Clinical trials: Burn Shock
Low Gelsolin, Trauma
Ascending Single Dose Study of Rhu-pGelsolin in Patients With Decreased Gelsolin Levels
This study is designed to assess the pharmacokinetics and safety of an infusion of a single dose of recombinant plasma gelsolin (rhu-pGelsolin) when given to patients admitted to the Intensive Care Unit with documented low levels…
- Conditions
- Low Gelsolin, Trauma, Infection, Burns
- Trial name
- NCT00671307
- Testing
- rhu-pGelsolin
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Critical Biologics Corporation
Burns
Comparison of Fluid Resuscitation in Pediatric Burn Patients Using Crystalloids and With Albumin on Day Two.
The goal of this comparative, interventional randomized controlled trial is to use albumin during resuscitation in pediatric burn patients on day 2, as it can reduce extravasation of fluids and decrease the overall fluid…
- Trial name
- NCT06224777
- Testing
- 5% Albumin (human) Solution, Paeds solution
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- King Edward Medical University
Burn Shock
Evaluation of Sublingual Microcirculation in Burn During Resuscitation
The adequacy of fluid resuscitation will be monitored in burn patients using microcirculation. Microcirculation camera will be placed on the base of the tongue and at different four quadrants.
- Trial name
- NCT05096559
- Testing
- Microcirculation cytocam
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Burns, Growth Factors, Combined Defect of
Keratinocyte Growth Factor and Cytokines in Burns.
KERATINOCYTE GROWTH FACTOR AND CYTOKINES IN SKIN BURNS. INTRODUCTION: Intense inflammatory responses are activated by burns that affect a large total body surface area.
- Conditions
- Burns, Growth Factors, Combined Defect of, Inflammation, Cytokine Storm
- Trial name
- NCT01302223
- Where
- Brazil
- Volunteers
- 8 people
- Sponsor
- Federal University of São Paulo
Burn Shock
Effect of Pre-emptive Intravenous Immunoglobulin (IVIG) on the Incidence of Septic Episodes in Pediatric Burn Patients
Effect of pre-emptive intravenous immunoglobulin administration on the incidence of septic episodes in pediatric burn patients: A randomized controlled study.
- Trial name
- NCT05134792
- Testing
- intravenous immunoglobulin
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hand Burn
The Clinical Utility of Extracorporeal Shock Wave Therapy on Hand Burns
No study has investigated the effect of extracorporeal shock wave therapy (ESWT) on hand function and hypertrophic scar characteristics.
- Trial name
- NCT04138355
- Testing
- Extracorporeal shock wave therapy
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Hangang Sacred Heart Hospital
Burns Shock
Study on Efficacy and Safety of Human Albumin in Burn Shock Recovery
To explore the effects and safety of human albumin in burn shock recovery, and then provide a theoretical basis for its rational use.
- Trial name
- NCT04928859
- Testing
- Albumin
- Volunteers
- 364 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Burn Scar, Burns
Shock Wave Therapy Versus Conventional Physical Therapy for Partial- Thickness Forearm Burn Scars
Burn injuries can lead to significant physical and psychological challenges, particularly when they result in scarring. Burn scars can lead to a variety of complications that significantly impact a patient's quality of life1.
- Trial name
- NCT07234305
- Testing
- Shock wave, Traditional Physical Therapy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- MTI University
Shock, Thermal Burn
VItamin C in Thermal injuRY: The VICToRY Trial
This study aims to show that giving high dose, intravenous vitamin C in addition to standard care to burned critically ill patients will be associated with less organ dysfunction, improved survival and a quicker rate of recovery.
- Trial name
- VICToRY (NCT04138394)
- Testing
- Ascorbic Acid
- Where
- 33 sites in United States, Belgium and 7 more
- Volunteers
- 666 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Burns, Ascorbic Acid Deficiency
Low Dose Vitamin C in Burns >20% Compared to Previous Studies With High Dose Vitamin C
Burn injury is marked by a large release of inflammatory mediators which disrupt the normal capillary barrier and cause a rapid shift of intravascular fluid into interstitial spaces, ultimately leading to shock and death.
- Conditions
- Burns, Ascorbic Acid Deficiency, Burn Shock, Burn Degree Second
- Trial name
- NCT05612867
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Arrowhead Regional Medical Center
Syndecan 1, Severe Burn
Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients
The purpose of this observational study is to examine whether Endotheliopathy of Trauma (EoT) is present in severely burned patients and how it is affected by burn debridement surgery.
- Conditions
- Syndecan 1, Severe Burn, Endotheliopathy of Trauma, Endothelial Glycocalyx
- Trial name
- GlycoBURN (NCT06670248)
- Testing
- Debridement Surgery, Sdc-1 Level Measurement
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Burn Injury
Efficacy of EPSW Plus HILT on Carpal Tunnel Syndrome Post Burn Injury
To study the effect of adding ESWT as a noninvasive short-term treatment plus high-level laser therapy for moderate carpal-tunnel syndrome post-burn injuries.
- Trial name
- NCT05876442
- Testing
- Extracorporeal Shock Wave Therapy., High Intensity Laser Therapy, Traditional Physical Therapy Exercise Program
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Burn Scar
Effect of Extracorporeal Shock Wave Therapy for Burn Scar Charateristics
No study has investigated the effect of extracorporeal shock wave therapy (ESWT) on hypertrophic scar characteristics. Thus, this study aimed to ascertain the effects ESWT on burn scars.
- Trial name
- NCT04187586
- Testing
- Extracorporeal shock wave therapy
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Hangang Sacred Heart Hospital
Hand Injuries, Extracorporeal Shock Wave Therapy
Clinical Utility of ESWT in Restoring Hand Function of Patients With Nerve Injury and Hypertrophic Scars Due to Burns
Joint contractures and nerve injuries are common after hand burns. Extracorporeal shock wave therapy (ESWT) is effective not only for the regeneration of various tissues, including scar tissues, but also for reducing pain and…
- Conditions
- Hand Injuries, Extracorporeal Shock Wave Therapy, Burns
- Trial name
- NCT06438224
- Testing
- Extracorporeal shock wave therapy (ESWT)
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Hangang Sacred Heart Hospital
Multiple Organ Failure
Efficacy of Coenzyme Q10 Supplementation on Multi-Organ Dysfunction in Severely Burned Patients
This multi-center prospective intervention study is designed to develop coenzyme Q10 (CoQ10) supplementation as a cost-effective adjunctive therapy for burn injury.
- Trial name
- NCT03968640
- Testing
- CoQ10
- Where
- United States
- Sponsor
- American Burn Association
Burns, Multiple Organ Failure
Early Haemadsorption in Major Burns
Major deep burns (>20% body surface, involving deep skin layers) and associated severe inflammatory reaction and their complication are one of the biggest challenge of intensive care.
- Conditions
- Burns, Multiple Organ Failure, Shock, Organ Dysfunction Syndrome, Multiple
- Trial name
- NCT04195126
- Testing
- CytoSorb haemadsorption device
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- University of Pecs
Inflammatory Response, Multi Organ Failure
Association of Cytokines With the Development of Complications in Burn and Toxic Epidermal Necrolysis (TENS) Patients
This study will involve blood draws to test for specific cytokines. The study goal is to gain a better understanding of the role of inflammatory response in the development of specific complications in burn and TENS patients.
- Conditions
- Inflammatory Response, Multi Organ Failure, Nosocomial Infection, Deep Vein Thrombosis
- Trial name
- NCT04252651
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Joseph M. Still Research Foundation, Inc.
Sepsis, Burn Injury
Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07249762
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Burn Injury, Acute Wound
Cutaneous Microcirculation After Extracorporeal Shock Wave Therapy
In plastic and reconstructive surgery, treatment strategies of second-degree burns, superficial wounds, hypertrophic burn scars, flaps and chronic wounds aim at reducing infection and improving microcirculation.
- Conditions
- Burn Injury, Acute Wound, Chronic Wound, Burn Scar
- Trial name
- NCT02417779
- Testing
- Extracorporeal Shock Wave Therapy (Device Name: PiezoWave), Repetitive Extracorporeal Shock Wave Therapy (Device Name: PiezoWave)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- University Hospital Schleswig-Holstein