Clinical trials: Brown Fat
Physical Activity
Brown Adipose Tissue Activation: Effect of Exercise Training and Irisin
This study investigates the brown adipose tissue (BAT) activation and metabolism using positron emission tomography (PET) imaging before and after exercise training intervention at fasting state under normal room temperature and…
- Trial name
- EXEBAT (NCT03359824)
- Testing
- Exercise
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Thermogenesis
Beta 2 Adrenergic Stimulation vs Cold Exposure to Activate Human Brown Adipose Tissue
The purpose of the study is to asses brown adipose tissue activity in humans after intravenous administration of the selective beta-2-adrenergic agonist fenoterol as compared to the natural activator of brown adipose tissue, a…
- Trial name
- ASCENT (NCT05294965)
- Testing
- Fenoterol, Mild cold exposure
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Diet-induced Thermogenesis, Brown Adipose Tissue Activation
Creatine Effect on Brown Adipose Tissue Activation
Pre-clinical studies indicate that creatine may play a substantial role in diet-induced thermogenesis and may have a profound effect on energy balance.
- Trial name
- CreaBAT (NCT04086381)
- Testing
- Creatine monohydrate
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Adipose Tissue, Brown, Brown Adipose Tissue
Cold Induced Activation of Brown Adipose Tissue in Humans
This study investigates cold-induced brown fat activation assessed using PET/MR scans. Subjects will participate in an acute cooling intervention day and a thermoneutral intervention day with PET/MR scans on both days.
- Conditions
- Adipose Tissue, Brown, Brown Adipose Tissue, Brown Fat, Uncoupling Protein 1
- Trial name
- COLDBAT (NCT03096535)
- Testing
- Cooling, Thermoneutral
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Susanna Søberg
Metabolic Diseases
Investigating Brown Adipose Tissue Activation in Humans
The purpose of this study is to determine what can activate brown adipose tissue (BAT).
- Trial name
- NCT01935791
- Testing
- Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT Vehicle, Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT Glucagon, Period 1 Visit 1 - Cold PET-CT Vehicle, no visit 2 as BAT negative
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Brown Adipose Tissue
The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
This study seeks to assess a novel imaging technique to image brown adipose tissue utilizing the norepinephrine transporter.
- Trial name
- NCT02038595
- Testing
- PET imaging
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity
Mirabegron and Brown Adipose Tissue
Obesity and type 2 diabetes (T2D) are emerging problems worldwide. In particular South Asian individuals (representing 20% of the world population) have an increased risk of obesity and related disorders.
- Trial name
- Mirab (NCT03012113)
- Testing
- Mirabegron, Short term mild cooling
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Gilbert Syndrome
Brown Adipose Tissue Activity in Gilbert's Syndrome
The goal of this case-control study is to investigate energy metabolism and brown adipose tissue (BAT) activity in individuals with Gilbert's syndrome (GS) and controls. The main focus of the study is to analyze: 1.
- Trial name
- NCT06336369
- Testing
- analyzing brown adipose tissue, body composition and metabolic health
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity
Dopaminergic Effects on Brown Adipose Tissue
In this study the investigators will investigate the effect of dopamine (bromocriptine) on Brown Adipose Tissue in lean, young, healthy males.
- Trial name
- DEBAT (NCT02428933)
- Testing
- Bromocriptine
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Obesity
Activation of Cervical and Upper Thoracic Brown Adipose Tissue in Humans Via Beta-adrenergic Stimulation
In this study the investigators aim to quantitate the extent of cervical and upper thoracic brown adipose tissue (BAT) activation in lean and obese humans via positron emission tomography-computed tomography (PET-CT) in response…
- Trial name
- NCT01015794
- Testing
- ephedrine hydrochloride
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Diabetes, Brown Adipose Tissue
Brown Fat as Therapeutic Strategy for Obesity and Associated Metabolic Diseases Via Functional Food/Nutraceutical Approach - Molecular Mechanisms of Pentacyclic Triterpenes (BRACE)
To examine MA (Maslinic Acid) safety and efficacy in ameliorating insulin resistance and the cardinal features of metabolic syndrome.
- Trial name
- NCT06484543
- Testing
- Maslinic Acid
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Brown Adipose Tissue (BAT) Physiology, Phenotyping
Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism
Background: The body uses energy from calories for basic functions like breathing and digesting food. Over time, when a person eats more calories than they burn, they may become overweight or obese.
- Conditions
- Brown Adipose Tissue (BAT) Physiology, Phenotyping, Brown Adipocytes
- Trial name
- NCT02692885
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type2 Diabetes, Obesity
Glucose Metabolism in Brown Adipose Tissue (BAT) in Young Healthy Men Evaluated by Deuterium Metabolic Imaging (DMI)
In this study the investigators wish to evaluate the glucose metabolism in brown adipose tissue (BAT) in young healthy men (aged 18-35).
- Conditions
- Type2 Diabetes, Obesity, Metabolic Syndrome
- Trial name
- NCT04060745
- Testing
- cooling using a water-perfused vest, thermoneutrality
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Type 2 Diabetes Mellitus
Brown Adipose Tissue and Body Mass Index
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between…
- Trial name
- NCT02173834
- Testing
- 18F- fluorodeoxyglucose-positron emission tomography Computed Tomography scan and 123I-metaiodobenzylguanidine-single-photon emission computed tomography scan
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Brown Adipose Tissue
Vitamin A in Brown Fat Activity
Vitamin A metabolites (retinoids) have shown to activate brown fat function in preclinical studies, however the role of retinoids in human brown fat physiology and energy metabolism remains elusive.
- Trial name
- NCT02381483
- Testing
- Cold exposure
- Where
- Austria
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity, Diabetes Mellitus
Activating Brown Adipose Tissue Through Exercise
The energy burning capacity of brown adipose tissue makes it an attractive target for anti-obesity therapies. Sympathetic nervous system (SNS) is the classical regulator of brown adipose tissue; however, recent findings show a…
- Conditions
- Obesity, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- ACTIBATE (NCT02365129)
- Testing
- Exercise training based on recommendations for adults (WHO)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Obesity, Atherosclerosis
Observational Study of Early Metabolic and Vascular Changes in Obesity
To work against the increasing burden of obesity, the STYJOBS / EDECTA (STYrian Juvenile OBesity Study / Early DetECtion of Atherosclerosis) project was started at the Medical University of Graz in 2003.
- Conditions
- Obesity, Atherosclerosis, Inflammation, Adiponectin Deficiency
- Trial name
- STYJOBS (NCT00482924)
- Testing
- Lifestyle intervention
- Where
- Austria
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Childhood Obesity Prevention, Childhood Obesity
Postnatal Exercise to Activate Baby's Brown Fat
The purpose of this study is to learn how exercise and physical activity during pregnancy and after pregnancy may affect the composition of breastmilk.
- Conditions
- Childhood Obesity Prevention, Childhood Obesity, Physical Activity, Lactation
- Trial name
- PEABaBy (NCT07467694)
- Testing
- Active group
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Obesity
Fasting Mimicking Diet and Beige/Brown Adipose Tissue in Humans
Obesity today has become one of the main public health concerns. As a consequence, different strategies have arisen to fight weight gain.
- Trial name
- NCT04385615
- Testing
- Fasting Mimicking Diet
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil