated pneumonia (VAP) is an important cause of morbidity and mortality in ventilated critically ill patients specially in intensive care unit (ICU).
- Trial name
- NCT01865266
- Testing
- Ulinaststin for injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Minhang Central Hospital
Thoracic Surgery
Effects of Permissive Hypercapnia During Lung Surgery on Inflammatory Biomarkers in Serum and Bronchoalveolar Lavage Fluid
The primary objective was to evaluate the effects of permissive hypercapnia on inflammatory biomarkers in bronchoalveolar lavage fluid and serum during one-lung ventilation.
- Trial name
- NCT07749456
- Testing
- Allowed permissive hypercapnia
- Volunteers
- 40 people
- Sponsor
- University of Nis
ARDS, Human, Aspiration Pneumonia
Potential Biomarkers and Pathogenic Mechanism for Reflux Aspiration-induced Lung Injury.
There is limited research on aspiration pneumonia-induced ARDS (Acute Respiratory Distress Syndrome), and currently there is a lack of studies on corresponding biomarkers and pathogenic mechanisms.
- Trial name
- NCT06164639
- Testing
- aspiration, bronchial alveolar fluid, EIT V/Q test
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai Zhongshan Hospital
COVID-19 Pneumonia
Hydroxychloroquine for the Treatment of SARS-CoV2 (COVID 19) : Pharmacokinetic Study
This study is a prospective, observational, open, monocentric multisite, pharmacokinetic study of hydroxychloroquine in critically ill patients.
- Trial name
- CHLORO-VID (NCT04625218)
- Where
- France
- Sponsor
- University Hospital, Toulouse
Pulmonary Infection
Massively Parallel Sequencing to Identify Microbiological Organisms in Bronchoalveolar Lavage Fluid
Patients who are post hematopoietic stem cell transplantation who require a bronchoalveolar lavage (BAL) for standard clinical car will have extra fluid collected and sent for massively parallel sequencing to see if it is as…
- Trial name
- NCT03995030
- Testing
- massively paralleled sequencing
- Volunteers
- 10 people
- Sponsor
- New York Medical College
Invasive Aspergillosis
Incidence of Invasive Aspergillosis and Its Relation to Galactomannan Clinical Outcomes
The goal of this observational study is to analyze the relationship between galactomannan index values and clinical outcomes , as well as to determine the annual and seasonal incidence of invasive aspergillosis in pediatric and…
- Trial name
- NCT07621263
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Hospital H+ Queretaro