Clinical trials: Butyrate
Metabolic Disease
Butyrate/Hexanoate in Metabolic Health
In this study, we aim to identify a well consumable butyrate/hexanoate-enriched oil that increases circulating SCFA concentrations and improves postprandial substrate metabolism, which could be further used for a long-term study.
- Trial name
- NCT04662411
- Testing
- butyrate and hexanoate amount 1, butyrate and hexanoate amount 2, butyrate and hexanoate amount 3
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm
Evaluating the Effects of Propionate and Butyrate Supplementation on the Intestinal Health of Healthy Volunteers
This clinical trial evaluates how propionate and butyrate supplementation alters intestinal health in healthy volunteers and whether it would be feasible to administer these supplements to patients undergoing allogeneic…
- Conditions
- Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT07611370
- Testing
- Biospecimen Collection, Microencapsulated Sodium Butyrate, Microencapsulated Sodium Propionate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Emotions, Stress
Effects of Butyrate on Affective Processes
The effects of butyrate on psychobiological processes are examined in a sample of healthy volunteers.
- Conditions
- Emotions, Stress, Fear
- Trial name
- NCT04722549
- Testing
- Butyrate
- Where
- Belgium
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Healthy, Gastrointestinal Discomfort
Effects of an Encapsulated Calcium Butyrate Dietary Supplement on Gut Health
The primary objective of this single-arm pilot study is to investigate the effects of an encapsulated calcium butyrate dietary supplement on gastrointestinal (GI) health outcomes in healthy adults, including GI symptom severity…
- Trial name
- NCT06397482
- Testing
- Encapsulated Calcium Butyrate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kemin Foods LC
Healthy
Effects of Butyrate Enemas on Colonic Health
Short chain fatty acids (mainly acetate, propionate and butyrate) are produced in the large intestine by bacterial fermentation of unabsorbed carbohydrates, such as dietary fibers.
- Trial name
- NCT00693355
- Testing
- Sodium butyrate, NaCl
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Health, Subjective, Healthy
RIGHTWHEY - Responders In Gut HealTh Markers Using Fermented WHEY
This 8-week intervention will investigate the effect of daily consumption of a fermented whey concentrate on the short-chain fatty acid profile of faeces in healthy individuals.
- Conditions
- Health, Subjective, Healthy, Microbial Colonization
- Trial name
- RIGHTWHEY (NCT03844152)
- Testing
- Fermented whey concentrate
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Chronic Mesenteric Ischemia
Chronic Mesenteric Ischemia Breath Testing
Background and aims: A gold standard diagnostic test to diagnose chronic mesenteric ischemia is currently lacking. Isotope labelled-butyrate and glucose breath testing could theoretically quantify mucosal oxygen consumption and…
- Trial name
- NCT06022588
- Testing
- Sodium butyrate, 1-13C, 99%, Cambridge Isotope Laboratories, Inc.USA, U-13C6, 99%; Cambridge Isotope Laboratories, Inc.USA, Breath test
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Exercised Induced Asthma, Asthma
The Effects of Prebiotics on Gut Bacterial Parameters, Immune Function & Exercise-Induced Airway Inflammation.
The current study aims to explore the role of prebiotic supplementation in adults with and without Asthma/Exercise-Induced Bronchoconstriction (A/EIB).
- Trial name
- NCT02872675
- Testing
- HOST-DM059, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Ulcerative Colitis
Hydrogen Sulfide Detoxification and Butyrate Metabolism in Ulcerative Colitis
The purpose of this study is to evaluate the relation between sulphide detoxification and butyrate metabolism at the level of gene expression and enzyme activity in ulcerative colitis patients and healthy controls.
- Trial name
- NCT01282905
- Where
- Belgium
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- KU Leuven
PreDiabetes
Study to Determine the Effect of Synbiotics in Patients With Pre-diabetes
The aim of this study is to examine the effect of Metabolic Rheostat™ and Butyrate Ultra on blood glucose levels after a liquid meal challenge in patients with prediabetes.
- Trial name
- Rheostat (NCT04428606)
- Testing
- Metabolic Rheostat, Butyrate Ultra
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhaoping Li
Metabolic Syndrome
ButCoIns GUTS: - Gut Immunological Effects of Resistant Starch and Arabinoxylans in Subjects With Metabolic Syndrome
Dietary fibers including resistent starch, RS, and arabinoxylans, AX, have been shown to have anti-inflammatory effects and to change the composition of the faecal micro flora in the colon.
- Trial name
- NCT01618526
- Testing
- Western Style Diet, Healthy Carbohydrate Diet
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Irritable Bowel Syndrome (IBS), Children, Only
Butyrate in Children With IBS: Double Blind Placebo Controlled Randomized Clinical Trial
We will perform a randomized, double-blind, placebo-controlled trial to establish whether calcium butyrate relieves symptoms in children with irritable bowel syndrome (IBS).
- Trial name
- BUZIR (NCT04566679)
- Testing
- Dibuzin
- Where
- 2 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bari
Hypertension
Gut Butyrate and Blood Pressure in African Americans
African Americans have the greatest burden of hypertension. Recently, the short-chain fatty acid, butyrate, has been reported to have some effect on blood pressure.
- Trial name
- NCT04415333
- Testing
- Sodium Butyrate 5 mmol, Sodium Butyrate 80 mmol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Adults 20 to 80 Years
Boosting Microbiota Butyrate Producers to Improve Gut Health
The human gut microbiota is a dynamic ecosystem essential to health, influenced by diet, age, and lifestyle. It plays a key role in digestion, immunity, and nervous system regulation.
- Trial name
- BOOST-Mi (NCT07198984)
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Contact Dermatitis
Clinical Evaluation of T.R.U.E. TEST® : Safety and Efficacy
We propose an open, prospective, multi-center Phase III study to evaluate the diagnostic performance and safety of seven new T.R.U.E.
- Trial name
- NCT00640614
- Testing
- T.R.U.E. TEST® Skin Patch Test: Dose Response Allergens
- Where
- 5 sites in United States, Denmark
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Allerderm
Endotoxemia, Inflammation
Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function
Short-chain fatty acids (SCFAs) are substances produced by gut bacteria when they ferment dietary fiber. They can act as signals between the gut and the brain and may help regulate the body's immune and stress responses.
- Conditions
- Endotoxemia, Inflammation, Executive Function (Cognition)
- Trial name
- NCT07713641
- Testing
- Short-Chain Fatty Acid Colon-Delivery Capsules, Lipopolysaccharide (LPS)
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Visceral (Hyper)Sensitivity
The Effects of Butyrate Enemas on Visceral Perception
During this double blind, placebo controlled, randomised cross over study, healthy volunteers received an enema once daily for one week containing either placebo (saline), 50mM butyrate or 100mM of butyrate.
- Trial name
- NCT00726817
- Testing
- Butyrate
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Exercise, Overreaching
Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men
The goal of this study is to learn how different amounts of supervised indoor cycling training change gut health (gut bacteria, the substances gut bacteria make, and the gut barrier integrity), and how these changes relate to…
- Conditions
- Exercise, Overreaching, Butyrate, Gut Microbiome
- Trial name
- ICARUS (NCT07481578)
- Testing
- Supplement, Moderate load exercise training, High load exercise training
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stefan De Smet
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Analysis of Microbiota Changes Induced by Microencapsulated Sodium Butyrate in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is characterized by severe inflammation of the small bowel and/or the colon leading to recurrent diarrhea and abdominal pain.
- Trial name
- IBDMicro (NCT04879914)
- Testing
- Butyrate
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Padova
Healthy
Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults
The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota.
- Trial name
- NCT06873204
- Testing
- Soluble Arabinoxylan, Rice Bran
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Purdue University