Clinical trials: Brown Fat
Obesity, Type 2 Diabetes
Cold Stress Stimulate the Browing of Subcutaneous White Adipose in Healthy Adults
Adipose tissues, which include white adipose tissue (WAT) and brown adipose tissue (BAT), play an essential role in regulating whole-body energy homeostasis.
- Trial name
- NCT02159144
- Testing
- cold stress
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da
Neonatal Hypothermia, Brown Adipose Tissue
Investigation of the Mechanisms of the Tendency to Hypothermia in Newborns and Premature Neonates
Newborns have thermoregulatory mechanisms that differ from those of adults. Instead of producing heat through shivering, newborns primarily rely on non-shivering thermogenesis by the brown adipose tissue.
- Conditions
- Neonatal Hypothermia, Brown Adipose Tissue, Preterm and Term Infants, Neonate
- Trial name
- NCT06803069
- Where
- 2 sites in Hungary
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Brown Adipose Tissue, Cold Exposure
Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia
This clinical trial explores how repeated short-term cold exposure impacts the molecular and physiological function of brown adipose tissue (BAT), a thermogenic organ associated with improved cardiometabolic health.
- Conditions
- Brown Adipose Tissue, Cold Exposure, 18F-FDG PET/CT
- Trial name
- ICEBATH (NCT07048405)
- Testing
- Cooling, Biopsies, Injection of 18F-FDG
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Obesity
Food Intake, Endocrine Factors and Brown Fat
This study will investigate how the acute intake of foods with high and low hedonic reward differentially affects brown adipose tissue and the interplay between gut peptides, brown fat, and the brain (gut-BAT-brain axis).
- Trial name
- FoodBAT (NCT06285461)
- Testing
- Non-palatable meal, Palatable meal
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Obesity
Exenatide and Brown Adipose Tissue
The obesity epidemic has led to a enormous increase in the prevalence of type 2 diabetes mellitus (T2D), dyslipidemia and cardiovascular events.
- Trial name
- exe01 (NCT03002675)
- Testing
- Bydureon
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Brown Adipose Tissue, Body Composition
Measurement of Body Fat in Infants
Up to 10 infants will complete the study aimed to establish a technique for measuring whole body adiposity and brown adipose tissue in infant subjects using dual energy x-ray absorptiometry and magnetic resonance imaging…
- Trial name
- Baby Fat Pilot (NCT03490227)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Type 2 Diabetes
Activation of Brown Adipose Tissue Metabolism Using Mirabegron
Could sympathomimetics and sympatholytics drugs safe for the management of Type 2 Diabetes (T2D)? Based on recent evidence, we propose that pharmacological stimulation of Beta-3 adrenergic receptor (ADBR3) at higher doses of…
- Trial name
- GB9 (NCT04823442)
- Testing
- Mirabegron, Bisoprolol Fumarate
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Diabetes, Hypothyroidism
Thyroid Study Type 2 Diabetes Mellitus (T2DM)
Background of the study: Thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are known to promote weight loss, which could be beneficial for treating obesity, and type 2 diabetes.
- Trial name
- NCT01379170
- Testing
- Euthyrox (levothyroxine)
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Brown Adipose Tissue
Effect of Glyceroltrinitrate on Human Energy Expenditure and Brown Adipose Tissue Thermogenesis
The aim of this study is to evaluate the efficacy of glyceroltrinitrate (Nitroderm® TTS) to activate and expand human BAT as compared to mild cold exposure.
- Trial name
- NEXT (NCT05711199)
- Testing
- Glyceroltrinitrat
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
STAGES Trial: Study of Adiposity, Growth and Endocrine Stages
The investigators propose to conduct a cross-sectional study of 60 participants who are 18-30 years of age to undergo research PET/CT.
- Trial name
- STAGES (NCT01460784)
- Where
- United States
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- University of Utah
Brown Adipose Tissue (BAT) Physiology, Cold Exposure
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
- Trial name
- ACROBAT (NCT06978777)
- Testing
- Caffeine (200 mg)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cachexia, Neoplasms
Brown Adipose Tissue Activity and Energy Metabolism in Cachexia
To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.
- Conditions
- Cachexia, Neoplasms, Pulmonary Disease, Chronic Obstructive, Pancreatic Neoplasms
- Trial name
- BAT-Cachexia (NCT02500004)
- Testing
- 18F-FDG PET-MRI-imaging, DXA scanning, Abdominal subcutaneous adipose tissue biopsy
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study
Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance.
- Trial name
- MIBAT (NCT02682706)
- Where
- 2 sites in Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
Longitudinal Follow-up of Brown Adipose Tissue Function and Structure
In Turku PET Centre, there have been 3 positron emission tomography studies on brown adipose tissue (BAT) activity in healthy adults. BATPET was performed between 2008 and 2009.
- Trial name
- BATFollowUp (NCT01985503)
- Where
- Finland
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cold Exposure
Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure
This clinical trial will assess the whether fish oil supplementation can modulate brown fat activation, shivering, thermal comfort and skin blood flow during cold exposure.
- Trial name
- NCT05822141
- Testing
- Fish Oil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Brown Adipose Tissue
Brown Adipose Tissue Activation and Energy Expenditure by Capsinoids Stimulation With Trimodality Imaging Using 18-FDG-PET, Fat Fraction MRI and Infrared Thermography
Brown adipose tissue (BAT) thermogenesis can be assessed by IR thermography, the accompanying increase metabolic rate can be measured by whole body calorimetry and BAT volume can be precisely measured by MRI.
- Trial name
- TACTICAL-II (NCT02964442)
- Testing
- Capsinoids, Cold Stimulus
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obesity
Cold Acclimation as a Modulator of Brown Adipose Tissue Function in Adults With Obesity
This study will investigate the effects of at least 12 weeks of weekly cold water immersions (water temperature 18ºC) on BAT perfusion in individuals with obesity.
- Trial name
- MOTORBAT (NCT05468151)
- Testing
- Cold acclimation, Intervention Control group - volunteers with obesity, Acute cold exposure
- Where
- Finland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Type 2 Diabetes, Obesity
Enhancement of Brown Adipose Tissue Function Via Chronic Pharmacological Treatment
Obesity is epidemic in Australia, and current preventative strategies have had limited success in alleviating this health crisis.
- Conditions
- Type 2 Diabetes, Obesity, Cardiovascular Disease
- Trial name
- NCT02236962
- Testing
- Ephedrine, pioglitazone
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Type 2 Diabetes
Brown Adipose Tissue Metabolism in Type 2 Diabetes
Activation of brown adipose tissue (BAT) by cold exposure. BAT thermogenesis and BAT volume of metabolic activity will be assessed by Positron-Emitting-Tomography (PET/CT) and MRI/MRS imaging and new pharmacological methods to…
- Trial name
- GB8 (NCT05092945)
- Testing
- Cold exposure, Oral Nicotinic acid
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Healthy
Inuit and Cold Exposure
Brown adipose tissue (BAT) produces heat through non-shivering thermogenesis. It is activated by cold exposure, and when activated it utilizes fatty acids and glucose in order to produce heat.
- Trial name
- ICE (NCT05884177)
- Testing
- Short-term cold exposure
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stig Andersen