Clinical trials: Brown Adipose Tissue Activation
Obesity, Type 2 Diabetes Mellitus
Influence of Liraglutide, a GLP-1 Receptor Agonist, on Brown Adipose Tissue (BAT) Activity in Humans
The purpose of this study is to access liraglutide influence brown adipose tissue recruitment and its thermogenic effect through hypothalamic activation in obese individuals.
- Trial name
- i-LAB (NCT02718950)
- Testing
- Liraglutide 3.0 mg
- Volunteers
- 20 people
- Sponsor
- University of Campinas, Brazil
Atrial Fibrillation (AF)
Finerenone After Catheter Ablation to Reduce Atrial Fibrillation Recurrence
Atrial fibrillation (AF) is a common heart rhythm disorder associated with stroke, heart failure, and increased mortality. Catheter ablation with pulmonary vein isolation (PVI) is an effective rhythm-control strategy, but 20-30%…
- Trial name
- FINE-CA (NCT07799519)
- Testing
- Finerenone
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Childhood Obesity Prevention, Childhood Obesity
Postnatal Exercise to Activate Baby's Brown Fat
The purpose of this study is to learn how exercise and physical activity during pregnancy and after pregnancy may affect the composition of breastmilk.
- Conditions
- Childhood Obesity Prevention, Childhood Obesity, Physical Activity, Lactation
- Trial name
- PEABaBy (NCT07467694)
- Testing
- Active group
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Brown Adipose Tissue
Brown Adipose Tissue Activation and Energy Expenditure by Capsinoids Stimulation With Trimodality Imaging Using 18-FDG-PET, Fat Fraction MRI and Infrared Thermography
Brown adipose tissue (BAT) thermogenesis can be assessed by IR thermography, the accompanying increase metabolic rate can be measured by whole body calorimetry and BAT volume can be precisely measured by MRI.
- Trial name
- TACTICAL-II (NCT02964442)
- Testing
- Capsinoids, Cold Stimulus
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obesity
Brown Fat Activity and Bariatric Surgery
The mechanisms of bariatric surgery-induced weight loss go beyond reductions in calorie intake and may involve several other pathways. Recently, brown adipose tissue (BAT) has been added as another potential player.
- Trial name
- NCT03168009
- Testing
- Bariatric Surgery
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Energy Expenditure, Obesity
Brown Fat Activation and Browning Efficiency Augmented by Chronic Cold and Nutraceuticals for Brown Adipose Tissue-mediated Effect Against Metabolic Syndrome (BEACON BEAMS Study)
Our body fat (adipose tissue) is largely made up of white adipose tissue (WAT) that stores surplus energy as white fat depots. In addition, adult humans have another type of fat similar to the brown fat in babies that burns up…
- Conditions
- Energy Expenditure, Obesity, Brown Adipose Tissue
- Trial name
- NCT04595006
- Testing
- Cold Stimulation (CS), Browning Nutraceutical (BN), Cold Stimulation and Browning Nutraceutical (CSBN)
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Factors Affecting BAT Activation in PET/CT
Factors Affecting BAT Activation in PET/CT
The aim of the present study is to evaluate the factors affecting BAT activation in 18F-FDG-PET/CT in different tumours
- Trial name
- NCT05577299
- Testing
- PET/CT
- Volunteers
- 80 people
- Sponsor
- Assiut University
Adiposity, Metabolic Complication
Insight Into New Brown Adipose Tissue Activators.
The general purpose of the study was to provide new information about the role of macronutrients intake, metabolomics, proteomics and microRNA on BAT activation.
- Conditions
- Adiposity, Metabolic Complication, Metabolic Disturbance, Healthy
- Trial name
- NCT04787952
- Testing
- cold expossure
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Weight Loss
The Effects of Capsinoids on Brown Adipose Tissue Activation in Obesity
This research study is being done to determine whether taking a dietary supplement called capsinoids, derived from sweet peppers, can activate brown fat that is already present or even generate new brown fat in individuals with…
- Trial name
- BATCAP (NCT03110809)
- Testing
- Capsinoid
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hodgkins Lymphoma, Non-hodgkins Lymphoma
Brown Fat Activity and White Fat Accumulation
White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions.
- Trial name
- NCT01517581
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Children's Hospital Los Angeles
Thermogenesis
Beta 2 Adrenergic Stimulation vs Cold Exposure to Activate Human Brown Adipose Tissue
The purpose of the study is to asses brown adipose tissue activity in humans after intravenous administration of the selective beta-2-adrenergic agonist fenoterol as compared to the natural activator of brown adipose tissue, a…
- Trial name
- ASCENT (NCT05294965)
- Testing
- Fenoterol, Mild cold exposure
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity, Type 2 Diabetes Mellitus
Brown Adipose Tissue and Body Mass Index
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between…
- Trial name
- NCT02173834
- Testing
- 18F- fluorodeoxyglucose-positron emission tomography Computed Tomography scan and 123I-metaiodobenzylguanidine-single-photon emission computed tomography scan
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Obese, Metabolic Syndrome
Brown Fat Activation Study
This is an open lable, pilot study in which the investigator will research the effect of two FDA approved drugs, Mirabegron and Pioglitazone on fat tissue.
- Trial name
- NCT02919176
- Testing
- Mirabegron, Pioglitazone, Mirabegron and Pioglitazone
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Philip Kern
Obesity
Activation of Cervical and Upper Thoracic Brown Adipose Tissue in Humans Via Beta-adrenergic Stimulation
In this study the investigators aim to quantitate the extent of cervical and upper thoracic brown adipose tissue (BAT) activation in lean and obese humans via positron emission tomography-computed tomography (PET-CT) in response…
- Trial name
- NCT01015794
- Testing
- ephedrine hydrochloride
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Pheochromocytoma, Paraganglioma
The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue (aBAT) in Patients With Pheochromocytoma or Paraganglioma (PPGLs)
White adipose tissue (WAT) and brown adipose tissue (BAT) form the main adipose tissue subtypes in humans and several animals. BAT, owing to its unique metabolic function, has been of increased focus and interest in metabolic…
- Trial name
- NCT06440122
- Testing
- FDG-PET Scan
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- King's College Hospital NHS Trust
Type 2 Diabetes, Obesity
Activation of Brown Adipose Tissue Thermogenesis in Humans Using Formoterol Fumarate (GB10)
One emerging, highly modifiable homeostatic mechanism for energy expenditure in humans is brown adipose tissue (BAT) thermogenesis.
- Trial name
- GB10 (NCT05553184)
- Testing
- Formoterol Fumarate 12 micrograms Inhalation Powder, Nicotinic Acid 50 MG Oral Tablet, Acute Cold Exposure
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Caffeine-Induced Thermogenesis, Brown Adipose Tissue Activation
Caffeine-Induced Thermogenesis Assessed by Infrared Thermography
This study evaluated thermogenic and physiological responses to 200 mg of caffeine administered following a carbohydrate gel in healthy adults.
- Trial name
- NCT07868302
- Testing
- Carbohydrate Gel, Caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul Health and Technology University
Brown Fat
Efficacy of Pharmacological Stimulation of BAT and WAT in Lean and Obese Young Adults
To determine whether pharmacological stimulation of supraclavicular Brown Adipose Tissue (BAT or "Brown Fat") and subcutaneous White Adipose Tissue (WAT) using an FDA-approved beta3 agonist is as effective in increasing oxidative…
- Trial name
- MiraBAT (NCT02354807)
- Testing
- Mirabegron, Cold exposure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Otto Muzik
Insulin Sensitivity, Obesity
The Effect of Brown Adipose Tissue Activation on Insulin Sensitivity in Humans
Recent findings document the presence of active brown adipose tissue (BAT) in humans. Cold exposure via adrenergic stimulation activates BAT, which combusts significant amounts of blood glucose and free fatty acid (FFA) to…
- Trial name
- NCT01791114
- Testing
- Cold exposure, Cold exposure plus propranolol, Thermoneutral Conditions
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Tumour
Effect of Mirabegron on Promoting Brown Adipose Tissue Activation
In previous preclinical studies, our group found that Mirabegron, a clinical drug, could activate brown adipose tissue and inhibit tumor growth in tumour-bearing mice.Investigators look forward to further evaluating the effect of…
- Trial name
- NCT05779514
- Testing
- Mirabegron
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial People's Hospital