Clinical trials: Bronchoalveolar Lavage Fluid
Soft Tissue Sarcoma (STS), Bronchoalveolar Lavage (BAL)
BAL Fluid Biomarkers in Sarcoma
This is a single-centre, Phase II, prospective study designed to assess BALF and TA-derived biomarkers in relation to metastatic burden in STS patients.
- Conditions
- Soft Tissue Sarcoma (STS), Bronchoalveolar Lavage (BAL), Bronchoalveolar Lavage Fluid
- Trial name
- NCT06815666
- Testing
- Bronchoscopy & Metastasectomy
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Non Small Cell Lung Cancer
Olmutinib Trial in T790M (+) NSCLC Patients Detected by Liquid Biopsy Using BALF Extracellular Vesicular DNA
The purpose of this study is to evaluate the efficacy of Olmutinib(Olita®) in patients with T790M-positive non-small cell lung cancer (NSCLC) confirmed using DNA extracted from extracellular vesicles of bronchoalveolar lavage…
- Trial name
- NCT03228277
- Testing
- Olmutinib
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Konkuk University Medical Center
Inflammation, Vasculitis
Analysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis
This study will collect fluid and tissue samples from the bronchi (air passages to the lungs) of patients with Wegener's granulomatosis for laboratory examination.
- Conditions
- Inflammation, Vasculitis, Wegener's Granulomatosis
- Trial name
- NCT00001541
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia, Aspiration
Preliminary Study on the Clinical Application Value of "Showering Cells" in Diagnosing Aspiration Pneumonia
Study Design and Participants: This single-center, retrospective case-control study enrolled adult patients (18-100 years) hospitalized in the RICU of the Chinese PLA General Hospital between January 2018 and December 2024, who…
- Trial name
- NCT07707206
- Where
- China
- Volunteers
- 430 people
- Sponsor
- Chinese PLA General Hospital
Alpha1-antitrypsin Deficiency
GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study
The purpose of the study is 2-fold: (1) to evaluate the safety and potential immunogenicity of GLASSIA following intravenous (IV) administration via in-line filtration; and (2) to assess the effects of GLASSIA augmentation…
- Trial name
- NCT02525861
- Testing
- GLASSIA
- Where
- 18 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Baxalta now part of Shire
Healthy
Study to Determine and Compare Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam in Healthy Subjects
This is a Phase 1, multiple dose, open-label pharmacokinetic study conducted in healthy adult male and female subjects to determine and compare plasma, epithelial lining fluid (ELF) and alveolar macrophage (AM) concentrations of…
- Trial name
- NCT03303924
- Testing
- ETX2514 and sulbactam
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Entasis Therapeutics
Acute Lung Injury
Omics Sequencing of Exosomes in Body Fluids of Patients With Acute Lung Injury
The exosomes in the experimental group and the control group were sequenced to find the difference of the two groups, providing a basis for subsequent basic research.
- Trial name
- NCT05058768
- Testing
- The lungs causes and extrapulmonary factors
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
IDIOPATHIC PULMONARY FIBROSIS
The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) is debatable. Looking for an insult to lung parenchyma that generates the pathogenesis of the disease is challenging.
- Trial name
- NCT01714934
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
ARDS, Human
Study of the Effects of Bronchoalveolar Lavage Liquid in the ARDS on the Functioning of the Neutrophil Polynuclear System
Firstly, the study assesses the effect of bronchoalveolar lavage fluid (BAL) from patients in (acute respiratory distress syndrome (ARDS) on the life span of PNNs and on the phagocytosis of apoptotic cells by macrophages and…
- Trial name
- BALARDS (NCT04008225)
- Testing
- Bronchoalveolar lavage
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Rennes University Hospital
Ventilator-associated Bacterial Pneumonia, Mechanical Ventilation Complication
The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia
Ventilator-associated pneumonia (VAP) is an important cause of morbidity and mortality in ventilated critically ill patients specially in intensive care unit (ICU).
- Trial name
- NCT01865266
- Testing
- Ulinaststin for injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Minhang Central Hospital
Asthma
A Study to Evaluate the Effect of a Single-Dose Intravenous Administration of MEDI-528
To evaluate the effect of MEDI-528 in adults with atopic asthma.
- Trial name
- NCT00483041
- Testing
- MEDI528 9 mg/kg
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- MedImmune LLC
Bronchoalveolar Lavage Fluid, Sensitivity and Specificity
Aspergillosis Detection Via EBC-GM in Ventilated Patients
Brief Research Proposal: Non-Invasive Detection of Invasive Pulmonary Aspergillosis in ICU Patients Background: Invasive Pulmonary Aspergillosis (IPA) is a critical threat to patients in ICUs, especially those undergoing…
- Conditions
- Bronchoalveolar Lavage Fluid, Sensitivity and Specificity, Critical Illness, Respiration Failure
- Trial name
- NCT06333379
- Testing
- Compare the levels of Galactomannan (GM) levels in exhaled breath condensate (EBC) and BALF
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Lin Chen
Sepsis, Acute Respiratory Distress Syndrome
Study of Biomarkers in Patients of Sepsis Complicated With Acute Respiratory Distress Syndrome (ARDS)
1. Title: Study of Biomarkers in Blood and Alveolar Lavage Fluid Samples of Sepsis Patients Complicated With Acute Respiratory Distress Syndrome (ARDS) 2. Research center: Single-center study. 3.
- Trial name
- NCT04552821
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Tianjin Nankai Hospital
Invasive Pulmonary Aspergillosis
PCR for Aspergillus Fumigatus in Blood and Bronchoalveolar Lavage Fluid for Monitoring Cases of Invasive Aspergillosis: What is Its Prognostic Value
Aspergillus fumigatus PCR is currently used in conjunction with serum galactomannan to support the diagnosis of invasive aspergillosis or for monitoring at-risk patients not receiving antifungal prophylaxis.
- Trial name
- ASP (NCT07313527)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Lung Neoplasms, Tumor Immune Microenvironment
Association of BAL Fluid T-Cell Immune Activity With Tumor PD-L1 Expression and Its Prognostic Value: A Prospective Observational Study
This prospective observational study aims to evaluate whether immune profiles of T-cell subsets in bronchoalveolar lavage fluid can complement tumor PD-L1 expression, assessed by immunohistochemistry in tumor tissue specimens, in…
- Trial name
- NCT07331701
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Premature Infants, Respiratory Distress Syndrome
Cytokine Change in Bronchoalveolar Lavage Fluid After Early Budesonide-Surfactant Treatment in Premature Infants
Pulmonary inflammation plays an important role in the development of chronic lung disease (CLD) in preterm infants. This inflammation occurs very early in postnatal life.
- Conditions
- Premature Infants, Respiratory Distress Syndrome, Chronic Lung Disease, Bronchoalveolar Lavage Fluid
- Trial name
- NCT00146497
- Testing
- Budesonide-Surfactant
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Immunoglobulin A
Comparison of IgA Levels in the Bronchoalveolar Lavage Fluid of Patients With and Without Antibiotic Therapy
Investigators hypothesize that Immunoglobine (Ig) production is influenced by the microbiota of the gut. Investigators will compare microbiota-dependent Ig production in the bronchoalveolar lavage fluid of patients with and…
- Trial name
- NCT02912520
- Testing
- Anti-Bacterial Agents
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Rapid Detection, Pseudomonas Aeruginosa Infection
Rapid Detection of Pseudomonas Aeruginosa in Bronchoalveolar Lavage Fluid Using Label-free Single-particle Imaging Technology and Assessment of Post-treatment Efficacy in Patients With Pseudomonas Aeruginosa Infection
The aim of this study is to observe specimens of bronchoalveolar lavage fluid from patients using a reflection enhanced dark-field scattering microscopy.
- Trial name
- NCT06986512
- Testing
- bronchoscopy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
HIV, ICL
Tissue Biopsy and Imaging Studies in HIV-Infected Patients
This study will examine tissue from the tonsils, lymph nodes and large bowel of HIV-infected patients to investigate changes in viral load and certain white blood cells during treatment.
- Conditions
- HIV, ICL, Healthy Volunteers
- Trial name
- NCT00001471
- Where
- United States
- Volunteers
- 386 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Occupational Exposure
Bio Metrology of Nonfibrous Mineral Particles in Bronchoalveolar Lavage Fluids
The main purpose of this study is to update the pulmonary retention values of non-fibrous mineral particles in the general population.
- Trial name
- REACTIT (NCT03917485)
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal Creteil