Clinical trials: Bypass, Cardiopulmonary
Cardio-pulmonary Bypass, AORTIC VALVE DISEASES
Clinical Validation of a Novel Handsfree Doppler Ultrasound Device, RescueDoppler, in Adult Cardiac Surgery Patients
The goal of this study is to evaluate a new device called RescueDoppler (RD), which measures continuous blood flow in the common carotid artery. The device is handsfree and operator- independent.
- Conditions
- Cardio-pulmonary Bypass, AORTIC VALVE DISEASES, Coronary Arterial Disease (CAD), Aortic Aneurysm of the Proximal Arch
- Trial name
- RD_CPB (NCT06637540)
- Testing
- RescueDoppler
- Where
- 3 sites in Norway
- Volunteers
- 42 people
- Sponsor
- St. Olavs Hospital
Heart Failure
CentriMag Ventricular Assist System in Treating Failure-to-Wean From Cardiopulmonary Bypass for Pediatric Patients
The purpose of the study is to evaluate the safety and effectiveness of the CentriMag ventricular assist system to help pediatric patients who have experienced heart failure during surgery and cannot be removed from cardiac…
- Trial name
- NCT01171950
- Testing
- CentriMag Ventricular Assist System
- Sponsor
- Abbott Medical Devices
Cardiac Surgery With Cardiopulmonary Bypass, Valve Heart Disease
Transfusion in Cardiac Valve Surgery
This prospective, randomized controlled study is aimed to figure out suitable transfusion threshold in patients undergoing cardiac valve surgery under cardiopulmonary bypass(CPB).
- Trial name
- TICVS (NCT06332547)
- Testing
- Restrictive Transfusion Strategy, Liberal Transfusion Strategy
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Guangdong Provincial People's Hospital
Cardiovascular Diseases
Groin Complications in Open Vs. Percutaneous Peripheral Cannulation in Minimally Invasive Cardiac Surgery
The aim of this randomized trial is to investigate the groin complications in open vs percutaneous peripheral cannulation for cardiopulmonary bypass in minimally invasive cardiac surgery
- Trial name
- ProGlide-II (NCT05598385)
- Testing
- Open cannulation, Percutaneous cannulation
- Sponsor
- Jessa Hospital
Bloodloss, Surgical Procedures, Operative
A Dose-ranging Safety and Efficacy Study of Ecallantide to Reduce Surgical Blood Loss Volume
The purpose of this study is to assess the efficacy and identify the optimal dose(s) of ecallantide in reducing blood loss in subjects undergoing coronary artery bypass surgery including the use of cardio pulmonary bypass.
- Trial name
- CONSERV-1 (NCT00816023)
- Testing
- ecallantide
- Where
- 29 sites in United States, Canada
- Volunteers
- 276 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Cardiac Surgery With Cardiopulmonary Bypass
Evaluation of Plasma Renin Concentrations in Cardiac Surgery
The purpose of this research is to learn more about how renin (a blood test) is affected by cardiopulmonary bypass, the heart-lung machine used during open heart surgery.
- Trial name
- NCT06895213
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Ischemic Heart Disease
Outcomes Following Myocardial Revascularization: On and Off Cardiopulmonary Bypass
Ischemic heart disease is one of the most frequent diagnoses in the VA system. Moreover, 5,819 coronary artery bypass graft (CABG-only) procedures were performed in the VA in Fiscal Year (FY) 1999.
- Trial name
- ROOBY (NCT00032630)
- Testing
- Coronary artery bypass - on-pump, Coronary artery bypass - off-pump
- Where
- 17 sites in United States
- Volunteers
- 2,203 people
- Sponsor
- US Department of Veterans Affairs
Heart Valve Surgery
Characterizations of Gut Microbiota and Postoperative Sleep in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass
The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass.
- Trial name
- NCT05136001
- Testing
- polysomnography
- Where
- China
- Volunteers
- 36 people
- Sponsor
- China Medical University, China
Renal Failure
Does Nesiritide Provide Renal Protection
This project evaluates whether nesiritide, human recombinant brain natriuretic peptide, confers renal protection during cardiovascular surgery by attenuating the inflammatory response.
- Trial name
- NCT01440881
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Florida
Cardiac Surgery, Cardiopulmonary Bypass
Benefits of GIK in Cardiac Surgery Patients
The purpose of this study is to evaluate the effects of modified glucose - insulin - potassium (GIK) therapy in cardiac surgery patients undergoing cardiopulmonary bypass (CPB).
- Trial name
- NCT01516138
- Testing
- GIK, Control
- Where
- China
- Volunteers
- 930 people
- Sponsor
- Xijing Hospital
Coronary Artery Disease, Low Cardiac Output Syndrome
Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass Grafting
Background: Despite improvements in surgical and anesthesia procedures over the past 15 years complications during cardiac surgery still remain high. Bridgewater B et al.
- Conditions
- Coronary Artery Disease, Low Cardiac Output Syndrome, Atrial Fibrillation, Postoperative Complications
- Trial name
- NCT05514652
- Testing
- Low opioid anesthesia
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Heart Institute, Ministry of Health of Ukraine
Coronary Artery Disease, Anemia
Clinical and Chemical Outcomes Following Cardiac Surgery: The Post-Operative Effects of MUF
It is hypothesized that on-line modified ultrafiltration (MUFF) post-cardiopulmonary bypass will result in improved patient outcomes over the 12-hour post-operative period as compared to control and off-line MUFF.
- Trial name
- MUF (NCT01864395)
- Testing
- Centrifugation Method, Online MUF, Offline MUF
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Saskatchewan
Analgesia
NOL-Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block
This clinical trial focuses on an elaborate, propensity-matched, non-inferiority comparison of NOL-guided Superficial Parasternal Intercostal Plane Block (SPIPB) and Erector Spinae Plane Block (ESPB) within the context of…
- Trial name
- NESP-II (NCT06070701)
- Testing
- Superficial Parasternal Block (SIPB), Erector Spinae Plane Block (ESPB), General anesthetic
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Myocardial Stunning
Safety and Efficacy of IV Diazoxide as an Additive to Hyperkalemic Cardioplegia in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
This study aims to confirm the safety and efficacy of diazoxide as an additive to hyperkalemic cardioplegia in patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT04830982
- Testing
- IV Diazoxide
- Where
- United States
- Sponsor
- Johns Hopkins University
Cardiac On-pump Surgery
Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass
Organ protection, volatile anesthetics, postconditioning. Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane.
- Trial name
- NCT00924222
- Testing
- Sevoflurane, Propofol
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Neurocognitive Outcome After Aortic Valve Replacement
Elimination of Microemboli During Aortic Valve Replacement
In a randomized controlled trial patients undergoing aortic valve replacement are recruited into 3 groups. Patients receive either an intra-aortic filter (Embol-X), designed to reduce solid microemboli during mechanical surgical…
- Trial name
- ELMAR (NCT01128751)
- Testing
- Embol-X intra-aortic emboli filter, DBT dynamic bubble trap, Control group
- Where
- 3 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University of Giessen
Heart Diseases, Cardiovascular Diseases
Algorithmic Protamine Dosing for Reversal of Heparin After Cardiopulmonary Bypass
The PRODOSE trial is investigating a bespoke pharmacokinetic algorithm that calculates a tailored dose of protamine, required after cardiopulmonary bypass to reverse the action of heparin, based on individual patients and their…
- Trial name
- PRODOSE (NCT03532594)
- Testing
- PRODOSE Algorithm, Standard Care
- Where
- United Kingdom
- Volunteers
- 228 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Cardiac Surgery Subjects
Ionized Calcium and Bleeding in Cardiac Surgery
This retrospective study investigates the association between perioperative plasma ionized calcium concentration and perioperative bleeding in open-heart surgery.
- Trial name
- NCT07634042
- Where
- Finland
- Volunteers
- 4,300 people
- Sponsor
- Helsinki University Central Hospital
Cardiovascular Surgical Procedures, Intensive Care
Energy Expenditure Estimation in Cardiac Surgery
Estimation of energy requirements is essential for adequate nutritional support in ICU. Indirect calorimetry being the golden standard of resting energy expenditure estimation is not available in most intensive care units.
- Trial name
- NCT02463123
- Testing
- Indirect calorimetry
- Where
- Russia
- Volunteers
- 240 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Hemostasis
In Vivo Effects of Fibrinogen Concentrate (FC) Versus Cryoprecipitate on the Neonatal Fibrin Network Structure After Cardiopulmonary Bypass (CPB)
This primary aim of this study is to compare the in vivo effects of fibrinogen concentrate and cryoprecipitate on the neonatal fibrin network after surgery with cardiopulmonary bypass to develop effective and safe strategies for…
- Trial name
- NCT03932240
- Testing
- Fibrinogen Concentrate (FC), Cryoprecipitate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Emory University