Clinical trials: Brown Adipose Tissue, Human
Obesity, Abdominal
Nicotinamide Adenine Dinucleotide (NAD+) Metabolism in Human Brown Adipose Tissue
A fully functional brown fat helps maintain a healthy weight and decreases the risk of metabolic diseases such as type II diabetes (T2DM).
- Trial name
- BATNAD (NCT06627868)
- Testing
- NAD+ precursor
- Where
- Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Turku
Obesity and Overweight
Adaptation of Human Brown Adipose Tissue to Calorie Restriction
The BATON study investigates how human brown adipose tissue (BAT) adapts to a controlled caloric restriction diet in young adults with obesity.
- Trial name
- BATON (NCT06878989)
- Testing
- Caloric restriction diet, Weight maintenance diet
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Granada
Obesity
Secretin Activates Human Brown Fat and Induces Satiation.
15 healthy males will be studied with PET/CT, using FDG to investigate glucose metabolism, and radiowater to investigate perfusion.
- Trial name
- GUTBAT (NCT03290846)
- Testing
- Secretin Human, Saline Solution, Cold exposure
- Where
- Finland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Breast Cancer
The Effects of HER2 Receptor Signaling on Human Brown Fat Activity
The objective of this observational study is to investigate the significance of the HER2 receptor for brown fat activity in humans.
- Trial name
- HEAT (NCT06222957)
- Testing
- None (Observational study)
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mitochondrial Metabolism Disorders, Adipose Tissue, Brown
Human Brown Adipose Tissue and Mitochondrial Respiration
This study is focused on measuring mitochondrial activity of human brown adipose tissue. During surgery, adipose tissue biopsies from white and brown adipose tissue will be collected from the deep neck area.
- Conditions
- Mitochondrial Metabolism Disorders, Adipose Tissue, Brown, Aging, Obesity
- Trial name
- NCT03111719
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Maastricht University Medical Center
Regulation of Energy Expenditure
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1
Brown adipose tissue becomes activated during cold conditions to increase thermogenesis (i.e., energy expenditure). Topical menthol application increases resting energy expenditure but it is unclear whether brown adipose tissue…
- Trial name
- NCT07030725
- Testing
- Menthol Gel, Time control
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
Brown Adipose Tissue
Short Term Effect of Glucocorticoids on Brown Adipose Tissue Thermogenesis in Humans
Interventional, Placebo controlled cross-over study to investigate the short-term effects of glucocorticoids (prednisone) on human brown adipose tissue.
- Trial name
- GlucoBAT (NCT03269747)
- Testing
- Prednisone
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
Collection of Human Tissue Samples From the Neck Region for Characterization of Its Molecular and Biochemical Signatures
The purpose of the study is to gather tissue (from the neck region), specimens (blood and urine) and medical record data from many patients and store them in one place so that scientists have the information they need to conduct…
- Trial name
- Human BAT (NCT02274805)
- Testing
- Adults presenting for surgery in the neck area
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity
Activation of Cervical and Upper Thoracic Brown Adipose Tissue in Humans Via Beta-adrenergic Stimulation
In this study the investigators aim to quantitate the extent of cervical and upper thoracic brown adipose tissue (BAT) activation in lean and obese humans via positron emission tomography-computed tomography (PET-CT) in response…
- Trial name
- NCT01015794
- Testing
- ephedrine hydrochloride
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Endurance Training, No Training
Effect of Chronic Exercise on Human Thermogenic Adipose Tissue & Elucidation of Mechanisms
Physical exercise can stimulate heat production in our bodies. This is healthy because it burns sugar and fat. Heat production is influenced, among other things, by what is known as 'brown or beige adipose tissue', which is…
- Trial name
- ExBat (NCT07299604)
- Testing
- Endurance Training
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Healthy
Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study
Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance.
- Trial name
- MIBAT (NCT02682706)
- Where
- 2 sites in Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Thermogenesis
Beta 2 Adrenergic Stimulation vs Cold Exposure to Activate Human Brown Adipose Tissue
The purpose of the study is to asses brown adipose tissue activity in humans after intravenous administration of the selective beta-2-adrenergic agonist fenoterol as compared to the natural activator of brown adipose tissue, a…
- Trial name
- ASCENT (NCT05294965)
- Testing
- Fenoterol, Mild cold exposure
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Adipose Tissue, Brown, Insulin Resistance
Effect of Fluvastatin on Brown Fat Activity
The purpose of this study is to elucidate the effects of Fluvastatin on brown adipose tissue activity in humans.
- Conditions
- Adipose Tissue, Brown, Insulin Resistance, Clinical Trial
- Trial name
- FluvaBAT (NCT03189511)
- Testing
- Fluvastatin
- Where
- 2 sites in Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Brown Adipose Tissue (BAT) Physiology, Phenotyping
Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism
Background: The body uses energy from calories for basic functions like breathing and digesting food. Over time, when a person eats more calories than they burn, they may become overweight or obese.
- Conditions
- Brown Adipose Tissue (BAT) Physiology, Phenotyping, Brown Adipocytes
- Trial name
- NCT02692885
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Type 2 Diabetes Mellitus
Influence of Liraglutide, a GLP-1 Receptor Agonist, on Brown Adipose Tissue (BAT) Activity in Humans
The purpose of this study is to access liraglutide influence brown adipose tissue recruitment and its thermogenic effect through hypothalamic activation in obese individuals.
- Trial name
- i-LAB (NCT02718950)
- Testing
- Liraglutide 3.0 mg
- Volunteers
- 20 people
- Sponsor
- University of Campinas, Brazil
Obesity
Fasting Mimicking Diet and Beige/Brown Adipose Tissue in Humans
Obesity today has become one of the main public health concerns. As a consequence, different strategies have arisen to fight weight gain.
- Trial name
- NCT04385615
- Testing
- Fasting Mimicking Diet
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Obesity
Adenosine and A2A Receptors in Human Brown Adipose Tissue
This study investigates the significance of adenosine and A2A receptors in human brown adipose tissue (BAT) in vivo. Using positron emission tomography (PET), perfusion and the density of A2A receptors will be measured in…
- Trial name
- AdenoBAT (NCT03327168)
- Testing
- Adenosine, Cold exposure
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Brown Adipose Tissue
Effect of Glyceroltrinitrate on Human Energy Expenditure and Brown Adipose Tissue Thermogenesis
The aim of this study is to evaluate the efficacy of glyceroltrinitrate (Nitroderm® TTS) to activate and expand human BAT as compared to mild cold exposure.
- Trial name
- NEXT (NCT05711199)
- Testing
- Glyceroltrinitrat
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Adipose Tissue, Brown, Brown Adipose Tissue
Cold Induced Activation of Brown Adipose Tissue in Humans
This study investigates cold-induced brown fat activation assessed using PET/MR scans. Subjects will participate in an acute cooling intervention day and a thermoneutral intervention day with PET/MR scans on both days.
- Conditions
- Adipose Tissue, Brown, Brown Adipose Tissue, Brown Fat, Uncoupling Protein 1
- Trial name
- COLDBAT (NCT03096535)
- Testing
- Cooling, Thermoneutral
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Susanna Søberg
Obesity
The Incidence and Factors of Brown Adipose Tissue in Chinese
Previous studies have shown active brown adipose tissue (BAT) is present in adults and may play important roles in regulating energy homeostasis.
- Trial name
- NCT01381042
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Huashan Hospital