Clinical trials: Buprenorphine
Opioid-use Disorder, Contraception
Averting NAS Among Opioid-Using Young Women Receiving MAT Using Buprenorphine
The primary objective of this study is to test the efficacy of a Motivational Interviewing and Educational Training intervention with immediate linkage to long acting reversible contraception (LARC) (hereafter known as MIET).
- Conditions
- Opioid-use Disorder, Contraception, Neonatal Abstinence Syndrome
- Trial name
- NAS-MIET (NCT04611659)
- Testing
- Motivational Interviewing and Educational Training (MIET)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Meharry Medical College
Opioid-use Disorder, Medication Adherence
CoMBAT Opioid Use Disorder: A Combined Medication and Behavioral Activation Treatment for People Living With Opioid Use Disorder
This study seeks primarily to test, in a two-arm randomized controlled trial (RCT), the feasibility, acceptability, and preliminary efficacy of CoMBAT OUD, an intervention that integrates Behavioral Activation (BA) and substance…
- Conditions
- Opioid-use Disorder, Medication Adherence, Health Care Utilization
- Trial name
- CoMBAT_OUD (NCT04240093)
- Testing
- Behavioral Activation (BA) Therapy, Substance Abuse and Health Navigation Counseling, Medications for Opioid Use Disorder
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Brown University
Back Pain Lower Back Chronic, Chronic Pain
True Functional Restoration and Analgesia in Non-Radicular Low Back Pain
To study the response of objective and quasi-objective 'True' functional outcomes, analgesia and safety in chronic non-radicular back pain to buprenorphine buccal film (BBF) using a small 'n' phase IV design.
- Trial name
- NCT05419297
- Testing
- Buprenorphine Buccal Film [Belbuca], Urine Drug Screening, actigraph
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Carolinas Pain Institute
Opioid-Related Disorders, Pregnancy
Opioid Dependence Treatment Therapies in Pregnancy
The incidence of opioid dependence in pregnancy increased over the last decade from 1.2 to 5.8 per 1,000 hospital births per year.1 While methadone is the current, standard treatment for opioid dependent (OD) pregnant women…
- Trial name
- NCT03098407
- Testing
- Buprenorphine, Methadone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Opioid-use Disorder
CBT4CBT-Buprenorphine + Recovery Coach for Office-based Buprenorphine
To conduct an 8-week pilot, randomized trial evaluating the feasibility, acceptability, and efficacy of an integrated intervention involving CBT4CBT-Buprenorphine + Recovery Coach in a population of 60 individuals who meet…
- Trial name
- NCT04824404
- Testing
- CBT4CBT-Buprenorphine + Recovery Coach
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Healthy
A Single-Dose Study of an Investigational Capsule Formulation of 2 mg/0.5 mg Buprenorphine/Naloxone
A single-dose pilot study of an investigational capsule formulation of 2 mg/.05 mg Buprenorphine/Naloxone. NIDA Contract No. HHSN271200577414C
- Trial name
- NCT00880841
- Testing
- Buprenorphine / Naloxone
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- NanoSHIFT LLC
Healthy
Buprenorphine Disposition and CYP3A
To evaluate role of CYP3A in buprenorphine disposition and effect
- Trial name
- NCT01576575
- Testing
- Buprenorphine Control, Buprenorphine + Rifampin, Buprenorphine + Grapefruit juice
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Opioid-use Disorder
Feasibility of Pediatric Emergency Department-Initiated Treatment for Adolescents With Opioid Use Disorder
ED-initiated buprenorphine with brief intervention and facilitated referral to treatment has been shown to be highly successful in increasing treatment engagement rates and reducing opioid use among adults.
- Trial name
- PEDsTREATOUD (NCT04737603)
- Testing
- ED-Initiated treatment with buprenorphine / naloxone
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Davis
Opioid-use Disorder
Buprenorphine as Adjunct to Outpatient Induction Onto Vivitrol
The study will enroll 30 opioid-dependent participants into an open-label pilot outpatient study of methods to facilitate induction and stabilization onto XR-NTX.
- Trial name
- NCT03113409
- Testing
- Buprenorphine, Naltrexone, Vivitrol
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Healthy, Opioid Use
Buprenorphine-Fentanyl Interaction Study
An increase in overdose deaths has been attributed to widespread access to fentanyl and carfentanyl. The study is designed to determine if buprenorphine can change the respiratory depression response to intravenous (IV) fentanyl.
- Trial name
- NCT03747341
- Testing
- Buprenorphine Injectable Solution - Part A, Fentanyl - Part A, Ondansetron - Parts A + B
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.
Healthy Volunteers
The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) on QT Intervals in Healthy Volunteers
The purpose of this study is to examine the effect of buprenorphine on QT interval corrected for heart rate (QTc) in healthy subjects.
- Trial name
- NCT01148537
- Testing
- Buprenorphine transdermal patch, Avelox (moxifloxacin hydrochloride) tablet
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Purdue Pharma LP
Pain
Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine
Tissue injury is associated with pain from the injured site (primary hyperalgesia) and pain from non-injured tissue in the vicinity of the trauma (secondary hyperalgesia).
- Trial name
- PASORII (NCT01296334)
- Testing
- morphine LO, Morphine Hi, Buprenorphine LO
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- mads u werner
Analgesia, Abuse Opioids
Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia
The goal of this study is to compare the abuse potential of low-dose equianalgesic buccal buprenorphine to a commonly used full mu opioid receptor (MOR) agonist in a highly controlled experimental setting.
- Conditions
- Analgesia, Abuse Opioids, Pain
- Trial name
- NCT05988710
- Testing
- Buccal Buprenorphine 300 mcg, Buccal Buprenorphine 600 mcg, Buccal Buprenorphine 900 mcg
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pain, Pharmacokinetics
Clinical Study in Healthy Men to Investigate the Uptake of Buprenorphine and Its Elimination From the Body After Dermal Application as Patches for 96 Hours and for 72 Hours
The purpose of the study was to investigate the pharmacokinetics (i.e. the uptake, distribution and elimination from the body) of dermally applied buprenorphine during and after different application periods, i.e., a 96-hour and…
- Trial name
- NCT03770234
- Testing
- Transtec 35 µg/hour transdermal patch
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Opioid-use Disorder, Pain, Acute
Effect of Buprenorphine/Naloxone Continuation on Pain Control and Opioid Use
The aim of this study is to determine the effect of continuation of buprenorphine/naloxone in patients with history of Opioid Use Disorder (OUD) scheduled for surgery compared to reduced dose buprenorphine/naloxone prior to…
- Conditions
- Opioid-use Disorder, Pain, Acute, Surgery
- Trial name
- NCT03266445
- Testing
- buprenorphine/naloxone
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Tobacco Dependence
Tobacco Intervention in Buprenorphine Treatment
Drug addiction treatment patients, including those in treatment for opioid dependence, have a high rate of tobacco dependence, especially cigarette smoking.
- Trial name
- IBIS (NCT01350011)
- Testing
- Innovative System, Standard Treatment Control (STC)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Opioid Abuse and Addiction
Innovatively Increasing PCP Prescribing of Buprenorphine: Measurement Based Care and Integrated Electronic Solution
The objective of this observational feasibility project is to assess the feasibility and acceptability of universal screening and measurement based care for opioid use disorder (OUD) utilizing a computer software program in a…
- Trial name
- MBC4OUD (NCT04059016)
- Testing
- MBC4OUD
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
HIV Infection, HIV Infections
Buprenorphine/Raltegravir Pharmacokinetic Interaction Study
The main purpose of this protocol is to study the effect of an HIV medication known as Raltegravir on Buprenorphine in people who have been receiving the same dose of Buprenorphine for at least 3 weeks before study entry.
- Trial name
- NCT00858962
- Testing
- Raltegravir
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Withdrawal, Chronic Pain
ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid…
- Trial name
- ACTION (NCT06442566)
- Testing
- Buprenorphine Patch, Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Opioid Use Disorder, Peer Recovery Supporters
Peer Recovery Support for Opioid Use Disorder Treatment Retention
The goal of this clinical trial is to learn whether adding peer recovery support services to standard opioid use disorder (OUD) treatment in primary care helps patients stay in treatment longer.
- Conditions
- Opioid Use Disorder, Peer Recovery Supporters, Peer Recovery Coaching, Primary Care
- Trial name
- NCT07620171
- Testing
- Peer Support
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania