Clinical trials: Burn Injuries, active
Burn Scar
Microneedling for Burn Hypertrophic Scars
Approximately 33 to 91% of severe burn victims will develop hypertrophic scars. Hypertrophic scars are defined as erythematous (red), raised and rigid scars that can cause pain and itching, among other things.
- Trial name
- NCT05423613
- Testing
- Microneedling
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Burn Injury
Non-Invasive Vagus Nerve Stimulation in Burn Patients During Dressing
This study will evaluate the effects of non-invasive vagus nerve stimulation on pain, anxiety, and quality of life in burn patients during the dressing process. Participants will be randomly assigned to one of three groups.
- Trial name
- NCT07566910
- Testing
- Non-Invasive Vagus Nerve Stimulation, Standard Dressing Care
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Fenerbahce University
Severe Burns
Effect of Early Dexamethasone on Major Complications and All-cause Mortality in Severe Burns
Burns affect more than 11 million people worldwide each year. These injuries are responsible for severe morbidity resulting in a high societal burden and account for more than 180,000 yearly deaths especially in low- and…
- Trial name
- DEXA-BURN (NCT06968559)
- Testing
- Dexamethasone
- Where
- 10 sites in France
- Volunteers
- 478 people
- Sponsor
- Nantes University Hospital
Autologous Fat Grafting, Burn
Autologous Fat Grafting in Upper Limb Burns Scars
Burn injuries are a complex form of trauma with a high risk of complications. When they affect the upper limbs, patients often develop functional contractures and/or pathological scars that significantly impair mobility, quality…
- Conditions
- Autologous Fat Grafting, Burn, Corticosteroid Injection
- Trial name
- BURNSCARCARE (NCT07186322)
- Testing
- Fat Graft
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Hypertrophic Scars, Post-burn Scars
Nano-Fat Grafting for Post-Burn Scars on the Chest, Shoulders, and Back
This study aims to evaluate the effectiveness of nano-fat grafting in treating hypertrophic scars caused by burns on the chest, shoulders, and back.
- Conditions
- Hypertrophic Scars, Post-burn Scars, Burns
- Trial name
- NCT07557472
- Testing
- Autologous Nano-Fat Grafting
- Volunteers
- 55 people
- Sponsor
- Assiut University
Unintentional Burn Injury, Depression
Integrated Case Management for Burns Care in Pakistan
To test whether a culturally adapted multicomponent intervention for improving burns care and patient/family rehabilitation is effective in improving survival among burn victims in Pakistan and is cost-effective.
- Conditions
- Unintentional Burn Injury, Depression, Anxiety, Burns
- Trial name
- BURNS (NCT06559501)
- Testing
- Integrated case manager care
- Where
- 11 sites in Pakistan
- Volunteers
- 1,045 people
- Sponsor
- Pakistan Institute of Living and Learning
Peer Bullying Intervention, Vodcast
Early Detection and Kinetics of Sepsis-Induced Coagulopathy in Severe Burn Patients
The purpose of this study is to evaluate the impact of an avatar-supported, teacher-student interactive, vodcast-based peer bullying prevention program-developed for adolescents-on students' ability to identify peer bullying…
- Conditions
- Peer Bullying Intervention, Vodcast, Students
- Trial name
- SIC-BURN-JAAM2 (NCT07905807)
- Testing
- Vodcast-Based Peer Bullying Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Burn, 3D Printing
Clinical Effectiveness of a Patient-tailored Orthosis Based on 3-dimensional (3D) Scanner Modeling and 3D Printing Technology for Microstomia Caused by Burns : Pilot Study
Mircostomia is not clearly defined in terms of size, but is diagnosed when it causes difficulty in eating, pronounciation, or maintaining oral hygiene.
- Conditions
- Burn, 3D Printing, Microstomia, Split Thickness Skin Graft
- Trial name
- NCT07264218
- Testing
- patient's tailored mouthpiece fitting
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Hangang Sacred Heart Hospital
Burns, Wound Heal
Microsurfaced Grafts in Deep Burn Wounds
This study is designed as a prospective, randomized, within subject controlled design to evaluate the effectiveness of Microsurfaced vs Control cadaveric grafts for coverage of acute deep-partial or full-thickness burn wounds to…
- Trial name
- NCT04589442
- Testing
- Split thickness skin graft, microsurfaced split thickness skin graft
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- CellTherX
Wound of Skin, Burns
Pilot Study: KeraStat® Gel for Topical Delivery of Morphine for Management of Non-Healing, Painful Open Wounds and Ulcers
This study is intended to provide information from subjects who currently have painful, chronically open wounds and assess the pain reduction capacity of KeraStat® Gel with Morphine.
- Trial name
- NCT05217160
- Testing
- KeraStat® Gel with Morphine application, KeraStat® Gel application
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The Metis Foundation
Smoking ( Cigarette), Smoking (Tobacco) Addiction
Smoking Cessation With Wearables to Improve General, Oral Health and Quality of Life
Tobacco smoking remains one of the leading preventable causes of disease, disability, and premature death worldwide. According to the World Health Organization, tobacco use is responsible for more than eight million deaths each…
- Conditions
- Smoking ( Cigarette), Smoking (Tobacco) Addiction, Smoking Behaviors, Smoking Cessation
- Trial name
- Wear-Smile (NCT07593742)
- Testing
- Telemedicine-Based Smoking Cessation Program, Conventional Smoking Cessation Behavioral Program
- Volunteers
- 102 people
- Sponsor
- University of Salerno
Thermal Burn, Amitriptyline
Pilot Studies Blocking Injury-Induced MVP Release in Skin Using Topical Amitriptyline
The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). Studies suggest these MVP are involved in many conditions such as after the thermal burn injury.
- Trial name
- NCT07716722
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wright State University
Burns
Phase 2 Pilot Study of the Safety and Efficacy of Topical MW-III in Thermal Burns
To compare MW-III to Silvadene® Cream 1% (Silver Sulfadiazine) with respect to "time to healing" (≥95% re-epithelialization) of a partial thickness target thermal burn.
- Trial name
- NCT01297400
- Testing
- Investigational Drug, MW-III, Silvadene® Cream 1% [Silver Sulfadiazine]
- Where
- 6 sites in United States, Mexico
- Volunteers
- 60 people
- Sponsor
- Skingenix, Inc.
Burn Scar
Scar Management Through Serial Casting
Scar management remains one of the major clinical challenges for burn survivors with hypertrophic scars. Beyond their visible appearance, hypertrophic scars can significantly impair physical function, reduce life satisfaction…
- Trial name
- NCT07645664
- Testing
- Serial casted scar
- Volunteers
- 38 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Romberg Disease, Craniofacial Microsomia
Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting
The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting…
- Conditions
- Romberg Disease, Craniofacial Microsomia, Burn Scar, Post-Traumatic Scar (Disorder)
- Trial name
- NCT05610878
- Testing
- Cultured ASCs enrichment fat grafting, Curcumin-preconditioned ASCs enrichment fat grafting, Conventional fat grafting
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- University of the Punjab
Experiences, Burn
Patients´ Experiences of Calorimetry Measurements
A severe burn injury affects not only the skin but also how the body uses energy. Many patients have increased energy needs during recovery, and healthcare professionals use a method called indirect calorimetry to measure the…
- Conditions
- Experiences, Burn, Calorimetry, Indirect
- Trial name
- NCT07839468
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University Hospital
Neuropathy, Burn
Efficacy of Hydrotherapy on Balance in Neuropathic Patients Post-Burn
Balance problems are common among neuropathic patients following burns, primarily due to sensory and motor impairments.The goal of the study is to investigate the effect of a hydrotherapy program on balance in neuropathic…
- Trial name
- NCT06862635
- Testing
- Hydrotherapy, traditional land-based balance exercises
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- MTI University
Burns Surgery
Antibioprophylaxis for Excision-graft Surgery in Burn Patient (A2B-TRIAL)
The indication of antibiotic prophylaxis in burn patients remains highly controversial and hasn't reached a consensus. The objective of antibiotic prophylaxis would be to reduce the risk of post-operative local and systemic…
- Trial name
- A2B (NCT04292054)
- Testing
- active intervention
- Where
- France
- Volunteers
- 506 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Burns, Acute Pain
VR-PAT During Home Burn Dressings - Multisite
This study will evaluate the effectiveness of smartphone Virtual Reality Pain Alleviation Therapy (VR-PAT) as a pain distraction tool during repeated at-home burn dressing changes among 100 children (age 6-17 years) with a burn…
- Conditions
- Burns, Acute Pain, Procedural Pain, Injuries
- Trial name
- NCT05673551
- Testing
- VR-PAT
- Where
- 2 sites in United States
- Volunteers
- 220 people
- Sponsor
- Nationwide Children's Hospital
Burn, Hypertrophic Scars
Carbon Dioxide Laser-Assisted Delivery of Triamcinolone With or Without 5-Fluorouracil for Hypertrophic Burn Scars
Burn scars can sometimes heal in a way that causes them to become thick, raised, and stiff. These scars may itch, feel uncomfortable, limit movement, and affect how the skin looks.
- Conditions
- Burn, Hypertrophic Scars, Scar Improvement by Laser, CO2 Laser in Scars
- Trial name
- NCT07660120
- Testing
- Fractional Ablative CO₂ Laser, Triamcinolone Acetonide, Fluorouracil (5-FU)
- Volunteers
- 65 people
- Sponsor
- University of California, Davis