Clinical trials: Burn Injury
Burns
A Between Patient Study of Plurogel® Compared to Standard Topical Dressing in Burn Injuries
Burn injuries can result in long term physical and mental sequelae, not only from the scarring but also the painful dressings. The standard of care today remains use of antibiotic topical dressings while awaiting demarcation of…
- Trial name
- NCT05000983
- Testing
- PluroGel, Standard dressing
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Manitoba
Wounds and Injuries
Acute Partial Thickness Burn Study Comparing Transforming Powder Dressing to Standard of Care Dressing
This study is being performed to assess the effectiveness of Altrazeal(R) Transforming Powder Dressing (TPD) in patients with partial thickness burns compared to the current standard of care (SOC) dressing.
- Trial name
- NCT05424354
- Testing
- Altrazeal (R) Transforming Powder Dressing, Standard of Care burn dressing
- Where
- 6 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ULURU Inc.
Burn Wound
Fluorescence-based Detection of Inflammation and Necrosis to Inform Surgical Decision-making and Enhance Outcomes
This study investigates fluorescence image-guided surgery to allow precise identification of necrotic tissue both preoperatively and intraoperatively in burn patients.
- Trial name
- NCT05593523
- Testing
- Indocyanine green (ICG), Clinical Fluorescence Imaging Device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Burns, Wound Infection
Topical Methylene Blue-Photodynamic Therapy (MB-PDT) for Burn Wound Infection
Burn wound infections remain a major source of morbidity in patients with thermal injuries and contribute to delayed healing, graft loss, and prolonged hospitalization.
- Trial name
- NCT07494773
- Testing
- Methylene Blue, Blue Light Illumination
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Healthy Subjects
Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn Injury
In several rodent studies, it has been demonstrated that very high doses of opioid antagonists (i.e., naloxone 3-10 mg/kg) administered after weeks after recovery from an inflammatory injury may lead to a reinstatement of…
- Trial name
- TCI-NX-BI (NCT02684669)
- Testing
- Naloxone, Normal saline
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- mads u werner
Hand Injuries
Effects of Virtual Reality Based Rehabilitation on Burned Hands
Hands are the most frequent injury sites caused by burn, and appropriate rehabilitation is essential to ensure that good functional recovery is achieved.
- Trial name
- NCT03865641
- Testing
- Virtual reality rehabilitation
- Where
- South Korea
- Volunteers
- 57 people
- Sponsor
- Hangang Sacred Heart Hospital
Burns
Calisthenics Exercise and Electromagnetic Therapy on Liver Function Following Burn Injuries.
Serum concentrations of alanine transaminase (ALT) and aspartate transaminase (AST) significantly increased immediately upon burn trauma and remained significantly elevated for about three years.
- Trial name
- NCT06138886
- Testing
- Pulsed electromagnetic therapy, calisthenics exercises
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Tranexamic Acid, Burns
TRANexamic Acid to Reduce Bleeding in BURN Surgery
Excision and grafting in burn patients can lead to severe blood loss. A preliminary study conducted in Saint Joseph Saint Luc Hospital showed that the total median blood loss was 1412 mL (1).
- Conditions
- Tranexamic Acid, Burns, Surgery, Wounds and Injuries
- Trial name
- TRANBURN (NCT03113253)
- Testing
- Tranexamic Acid
- Where
- 4 sites in France
- Volunteers
- 121 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Hyperalgesia
The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers
Treatment of chronic pain is a major clinical challenge since chronic pain is frequent and leads to deterioration of quality of life.
- Trial name
- RemiSun 1 (NCT00811837)
- Testing
- Midazolam, Remifentanil
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Burns
Education Program for Burn Patients
The purpose of this study is to assess the effect of an educative program including telephone follow-up for burn patients regarding the impact of this intervention on the health status and return to work at six months after…
- Trial name
- NCT01379495
- Testing
- educational program+telephone follow up
- Where
- Brazil
- Volunteers
- 83 people
- Sponsor
- University of Sao Paulo
Hypertrophic Scar
Use of Autologous Platelet-Rich Plasma to Treat Hypertrophic Burn Scars
Hypertrophic burn scars are experienced by more than 70% of burn victims. They are a major source of decreased quality of life in burn patients due to pain, decreased range of motion, and poor cosmetic appearance.
- Trial name
- NCT03935594
- Testing
- PRP Injection, Saline Injection
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Burn Patients, Psychosocial
Effect of Psychosocial Intervention on Body Image, Self Esteem, Burn Anxiety and Depression Among Patients With Burn
Burn injuries are a widespread health problem, one of the most devastating injuries, and the fourth frequent most type of trauma following traffic accidents, falls, and interpersonal violence, causing death and disability…
- Conditions
- Burn Patients, Psychosocial, Body Image, Self Esteem
- Trial name
- NCT07853794
- Testing
- Psychosocial Intervention
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Ain Shams University
Stress
Associations of Communication Skills Workshop and Improvements in Stress, Burnout and Empathy and Psychometric Properties of Chinese Version of Perceived Stress Scale, Professional Fulfillment and Burnout Scale and Empathy Among Health Care Professionals
This study aims to explore associations of burn out, stress, communication skills, interpersonal effectiveness and empathy level using data collected in pre and post assessments from "Workshop of Enhancing Interpersonal…
- Trial name
- NCT04964102
- Testing
- Workshop of Enhancing Interpersonal Effectiveness, Emotional Regulation and Clinical Communication Skills
- Where
- Taiwan
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Acute Deep Partial Thickness Thermal Burns
Applying Platelet Rich Plasma (PRP) Gel to Acute Deep Partial Thickness Thermal Injuries
The study will examine the safety of using a concentration of proteins from a patient's own blood, referred to as platelet rich plasma or (PRP) and applying it to a second degree burn wound.
- Trial name
- NCT02169362
- Testing
- Autologous Platelet Rich Plasma (PRP) Gel (Magellan® Bio-Bandage™)
- Where
- 8 sites in United States
- Volunteers
- 36 people
- Sponsor
- Arteriocyte, Inc.
Burns, Hand Burn
Effect of Task Oriented Training and Xbox KinectTM on Hand Function in Pediatric Burn
The Jebsen-Taylor Hand Function Test and Canadian Occupational Performance Measure (COPM) were considered as primary outcome measurements.
- Trial name
- HandBurn (NCT04497103)
- Testing
- control, Xbox kinect, task oriented training
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Qassim University
Inflammation, Sleep Deprivation
Circadian Rhythm Disruption Effects on Smoke Inhalation
Particulate matter exposure during smoke inhalation provokes inflammatory immune responses in people exposed to burning biomass including fire fighters and civilians.
- Conditions
- Inflammation, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Shift Work Type, Smoke Inhalation
- Trial name
- NCT04955431
- Testing
- Sleep Restriction, Normal Sleep
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Montana
Microvesicle Particles, Thermal Burn
Pilot Studies Testing the Use of Oral Amitriptyline in Reducing Localized Burn Injury-induced Microvesicle Particle Release
The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). The hypothesis to be tested in this study is that treatment with a single dose of 75mg of amitriptyline…
- Trial name
- NCT07640061
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wright State University
Burns, Gait Dysfunction
The Effect of Mobile Robot Assisted Gait Training on Gait Performance in Chronic Patients With Impaired Gait Function After Burn Injury
This study aims to examine the clinical effectiveness of gait training using wearable robots in patients with impaired gait function after burn injury.
- Conditions
- Burns, Gait Dysfunction, Robot Training
- Trial name
- NCT07277166
- Testing
- wearable robot training
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Hangang Sacred Heart Hospital
Burns, Skin Burn Requiring Skin Graft
Study of Low Adherent Dressing Versus the Standard of Care for the Management of Skin Grafts Over Thermal Burns
The purpose of this study is to evaluate the P6 Low Adherent Study Dressing relative to the Standard of Care (SOC, Mafenide Acetate 5% Solution) for the management of skin grafts in burn wounds resulting from thermal burn…
- Trial name
- NCT01654094
- Testing
- P6 Low Adherent Dressing, Standard of Care (SOC)
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Milliken Healthcare Products, LLC
Burns
Phase 2 Pilot Study of the Safety and Efficacy of Topical MW-III in Thermal Burns
To compare MW-III to Silvadene® Cream 1% (Silver Sulfadiazine) with respect to "time to healing" (≥95% re-epithelialization) of a partial thickness target thermal burn.
- Trial name
- NCT01297400
- Testing
- Investigational Drug, MW-III, Silvadene® Cream 1% [Silver Sulfadiazine]
- Where
- 6 sites in United States, Mexico
- Volunteers
- 60 people
- Sponsor
- Skingenix, Inc.