Clinical trials: Bronchoalveolar Lavage (BAL)
Lung Diseases
Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children.
The INSPIRE CHILD-study is a clinical research project focused on understanding lung diseases in children. The study aims to explore how the presence of certain bacteria, immune responses, and inflammatory markers in the lungs…
- Trial name
- INSPIRE CHILD (NCT06746077)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aarhus University Hospital
Sarcoidosis
Comparison of Characteristics of Bronchoalveolar Lavage Dusting and of Specific Questionnary Data in Healthy Volunteers and Patients Suffering From Sarcoidosis
Comparison of dusting rate of bronchoalveolar lavage in healthy volunteers and patients suffering from sarcoidosis. Blind analysis of bronchoalveolar lavage with Optical Microscopy, Transmission Electron Microscopy and…
- Trial name
- MINASARC01 (NCT02863406)
- Testing
- Bronchoalveolar lavage
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Pulmonary Nodules
Clinical Study of ctDNA and Exosome Combined Detection to Identify Benign and Malignant Pulmonary Nodules
This study through the detection of EGFR、ALK、ROS1、KRAS、HER2、BARF、NTRG1 seven ctDNA and exosome RNA in the blood and alveolar lavage of lung nodules patients and heavy smoking healthy population.
- Trial name
- ctDNA (NCT04182893)
- Testing
- ctDNA and Exosome Combined Detection
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Bronchiectasis Adult
Airway Clearance and Bronchoalveolar Lavage for Bronchiectasis Patients With Exacerbation
No study have evaluated the efficacy and safety of airway clearance therapy (ACT) and bronchoalveolar lavage (BAL) under bronchoscope for bronchiectasis.
- Trial name
- NCT03643302
- Testing
- Version BF-1T26 electronic bronchoscope
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Alpha1-antitrypsin Deficiency
GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study
The purpose of the study is 2-fold: (1) to evaluate the safety and potential immunogenicity of GLASSIA following intravenous (IV) administration via in-line filtration; and (2) to assess the effects of GLASSIA augmentation…
- Trial name
- NCT02525861
- Testing
- GLASSIA
- Where
- 18 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Baxalta now part of Shire
Soft Tissue Sarcoma (STS), Bronchoalveolar Lavage (BAL)
BAL Fluid Biomarkers in Sarcoma
This is a single-centre, Phase II, prospective study designed to assess BALF and TA-derived biomarkers in relation to metastatic burden in STS patients.
- Conditions
- Soft Tissue Sarcoma (STS), Bronchoalveolar Lavage (BAL), Bronchoalveolar Lavage Fluid
- Trial name
- NCT06815666
- Testing
- Bronchoscopy & Metastasectomy
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Lung Cancer
Pattern of Isolated Fungi From Bronchoalveolar Lavage Among Patients With Lung Cancer
The aim of the study is to assess the prevalence and pattern of isolated fungi from patients with lung cancer at the time of diagnosis.
- Trial name
- NCT05575388
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Pharmacokinetics Study on Healthy Volunteers Adults
Evaluation of the Concentration of ANT3310 and Meropenem in the Lung in Healthy Adult Participants
This is an open-label, non-randomized, single-center, repeated i.v. doses, Phase 1 trial to evaluate the pharmacokinetics, safety, and tolerability of a combination of MEM-ANT3310 in healthy adult female and male participants who…
- Trial name
- NCT06916156
- Testing
- ANT3310, Meropenem
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Antabio
Atelectasis, Bronchoscopy
Evaluation of BAL Procedure With Ambu aScope 3 Large in Patients in an ICU Setting
An Investigation to determine the single-use scope's ability to suction secretion from the lungs to resolve the collapse of the lung.
- Trial name
- NCT03581474
- Testing
- Bronchoscopic procedure
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ambu A/S
Bronchoscopy
Utility of Syringe Based Suction Versus Channel Suction in Bronchoalveolar Lavage
Bronchoalveolar lavage (BAL) is a common technique among pulmonologists. Its goal is to collect cells from alveolar units. This is done by wedging a flexible bronchoscope in a bronchus, instilling saline, and removing the saline…
- Trial name
- NCT01853904
- Testing
- Bronchoscopy/ BAL with Channel Suction, Bronchoscopy/BAL with Syringe Suction
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Pneumonia, Viral, Ventilator Associated Pneumonia
Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BAL
Almost 90 out of 100 people carry herpes simplex viruses (HSV). Once a person has been infected with the herpes viruses, he or she can't get rid of them for the rest of her/his life.
- Conditions
- Pneumonia, Viral, Ventilator Associated Pneumonia, Community-acquired Pneumonia, Herpes Simplex
- Trial name
- HerpMV (NCT06134492)
- Testing
- Acyclovir
- Where
- 28 sites in Germany
- Volunteers
- 616 people
- Sponsor
- Jena University Hospital
HIV, ICL
Tissue Biopsy and Imaging Studies in HIV-Infected Patients
This study will examine tissue from the tonsils, lymph nodes and large bowel of HIV-infected patients to investigate changes in viral load and certain white blood cells during treatment.
- Conditions
- HIV, ICL, Healthy Volunteers
- Trial name
- NCT00001471
- Where
- United States
- Volunteers
- 386 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Invasive Pulmonary Aspergillosis
PCR for Aspergillus Fumigatus in Blood and Bronchoalveolar Lavage Fluid for Monitoring Cases of Invasive Aspergillosis: What is Its Prognostic Value
Aspergillus fumigatus PCR is currently used in conjunction with serum galactomannan to support the diagnosis of invasive aspergillosis or for monitoring at-risk patients not receiving antifungal prophylaxis.
- Trial name
- ASP (NCT07313527)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Patients Scheduled for Bronchoscopy
Prevalence of Pneumocystis Jirovecii and of Cytomegalovirus in Bronchial Wash Fluid of Patients Undergoing Bronchoscopy
The purpose of this study is to determine the incidence of the "carriage" state (asymptomatic colonization) with Pneumocystis Jirovecii (Pneumocystic Carinii Pneumonia, PCP) and Cytomegalovirus (CMV)in the human lung.
- Trial name
- PCP-CMV (NCT01395498)
- Testing
- laboratory testing of PCP and CMV genetic material
- Where
- Israel
- Volunteers
- 93 people
- Sponsor
- Carmel Medical Center
Acute Respiratory Distress Syndrome
Immune Alveolar Alterations During Pneumonia-Associated Acute Respiratory Distress Syndrome
Sepsis is a dysregulated host response to severe life-threatening infections, leading to organ failure and death in up to 40% of patients with septic shock.
- Trial name
- PICARD2 (NCT03971006)
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pneumonia
Measuring Auto-fluorescence of White Corpuscles for the Early Diagnosis and the Monitoring of Pneumonia in ICU
The diagnosis of pneumonia is challenging in Intensive Care Unit. The auto-fluorescence of white corpuscles is altered during pneumonia.
- Trial name
- BIONAGA (NCT02717767)
- Testing
- Autofluorescence of white corpuscle
- Where
- 4 sites in France
- Volunteers
- 69 people
- Sponsor
- Nantes University Hospital
Bronchoalveolar Lavaage, Diffuse Lung Disease
Comparison of Procedural Yield of Bronchoalveolar Lavage Using Three Different Techniques in Subjects Undergoing Flexible Bronchoscopy
Bronchoalveolar lavage (BAL) via flexible bronchoscopy is a method used to sample the cellular and microbiological components of the alveolar space.
- Trial name
- BAL-3T (NCT05425875)
- Testing
- Bronchoalveolar lavage using wall mount suction, Bronchoalveolar lavage using manual suction, Bronchoalveolar lavage using manual suction with rubber tubing
- Where
- 2 sites in India
- Volunteers
- 942 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hospital-acquired Pneumonia
E Test Strips Applied to Bronchoalveolar Lavage for Suspicion of Hospital-acquired Pneumonia to Accelerate Antibiogram Analysis.
To rapidly adapt or deescalate the initially broad antibiotic treatment, an antibiogram analysis is required. E test strips have successfully provided an antibiogram 24 h after having been directly applied to bronchoalveolar…
- Trial name
- NCT01266863
- Testing
- E test method
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Université Victor Segalen Bordeaux 2
Ventilator Associated Pneumonia, Covid19
Incidence of VAP in Patients With Severe COVID-19
Combined retrospective and prospective cohort study to evaluate the incidence of microbiologically confirmed VAP in mechanically ventilated patients with COVID-19.
- Trial name
- CoV-AP (NCT04766983)
- Testing
- bronchoalveolar lavage
- Where
- Italy
- Volunteers
- 323 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Bronchoalveolar Lavage, Pneumonia
Standardized BAL Procedure for Critical Patients to Diagnose Pneumonia Pathogens
In order to improve the accuracy of the diagnosis of pulmonary pathogens and reduce the adverse impact of excessive BAL volume on patients, this study intends to explore the most optimal lavage volume in the middle lobe and the…
- Trial name
- STABAL (NCT04200742)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Wu Jianfeng