Clinical trials: Bronchoalveolar Lavage (BAL)
Pneumonia, Bronchoalveolar Lavage
HCAPPED I: HCAP-Pcr in Emergency Department
Prospective Observational Study (on Diagnostic Procedure) - Single-Center, Non-Profit. A pilot study will be conducted on a prospective cohort of patients with HCAP (Healthcare-Associated Pneumonia).
- Conditions
- Pneumonia, Bronchoalveolar Lavage, Antimicrobial Treatment, Sputum
- Trial name
- HCAPPED-I (NCT06506617)
- Where
- Italy
- Volunteers
- 93 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Nontuberculous Mycobacterial Pulmonary Disease, Nontuberculous Mycobacterial Lung Disease
Association of Nutrition and T Cell Immune Activity With Disease Progression in Nontuberculous Mycobacterial Pulmonary Disease
Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic lung infection caused by environmental mycobacteria. The clinical course of NTM-PD varies widely among patients.
- Trial name
- NCT07363798
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Pulmonary Nodules
Clinical Study of ctDNA and Exosome Combined Detection to Identify Benign and Malignant Pulmonary Nodules
This study through the detection of EGFR、ALK、ROS1、KRAS、HER2、BARF、NTRG1 seven ctDNA and exosome RNA in the blood and alveolar lavage of lung nodules patients and heavy smoking healthy population.
- Trial name
- ctDNA (NCT04182893)
- Testing
- ctDNA and Exosome Combined Detection
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
NSCLC
TAGRISSO (Osimertinib) in NSCLC Patients in Whom T790 Mutations Are Detected by Liquid Biopsy
In this trial, anti-tumor efficacy of TAGRISSO in NSCLC patients in whom T790 mutations are detected by liquid biopsy.
- Trial name
- NCT03394118
- Testing
- Osimertinib
- Where
- South Korea
- Volunteers
- 63 people
- Sponsor
- Asan Medical Center
Healthy
Validating the Use of Disposable Bronchoscopes for Research Bronchoalveolar Lavage
Validation study to use the disposable bronchoscopes in healthy volunteer research bronchoscopies to ensure adequate sample and cell yield.
- Trial name
- BALval (NCT02515591)
- Testing
- Bronchoalveolar Lavage validation study
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Asthma, Pulmonary Fibrosis
Segmental Bronchoalveolar Lavage
Bronchoalveolar lavage (BAL) is a diagnostic and therapeutic procedure conducted by placing a small fiberoptic scope into the lung of a patient, and injecting sterile water (saline) into the lung and removing the fluid.
- Trial name
- NCT00001618
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
ARDS (Acute Respiratory Distress Syndrome)
Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome
The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion.
- Trial name
- NCT07380373
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Ain Shams University
Pneumonia
Bronchoalveolar Lavage Combined With High-throughput Sequencing Technology
High-throughput sequencing technology/Metagenomic next generation sequencing (mNGS) has extensive applications in fields such as whole-genome sequencing, transcriptome, gene expression regulation, and epigenetics.
- Trial name
- NCT07005466
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
ARDS (Acute Respiratory Distress Syndrome)
BALance: ARDS Deconvolution by Bronchoalveolar Lavage Multiomics and Radiomics
Acute respiratory distress syndrome (ARDS) is a major contributor to ICU mortality and is characterised by hypoxaemia and pulmonary oedema.
- Trial name
- BALance (NCT07633366)
- Testing
- sampling blood, Lavage with physiologic saline solution
- Where
- Austria
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Asthma
A Study to Evaluate the Effect of a Single-Dose Intravenous Administration of MEDI-528
To evaluate the effect of MEDI-528 in adults with atopic asthma.
- Trial name
- NCT00483041
- Testing
- MEDI528 9 mg/kg
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- MedImmune LLC
Alpha1-antitrypsin Deficiency
GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study
The purpose of the study is 2-fold: (1) to evaluate the safety and potential immunogenicity of GLASSIA following intravenous (IV) administration via in-line filtration; and (2) to assess the effects of GLASSIA augmentation…
- Trial name
- NCT02525861
- Testing
- GLASSIA
- Where
- 18 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Baxalta now part of Shire
Bronchiectasis Adult
Airway Clearance and Bronchoalveolar Lavage for Bronchiectasis Patients With Exacerbation
No study have evaluated the efficacy and safety of airway clearance therapy (ACT) and bronchoalveolar lavage (BAL) under bronchoscope for bronchiectasis.
- Trial name
- NCT03643302
- Testing
- Version BF-1T26 electronic bronchoscope
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Bronchoalveolar Lavage
Bronchoalveolar Lavage in Recovered From COVID-19 Pneumonia
Coronaviruses such as SARS-CoV2, MERS-CoV, and SARS-CoV can cause significant morbidity and mortality in infected persons. Lung is the most common site of infection for these viruses, which may manifest as acute respiratory…
- Trial name
- NCT06022198
- Testing
- Bronchoalveolar Lavage
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mohamed Abd Elmoniem Mohamed
Invasive Aspergillosis, Acute Leukemia
Diagnostic Study of Combined Biomnarker Testing in Bronchoalveolar Lavage Samples of Immunocompromised Patients
The aim of our prospective and multicentre diagnostic study is therefore to elucidate on the sensitivity and specificity rates of these serologic markers in combination with molecular tools (both an Aspergillus specific and a…
- Conditions
- Invasive Aspergillosis, Acute Leukemia, Biomarkers, Stem Cell Transplantation
- Trial name
- NCT01695512
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Pneumonia, Meningitis
Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine in Lung Fluid of Adults With and Without HIV Infection
Lung immune responses are regulated independently of systemic responses. Injected vaccines may induce optimal responses in blood but not at mucosal surfaces.
- Conditions
- Pneumonia, Meningitis, Invasive Pneumococcal Disease, HIV
- Trial name
- NCT00371878
- Testing
- 7-valent pneumococcal conjugate vaccine (Prevnar)
- Where
- Malawi
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Royal Liverpool University Hospital
Bronchoalveolar Lavage, Pneumonia
Standardized BAL Procedure for Critical Patients to Diagnose Pneumonia Pathogens
In order to improve the accuracy of the diagnosis of pulmonary pathogens and reduce the adverse impact of excessive BAL volume on patients, this study intends to explore the most optimal lavage volume in the middle lobe and the…
- Trial name
- STABAL (NCT04200742)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Wu Jianfeng
Ventilator-associated Bacterial Pneumonia, Mechanical Ventilation Complication
The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia
Ventilator-associated pneumonia (VAP) is an important cause of morbidity and mortality in ventilated critically ill patients specially in intensive care unit (ICU).
- Trial name
- NCT01865266
- Testing
- Ulinaststin for injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Minhang Central Hospital
Lung Cancer
Impact of PD1-lymphocytes in Bronchoalveolar Lavage of Patients With Lung Cancer
The aim of this trial is to assess PD1-lymphocytes in bronchoalveolar lavage in patients with lung cancer, ILD and asthma.
- Trial name
- NCT04827667
- Testing
- bronchoalveolar lavage
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- University of Vienna
Vaping Related Disorder
Radiology and BAL in Vaping Associated Lung Injury
Radiology and BAL in Vaping associated lung disease
- Trial name
- NCT07499557
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Interstitial Lung Disease, Pneumonia
Predictors for Bronchoalveolar Lavage (BAL) Recovery Rate Derived From Quantified Computed Tomography (qCT)
Bronchoalveolar lavage (BAL) is an important diagnostic method. The percentage of fluid extracted after instillation (recovery rate) is crucial for following diagnostic tests.
- Conditions
- Interstitial Lung Disease, Pneumonia, Malignant Neoplasm
- Trial name
- NCT03388580
- Testing
- bronchoalveolar lavage (BAL)
- Volunteers
- 33 people
- Sponsor
- Universitätsmedizin Mannheim